LOCUS       NM_024704               5276 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens kinesin family member 16B (KIF16B), transcript variant
            2, mRNA.
ACCESSION   NM_024704 NM_017683
VERSION     NM_024704.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5276)
  AUTHORS   Hey,S., Wiesner,C., Barcelona,B. and Linder,S.
  TITLE     KIF16B drives MT1-MMP recycling in macrophages and promotes
            co-invasion of cancer cells
  JOURNAL   Life Sci Alliance 6 (11), e202302158 (2023)
   PUBMED   37696580
  REMARK    GeneRIF: KIF16B drives MT1-MMP recycling in macrophages and
            promotes co-invasion of cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5276)
  AUTHORS   Yang,S., Tang,D., Zhao,Y.C., Liu,H., Luo,S., Stinchcombe,T.E.,
            Glass,C., Su,L., Shen,S., Christiani,D.C., Wang,Q. and Wei,Q.
  TITLE     Novel genetic variants in KIF16B and NEDD4L in the endosome-related
            genes are associated with nonsmall cell lung cancer survival
  JOURNAL   Int J Cancer 147 (2), 392-403 (2020)
   PUBMED   31618441
  REMARK    GeneRIF: Novel genetic variants in KIF16B and NEDD4L in the
            endosome-related genes are associated with nonsmall cell lung
            cancer survival.
REFERENCE   3  (bases 1 to 5276)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5276)
  AUTHORS   Alsahli,S., Arold,S.T., Alfares,A., Alhaddad,B., Al Balwi,M.,
            Kamsteeg,E.J., Al-Twaijri,W. and Alfadhel,M.
  TITLE     KIF16B is a candidate gene for a novel autosomal-recessive
            intellectual disability syndrome
  JOURNAL   Am J Med Genet A 176 (7), 1602-1609 (2018)
   PUBMED   29736960
  REMARK    GeneRIF: KIF16B mutation is associated with autosomal-recessive
            intellectual disability syndrome.
REFERENCE   5  (bases 1 to 5276)
  AUTHORS   Perez Bay,A.E., Schreiner,R., Mazzoni,F., Carvajal-Gonzalez,J.M.,
            Gravotta,D., Perret,E., Lehmann Mantaras,G., Zhu,Y.S. and
            Rodriguez-Boulan,E.J.
  TITLE     The kinesin KIF16B mediates apical transcytosis of transferrin
            receptor in AP-1B-deficient epithelia
  JOURNAL   EMBO J 32 (15), 2125-2139 (2013)
   PUBMED   23749212
  REMARK    GeneRIF: The kinesin KIF16B mediates apical transcytosis of
            transferrin receptor in AP-1B-deficient epithelia.
REFERENCE   6  (bases 1 to 5276)
  AUTHORS   Seet,L.F. and Hong,W.
  TITLE     The Phox (PX) domain proteins and membrane traffic
  JOURNAL   Biochim Biophys Acta 1761 (8), 878-896 (2006)
   PUBMED   16782399
  REMARK    Review article
REFERENCE   7  (bases 1 to 5276)
  AUTHORS   Miki,H., Okada,Y. and Hirokawa,N.
  TITLE     Analysis of the kinesin superfamily: insights into structure and
            function
  JOURNAL   Trends Cell Biol 15 (9), 467-476 (2005)
   PUBMED   16084724
  REMARK    Review article
REFERENCE   8  (bases 1 to 5276)
  AUTHORS   Hoepfner,S., Severin,F., Cabezas,A., Habermann,B., Runge,A.,
            Gillooly,D., Stenmark,H. and Zerial,M.
  TITLE     Modulation of receptor recycling and degradation by the endosomal
            kinesin KIF16B
  JOURNAL   Cell 121 (3), 437-450 (2005)
   PUBMED   15882625
  REMARK    GeneRIF: KIF16B, a kinesin-3, transports early endosomes to the
            plus end of microtubules in a process regulated by the small GTPase
            Rab5 and its effector.
REFERENCE   9  (bases 1 to 5276)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 5276)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049794.16, BC050577.1,
            AY166853.1 and AL117376.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_024704.4.
