LOCUS       NM_006612               7917 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens kinesin family member 1C (KIF1C), mRNA.
ACCESSION   NM_006612 XM_375394
VERSION     NM_006612.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7917)
  AUTHORS   Laragione,T., Harris,C. and Gulko,P.S.
  TITLE     KIF1C and new Huntingtin-interacting protein 1 binding proteins
            regulate rheumatoid arthritis fibroblast-like synoviocytes'
            phenotypes
  JOURNAL   Front Immunol 15, 1323410 (2024)
   PUBMED   38726004
  REMARK    GeneRIF: KIF1C and new Huntingtin-interacting protein 1 binding
            proteins regulate rheumatoid arthritis fibroblast-like
            synoviocytes' phenotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7917)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 7917)
  AUTHORS   Hancock,W.O.
  TITLE     Intracellular transport: KIF1C produces force along with a few
            slips
  JOURNAL   Curr Biol 32 (17), R914-R916 (2022)
   PUBMED   36099894
  REMARK    GeneRIF: Intracellular transport: KIF1C produces force along with a
            few slips.
REFERENCE   4  (bases 1 to 7917)
  AUTHORS   Siddiqui,N., Roth,D., Toleikis,A., Zwetsloot,A.J., Cross,R.A. and
            Straube,A.
  TITLE     Force generation of KIF1C is impaired by pathogenic mutations
  JOURNAL   Curr Biol 32 (17), 3862-3870 (2022)
   PUBMED   35961316
  REMARK    GeneRIF: Force generation of KIF1C is impaired by pathogenic
            mutations.
REFERENCE   5  (bases 1 to 7917)
  AUTHORS   Saji,T., Nishita,M., Ikeda,K., Endo,M., Okada,Y. and Minami,Y.
  TITLE     c-Src-mediated phosphorylation and activation of kinesin KIF1C
            promotes elongation of invadopodia in cancer cells
  JOURNAL   J Biol Chem 298 (7), 102090 (2022)
   PUBMED   35654143
  REMARK    GeneRIF: c-Src-mediated phosphorylation and activation of kinesin
            KIF1C promotes elongation of invadopodia in cancer cells.
REFERENCE   6  (bases 1 to 7917)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 7917)
  AUTHORS   Kopp,P., Lammers,R., Aepfelbacher,M., Woehlke,G., Rudel,T.,
            Machuy,N., Steffen,W. and Linder,S.
  TITLE     The kinesin KIF1C and microtubule plus ends regulate podosome
            dynamics in macrophages
  JOURNAL   Mol Biol Cell 17 (6), 2811-2823 (2006)
   PUBMED   16554367
  REMARK    GeneRIF: Hairpin RNA-based depletion of KIF1C resulted in decreased
            podosome dynamics and ultimately in podosome deficiency.
REFERENCE   8  (bases 1 to 7917)
  AUTHORS   Dorner,C., Ullrich,A., Haring,H.U. and Lammers,R.
  TITLE     The kinesin-like motor protein KIF1C occurs in intact cells as a
            dimer and associates with proteins of the 14-3-3 family
  JOURNAL   J Biol Chem 274 (47), 33654-33660 (1999)
   PUBMED   10559254
REFERENCE   9  (bases 1 to 7917)
  AUTHORS   Dorner,C., Ciossek,T., Muller,S., Moller,P.H., Ullrich,A. and
            Lammers,R.
  TITLE     Characterization of KIF1C, a new kinesin-like protein involved in
            vesicle transport from the Golgi apparatus to the endoplasmic
            reticulum
  JOURNAL   J Biol Chem 273 (32), 20267-20275 (1998)
   PUBMED   9685376
REFERENCE   10 (bases 1 to 7917)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM458656.1, BC034993.1,
            AC012146.25 and BC040307.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006612.5.
            
            Summary: The protein encoded by this gene is a member of the
            kinesin-like protein family. The family members are
            microtubule-dependent molecular motors that transport organelles
            within cells and move chromosomes during cell division. Mutations
            in this gene are a cause of spastic ataxia 2, autosomal recessive.
