LOCUS       NM_153209               3629 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 19 (KIF19), mRNA.
ACCESSION   NM_153209
VERSION     NM_153209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA955730.1, BC110989.1, BE219924.1, AW339468.1, AW014742.1,
            AC103809.2 and AA527573.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153209.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.11422.1,
                                           SRR1660803.66826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389916.5/ ENSP00000374566.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA955730.1         15-36
            23-2613             BC110989.1         1-2591
            2614-3121           BE219924.1         1-508
            3122-3176           AW339468.1         493-547
            3177-3430           AW014742.1         216-469             c
            3431-3454           AC103809.2         14725-14748         c
            3455-3629           AA527573.1         28-202              c
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3629
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /note="kinesin family member 19"
                     /db_xref="GeneID:124602"
                     /db_xref="HGNC:HGNC:26735"
                     /db_xref="MIM:619610"
     exon            1..163
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..3121
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /codon_start=1
                     /product="kinesin-like protein KIF19"
                     /protein_id="NP_694941.2"
                     /db_xref="CCDS:CCDS32718.2"
                     /db_xref="GeneID:124602"
                     /db_xref="HGNC:HGNC:26735"
                     /db_xref="MIM:619610"
                     /translation="MKDSGDSKDQQLMVALRVRPISVAELEEGATLIAHKVDEQMVVL
                     MDPMEDPDDILRAHRSREKSYLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFA
                     YGPTGCGKTYTMLGTDQEPGIYVQTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRD
                     LLNPSLGYLELREDSKGVIQVAGITEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSS
                     RSHAVLQVTVRQRSRVKNILQEVRQGRLFMIDLAGSERASQTQNRGQRMKEGAHINRS
                     LLALGNCINALSDKGSNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISPASSAFEESR
                     NTLTYAGRAKNIKTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKRKIDEQTGRGQAR
                     GRQDRGDIRHIQAEVQLHSGQGEKAGMGQLREQLASAFQEQMDVRRRLLELENRAMEV
                     QIDTSRHLLTIAGWKHEKSRRALKWREEQRKECYAKDDSEKDSDTGDDQPDILEPPEV
                     AAARESIAALVDEQKQLRKQKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLL
                     CRVHELEVENTEMQSHALLRDGALRHRHEAVRRLEQHRSLCDEIIQGQRQIIDDYNLA
                     VPQRLEELYEVYLRELEEGSLEQATIMDQVASRALQDSSLPKITPAGTSLTPDSDLES
                     VKTLSSDAQHLQNSALPPLSTESEGHHVFKAGTGAWQAKSSSVPTPPPIQLGSLVTQE
                     APAQDSLGSWINSSPDSSENLSEIPLSHKERKEILTGTKCIWVKAARRRSRALGTEGR
                     HLLAPATERSSLSLHSLSEGDDARPPGPLACKRPPSPTLQHAASEDNLSSSTGEAPSR
                     AVGHHGDGPRPWLRGQKKSLGKKREESLEAKRRKRRSRSFEVTGQGLSHPKTHLLGPH
                     QAERISDHRMPVCRHPAPGIRHLGKVTLPLAKVKLPPSQNTGPGDSSPLAVPPNPGGG
                     SRRATRGPRLPHGTSTHGKDGCSRHN"
     exon            164..244
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            245..355
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            356..443
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            444..580
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            581..706
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            707..901
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1048
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1171
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1337
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1512
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1711
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1982
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2104
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2238
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2344
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2432
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2830
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2990
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3629
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /note="hexamer: AATAAA"
     polyA_site      3629
                     /gene="KIF19"
                     /gene_synonym="KIF19A"
