LOCUS       NM_001265577            4088 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens kinesin family member 18B (KIF18B), transcript variant
            1, mRNA.
ACCESSION   NM_001265577
VERSION     NM_001265577.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4088)
  AUTHORS   Gan,L.H., Yao,L., Yan,J.H., Huang,Y.Q., Zheng,L., Liu,P. and Lei,L.
  TITLE     Differential Expression of KIF18B in Gastric Cancer and Its Role in
            Chemotherapy Sensitivity
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 37-48 (2024)
   PUBMED   38305287
  REMARK    GeneRIF: Differential Expression of KIF18B in Gastric Cancer and
            Its Role in Chemotherapy Sensitivity.
REFERENCE   2  (bases 1 to 4088)
  AUTHORS   Ishikawa,A., Yasumatsu,R., Fukui,T., Kido,A., Katsuya,N.,
            Sentani,K., Kuraoka,K., Oue,N., Suzuki,T., Oka,S., Kotachi,T.,
            Tanabe,K., Ohdan,H., Ashktorab,H., Smoot,D. and Yasui,W.
  TITLE     Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and
            Contributes to Gastric Cancer Progression by Regulating
            Epithelial-Mesenchymal Transition
  JOURNAL   Oncology 102 (4), 354-365 (2024)
   PUBMED   37812924
  REMARK    GeneRIF: Kinesin Family Member B18 Is Related to Gastric Mucin
            Phenotype and Contributes to Gastric Cancer Progression by
            Regulating Epithelial-Mesenchymal Transition.
REFERENCE   3  (bases 1 to 4088)
  AUTHORS   Xie,J., Wang,B., Luo,W., Li,C. and Jia,X.
  TITLE     Upregulation of KIF18B facilitates malignant phenotype of
            esophageal squamous cell carcinoma by activating CDCA8/mTORC1
            pathway
  JOURNAL   J Clin Lab Anal 36 (10), e24633 (2022)
   PUBMED   36085568
  REMARK    GeneRIF: Upregulation of KIF18B facilitates malignant phenotype of
            esophageal squamous cell carcinoma by activating CDCA8/mTORC1
            pathway.
REFERENCE   4  (bases 1 to 4088)
  AUTHORS   Ke,H., Wu,S., Zhang,Y. and Zhang,G.
  TITLE     miR-139-3p/Kinesin family member 18B axis suppresses malignant
            progression of gastric cancer
  JOURNAL   Bioengineered 13 (2), 4528-4536 (2022)
   PUBMED   35137670
  REMARK    GeneRIF: miR-139-3p/Kinesin family member 18B axis suppresses
            malignant progression of gastric cancer.
REFERENCE   5  (bases 1 to 4088)
  AUTHORS   Hong,B., Lu,R., Lou,W., Bao,Y., Qiao,L., Hu,Y., Liu,K., Chen,J.,
            Bao,D., Ye,M., Fang,Z., Gong,C. and Zhang,X.
  TITLE     KIF18b-dependent hypomethylation of PARPBP gene promoter enhances
            oxaliplatin resistance in colorectal cancer
  JOURNAL   Exp Cell Res 407 (2), 112827 (2021)
   PUBMED   34508743
  REMARK    GeneRIF: KIF18b-dependent hypomethylation of PARPBP gene promoter
            enhances oxaliplatin resistance in colorectal cancer.
REFERENCE   6  (bases 1 to 4088)
  AUTHORS   Itzel,T., Scholz,P., Maass,T., Krupp,M., Marquardt,J.U., Strand,S.,
            Becker,D., Staib,F., Binder,H., Roessler,S., Wang,X.W.,
            Thorgeirsson,S., Muller,M., Galle,P.R. and Teufel,A.
  TITLE     Translating bioinformatics in oncology: guilt-by-profiling analysis
            and identification of KIF18B and CDCA3 as novel driver genes in
            carcinogenesis
  JOURNAL   Bioinformatics 31 (2), 216-224 (2015)
   PUBMED   25236463
  REMARK    GeneRIF: High KIF18B expression is associated with neoplasms.