            [provided by RefSeq, May 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014606.2, BC034993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320785.10/ ENSP00000320821.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BM458656.1         3-33
            32-4217             BC034993.1         8-4193
            4218-7383           AC012146.25        153220-156385       c
            7384-7915           BC040307.1         1756-2287
            7916-7917           AC012146.25        152686-152687       c
FEATURES             Location/Qualifiers
     source          1..7917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..7917
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /note="kinesin family member 1C"
                     /db_xref="GeneID:10749"
                     /db_xref="HGNC:HGNC:6317"
                     /db_xref="MIM:603060"
     exon            1..207
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            208..328
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            329..461
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..3667
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /note="spastic ataxia 2 (autosomal recessive)"
                     /codon_start=1
                     /product="kinesin-like protein KIF1C"
                     /protein_id="NP_006603.2"
                     /db_xref="CCDS:CCDS11065.1"
                     /db_xref="GeneID:10749"
                     /db_xref="HGNC:HGNC:6317"
                     /db_xref="MIM:603060"
                     /translation="MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSK
                     DAPKSFTFDYSYWSHTSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAG
                     KSYTMMGRQEPGQQGIVPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNP
                     KSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSH
                     AVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLT
                     TLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEE
                     TLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGLKT
                     EEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKI
                     IAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDP
                     LMSECLLYHIKDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGA
                     ETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDW
                     NFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDK
                     RSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPR
                     WATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPDGPGDAWRA
                     VARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDR
                     ELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPP
                     SPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPP
                     HDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRPPSPRRSHHPR
                     RNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPPYTTPPRMR
                     RQRSAPDLKESGAAV"
     exon            462..538
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            539..718
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            719..784
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            785..963
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1075
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1153
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1219
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1295
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1374
