LOCUS       NM_020242               4760 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens kinesin family member 15 (KIF15), mRNA.
ACCESSION   NM_020242
VERSION     NM_020242.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4760)
  AUTHORS   Yu,W., Han,S., Hu,S., Ru,L., Hua,C., Xue,G., Zhang,G., Lv,K.,
            Ge,H., Wang,M., Zheng,L., Zhou,J., Hou,S., Teng,Y., Deng,W. and
            Guo,W.
  TITLE     KIF15 promotes human glioblastoma progression under the synergistic
            transactivation of REST and P300
  JOURNAL   Int J Biol Sci 20 (13), 5127-5144 (2024)
   PUBMED   39430242
  REMARK    GeneRIF: KIF15 promotes human glioblastoma progression under the
            synergistic transactivation of REST and P300.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4760)
  AUTHORS   Salazar,B.M. and Ohi,R.
  TITLE     Antiparallel microtubule bundling supports KIF15-driven mitotic
            spindle assembly
  JOURNAL   Mol Biol Cell 35 (6), ar84 (2024)
   PUBMED   38598297
  REMARK    GeneRIF: Antiparallel microtubule bundling supports KIF15-driven
            mitotic spindle assembly.
REFERENCE   3  (bases 1 to 4760)
  AUTHORS   Hollmen,M., Laaka,A., Partanen,J.J., Koskela,J., Sutinen,E.,
            Kaarteenaho,R., Ainola,M. and Myllarniemi,M.
  TITLE     KIF15 missense variant is associated with the early onset of
            idiopathic pulmonary fibrosis
  JOURNAL   Respir Res 24 (1), 240 (2023)
   PUBMED   37777755
  REMARK    GeneRIF: KIF15 missense variant is associated with the early onset
            of idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4760)
  AUTHORS   Huang,J., Sun,X., Diao,G., Li,R., Guo,J. and Han,J.
  TITLE     KIF15 knockdown inhibits the development of endometrial cancer by
            suppressing epithelial-mesenchymal transition and stemness through
            Wnt/beta-catenin signaling
  JOURNAL   Environ Toxicol 38 (8), 1824-1834 (2023)
   PUBMED   37186152
  REMARK    GeneRIF: KIF15 knockdown inhibits the development of endometrial
            cancer by suppressing epithelial-mesenchymal transition and
            stemness through Wnt/beta-catenin signaling.
REFERENCE   5  (bases 1 to 4760)
  AUTHORS   Quan,G., Xu,J., Wang,J., Liu,X., Xu,J. and Jiang,J.
  TITLE     KIF15 is essential for USP10-mediated PGK1 deubiquitination during
            the glycolysis of pancreatic cancer
  JOURNAL   Cell Death Dis 14 (2), 137 (2023)
   PUBMED   36807568
  REMARK    GeneRIF: KIF15 is essential for USP10-mediated PGK1
            deubiquitination during the glycolysis of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4760)
  AUTHORS   Vanneste,D., Takagi,M., Imamoto,N. and Vernos,I.
  TITLE     The role of Hklp2 in the stabilization and maintenance of spindle
            bipolarity
  JOURNAL   Curr Biol 19 (20), 1712-1717 (2009)
   PUBMED   19818619
  REMARK    GeneRIF: Hklp2 participates in the assembly and stabilization of
            the bipolar spindle.
REFERENCE   7  (bases 1 to 4760)
  AUTHORS   Tanenbaum,M.E., Macurek,L., Janssen,A., Geers,E.F.,
            Alvarez-Fernandez,M. and Medema,R.H.
  TITLE     Kif15 cooperates with eg5 to promote bipolar spindle assembly
  JOURNAL   Curr Biol 19 (20), 1703-1711 (2009)
   PUBMED   19818618
  REMARK    GeneRIF: Kif15 can replace all essential functions of Eg5 in
            bipolar spindle assembly.