            
            Summary: The protein encoded by this gene is a kinesin-like protein
            that may be involved in intracellular trafficking. Three transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005614.1, AY166853.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354981.7/ ENSP00000347076.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL049794.16        88309-88335         c
            28-2168             BC050577.1         14-2154
            2169-3902           AY166853.1         2154-3887
            3903-5107           BC050577.1         3736-4940
            5108-5108           AL117376.28        30659-30659         c
            5109-5276           BC050577.1         4942-5109
FEATURES             Location/Qualifiers
     source          1..5276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..5276
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /note="kinesin family member 16B"
                     /db_xref="GeneID:55614"
                     /db_xref="HGNC:HGNC:15869"
                     /db_xref="MIM:618171"
     exon            1..220
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..4127
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /note="isoform 2 is encoded by transcript variant 2;
                     sorting nexin 23; kinesin motor protein; kinesin-like
                     protein KIF16B; testis secretory sperm-binding protein Li
                     201a"
                     /codon_start=1
                     /product="kinesin-like protein KIF16B isoform 2"
                     /protein_id="NP_078980.3"
                     /db_xref="CCDS:CCDS13122.1"
                     /db_xref="GeneID:55614"
                     /db_xref="HGNC:HGNC:15869"
                     /db_xref="MIM:618171"
                     /translation="MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGG
                     TGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYG
                     QTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRD
                     LLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMND
                     VSSRSHAIFTIKFTQAKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNIN
                     KSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIAT
                     ISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQ
                     IALLDSPTALSMEEKLQQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLD
                     SELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHCIFENI
                     GGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKS
                     GLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFERQQREELEKLESKRKLIEEMEEKQK
                     SDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEE
                     RLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQ
                     YAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGIR
                     ESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQE
                     EQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQ
                     NHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQAT
                     FEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIE
                     EQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDH
                     HGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEGCSTSAD
                     TMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEF
                     EVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRS
                     HLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG"
     exon            221..290
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            291..404
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            405..521
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            522..619
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            620..729
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            730..872