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1520
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1690
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1770
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1846
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1926
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2021
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2105
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2292
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2365
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2983
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..7917
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4198..4203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /note="hexamer: AATAAA"
     polyA_site      4219
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /note="major polyA site"
     regulatory      7895..7900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
                     /note="hexamer: AATAAA"
     polyA_site      7917
                     /gene="KIF1C"
                     /gene_synonym="LTXS1; SATX2; SAX2; SPAX2; SPG58"
ORIGIN      
        1 agctcgcgct gcccgggcgg gcgccggccg ctggcgccgc tactgctgcc gcccccgggg
       61 cgcgagtccg ccgcccgccg cccgggcacc cggcgagggg cgggggcagc tccgaaccgg
      121 ccccagatcc ttcccgcttc cgcctcacgc ttcccggaaa gcttgtccct ctccgccgag
      181 ctgctccggg agccccgccg cgccgagggt atctcccaga gccccagctg gtgtggccag
      241 gccccaggag taggatgggg ctccccctac gagggccggt ggcagccaga actgatacag
      301 cccccctggt ctggggccag gacgccagct gaggagggca ggagtgtctg gagctatggc
      361 tggtgcctcg gtgaaagtgg cagtgagggt tcggcccttt aacgcccgtg agaccagcca
      421 ggatgccaag tgtgtggtca gcatgcaggg caacaccacc tccatcatca atcctaaaca
      481 gagcaaggat gcccccaaaa gcttcacctt tgactactcc tactggtcac acacttcgac
      541 ggaggacccc cagtttgcat ctcagcagca agtgtatcgg gacattggag aagagatgct
      601 gctccacgcc tttgaaggct acaacgtgtg catctttgcc tatgggcaga ccggggctgg
      661 gaaatcctat accatgatgg ggcgacagga gccagggcag cagggcatcg tgccccagct
      721 ctgtgaggac ctcttctctc gcgttagtga gaaccagagt gctcagctat cctactctgt
      781 ggaggtgagc tatatggaga tctactgtga gcgggtacga gacctcttga accccaagag
      841 tcggggttct ctgcgggtcc gggagcaccc catcctgggc ccgtacgtgc aggacctgtc
      901 caaattggct gtgacctcct acgcagacat tgctgacctc atggactgtg gaaataaagc
      961 acggactgtg gctgccacca acatgaatga gaccagcagc cgttcccatg ccgtctttac
     1021 catcgtcttc acacagcgct gccatgacca gctcacgggg ctggactcgg agaaggtcag
     1081 taagatcagt ttggtggacc ttgctgggag tgagcgagcc gactcctcag gggcccgggg
     1141 catgcgcctg aaggaaggag ccaacatcaa taagtccctg actacactag ggaaagtgat
     1201 ctcggccctt gcagatatgc aatcaaagaa gcgaaagtcg gattttatcc cctacaggga
     1261 ctctgtgctc acctggctgc tcaaggaaaa tttggggggg aactcacgca cagccatgat
     1321 tgcagccctg agccctgctg acatcaatta cgaggagact ctcagcaccc tcaggtatgc
     1381 tgaccgcacc aagcaaatcc gctgcaatgc catcatcaac gaggacccta atgcccggct
     1441 gattagagag ctgcaggagg aagtagcccg gctgcgggaa ctgctgatgg ctcagggact
     1501 gtcagcctct gctctggaag gcctgaagac ggaagaaggg agtgtcagag gcgccctgcc
     1561 agctgtgtca tctcccccag ctccagtttc accctcatca cccaccacac ataatgggga
     1621 gctggagccg tcattctccc ccaacacgga gtcccagatt gggcctgagg aagccatgga
     1681 gaggctgcag gagacagaga agattatagc tgagctgaac gagacatggg aggagaagct
     1741 acgcaagaca gaagccctga ggatggagag agaagcattg ctggctgaga tgggggtggc
     1801 cgtccgggag gatgggggaa ctgtgggcgt cttctctcca aagaagactc cccacctggt
     1861 gaacctgaac gaagaccctc tgatgtctga gtgtctgctc taccacatca aagatggcgt
     1921 caccagggtc ggccaagtag atatggacat caagctgacc ggacagttca ttcgggagca
     1981 acactgtctg ttccggagca tcccccagcc agatggagaa gtggtggtca ctctggagcc