REFERENCE   7  (bases 1 to 4088)
  AUTHORS   Stout,J.R., Yount,A.L., Powers,J.A., Leblanc,C., Ems-McClung,S.C.
            and Walczak,C.E.
  TITLE     Kif18B interacts with EB1 and controls astral microtubule length
            during mitosis
  JOURNAL   Mol Biol Cell 22 (17), 3070-3080 (2011)
   PUBMED   21737685
  REMARK    GeneRIF: Kif18B is a new microtubule dynamics regulatory protein
            that interacts with EB1 to control astral microtubule length
REFERENCE   8  (bases 1 to 4088)
  AUTHORS   Tanenbaum,M.E., Macurek,L., van der Vaart,B., Galli,M.,
            Akhmanova,A. and Medema,R.H.
  TITLE     A complex of Kif18b and MCAK promotes microtubule depolymerization
            and is negatively regulated by Aurora kinases
  JOURNAL   Curr Biol 21 (16), 1356-1365 (2011)
   PUBMED   21820309
  REMARK    GeneRIF: Results uncover a novel role for Aurora A/B kinases in
            regulating spindle MT dynamics through Kif18b-MCAK and suggest that
            the Kif18b-MCAK complex constitutes the major MT plus-end
            depolymerizing activity in mitotic cells.
REFERENCE   9  (bases 1 to 4088)
  AUTHORS   Lee,Y.M., Kim,E., Park,M., Moon,E., Ahn,S.M., Kim,W., Hwang,K.B.,
            Kim,Y.K., Choi,W. and Kim,W.
  TITLE     Cell cycle-regulated expression and subcellular localization of a
            kinesin-8 member human KIF18B
  JOURNAL   Gene 466 (1-2), 16-25 (2010)
   PUBMED   20600703
  REMARK    GeneRIF: the expression of KIF18B is regulated in a cell
            cycle-dependent manner and therefore may play an important role(s)
            in cell division.
REFERENCE   10 (bases 1 to 4088)
  AUTHORS   Miki,H., Okada,Y. and Hirokawa,N.
  TITLE     Analysis of the kinesin superfamily: insights into structure and
            function
  JOURNAL   Trends Cell Biol 15 (9), 467-476 (2005)
   PUBMED   16084724
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015936.14, BX405609.2, BC136590.1 and BC067365.1.
            
            On May 17, 2019 this sequence version replaced NM_001265577.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2555240.1,
                                           SRR18074967.2302836.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000593135.6/ ENSP00000465992.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC015936.14        122033-122094       c
            63-131              BX405609.2         1-69
            132-132             AC015936.14        121963-121963       c
            133-147             BX405609.2         70-84
            148-2807            BC136590.1         12-2671
            2808-4088           BC067365.1         1171-2451
FEATURES             Location/Qualifiers
     source          1..4088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4088
                     /gene="KIF18B"
                     /note="kinesin family member 18B"
                     /db_xref="GeneID:146909"
                     /db_xref="HGNC:HGNC:27102"
                     /db_xref="MIM:614570"
     exon            1..146
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            147..473
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2719
                     /gene="KIF18B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF18B"
                     /codon_start=1
                     /product="kinesin-like protein KIF18B isoform 1"
                     /protein_id="NP_001252506.1"
                     /db_xref="CCDS:CCDS45709.2"
                     /db_xref="GeneID:146909"
                     /db_xref="HGNC:HGNC:27102"
                     /db_xref="MIM:614570"
                     /translation="MAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEE
                     PDGGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYN
                     CSVFAYGATGAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYN
                     EQIHDLLEPKGPLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDAN
                     ATSSRSHAIFQIFVKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGAN
                     INRSLLALINVLNALADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLT
                     YEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEG
                     GGQPPPQDLPGSPKSGPPPEHQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQE
                     QSPEDEDEGPAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLA
                     LKVLCVAQRQYSLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPL
                     AQELCSESIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWP
                     MEKKRRRPSALEADSPMAPKRGTKRQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASS
                     PCHSPRVCPATVIKSRVPLGPSAMQNCSTPLALPTRDLNATFDLSEEPPSKPSFHECI
                     GWDKIPQELSRLDQPFIPRAPVPLFTMKGPKPTSSLPGTSACKKKRVASSSVSHGRSR
                     IARLPSSTLKRPAGPLVLPELPLSPLCPSNRRNGKDLIRVGRALSAGNGVTKVS"
     exon            474..631
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            632..736
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            737..847
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1045
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1222
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1297
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1398
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1549
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1677
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1883
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2436
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2526
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2612
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..4088
                     /gene="KIF18B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4069..4074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF18B"
                     /note="hexamer: AATAAA"
     polyA_site      4088
                     /gene="KIF18B"
                     /note="major polyA site"
ORIGIN      
        1 aatttgaacg caaggcgccg ggtggaggtt ggcgcgggta ggggagggtg tggggcgctc
       61 tctcccggtg tgggtactgc tgtctgtggt gtggctgtgg gacccgtgag caagcagcga
      121 cgccagcggc ggagaaccga cgaaaggtgt caccacagtg atggcagtgg aggacagcac
      181 gctgcaagta gtggtacggg tgcggccccc cacccctcgg gagctggaca gtcagcggcg
      241 gccagtggtt caggtggtgg acgagcgggt gctggtgttt aaccctgagg agcccgatgg
      301 agggttccct ggcctgaaat ggggtggcac ccatgatggc cccaagaaga agggcaaaga
      361 cctgacgttt gtctttgacc gggtctttgg cgaggcggcc acccaacagg acgtgttcca
      421 gcacaccacg cacagcgtcc tggacagctt cctccagggc tacaactgct cagtgtttgc
      481 ctacggggcc accggggctg ggaagacaca caccatgctg ggaagggagg gggaccccgg
      541 catcatgtac ctgaccaccg tggaactgta caggcgcctg gaggcccgcc agcaggagaa
      601 gcacttcgag gtgctcatca gctaccagga ggtgtataat gaacagatcc atgacctcct
      661 ggagcccaag gggccccttg ccatccgcga ggaccccgac aagggggtgg tggtgcaagg
      721 actttctttc caccagccag cctcagccga gcagctgctg gagatactga ccagggggaa
      781 ccgtaaccgc acgcagcacc ccactgatgc caacgcgact tcctcccgct cccatgccat
      841 cttccagatc tttgtgaagc agcaggaccg ggttccagga ctgacccagg ctgtccaggt
      901 ggccaagatg agcctgattg acctggctgg ctcagagcgg gcatccagca cccatgcgaa
      961 gggggagcgg ctgcgggagg gggccaacat caaccgctct ctgctggcgc tcatcaacgt
     1021 cctcaatgcc ttggccgatg caaagggccg caagacccat gtgccctacc gggacagcaa
     1081 actgacccgc ctgctcaaag actccctcgg gggcaactgc cgcacagtga tgatcgctgc