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1041
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1173
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1349
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1415
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1475
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1595
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1647
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1785
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1868
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1957
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2011
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..3370
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3523
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3620
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3671
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3794
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3884
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..3968
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..5276
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /note="hexamer: ATTAAA"
     polyA_site      5237
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
     regulatory      5254..5259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /note="hexamer: ATTAAA"
     polyA_site      5276
                     /gene="KIF16B"
                     /gene_synonym="C20orf23; KISC20ORF; SNX23"
                     /note="major polyA site"
ORIGIN      
        1 atgctcagtg gcctggcagg tggggctgcc gcggaactcc aggtccggcc gggagcagag
       61 gggcgggggc gagagggaag tgggcgggag ccgcgatctg agtagccagc gtcgccggcg
      121 accgcggagt tctgggctag tgggaccccg cgcgggctgg ttcgggatga gcgatggcat
      181 cggtcaaggt ggccgtgagg gtccggccca tgaatcgcag ggaaaaggac ttggaggcca
      241 agttcattat tcagatggag aaaagcaaaa cgacaatcac aaacttaaag ataccagaag
      301 gaggcactgg ggactcagga agagaacgga ccaagacctt cacctatgac ttttcttttt
      361 attctgctga tacaaaaagc ccagattacg tttcacaaga aatggttttc aaaaccctcg
      421 gcacagatgt cgtgaagtct gcatttgaag gttataatgc ttgtgtcttt gcatatgggc
      481 aaactggatc tggaaagtca tacactatga tgggaaattc tggagattct ggcttaatac
      541 ctcggatctg tgaaggactc ttcagtcgga taaatgaaac caccagatgg gatgaagctt
      601 cttttcgaac tgaagtcagc tacttagaaa tttataacga acgtgtgaga gatctacttc
      661 ggcggaagtc atctaaaacc ttcaatttga gagtccgtga gcatcccaaa gaaggccctt
      721 atgttgagga tttatccaaa catttagtac agaattatgg tgacgtagaa gaacttatgg
      781 atgcgggcaa tatcaaccgg accaccgcag cgactgggat gaacgacgtc agtagcaggt
      841 ctcatgccat cttcaccatc aagttcactc aggctaaatt tgattctgaa atgccatgtg
      901 aaaccgtcag taagatccac ttggttgatc ttgccggaag tgagcgtgca gatgccaccg
      961 gagccaccgg ggttaggcta aaggaagggg gaaatattaa caagtccctc gtgactctgg
     1021 ggaacgtcat ttctgcctta gctgatttat ctcaggatgc tgcaaatact cttgcaaaga
     1081 agaagcaagt tttcgtgcct tacagggatt ctgtgttgac ttggttgtta aaagatagcc
     1141 ttggaggaaa ctctaaaact atcatgattg ccaccatttc acctgctgat gtcaattatg
     1201 gagaaaccct aagtactctt cgctatgcaa atagagccaa aaacatcatc aacaagccta
     1261 ccattaatga ggatgccaac gtcaaactta tccgtgagct gcgagctgaa atagccagac
     1321 tgaaaacgct gcttgctcaa gggaatcaga ttgccctctt agactccccc acagctttaa
     1381 gtatggagga aaaacttcag cagaatgaag caagagttca agaattgacc aaggaatgga
     1441 caaataagtg gaatgaaacc caaaatattt tgaaagaaca aactctagcc ctcaggaaag
     1501 aagggattgg agttgttttg gattctgaac tgcctcattt gattggcatc gatgatgacc
     1561 ttttgagtac tggaatcatc ttatatcatt taaaggaagg tcagacatac gttggtagag
     1621 acgatgcttc cacggagcaa gatattgttc ttcatggcct tgacttggag agtgagcatt
     1681 gcatctttga aaatatcggg gggacagtga ctctgatacc cctgagtggg tcccagtgct
     1741 ctgtgaatgg tgttcagatc gtggaggcca cacatctaaa tcaaggtgct gtgattctct
     1801 tgggaagaac caatatgttt cgctttaacc atccaaagga agccgccaag ctcagggaga
     1861 agaggaagag tggccttctg tcctccttca gcttgtccat gaccgacctc tcgaagtccc
     1921 gtgagaacct gtctgcagtc atgttgtata accccggact tgaatttgag aggcaacagc
     1981 gtgaagaact tgaaaaatta gaaagtaaaa ggaaactcat agaagaaatg gaggaaaagc
