LOCUS       NM_031217               3417 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens kinesin family member 18A (KIF18A), mRNA.
ACCESSION   NM_031217
VERSION     NM_031217.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Ren,J., Yao,X., Yang,M., Cheng,S., Wu,D., Xu,K., Li,R., Zhang,H.
            and Zhang,D.
  TITLE     Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and
            Metastasis in Hepatocellular Carcinoma
  JOURNAL   Dig Dis Sci 69 (4), 1274-1286 (2024)
   PUBMED   38446308
  REMARK    GeneRIF: Kinesin Family Member-18A (KIF18A) Promotes Cell
            Proliferation and Metastasis in Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   Zhang,H., Xia,T., Xia,Z., Zhou,H., Li,Z., Wang,W., Zhai,X. and
            Jin,B.
  TITLE     KIF18A inactivates hepatic stellate cells and alleviates liver
            fibrosis through the TTC3/Akt/mTOR pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 96 (2024)
   PUBMED   38372748
  REMARK    GeneRIF: KIF18A inactivates hepatic stellate cells and alleviates
            liver fibrosis through the TTC3/Akt/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3417)
  AUTHORS   Sun,F. and Zhao,T.
  TITLE     KIF18A promotes cervical squamous cell carcinoma progression by
            activating the PI3K/AKT pathway through upregulation of CENPE
  JOURNAL   Cancer Biomark 41 (2), 165-178 (2024)
   PUBMED   39331093
  REMARK    GeneRIF: KIF18A promotes cervical squamous cell carcinoma
            progression by activating the PI3K/AKT pathway through upregulation
            of CENPE.
REFERENCE   4  (bases 1 to 3417)
  AUTHORS   Risteski,P., Bozan,D., Jagric,M., Bosilj,A., Pavin,N. and
            Tolic,I.M.
  TITLE     Length-dependent poleward flux of sister kinetochore fibers
            promotes chromosome alignment
  JOURNAL   Cell Rep 40 (5), 111169 (2022)
   PUBMED   35926461
  REMARK    GeneRIF: Length-dependent poleward flux of sister kinetochore
            fibers promotes chromosome alignment.
REFERENCE   5  (bases 1 to 3417)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3417)
  AUTHORS   Luboshits,G. and Benayahu,D.
  TITLE     MS-KIF18A, a kinesin, is associated with estrogen receptor
  JOURNAL   J Cell Biochem 100 (3), 693-702 (2007)
   PUBMED   17006958
REFERENCE   7  (bases 1 to 3417)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   8  (bases 1 to 3417)
  AUTHORS   Luboshits,G. and Benayahu,D.
  TITLE     MS-KIF18A, new kinesin; structure and cellular expression
  JOURNAL   Gene 351, 19-28 (2005)
   PUBMED   15878648
REFERENCE   9  (bases 1 to 3417)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 3417)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB080843.1, AL136819.1 and AW770226.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031217.3.
            
            Summary: KIF18A is a member of the kinesin superfamily of
            microtubule-associated molecular motors (see MIM 148760) that use
            hydrolysis of ATP to produce force and movement along microtubules
            (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM,
            Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY791349.1, AL136819.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263181.7/ ENSP00000263181.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB080843.1         44-53
            11-3037             AL136819.1         1-3027
            3038-3417           AW770226.1         4-383               c
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.1"
     gene            1..3417
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /note="kinesin family member 18A"
                     /db_xref="GeneID:81930"
                     /db_xref="HGNC:HGNC:29441"
                     /db_xref="MIM:611271"
     exon            1..93
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            94..464
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2836
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /note="protein phosphatase 1, regulatory subunit 99"
                     /codon_start=1
                     /product="kinesin-like protein KIF18A"
                     /protein_id="NP_112494.3"
                     /db_xref="CCDS:CCDS7867.1"
                     /db_xref="GeneID:81930"
                     /db_xref="HGNC:HGNC:29441"
                     /db_xref="MIM:611271"
                     /translation="MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVF
                     DPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFL
                     NGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYL
                     EVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHP
                     TDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFV
                     EGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSP
                     SSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLK
                     AYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKEN
                     ELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDEN
                     TNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQH
                     RQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQP
                     KQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTL
                     KSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNIN
                     SDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQ
                     RLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQ
                     DNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR"
     exon            465..622
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            623..727
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            728..838
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1036
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1213
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1288
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1401
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1564
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1729
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1851
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2087
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2535
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2643
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2753
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..3417
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /note="hexamer: ATTAAA"
     polyA_site      3417
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /note="major polyA site"
ORIGIN      
        1 gtggttgagt ctgaagcgct gggaggcgga cattaaagtg aagtggttgc ggtaacctgg
       61 cctgggcctg aagtgagtga gaggcacatg aagagaagta ttcaagtatt tatacagata
      121 ggaatcaaga taatcaacaa tgtctgtcac tgaggaagac ctgtgccacc atatgaaagt
      181 agtagttcgt gtacgtccgg aaaacactaa agaaaaagca gctggatttc ataaagtggt
      241 tcatgttgtg gataaacata tcctagtttt tgatcccaaa caagaagaag tcagtttttt
      301 ccatggaaag aaaactacaa atcaaaatgt tataaagaaa caaaataagg atcttaaatt
      361 tgtatttgat gctgtttttg atgaaacgtc aactcagtca gaagtttttg aacacactac
      421 taagccaatt cttcgtagtt ttttgaatgg atataattgc acagtacttg cctatggtgc
      481 cactggtgct gggaagaccc acactatgct aggatcagct gatgaacctg gagtgatgta
      541 tctaacaatg ttacaccttt acaaatgcat ggatgagatt aaagaagaga aaatatgtag
      601 tactgcagtt tcatatctgg aggtatataa tgaacagatt cgtgatctct tagtaaattc
      661 agggccactt gctgtccggg aagataccca aaaaggggtg gtcgttcatg gacttacttt
      721 acaccagccc aaatcctcag aagaaatttt acatttattg gataatggaa acaaaaacag
      781 gacacaacat cccactgata tgaatgccac atcttctcgt tctcatgctg ttttccaaat
      841 ttacttgcga caacaagaca aaacagcaag tatcaatcaa aatgtccgta ttgccaagat
      901 gtcactcatt gacctggcag gatctgagcg agcaagtact tccggtgcta aggggacccg
      961 atttgtagaa ggcacaaata ttaatagatc acttttagct cttgggaatg tcatcaatgc
     1021 cttagcagat tcaaagagaa agaatcagca tatcccttac agaaatagta agcttactcg
     1081 cttgttaaag gattctcttg gaggaaactg tcaaactata atgatagctg ctgttagtcc
     1141 ttcctctgta ttctacgatg acacatataa cactcttaag tatgctaacc gggcaaagga
     1201 cattaaatct tctttgaaga gcaatgttct taatgtcaat aatcatataa ctcaatatgt
     1261 aaagatctgt aatgagcaga aggcagagat tttattgtta aaagaaaaac taaaagccta
     1321 tgaagaacag aaagccttca ctaatgaaaa tgaccaagca aagttaatga tttcaaaccc
     1381 tcaggaaaaa gaaatcgaaa ggtttcaaga aatcctgaac tgcttgttcc agaatcgaga
     1441 agaaattaga caagaatatc tgaagttgga aatgttactt aaagaaaatg aacttaaatc
     1501 attctaccaa caacagtgcc ataaacaaat agaaatgatg tgttctgaag acaaagtaga
     1561 aaaggccact ggaaaacgag atcatagact tgcaatgttg aaaactcgtc gctcctacct
     1621 ggagaaaagg agggaggagg aattgaagca atttgatgag aatactaatt ggctccatcg
     1681 tgtcgaaaaa gaaatgggac tcttaagtca aaacggtcat attccaaagg aactcaagaa
     1741 agatcttcat tgtcaccatt tgcacctcca gaacaaagat ttgaaagcac aaattagaca
     1801 tatgatggat ctagcttgtc ttcaggaaca gcaacacagg cagactgaag cagtattgaa
     1861 tgctttactt ccaaccctaa gaaaacaata ttgcacatta aaagaagccg gcctgtcaaa
     1921 tgctgctttt gaatctgact tcaaagagat cgaacatttg gtagagagga aaaaagtggt
     1981 agtttgggct gaccaaactg ccgaacaacc aaagcaaaac gatctaccag ggatttctgt
     2041 tcttatgacc tttccacaac ttggaccagt tcagcctatt ccttgttgct catcttcagg
     2101 tggaactaat ctggttaaga ttcctacaga aaaaagaact cggagaaaac taatgccatc
     2161 tcccttgaaa ggacagcata ctctaaagtc tccaccatct caaagtgtgc agctcaatga
     2221 ttctcttagc aaagaacttc agcctattgt atatacacca gaagactgta gaaaagcttt
     2281 tcaaaatccg tctacagtaa ccttaatgaa accatcatca tttactacaa gttttcaggc
     2341 tatcagctca aacataaaca gtgataattg tctgaaaatg ttgtgtgaag tagctatccc
     2401 tcataataga agaaaagaat gtggacagga ggacttggac tctacattta ctatatgtga
     2461 agacatcaag agctcgaagt gtaaattacc cgaacaagaa tcactaccaa atgataacaa
     2521 agacatttta caacggcttg atccttcttc attctcaact aagcattcta tgcctgtacc
     2581 aagcatggtg ccatcctaca tggcaatgac tactgctgcc aaaaggaaac ggaaattaac
     2641 aagttctaca tcaaacagtt cgttaactgc agacgtaaat tctggatttg ccaaacgtgt
     2701 tcgacaagat aattcaagtg agaagcactt acaagaaaac aaaccaacaa tggaacataa
     2761 aagaaacatc tgtaaaataa atccaagcat ggttagaaaa tttggaagaa atatttcaaa
     2821 aggaaatcta agataaatca cttcaaaacc aagcaaaatg aagttgatca aatctgcttt
     2881 tcaaagttta tcaataccct ttcaaaaata tatttaaaat ctttgaaaga agacccatct
     2941 taaagctaag tttacccaag tactttcagc aagcagaaaa atgaaactct ttgttttctt
     3001 cttttgtgtt ctaaaaaaat aaaatttcaa aagaaaaggt tgtcttttaa gttttttaaa
     3061 tatttgttgc cttttaaaat ccctgagtgt aagttaccat ggtggcagct tagttttact
     3121 atgccacaac aagttgacta ggacatttta gtaaatggta gtgagttaaa ttatctttat
     3181 tattttttaa aaataagaat ttagaagtgg taaaattatg gcccaagatg tatttggttc
     3241 tctattatgt tttgatacat tattttaatc atatatatga ctttcctttt caaaaatact
     3301 ttaatgtaca agtgtaaata tatgtgccca taaaatcatt gtaaatatta tttagtcatc
     3361 acaaataaaa tattgtccct tgctacttga tatattaaag atgtagattt taaagtg
//