REFERENCE   8  (bases 1 to 4760)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 4760)
  AUTHORS   Scanlan,M.J., Gout,I., Gordon,C.M., Williamson,B., Stockert,E.,
            Gure,A.O., Jager,D., Chen,Y.T., Mackay,A., O'Hare,M.J. and Old,L.J.
  TITLE     Humoral immunity to human breast cancer: antigen definition and
            quantitative analysis of mRNA expression
  JOURNAL   Cancer Immun 1, 4 (2001)
   PUBMED   12747765
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4760)
  AUTHORS   Sueishi,M., Takagi,M. and Yoneda,Y.
  TITLE     The forkhead-associated domain of Ki-67 antigen interacts with the
            novel kinesin-like protein Hklp2
  JOURNAL   J Biol Chem 275 (37), 28888-28892 (2000)
   PUBMED   10878014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR005852.1, AK307674.1, AB035898.1 and AL832908.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020242.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035898.1, SRR11853565.20219.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326047.9/ ENSP00000324020.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DR005852.1         84-87
            5-2646              AK307674.1         1-2642
            2647-4711           AB035898.1         2648-4712
            4712-4760           AL832908.1         3628-3676
FEATURES             Location/Qualifiers
     source          1..4760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4760
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /note="kinesin family member 15"
                     /db_xref="GeneID:56992"
                     /db_xref="HGNC:HGNC:17273"
                     /db_xref="MIM:617569"
     exon            1..91
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..4239
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /note="kinesin-like 7; kinesin-like protein 2;
                     kinesin-like protein 7; serologically defined breast
                     cancer antigen NY-BR-62"
                     /codon_start=1
                     /product="kinesin-like protein KIF15"
                     /protein_id="NP_064627.1"
                     /db_xref="CCDS:CCDS33744.1"
                     /db_xref="GeneID:56992"
                     /db_xref="HGNC:HGNC:17273"
                     /db_xref="MIM:617569"
                     /translation="MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSAD
                     GEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYN
                     GTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSF
                     LCKCSFIEIYNEQIYDLLDSASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGG
                     WRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTH
                     AEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKT
                     AIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLA
                     ELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKE
                     KFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHP
                     RVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQG
                     FSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQ
                     KANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGS
                     FGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKN
                     LKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKS
                     EVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKL
                     LESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNN
                     KLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISS
                     LEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESR
                     VLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQS
                     AQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPP
                     HFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENL
                     RLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEE
                     MLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE
                     RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENV
                     FLKEKKRSES"
     exon            92..134
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            135..318
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            319..395
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            396..433
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            434..531
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            532..711
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            712..921
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1047
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1170
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1294
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1371
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1581
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1759
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1901
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2043
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2241
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2349
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2455
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2621
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2772
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2858
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2928
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3015
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3120
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3243
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3390
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3492
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3657
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3767
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3840
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..3878
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            3879..4044
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4176
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4760
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4735..4740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /note="hexamer: AATAAA"
     polyA_site      4760
                     /gene="KIF15"
                     /gene_synonym="BRDCS2; HKLP2; KLP2; KNSL7; NY-BR-62"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc ggtgcagtcg ggaggtggag gcaccggctg cattgttttc gggatcgagg
       61 ggtgagggcg ctatggcacc cggctgcaaa actgagttac gcagcgtgac aaatggtcag
      121 tctaaccaac caagtaatga aggtgatgcc atcaaagttt ttgtgcgaat tcgtcctcct
      181 gcagaaagat ctgggtcagc tgatggagag cagaacttat gcttatctgt gctgtcctcc
      241 acgagtctcc ggctgcactc caaccctgag cccaagacct tcacgtttga tcatgttgca
      301 gatgtggata ccactcagga atctgtattc gcaactgtgg ctaaaagcat tgtggagtct
      361 tgcatgagcg gttataatgg taccatcttt gcatatggac agactggctc agggaagaca
      421 tttactatga tgggaccatc tgaatctgat aatttttctc ataacctgag aggagtaatc
      481 ccacgaagtt ttgaatattt gttttcctta attgatcgtg aaaaagaaaa ggctggagct
      541 ggaaagagtt tcctttgtaa gtgttccttt attgaaatct acaacgagca gatatatgat
      601 ctactggact ctgcatcggc tggactgtac ttaagggagc atatcaagaa gggagtcttt
      661 gttgttggtg cggtggagca ggtggtaacc tcagctgctg aagcctatca ggtgttgtct
      721 ggaggatgga ggaatagacg tgtggcatca acatcaatga acagagaatc gtctaggtct
      781 catgccgtct ttacaattac aatagagtca atggagaaaa gtaatgagat tgtgaatata
      841 cggacctccc tactcaacct ggtggattta gcaggatctg aaaggcaaaa agatacccat
      901 gcagaaggga tgagattgaa ggaagcaggt aacataaatc gatcattgag ctgcctgggc
      961 caagtgatta cagcacttgt cgacgtgggt aatggaaaac agagacatgt ttgctacaga
     1021 gactccaaac ttaccttctt actacgggat tcccttggag gtaatgccaa aacagccata
     1081 attgcaaatg ttcatcctgg atccaggtgt tttggggaaa ccctatcaac acttaacttt
     1141 gctcaaagag ccaagctgat taaaaacaag gcagtagtaa atgaagacac ccaaggaaat
     1201 gtgagccagc tccaagctga agtgaagagg ctcaaagaac aactggcgga gcttgcttca
     1261 ggacagacac caccagaaag cttcctgacc agagacaaaa agaagactaa ctatatggag
     1321 tatttccagg aagcaatgtt attctttaag aaatctgaac aggaaaagaa gtctctgata
     1381 gaaaaagtta cccaattaga agacctcacc ctcaaaaagg aaaaatttat tcaatctaat
