LOCUS       NM_001122819            3958 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens kinesin family member 17 (KIF17), transcript variant
            2, mRNA.
ACCESSION   NM_001122819
VERSION     NM_001122819.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3958)
  AUTHORS   Liu,Y., Tian,X., Ke,P., Gu,J., Ma,Y., Guo,Y., Xu,X., Chen,Y.,
            Yang,M., Wang,X. and Xiao,F.
  TITLE     KIF17 Modulates Epileptic Seizures and Membrane Expression of the
            NMDA Receptor Subunit NR2B
  JOURNAL   Neurosci Bull 38 (8), 841-856 (2022)
   PUBMED   35678994
REFERENCE   2  (bases 1 to 3958)
  AUTHORS   Riva,A., Gambadauro,A., Dipasquale,V., Casto,C., Ceravolo,M.D.,
            Accogli,A., Scala,M., Ceravolo,G., Iacomino,M., Zara,F.,
            Striano,P., Cuppari,C., Di Rosa,G., Cutrupi,M.C., Salpietro,V. and
            Chimenz,R.
  TITLE     Biallelic Variants in KIF17 Associated with Microphthalmia and
            Coloboma Spectrum
  JOURNAL   Int J Mol Sci 22 (9), 4471 (2021)
   PUBMED   33922911
  REMARK    GeneRIF: Biallelic Variants in KIF17 Associated with Microphthalmia
            and Coloboma Spectrum.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3958)
  AUTHORS   Milic,B., Andreasson,J.O.L., Hogan,D.W. and Block,S.M.
  TITLE     Intraflagellar transport velocity is governed by the number of
            active KIF17 and KIF3AB motors and their motility properties under
            load
  JOURNAL   Proc Natl Acad Sci U S A 114 (33), E6830-E6838 (2017)
   PUBMED   28761002
  REMARK    GeneRIF: The rate of transport is set by an equilibrium between a
            faster state, where only kinesin family member 17 protein (KIF17)
            motors move the train, and a slower state, where at least one
            kinesin family member 3A/B protein (KIF3AB) motor on the train
            remains active in transport.
REFERENCE   4  (bases 1 to 3958)
  AUTHORS   Funabashi,T., Katoh,Y., Michisaka,S., Terada,M., Sugawa,M. and
            Nakayama,K.
  TITLE     Ciliary entry of KIF17 is dependent on its binding to the IFT-B
            complex via IFT46-IFT56 as well as on its nuclear localization
            signal
  JOURNAL   Mol Biol Cell 28 (5), 624-633 (2017)
   PUBMED   28077622
  REMARK    GeneRIF: In mammalian cells, KIF17 is dispensable for ciliogenesis
            and IFT-B trafficking but requires IFT-B, as well as its NLS, for
            its ciliary entry across the permeability barrier located at the
            ciliary base.
REFERENCE   5  (bases 1 to 3958)
  AUTHORS   Bai,X., Karasmanis,E.P. and Spiliotis,E.T.
  TITLE     Septin 9 interacts with kinesin KIF17 and interferes with the
            mechanism of NMDA receptor cargo binding and transport
  JOURNAL   Mol Biol Cell 27 (6), 897-906 (2016)
   PUBMED   26823018
  REMARK    GeneRIF: The first evidence of an interaction between septins and a
            nonmitotic kinesin is provided and it is suggested that SEPT9
            modulates the interactions of KIF17 with membrane cargo.
REFERENCE   6  (bases 1 to 3958)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 3958)
  AUTHORS   Chennathukuzhi,V., Morales,C.R., El-Alfy,M. and Hecht,N.B.
  TITLE     The kinesin KIF17b and RNA-binding protein TB-RBP transport
            specific cAMP-responsive element modulator-regulated mRNAs in male
            germ cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15566-15571 (2003)
   PUBMED   14673085
  REMARK    GeneRIF: KIF17b serves as a molecular motor component of a
            TB-RBP-mouse ribonucleoprotein complex transporting a group of
            specific CREM-regulated mRNAs.
REFERENCE   8  (bases 1 to 3958)
  AUTHORS   Guillaud,L., Setou,M. and Hirokawa,N.
  TITLE     KIF17 dynamics and regulation of NR2B trafficking in hippocampal
            neurons
  JOURNAL   J Neurosci 23 (1), 131-140 (2003)
   PUBMED   12514209
REFERENCE   9  (bases 1 to 3958)
  AUTHORS   Macho,B., Brancorsini,S., Fimia,G.M., Setou,M., Hirokawa,N. and
            Sassone-Corsi,P.
  TITLE     CREM-dependent transcription in male germ cells controlled by a
            kinesin
  JOURNAL   Science 298 (5602), 2388-2390 (2002)
   PUBMED   12493914
REFERENCE   10 (bases 1 to 3958)
  AUTHORS   Setou,M., Nakagawa,T., Seog,D.H. and Hirokawa,N.
