LOCUS       NP_005724                890 aa            linear   PRI 06-JUN-2024
DEFINITION  kinesin-like protein KIF20A [Homo sapiens].
ACCESSION   NP_005724
VERSION     NP_005724.1
DBSOURCE    REFSEQ: accession NM_005733.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 890)
  AUTHORS   Wu,M., Wu,X. and Han,J.
  TITLE     KIF20A Promotes CRC Progression and the Warburg Effect through the
            C-Myc/HIF-1alpha Axis
  JOURNAL   Protein Pept Lett 31 (2), 107-115 (2024)
   PUBMED   38037834
  REMARK    GeneRIF: KIF20A Promotes CRC Progression and the Warburg Effect
            through the C-Myc/HIF-1alpha Axis.
REFERENCE   2  (residues 1 to 890)
  AUTHORS   Zhang,L., Song,W., Shi,J. and Chen,Y.
  TITLE     Circ_0084188 Regulates the progression of colorectal cancer through
            the miR-769-5p/KIF20A axis
  JOURNAL   Biochem Genet 61 (5), 1727-1744 (2023)
   PUBMED   36763221
  REMARK    GeneRIF: Circ_0084188 Regulates the progression of colorectal
            cancer through the miR-769-5p/KIF20A axis.
REFERENCE   3  (residues 1 to 890)
  AUTHORS   Ye,L., Tong,S., Wang,Y., Wang,Y. and Ma,W.
  TITLE     Grade scoring system reveals distinct molecular subtypes and
            identifies KIF20A as a novel biomarker for predicting temozolomide
            treatment efficiency in gliomas
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 9857-9876 (2023)
   PUBMED   37248320
  REMARK    GeneRIF: Grade scoring system reveals distinct molecular subtypes
            and identifies KIF20A as a novel biomarker for predicting
            temozolomide treatment efficiency in gliomas.
REFERENCE   4  (residues 1 to 890)
  AUTHORS   Liu,B., Su,J., Fan,B., Ni,X. and Jin,T.
  TITLE     High expression of KIF20A in bladder cancer as a potential
            prognostic target for poor survival of renal cell carcinoma
  JOURNAL   Medicine (Baltimore) 102 (2), e32667 (2023)
   PUBMED   36637953
  REMARK    GeneRIF: High expression of KIF20A in bladder cancer as a potential
            prognostic target for poor survival of renal cell carcinoma.
REFERENCE   5  (residues 1 to 890)
  AUTHORS   Jin,Z., Tao,S., Zhang,C., Xu,D. and Zhu,Z.
  TITLE     KIF20A promotes the development of fibrosarcoma via PI3K-Akt
            signaling pathway
  JOURNAL   Exp Cell Res 420 (1), 113322 (2022)
   PUBMED   36037925
  REMARK    GeneRIF: KIF20A promotes the development of fibrosarcoma via
            PI3K-Akt signaling pathway.
REFERENCE   6  (residues 1 to 890)
  AUTHORS   Hill,E., Clarke,M. and Barr,F.A.
  TITLE     The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis
  JOURNAL   EMBO J 19 (21), 5711-5719 (2000)
   PUBMED   11060022
  REMARK    GeneRIF: KIF20A (Rab6KIFL/MKlp2) is required for cytokinesis
REFERENCE   7  (residues 1 to 890)
  AUTHORS   Opdam,F.J., Echard,A., Croes,H.J., van den Hurk,J.A., van de
            Vorstenbosch,R.A., Ginsel,L.A., Goud,B. and Fransen,J.A.
  TITLE     The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type
            specifically expressed and localised to the Golgi apparatus
  JOURNAL   J Cell Sci 113 (Pt 15), 2725-2735 (2000)
   PUBMED   10893188
REFERENCE   8  (residues 1 to 890)
  AUTHORS   Lai,F., Fernald,A.A., Zhao,N. and Le Beau,M.M.
  TITLE     cDNA cloning, expression pattern, genomic structure and chromosomal
            location of RAB6KIFL, a human kinesin-like gene
  JOURNAL   Gene 248 (1-2), 117-125 (2000)
   PUBMED   10806357
REFERENCE   9  (residues 1 to 890)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
REFERENCE   10 (residues 1 to 890)
  AUTHORS   Echard,A., Jollivet,F., Martinez,O., Lacapere,J.J., Rousselet,A.,
            Janoueix-Lerosey,I. and Goud,B.