     1441 aaaatgattg tgaaattccg agaggatcaa ataatacgct tggaaaagct ccacaaggaa
     1501 tcccggggag gttttctgcc tgaggagcag gatcgtttgc tctcagaatt aaggaatgag
     1561 attcaaactc tgcgagaaca aatagagcac caccccagag ttgcaaagta tgctatggaa
     1621 aatcattccc tcagggagga gaatagaaga ctgagattat tagagcctgt gaaaagagct
     1681 caagaaatgg atgcccagac cattgcaaaa ctagaaaaag ctttctctga aataagtggc
     1741 atggagaaaa gtgacaaaaa tcagcaagga ttttcaccta aagctcagaa agagccatgt
     1801 ttgtttgcaa acactgagaa gttaaaagca caactcctgc aaattcagac agagctgaat
     1861 aattcaaagc aagaatatga agaattcaaa gaacttacta ggaaaaggca gctagaattg
     1921 gaatcagagc ttcagtcttt gcaaaaagcg aaccttaatc ttgaaaacct tttggaagca
     1981 acaaaagcct gcaagcggca agaagtttct cagctgaata aaattcatgc tgaaacactt
     2041 aagattataa ctacaccaac caaggcctac caacttcatt cccgaccagt accaaaatta
     2101 agccctgaaa tgggaagctt tggctctcta tacactcaga attctagcat attagataat
     2161 gatatattaa atgagccagt tcctcctgag atgaatgaac aagcttttga ggccatttct
     2221 gaagagctta gaacagtgca ggaacaaatg agtgctcttc aagccaaact ggatgaagaa
     2281 gagcataaaa acctaaagct tcagcagcat gttgacaaac tggaacatca ttctacccaa
     2341 atgcaggagc ttttctcatc agaaagaatt gattggacca aacagcagga agagcttctc
     2401 tcacagttga atgtccttga aaagcagctt caagagactc aaactaaaaa tgactttttg
     2461 aaaagtgagg tacatgacct gcgagtagtc cttcattctg ctgacaagga gctttcttca
     2521 gtgaaattgg aatatagttc attcaaaacg aatcaggaga aagaattcaa caaactttcc
     2581 gaaagacaca tgcatgtaca gcttcaatta gataatctca ggttagaaaa cgaaaagctg
     2641 cttgagagca aagcctgcct acaggattcc tatgacaact tacaagaaat aatgaaattt
     2701 gagattgacc aactttcaag aaacctccaa aacttcaaaa aagaaaatga aactctgaaa
     2761 tctgatctga ataatttgat ggagcttctt gaggcagaaa aagaacgcaa taacaaatta
     2821 tcattacagt ttgaagaaga taaagaaaac agttctaaag aaatcttaaa agttcttgag
     2881 gctgtacgtc aggagaaaca gaaagagacg gccaagtgtg agcagcagat ggcaaaagta
     2941 cagaaactag aagagagctt gcttgctact gaaaaagtga tcagttccct ggaaaagtct
     3001 agagattctg ataagaaagt tgtagctgac ctcatgaacc agatccagga gctaagaaca
     3061 tcggtctgtg agaaaacaga aactatagac accctgaaac aagaactgaa ggacataaat
     3121 tgcaaataca actctgcttt ggttgacaga gaagagagca gagtgttgat caagaagcag
     3181 gaagtggata ttctggatct gaaagaaacc cttaggctga gaatactttc tgaggacata
     3241 gagagggata tgctctgtga ggacctggct catgccactg agcagctgaa catgctcaca
     3301 gaggcctcaa aaaaacactc ggggctgctg cagtctgccc aggaagaact gaccaagaag
     3361 gaagccctga ttcaggaact tcagcacaag ctaaaccaaa agaaagagga agtagaacag
     3421 aagaagaatg aatataactt caaaatgagg caactagaac atgtgatgga ttctgctgct
     3481 gaggatcccc agagtcctaa gacaccacct cactttcaaa cacatttggc aaaactcctg
     3541 gaaacacaag aacaagagat agaagatgga agagcctcta agacttcttt ggaacacctt
     3601 gtaacaaagc taaatgaaga cagagaagtc aaaaatgctg aaatcctcag aatgaaggag
     3661 cagttgcgtg aaatggaaaa cctacgcctg gaaagtcagc agttaataga gaaaaactgg
     3721 ctcctgcaag gtcagctgga tgatattaaa agacaaaagg aaaacagtga tcagaatcat
     3781 ccagataatc aacagctgaa gaatgaacaa gaagaaagta tcaaagaaag acttgcaaaa
     3841 agtaaaatag ttgaagaaat gctgaaaatg aaagcagacc tagaagaagt ccaaagtgcc
     3901 ctttacaaca aagagatgga atgccttaga atgactgatg aagtcgaacg aacccaaact
     3961 ttggagtcta aagcattcca ggaaaaagaa caactgagat caaagctgga agaaatgtat
     4021 gaagaaagag agagaacatc ccaggagatg gaaatgttaa ggaagcaggt ggagtgtctt
     4081 gctgaggaaa atggaaagtt ggtaggtcac caaaatttgc atcagaagat tcagtacgta
     4141 gtgcgactaa agaaggaaaa tgtcaggctt gctgaggaga cagaaaagtt gcgtgccgaa
     4201 aatgtatttt taaaagaaaa gaaaagaagt gaatcttgag gattccggtc agctacctag
     4261 gcatcacctt gtttgaagat gtttcttctc ttttacaagt aagacctact cctggccact
     4321 taggagagct gaatttatgg accttaatta ttaaatgttt ataaggtggt ggtaaccacc
     4381 tcaagtttct gatgaacatt ctgcatccat atacaccctg tgacagtcag cagtctgcta
     4441 ttaagtggcc tacttcaagg ctttgaatca acttaaggga aaaccttttg tctttgtaaa
     4501 aataaaagcc tgtagctaag gtttacagtg gacattagcc agatcatttt cttcttagat
     4561 tatgccataa tctcctttga ttcttatgga agttctaaca atatatggtg gttccaacac
     4621 ctgcagtgag tttaatgact gacttagtag caggtacaag aagcaaactt gttaatatag
     4681 attatttttg tattcttact ttaggtattt tcttgagcat tttccatgac tgtaaataaa
     4741 gccatttttt aagataataa
//