     2041 agaaatcaga caaggctgaa ctggagcgga tgcagcagga ggtggagacc cagcgcaagg
     2101 agacagaaat cgtgcagctc cagattcgca agcaggagga gagcctcaaa cgccgcagct
     2161 tccacatcga gaacaagcta aaggatttac ttgcggagaa ggaaaaattt gaagaggaga
     2221 ggctgaggga acagcaggaa atcgagctgc agaagaagag acaagaagaa gagacctttc
     2281 tccgcgtcca agaagaactc caacgactca aagaactcaa caacaacgag aaggctgaga
     2341 agtttcagat atttcaagaa ctggaccagc tccaaaagga aaaagatgaa cagtatgcca
     2401 agcttgaact ggaaaaaaag agactagagg agcaggagaa ggagcaggtc atgctcgtgg
     2461 cccatctgga agagcagctc cgagagaagc aggagatgat ccagctcctg cggcgtgggg
     2521 aggtacagtg ggtggaagag gagaagaggg acctggaagg cattcgggaa tccctcctgc
     2581 gggtgaagga ggctcgtgcc ggaggggatg aagatggcga ggagttagaa aaggctcaac
     2641 tgcgtttctt cgaattcaag agaaggcagc ttgtcaagct agtgaacttg gagaaggacc
     2701 tggttcagca gaaagacatc ctgaaaaaag aagtccaaga agaacaggag atcctagagt
     2761 gtttaaaatg tgaacatgac aaagaatcta gattgttgga aaaacatgat gagagtgtca
     2821 cagatgtcac ggaagtgcct caagatttcg agaaaataaa gccagtggag tacaggctgc
     2881 aatataaaga acgccagcta cagtacctcc tgcagaatca cttgccaact ctgttggaag
     2941 aaaagcagag agcatttgaa attcttgaca gaggccctct cagcttagac aacactcttt
     3001 atcaagtaga aaaggaaatg gaagaaaaag aagaacagct tgcacagtac caggccaatg
     3061 caaaccagct gcaaaagctc caagccacct ttgaattcac tgccaacatt gcacgtcagg
     3121 aggaaaaagt gaggaaaaag gaaaaggaga ttttggagtc cagagagaag cagcagagag
     3181 aggcgctgga gcgggccctg gccaggctgg agaggagaca ttctgcgctg cagaggcact
     3241 ccaccctggg catggagatt gaagagcaga ggcagaaact tgccagtctg aacagtggca
     3301 gcagagagca gtcagggctc caggctagcc tggaggctga gcaggaagcc ctggagaagg
     3361 accaggagag gttagaatat gaaatccagc agctgaaaca gaagatttat gaggtcgatg
     3421 gtgttcaaaa agatcatcat gggaccctgg aagggaaggt ggcttcttcc agcttgccag
     3481 tcagtgctga aaaatcacac ctggttcccc tcatggatgc caggatcaat gcttacattg
     3541 aagaagaagt ccaaagacgc cttcaggatt tgcatcgtgt gattagtgaa ggctgcagta
     3601 catctgcaga cacgatgaag gataatgaga aacttcacaa tggcaccatt caacgtaaac
     3661 taaaatatga gcggatggtt tctcgctctt tgggcgcaaa tccagatgac ctgaaggacc
     3721 caattaaaat tagtatccca cgctacgtcc tctgcgggca aggaaaggat gcacacttcg
     3781 agtttgaggt caagattact gtcctagatg agacatggac tgtattcagg cgttacagtc
     3841 gttttcgaga aatgcataaa acattgaagt taaagtatgc agagcttgct gcccttgaat
     3901 ttcctccaaa gaaactattt ggaaataagg atgaacgtgt gattgctgag agacgaagtc
     3961 acttagagaa atacctcagg gactttttca gcgtgatgct ccagtccgca acatctcccc
     4021 tccacatcaa caaagtggga ctgactctct cgaaacatac catttgtgag ttttcaccat
     4081 tcttcaagaa aggagtcttt gactacagca gccacgggac ggggtagagc caggggtgat
     4141 ggaggaacca ccacagcagt gccttctcgt cgaagcgggc tccgatgcag ggcagctccc
     4201 ccatgcgagg atccgggtct gcctcctcct gctgaagaca gacatgcagc agcgggcccg
     4261 ggccacctca cgtttccata cctagtgcct gagtttgggg atgggatgct ctgcctgctg
     4321 atgtggccct gacaggcagc cgttaccgtt ccattgcggt tgaacgtggc cttttcccac
     4381 agtgcttcct tctcactgcg cagcaaagtt cgtcccctgt ggcaagatag atgtggttgg
     4441 gccatcgtgg gttccctgag cccagccagc ctgggacctc ccaaagtggg tggcttacca
     4501 gaccaccctt aaatgacttt catctggttt cctctttcac caaaatatac tcgtattttt
     4561 tatatttctt ccatgtggct ggctatattc caagaaaagc attttaaatt atttcattgt
     4621 atttttttct ttttttccct catttgaatc agaactttta tataaaaccc aaacactgat
     4681 gtttacacag aatttcatat tctgcaaaag ggattttttg atccaatcat gactgtagtc
     4741 ttccatgctt gacaaattgg atgtagacaa cattacttaa aacttctata aatccctaca
     4801 attaggatat ttatttaacc ttgaatattc aagaacattc tcccaaatct aaatggctac
     4861 tgtgcattct tgagcttttt ctgctaagca caaaatgaac gcaaagctaa atgcatattt
     4921 ttaagtatta ttcacatttt ttgttacaga atctattgga tctttggctg gaaaactaga
     4981 atttatagca gtttattaat gataccttaa attactcagg acttaatgta gcattgcact
     5041 tctgtgtaca gtaaaactgc tttgttttac taaagagaaa aatgtgagtg gaaaaaatat
     5101 gtatgtggta tatactcaaa tgtatataat tctatctata gatttatata tgtatacatt
     5161 ctgtacagta gttccatcaa aatatgtaat aattcacacc aattttatta aatgtatttg
     5221 ctttttcaaa atttaaattg agctgctatc aatattaaat gaagttatgg catcta
//