                     /note="major polyA site"
ORIGIN      
        1 gggttgtcag gcagcgcgcg aggcggcggg cagctagcag ctggcggacg cgacccggag
       61 gcggtggggg tgcggctgag ccatgcccgg tggcgcggcc tgagcccctc cacctgctgc
      121 aatcatgaag gacagcgggg actccaagga ccagcaactc atggtggcgc ttcgggtccg
      181 gcccatcagc gtggcagagc tggaggaagg agctaccctc atcgcccata aagtggatga
      241 gcagatggtg gttctcatgg acccaatgga ggatcccgac gacatcctgc gggcgcatcg
      301 ctcccgggag aagtcctacc tgttcgacgt ggcctttgac ttcaccgcca cccaggagat
      361 ggtgtatcag gccaccacca agagcctcat cgagggcgtc atctcaggct acaatgccac
      421 tgtctttgcc tatggcccca caggctgtgg gaaaacctac accatgctgg gcacagacca
      481 ggagcctggc atctatgttc agaccctcaa cgacctcttc cgtgccatcg aggagaccag
      541 caatgacatg gagtatgagg tctccatgtc ctacctggag atctacaatg agatgatccg
      601 ggacctgctg aacccctccc tgggctacct ggagctgcgg gaggactcta agggggtgat
      661 ccaggtggcc ggcatcaccg aagtctccac catcaatgcc aaggagatca tgcagctgct
      721 gatgaagggg aaccggcaga ggacccagga gcccacggcc gccaaccaga cgtcctcccg
      781 ctcccacgcg gtactgcagg tgaccgtgcg ccagcgcagc cgggtcaaga acatcttgca
      841 ggaggtgcgg cagggccgcc tgttcatgat cgacctggct ggctcagagc gcgcctcgca
      901 gacacagaat cgtgggcagc gtatgaagga gggggcccac atcaaccgct cactgctggc
      961 actgggcaac tgcatcaacg ccctgagcga caagggtagc aacaagtaca tcaactatcg
     1021 cgacagcaag ctcacccggc tcctgaagga ctctctggga ggaaacagcc gcacagtgat
     1081 gatcgctcac atcagtcctg cgagcagtgc cttcgaggag tcccggaaca ccctgaccta
     1141 cgccggccgg gccaagaaca ttaagactag ggtgaagcag aacctcctga acgtctccta
     1201 ccacatcgcc cagtacacca gcatcatcgc tgacctgcgg ggcgagatcc agcgactcaa
     1261 gcgcaagatt gatgagcaga ctgggcgggg ccaggcccgg ggccggcagg atcggggtga
     1321 catccgccac atccaagctg aggtccagct gcacagcggg cagggtgaga aggctggcat
     1381 gggacagctt cgggagcagc tcgccagcgc cttccaggag cagatggatg tgcggaggcg
     1441 cctgctggag ctggagaacc gcgccatgga ggtccagatt gacacctccc gacacctgct
     1501 caccatcgcc ggctggaagc atgagaagtc ccgccgggcc ctcaaatggc gggaggagca
     1561 gcgaaaggag tgctacgcta aggacgacag cgagaaggac tcagacacag gtgatgacca
     1621 accagacatc ctggagccac ccgaggtggc cgcagcccgg gagagcattg cagccctggt
     1681 ggacgagcag aagcaactgc gcaagcagaa gctggcgctg gagcagcgct gccgggagct
     1741 gcgcgcgcgg ggccggcgcc tggaggagac gctgccgcgg cgcatcggct ccgaggagca
     1801 gcgcgaggtg ctcagcctgc tgtgccgcgt gcacgagctc gaggtggaga acaccgagat
     1861 gcagtcgcac gcgctgctcc gcgacggtgc gctccgccac cgccacgagg ccgtgcgccg
     1921 cctggagcag caccgcagtc tctgcgacga gattatccag ggccagcggc agatcatcga
     1981 cgactacaac ctggccgtcc cgcagcgcct ggaagagctc tacgaagtgt acctgcggga
     2041 gctggaggag ggcagcctgg agcaggccac catcatggac caagtggcct ccagggccct
     2101 gcaggacagc tccttgccca aaattacccc agcaggaacc tcactgaccc cagattctga
     2161 cctggagagt gtgaagacat tgagctctga tgcccagcac ctgcagaaca gcgccctccc
     2221 tcccctcagc acagagagtg aaggccacca cgtgttcaag gctggtactg gggcctggca
     2281 ggcaaaaagc tcctctgtgc ccaccccacc tcccatccag ctcggcagcc tggtgacgca
     2341 ggaggccccg gctcaggaca gcctgggcag ctggatcaac tcttcccctg acagcagtga
     2401 gaacctgtcg gagatcccct tgtcccacaa agagaggaag gagatcctga ctggcaccaa
     2461 gtgcatctgg gtgaaggccg cccggcggcg ctcgcgggcc ctgggaaccg aggggcgaca
     2521 cctgctggca cccgcgacag agcgcagcag cctgtccctg cactcactga gcgagggcga
     2581 cgatgcgcgg ccaccaggcc cactggcctg caagcggccg cccagcccca cactacagca
     2641 tgctgccagt gaggacaacc tgtccagcag cacgggcgag gccccgtccc gggcagtcgg
     2701 acatcatggg gacggcccca ggccctggct gcgtggccag aagaaaagcc tgggcaagaa
     2761 aagggaggag tcgctggagg caaagagaag gaagcggagg tcccgatcct tcgaggtcac
     2821 cgggcaaggg ctctcccacc ccaagacaca cctcctgggg ccccatcagg cggagcgcat
     2881 ctcggaccac aggatgccag tgtgcaggca cccagcccct ggtatccggc atctgggaaa
     2941 ggtcacgcta cctttggcca aagtcaaact ccctccaagc cagaacacgg gcccggggga
     3001 ctcctcaccc ctggctgttc cccccaaccc aggtggtggt tctcgacggg ctacccgtgg
     3061 gccccgcctg ccccacggca caagcaccca tggcaaagat ggatgctccc ggcataactg
     3121 aggggccctg cctggaactg gctctctcac ctcccaagac tgaatggggt ctagcagggc
     3181 atgggaggtg gaggctgggc agatggagat gaccaggaag taagctcagg atctcagcag
     3241 gccagggctc ctgagaccca ggaactgggg tctctgccca accctcccat gctttcagtg
     3301 ccactgggga aaagaggtga ggccagggga catggccagg acggctgggc tccctggctt
     3361 cccagccctg gacagaatgc tgttgccaaa acctgcacag ccctgaggcc agcctcggcc
     3421 ttggtaacgg aggaaagcag ctgacagtga gacggggctc ctggcccacg tgtggggcac
     3481 gggcatcctg gatggttggg gaggcgccga caggcacttc acgtattaca attggggatg
     3541 tgggtgaggg agggaatctg gttttgttac ttggcagtgg ttttttctca cccttccttt
     3601 ttaacaataa aatcccattt gggtcttga
//