  TITLE     Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA
            receptor-containing vesicle transport
  JOURNAL   Science 288 (5472), 1796-1802 (2000)
   PUBMED   10846156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY484427.1, AL663074.13, BC065927.1, BX387401.1 and BC040639.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001122819.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (b) is shorter, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065927.1, SRR18074969.1292526.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400463.8/ ENSP00000383311.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AY484427.1         11-147
            138-138             AL663074.13        46601-46601         c
            139-282             AY484427.1         148-291
            283-1504            BC065927.1         56-1277
            1505-1505           BX387401.1         479-479
            1506-3096           BC065927.1         1279-2869
            3097-3958           BC040639.1         1070-1931
FEATURES             Location/Qualifiers
     source          1..3958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..3958
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /note="kinesin family member 17"
                     /db_xref="GeneID:57576"
                     /db_xref="HGNC:HGNC:19167"
                     /db_xref="MIM:605037"
     exon            1..532
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..3388
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /note="isoform b is encoded by transcript variant 2;
                     KIF3-related motor protein; kinesin-like protein KIF17;
                     KIF17 variant protein"
                     /codon_start=1
                     /product="kinesin-like protein KIF17 isoform b"
                     /protein_id="NP_001116291.1"
                     /db_xref="CCDS:CCDS44079.1"
                     /db_xref="GeneID:57576"
                     /db_xref="HGNC:HGNC:19167"
                     /db_xref="MIM:605037"
                     /translation="MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGA
                     ADEPPKQFTFDGAYHVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQ
                     GLPDPPSQRGIIPRAFEHVFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLE
                     LKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISI
                     EMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISA
                     LVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKN
                     IRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKL
                     LPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLS
                     TLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLP
                     SDDVSKTQVSSRFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSM
                     PTEESRSRYFLDECLGQEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLA
                     RLSSTVARTDAPQADVPKVPVQVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVA
                     LEVVRTAEPGVWLEAQAPVALVAQPEPLPATAGVKRESVGMEVAVLTDDPLPVVDQQQ
                     VLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQLVAALQNSDEDSGDWVLL
                     NVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIRRQERDSML
                     LQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVITKTSLPVVSTGPQN
                     KPARKTSAADNGEPNMEDDRYRLMLSRSNSENIASNYFRSKRASQILSTDARKSLTHH
                     NSPPGLSCPLSNNSAIPPTQAPEMPQPRPFRLESLDIPFTKAKRKKSKSNFGSEPL"
     exon            533..679
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            680..781
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..971
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1424
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1534
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1682
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2239
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2320
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2532
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2764
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..3023
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3091
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3209
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3958
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /note="hexamer: AATAAA"
     polyA_site      3958
                     /gene="KIF17"
                     /gene_synonym="KIF17B; KIF3X; KLP-2; OSM-3"
                     /note="major polyA site"
ORIGIN      
        1 gggctcgggt tctgcggcgg cgcctgcagc gcggatcccc cacgtccccg ctcgggccgg
       61 gcctcagaaa cgggcgagcc cgggcgcggg aggaagcggc ggccccggct cgggtcctgc