     2041 ttgtgaagga gctgagacat atgtgaatgg gaagcttgtg acggagccgc tggtgctgaa
     2101 gtcagggaat aggattgtga tgggcaagaa ccacgttttc cgcttcaacc acccggagca
     2161 ggcaaggctg gaacgggaac gaggggtccc cccaccccca ggaccgccct ctgagccagt
     2221 cgactggaac tttgcccaga aggaactgct ggagcagcaa ggcatcgaca taaagctgga
     2281 aatggagaag aggctgcagg atctggagaa tcagtaccgg aaagaaaagg aagaagccga
     2341 tcttctgctg gagcagcagc gactgtatgc agactcggac agcggggatg actctgacaa
     2401 gcgctcttgt gaagagagct ggaggctcat ctcctccttg cgggagcagc tgccgcccac
     2461 cacggtccag accattgtca aacgctgtgg tctgcccagc agtggcaagc gcagggcccc
     2521 tcgcagggtt tatcagatcc cccagcgacg caggctgcag ggcaaagacc cccgctgggc
     2581 caccatggct gacctgaaga tgcaggcggt gaaggagatc tgctacgagg tggccctggc
     2641 tgacttccgc cacgggcggg ctgagattga ggccctggcc gccctcaaga tgcgggagct
     2701 gtgtcgcacc tatggcaagc cagacggccc cggagacgcc tggagggctg tggcccggga
     2761 tgtctgggac actgtaggcg aggaggaagg aggtggagct ggcagtggtg gtggcagtga
     2821 ggagggagcc cgaggggcgg aggtggagga cctccgggcc cacatcgaca agctgacggg
     2881 gattctgcag gaggtgaagc tgcagaacag cagcaaggac cgggagctgc aggccctgcg
     2941 ggaccgcatg ctccgcatgg agagggtcat ccccctggcc caggatcatg aggatgagaa
     3001 tgaagaaggt ggtgaggtcc cctgggcccc gcctgaagga tcagaggcag cagaggaggc
     3061 agcccccagt gaccgcatgc cgtcagcccg gcccccctcg ccaccactgt caagctggga
     3121 gcgggtgtca cggctcatgg aggaggaccc tgccttccgt cgtggtcgtc ttcgctggct
     3181 caagcaggag cagctacggc tgcagggact gcagggctct gggggccggg gcggggggct
     3241 gcgcaggccc ccagcccgct ttgtgccccc tcacgactgc aagctacgct tccccttcaa
     3301 gagcaacccc cagcaccggg agtcttggcc agggatgggg agcggggagg ctccaactcc
     3361 gctccaaccc cctgaggagg tcactcccca tccagccacc cctgcccgcc ggcctccgag
     3421 tccccgaagg tcccaccatc cccgcaggaa ctccctggat ggagggggcc gatcccgggg
     3481 agcgggttct gcacagcctg aaccccagca cttccagccc aaaaagcaca actcttatcc
     3541 ccagccaccc caaccctacc cagcccagcg gcccccaggg ccccgctacc ccccatacac
     3601 tactccccca cgaatgagac ggcagcgttc tgcccctgac ctcaaggaga gtggggcagc
     3661 tgtgtgagtc ccacatcctg ggcagagggc ctggtggggc cccttgctag gagaagggaa
     3721 gacgcccgag acgctgcttc cccagaagtg ctggggcagg gaggcccagg agatgagaga
     3781 gaaggtccga gtaggtgata gaagacaagg gggagaccga gccggaggct gaggaaagga
     3841 agagggcacg gagttgccag gagcaaacca aagtgaagag agagatagga agctgcctcg
     3901 gggccacccc ttgcaaaggg ggtgtgtccc acaaacgctg ctatgggtgg ggtggggggc
     3961 tggggtgctg cgtagccagt gtttgacttt cttttcaagt gggggaaagt gggagaggac
     4021 tgagagtgag gcaagttctc cccagcccct gtccgtctgt ctgtctgtct gtggtggttt
     4081 ctgtttcttg ggaggcatgg taggatcata agtcattccc ctccccttcc aggcctcctg
     4141 ctatatttgg gggacctgac tggtttggct ggagtcccat gaggatgtgg gccctttaat
     4201 aaaggatagc aaacagggag cttgtggcct gtttgttttg ggttttcatg gaggtgtagg
     4261 ttatataagg caatggcaca ggtcttaagc atacttatca gtgaagtatt gtatgtgtgc
     4321 tctgtgcagg caccacccag atctggatat aagaatgttt ccatcttgtc ttcctgaact
     4381 tcaccctcct gtctcttcct tcagggtgcg cagcccgatc ttttccccgc tttttttttt
     4441 tgggagacag ggtcttgctt tgttgcccag gctggaggta cagtcttggc tcactgcagc
     4501 ctccgcctcc tgagtagctg ggattacagg catgtgccac cacgcccggc tcattactgt
     4561 tttttttgta gtgacgaggt ttcaccatat tggccaggct ggtctcgaac tcctgatgac
     4621 ctcaagtgat ccgcccacct tggcctccca aagtggtggg attacaggtg tgagccaccg
     4681 cgcccggcct cccctgcttt catgtttgct tacccagtgt ctcagtctgt gccagcagca
     4741 ccactgtctg ttatggacaa agcacagaag cggggatgcg aggggaggta gagggaccgc
     4801 cagcctgtca atgcttaact ggctgttgct gacagataca gaaggatttg tggggtacag
     4861 aggagttctg ctttaagtca cctaacttac ttgaaaggtc tcccaagcag ccagtttctc
     4921 ttgatagtga atgggttggg caagcatact gcgcttacct gattgttttc atcctggttg