  TITLE     Interaction of a Golgi-associated kinesin-like protein with Rab6
  JOURNAL   Science 279 (5350), 580-585 (1998)
   PUBMED   9438855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC402781.1, BC012999.2, AK025790.1 and AC106752.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025790.1, BC012999.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394894.8/ ENSP00000378356.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     Protein         1..890
                     /product="kinesin-like protein KIF20A"
                     /note="RAB6 interacting, kinesin-like (rabkinesin6);
                     mitotic kinesin-like protein 2; GG10_2; rabkinesin-6;
                     rab6-interacting kinesin-like protein"
                     /calculated_mol_wt=100147
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Region          63..505
                     /region_name="KISc_KIF23_like"
                     /note="Kinesin motor domain, KIF23-like subgroup; cd01368"
                     /db_xref="CDD:276819"
     Site            order(72,160,163,165..168,408)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276819"
     Site            order(460,463,466)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276819"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK1.
                     /evidence=ECO:0000269|PubMed:12939256,
                     ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            532
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Region          <547..>795
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          602..657
                     /region_name="RBD_KIF20A"
                     /note="RAB6 binding domain (RBD) found in kinesin-like
                     protein KIF20A, and similar proteins; cd21787"
                     /db_xref="CDD:409645"
     Site            order(603..604,606..607,610..612,614..615,618..619,
                     622..623,625..626,629..630,633..634,637..638,640..641,
                     644..645)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:409645"
     Site            order(623,625..626,628..630,632..633,635..637,639)
                     /site_type="other"
                     /note="RAB6 binding site [polypeptide binding]"
                     /db_xref="CDD:409645"
     Site            662
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:12939256; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:12939256; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            685
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Region          763..890
                     /region_name="Globular. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O95235.1)"
     Site            825
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Region          832..865
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O95235.1)"
     Site            857
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            867
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            878
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     Site            883
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O95235.1)"
     CDS             1..890
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /coded_by="NM_005733.3:113..2785"
                     /db_xref="CCDS:CCDS4199.1"
                     /db_xref="GeneID:10112"
                     /db_xref="HGNC:HGNC:9787"
                     /db_xref="MIM:605664"
ORIGIN      
        1 msqgilsppa gllsdddvvv spmfestaad lgsvvrknll sdcsvvstsl edkqqvpsed
       61 smekvkvylr vrpllpsele rqedqgcvri envetlvlqa pkdsfalksn ergigqathr
      121 ftfsqifgpe vgqasffnlt vkemvkdvlk gqnwliytyg vtnsgkthti qgtikdggil
      181 prslalifns lqgqlhptpd lkpllsnevi wldskqirqe emkklsllng glqeeelsts
      241 lkrsvyiesr igtstsfdsg iaglssisqc tsssqldets hrwaqpdtap lpvpanirfs
      301 iwisffeiyn ellydllepp sqqrkrqtlr lcedqngnpy vkdlnwihvq daeeawkllk
      361 vgrknqsfas thlnqnssrs hsifsirilh lqgegdivpk iselslcdla gserckdqks
      421 gerlkeagni ntslhtlgrc iaalrqnqqn rskqnlvpfr dskltrvfqg fftgrgrscm
      481 ivnvnpcast ydetlhvakf saiasqlvha ppmqlgfpsl hsfikehslq vspslekgak
      541 adtgldddie neadismygk eellqvveam ktlllkerqe klqlemhlrd eicnemveqm
      601 qqreqwcseh ldtqkellee myeeklnilk esltsfyqee iqerdekiee leallqearq
      661 qsvahqqsgs elalrrsqrl aasastqqlq evkaklqqck aelnstteel hkyqkmlepp
      721 psakpftidv dkkleegqkn irllrtelqk lgeslqsaer acchstgagk lrqalttcdd
      781 ilikqdqtla elqnnmvlvk ldlrkkaaci aeqyhtvlkl qgqvsakkrl gtnqenqqpn
      841 qqppgkkpfl rnllprtptc qsstdcspya rilrsrrspl lksgpfgkky
//