      121 gacgcccagc tcccctccgg ggcgcccccc gaggggtccc cgccccccgc cgcggccccg
      181 cccctgcctc aaggccccgc cccccgtggc cggcgctggc cccgcccctt ggcccgggct
      241 gctgggagtc cccggcgggg cgggggtcag ctctggtccc gttggtcctg ggcgcggcgc
      301 catggcctcc gaggcggtga aggttgtcgt gcgctgccgt cccatgaacc agcgggagcg
      361 agagctgcgc tgccagcccg tggtgactgt ggactgcgcg cgcgcccagt gctgcatcca
      421 gaacccgggc gccgccgacg agccgcccaa gcagttcacc ttcgacggcg cctaccacgt
      481 ggaccacgtc accgagcaga tctacaacga gatcgcctat ccgctggtgg agggcgtcac
      541 tgagggctac aatggcacca tctttgccta cggccagaca ggcagcggga agtccttcac
      601 catgcagggc ctgccggatc cgccctccca gagaggcatc atccccaggg ccttcgagca
      661 cgtgttcgag agcgtccagt gtgcagagaa cactaagttc ctggtccggg cctcctacct
      721 ggagatctac aatgaagatg tccgggacct ccttggggct gacaccaagc agaagctgga
      781 gctgaaggag cacccagaga agggcgtgta cgtgaagggg ctgtccatgc acacggtgca
      841 cagcgtggcc cagtgtgagc acatcatgga gactggctgg aagaaccgtt cggtcggcta
      901 cacgctgatg aacaaggatt cctcacgctc gcactccatc ttcaccatca gcatcgagat
      961 gtctgccgtg gatgagcggg gcaaggacca cctccgggcg ggcaagctga acctggtgga
     1021 cctggcgggc agcgagcggc agtccaagac cggggccacg ggcgagcggc tcaaggaggc
     1081 caccaagatc aacctgtcgc tctcggcact gggcaatgtc atctcggcgc tggtggacgg
     1141 gcgctgtaag cacgtcccct accgtgactc gaagctgacg cggctgctgc aggactcact
     1201 gggcggcaac accaagacgc tcatggtggc ctgcctgtcg cctgcggaca acaactacga
     1261 tgagacactc agcacgctgc gctacgccaa ccgggccaag aacatcagga acaagccgcg
     1321 catcaatgag gaccccaagg atgcgctgct tcgcgagtac caggaggaga tcaagaagct
     1381 caaggccatc ctgacacagc agatgagccc cagcagcctg tcagccctgc tgtccaggca
     1441 ggtgccccca gaccctgtgc aggtggagga gaagctgttg ccccaacctg tgatccagca
     1501 tgacgtggag gccgagaagc agctgatccg ggaggagtat gaagagcgcc tggcccggct
     1561 gaaagccgac tataaggccg agcaggagtc tcgggccagg ctggaggaag acatcactgc
     1621 catgcgcaac tcatatgacg tcaggctgtc cacgctggag gagaacctgc ggaaggagac
     1681 agaggctgtc ctgcaggtgg gagtcctcta caaggctgag gtcatgtcca gggctgagtt
     1741 tgccagcagc gctgagtacc cgcctgcttt tcagtatgag acagtggtga aacccaaggt
     1801 cttctccacg actgacactc tgcccagtga cgatgtctcc aagactcagg tttcctccag
     1861 gtttgcggag ctgcccaagg tggaaccctc caaatctgag atttctctgg gctccagtga
     1921 gtcatcctcg ctcgaagaaa cctctgtgtc cgaggctttc cctgggcctg aggagccctc
     1981 caacgtggag gtctccatgc ccactgagga gtccaggagc agatacttcc tggatgagtg
     2041 cctcgggcag gaggccgctg ggcacctgct gggggaacag aactacctcc cgcaagagga
     2101 gccgcaggag gtgcccctgc aggggttact aggcctgcag gacccgtttg ccgaggtgga
     2161 agccaagctg gccagactct cctccaccgt ggccaggaca gatgcacccc aggcagacgt
     2221 ccccaaggtc cctgtgcagg tccctgcgcc gacagacctg ctggagccca gtgatgccag
     2281 gcccgaagcc gaggcggctg atgacttccc gcccaggcct gaggtagatc tggcctcgga
     2341 agtggcctta gaggtggtgc ggacagcaga gcctggcgtg tggttggagg ctcaggcccc
     2401 ggtggccctg gtggctcagc ctgagcccct gccggccaca gctggtgtga agagggagag
     2461 cgtgggcatg gaggtggcag tgctgactga tgacccgctg cccgttgtgg accagcagca
     2521 ggtgctggcc cgtctgcagc tgttggagca gcaggttgtg ggtggagagc aggccaagaa
     2581 caaggacctg aaggagaagc acaagcggcg caagcgctac gcagacgagc gcaggaagca
     2641 gctggtggct gccctgcaga actcggatga ggacagcggg gactgggtgc tgcttaacgt
     2701 ctacgactcc atccaggagg aagtgcgggc caagagcaag ctgctggaga agatgcagag
     2761 gaagcttcgg gcagcagagg tggagatcaa agatctgcag tccgagtttc agctggagaa
     2821 gatcgattac ttggccacca tccgccggca ggagcgtgac tccatgctct tgcagcagct
     2881 cctggagcag gtgcagcccc tgattcgcag ggactgtaac tacagcaacc tggagaagat
     2941 tctgcgtgag tcctgctggg acgaagataa cggcttctgg aagatcccac atcccgtcat
     3001 cacaaaaacc agcctcccag tagtttcaac tgggccacag aacaaaccag cccgcaaaac
     3061 ctctgcagca gacaatggcg agccgaacat ggaggacgac cgctacaggc tcatgctcag
     3121 tcggagcaac agtgaaaaca ttgccagcaa ctacttccga tctaagcggg ccagccagat
     3181 cctcagcaca gacgccagga agagcctcac acatcacaac tcgccaccag gcctcagctg
     3241 cccactcagc aacaactctg ccatcccacc cacccaggcc cctgaaatgc cccagccccg
     3301 gcccttccgc ctcgagtccc tcgacatccc tttcaccaag gccaagcgta agaaaagcaa
     3361 aagcaacttt ggcagtgagc ctctgtgagc acagctgctt gccattgcct gccttatagg
     3421 catgtagaga ctgccaggcc ctcccagggc agccccaacc aggtctcctc ccacctgcca
     3481 cacagcgctc cggggcctga gggctccctc agccctggga agacacattc ccttccctgt
     3541 tccccagaga gcccacctcc gccctgggca ggagcccctc ggaggctgta tagtcctcct
     3601 tagagaggcc tgctccagct gttcatacca catcagtgtt tccgtctgct cacctgccac
     3661 agagcccaca cccatgccca ccagtgttgg tctttgcctc aaagcctgag acctgcttca
     3721 cggccttcac cagccctgat ggagagggca gcagctgcca cgtggaggaa gctcaatatc
     3781 agctgggaag gaactgtgcc tctgtctgac tggccccact tcctaagcac tgccctgccc
     3841 catggggtgg cacaggggtc ccacagcagg tcttcctgca ctgcccaccc ctggctggtc
     3901 tgtggcccaa ggaaggccac tccacattaa gctgcccaat aaactgcttt taagataa
//