     4981 tgttacctgc cttctggcag gctacatcat tgttcccagt cgttatttta tttgtgttaa
     5041 gactgtttgt tggccaggcg cagtggttca cgcctgtaat gccagcactg ggaggccgag
     5101 gcaggtggat cacgaggtca ggagatcgag accatcctgg ctatcatggt gaaaccccat
     5161 ctctactaaa aataaaaata aaaaaattag ccgggcatgg tggcgggggc ctgtagtccc
     5221 agctactcag gaggctgagg caggagaatg gcatgaacct gggaggcgga gcttgcagtg
     5281 agctgagatt gcgccactgc actccagcct gggcgacaga gcgagactcc atttcaagaa
     5341 aaattaaaaa actgtttgtt gcctgcttgt tttaatgttc tggcttgagg cagcgagccc
     5401 ttgactatgc cacattgcca ggattttgca ggttagattg tactacagca ctgcctttgg
     5461 cttgccagac tctggagtcc ccacattttc atcctgttct caggaaaaca ctttgaccca
     5521 cttgaagctc tgagctactg cttcacagct tcctggggtc agtctccagc caaaaccata
     5581 gatatcccaa ctgcagccaa accacggctc tgggcgaagg aacgattagg tttactctag
     5641 gtttccacac cctgatgctc ctgcctttac tttgacacct ctgactgcca ggttttcaca
     5701 gacctgttga cagtgactca agatctggaa tgtaatggat ggtttggcaa cagtgtttgc
     5761 ttgagcagtt taaaatctgg ccagggagac tcaatgtgag caagaaaatg atagaatacc
     5821 aagttttctg gaggtcagag ggagctgagt tgagtgttac cgagaatgct gtggggtttg
     5881 agatgagaaa aatagcttgc taatttaaaa gacggattat ttttccctaa agaccttgac
     5941 ttatgtaaat gtatattatc cataatttta aaaatccact tatggctggg cacagaagct
     6001 cacacctgta atcccagcac tttgggaggc tgaggcagga ggatcagttg agtccaggag
     6061 ttcgagacca gcctgggcaa catagtgaaa ccctgtatct acaaaacata gaaaaactag
     6121 ttgggtgtgg tggtgtgtac ctgtagttcc agctactagg gaggtaggaa gatcacctga
     6181 gcccatggag attgaggctg tggtgagctg tgaaggcacc acagcactct ggcctgggca
     6241 agagtgggac tctctcaaaa aaaaaaaaaa aaaaaaatcc acatatccag ccttccaagt
     6301 cagtctttaa taatgtgcac gggccaggca cagtggctca cacccgtaat cccaacactt
     6361 tggaatatta gggtgggagc atcacttgag gccaggaatt tgagaccagc ctgggcaaca
     6421 tagtgagact gcccccccca tctctacaaa aaataaaaat caaaaataat actgtgggca
     6481 aactttactt agattttatt cagagtagtg cctgtttatt tttcatctgt gctacctgtg
     6541 ccggcattcc atatgcattt gatttagtct ttaaagtacc ccggtaaaat aggtcttttg
     6601 tctgcatttt tcagatggga agactgaggt tttgtttatt tatttttatt tatttatttt
     6661 ttgagacgga gtctcgctct gttgcctagg ctggagtgcg atggcacaat cttggctcac
     6721 tacaacctcc gcttcctggg ttcaagcgat tctcctgcct cagcctcctg agtagctagg
     6781 attacaggcg cccacaaccg cacccggcta attttttgta tctttagtag agacagggtt
     6841 tcactatgtt gtccaagctg gtttcgaatt cctgacctca ggtgatccac ccgcctctgc
     6901 ctcccaaaat gttgggatta caggcgtgag ccaccacgcc cagcctattt atttattttt
     6961 ttagaatcaa gatcttgcta tgttgcccag gctgaactcg aactcctggg ctcaagcaat
     7021 cctgcctccc aagccaagca gctggtactg caagcatgtg ccaccgtgcc tggctcctga
     7081 agactgaggt tggtttagat taatgagttg cccaaattca gacagttctt aagtggcaaa
     7141 gttaggattc caacccaggt caacataact aaagcccaaa ccccatctca cccctctagg
     7201 ccatcaagta ttggctgggt gcggtggttt atgtctgtaa tcccagcact ttgggaggcg
     7261 gaggcgggag gactgtttga gctcaggagt ttgagaccag cctgggcaac ataacaagac
     7321 cctgtctcta caaaaatata taaattagcc gggtgtactg gctcacacct gtagctactt
     7381 gggaggctga ggtgggagga tcgcttgagc ctgggaggtc aaggctgcgg tgacctgtga
     7441 ttgcaccacc aggagaccct gtcttaaaaa tgtatatata aaaataaaaa gaacatcaga
     7501 catcaccatc acctcgctta gaatccatgg ggccttctcc tcaaattcaa tcttcccagg
     7561 catttcatga acttgcgtct agtttctgtt ccctctcaaa ttgcccaggc tgtcctgtga
     7621 gtgacagcag ctatttcgtg ggcctcctct ggaatcatga gaagtcaccc aaacaatctc
     7681 agttttctag ctcactccgt cttgacattt ctacactgtc atccttggtt ttcttggaaa
     7741 ttaatttgct tttcttcatt gtctttcttt ggagctgctt tccttttgtt ggttactatt
     7801 ttatttttag cttctcacac cataccgaca tatgttggtt attcttttag acatgttttt
     7861 tgttgttgtt gtcacctgga acttttgtat cttgaataaa tttggggatc aaataca
//