     1141 catcagcccc tccagcctga cctacgagga cacgtacaac accctcaaat atgccgaccg
     1201 ggccaaggag atcaggctct cgctgaagag caatgtgacc agcctggact gtcacatcag
     1261 ccagtatgct accatctgcc aacagctcca ggctgaggta gccgctctga ggaagaagct
     1321 ccaagtgtat gaggggggag gccagccccc accacaggac ctcccaggat ctcccaagtc
     1381 gggaccacca ccagaacacc agccctgcac cccagagctc cctgcagggc ctagagccct
     1441 tcaagaggag agtctgggga tggaggccca ggtggagagg gccatggaag ggaactcttc
     1501 agaccaggag cagtccccag aggatgagga tgaaggccca gctgaggagg ttccaaccca
     1561 gatgccagag cagaacccca cacatgcact gccagagtcc cctcgcctga ccctgcagcc
     1621 caagccagtc gtgggccact tctcagcacg ggaactggat ggggaccgtt ctaagcagtt
     1681 ggccctaaag gtgctgtgcg ttgcccagcg gcagtactcc ctgctccaag cagccaacct
     1741 cctgacgccc gacatgatca cagagtttga gaccctacag cagctggtgc aagaggaaaa
     1801 aattgagcct ggggcagagg ccttgaggac ttcaggcctg gccagggggg cacctctggc
     1861 tcaggagctg tgttcagagt caatccctgt gccgtctcct ctctgcccag agcctccagg
     1921 atacactggc cctgtgaccc ggactatggc gaggcgactg agtggccccc tgcacaccct
     1981 gggaatcccg cctggaccca actgcacccc agcccagggg tcccgatggc ccatggagaa
     2041 gaagaggagg agaccaagcg ccttggaggc agacagtccc atggccccaa agcggggcac
     2101 caagcgccag cgccagtcct tcctgccctg cctaaggaga gggtctctgc ctgacaccca
     2161 accttcacag gggcccagca cccccaaagg agaaagggcc tcctccccct gccattcccc
     2221 tcgcgtttgc ccagccacag tcatcaaaag ccgggtgccc ctgggccctt ccgccatgca
     2281 gaactgctcc accccgctgg ctctgcccac tcgagacctc aatgccacct ttgatctctc
     2341 tgaggagcct ccctcaaagc ccagtttcca tgaatgcatt ggctgggaca aaatacccca
     2401 ggagctgagc aggctggacc agcccttcat ccccagggca cctgtgcccc tgttcaccat
     2461 gaagggcccc aagccaacat cttccctccc tgggacctct gcctgcaaga agaagcgcgt
     2521 tgcgagttcc tcagtctccc atggccgcag ccgcatcgcc cgcctcccca gcagcacttt
     2581 gaagaggcca gctgggcccc ttgtactccc agagctgccc ttgagtcccc tgtgccctag
     2641 caaccggagg aatggaaagg acctcatcag ggtggggaga gcactctcag cagggaacgg
     2701 cgtcaccaag gtgtcctgac cgccagaatg tcctgaccac caaggtgtcc taacctaccg
     2761 gcccctctgc tggatacccc tcttggacct gtagccacct gcaccaggag ctggacctgc
     2821 cttccttacc tgggagcaat tagtgccaac acacctttgc tgtattaaca tccctcccca
     2881 gacatccatc ctgctactca ccctctgtta atctcctgtt acactcagct tcttggcatg
     2941 tacatattca tttgtgagtg ttaatgtgct gctgtttttt gttttttggt ggtttttgtt
     3001 ttttgttttt tttgttttga gatggagtct tactctgtcg cccaggctgg agtgcagtgg
     3061 tacgatcttg gctcactgca acctccgcct cctgggttca agtaattctc ctgcctcagc
     3121 tttccaagta gctgggatta caggcaccca tcaccacacc cagctaattt tcgtcttttt
     3181 aatagagagg gggtttttcc atgttggcca ggctggtctt gaactcctga cctcaggtga
     3241 tccgcctgcc tcagcttccc aaagtgctga gattacaggc atgagctacc acgcctggcc
     3301 cgtgttgctg ttttaaaggt gctgccatgt tcccccatct tttttttttt tgagatggag
     3361 tctcgctctg tcgcccaggc tggagtgcag tggtggcgat cttggctcac tgcaagctcc
     3421 gcctcccagg ttcacaccat tctcctgcct cagcctccca agtagctggg actacaggcg
     3481 cccaccacca cgcctggcta attttttgta tttttagtag agatggggtt tcaccgtgtt
     3541 agccaggctg gtctcgatct gacctcatga tccacccgcc tcggcctccc aaagtgctgg
     3601 gattacaggc gtgagccact gcgcccggcc tcccctctca tttatgatgc cctctgtgca
     3661 ggcagacggc tcttgggctc ttttccccac ctgtctctaa cacaggcccc acggtgatgg
     3721 ccacaggcag tagaggagga atgaggatgg gttggggagc ggggagtcgc ggcttggctc
     3781 ttcctggttt ctgagaggga catcttcatc cctactcccc ttggtcccca accacagtcc
     3841 tggtgaagat gtggatgata atggtgcctt gatttccaaa tgaagacagc tttattgctt
     3901 aactctattg tacataggat acacgttcag tgtaaaataa agtgtaaagg ggaattcagg
     3961 cttaatgctg cacctagata taaatgctaa tgatacttgg gtttatagcc ttctgatcct
     4021 ttatttctgc atatatatat agatatatac atatattttt ggtataacaa taaaccgtct
     4081 ccatcctt
//
