LOCUS       NM_014875               7291 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens kinesin family member 14 (KIF14), transcript variant
            1, mRNA.
ACCESSION   NM_014875 XM_375825
VERSION     NM_014875.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7291)
  AUTHORS   Meng,F. and Zhang,Z.
  TITLE     MicroRNA-152 specifically targets kinesin family member 14 to
            suppress the advancement of bladder cancer cells via PI3K/AKT
            pathway
  JOURNAL   Biochem Biophys Res Commun 692, 149337 (2024)
   PUBMED   38070277
  REMARK    GeneRIF: MicroRNA-152 specifically targets kinesin family member 14
            to suppress the advancement of bladder cancer cells via PI3K/AKT
            pathway.
REFERENCE   2  (bases 1 to 7291)
  AUTHORS   Jiang,W., Wang,J., Yang,X., Shan,J., Zhang,Y., Shi,X., Wang,Y.,
            Chenyan,A., Chang,J., Wang,Y., Yu,Y., Li,C. and Li,X.
  TITLE     KIF14 promotes proliferation, lymphatic metastasis and
            chemoresistance through G3BP1/YBX1 mediated NF-kappaB pathway in
            cholangiocarcinoma
  JOURNAL   Oncogene 42 (17), 1392-1404 (2023)
   PUBMED   36922675
  REMARK    GeneRIF: KIF14 promotes proliferation, lymphatic metastasis and
            chemoresistance through G3BP1/YBX1 mediated NF-kappaB pathway in
            cholangiocarcinoma.
REFERENCE   3  (bases 1 to 7291)
  AUTHORS   Liu,L., Li,M., Zhang,J., Xu,D., Guo,Y., Zhang,H. and Cang,S.
  TITLE     KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced
            prostate cancer by promoting AKT phosphorylation
  JOURNAL   Arch Biochem Biophys 737, 109551 (2023)
   PUBMED   36822388
  REMARK    GeneRIF: KIF14 mediates cabazitaxel-docetaxel cross-resistance in
            advanced prostate cancer by promoting AKT phosphorylation.
REFERENCE   4  (bases 1 to 7291)
  AUTHORS   Wang,H., Tang,F., Tang,P., Zhang,L., Gan,Q. and Li,Y.
  TITLE     Noncoding RNAs-mediated overexpression of KIF14 is associated with
            tumor immune infiltration and unfavorable prognosis in lung
            adenocarcinoma
  JOURNAL   Aging (Albany NY) 14 (19), 8013-8031 (2022)
   PUBMED   36227151
  REMARK    GeneRIF: Noncoding RNAs-mediated overexpression of KIF14 is
            associated with tumor immune infiltration and unfavorable prognosis
            in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 7291)
  AUTHORS   Corson,T.W. and Gallie,B.L.
  TITLE     KIF14 mRNA expression is a predictor of grade and outcome in breast
            cancer
  JOURNAL   Int J Cancer 119 (5), 1088-1094 (2006)
   PUBMED   16570270
  REMARK    GeneRIF: KIF14 is overexpressed in primary breast cancer; predicts
            disease-free and overall survival
REFERENCE   6  (bases 1 to 7291)
  AUTHORS   Carleton,M., Mao,M., Biery,M., Warrener,P., Kim,S., Buser,C.,
            Marshall,C.G., Fernandes,C., Annis,J. and Linsley,P.S.
  TITLE     RNA interference-mediated silencing of mitotic kinesin KIF14
            disrupts cell cycle progression and induces cytokinesis failure
  JOURNAL   Mol Cell Biol 26 (10), 3853-3863 (2006)
   PUBMED   16648480
  REMARK    GeneRIF: RNA interference-mediated silencing of KIF14 disrupts cell
            cycle progression and induces cytokinesis failure.
REFERENCE   7  (bases 1 to 7291)
  AUTHORS   Gruneberg,U., Neef,R., Li,X., Chan,E.H., Chalamalasetty,R.B.,
            Nigg,E.A. and Barr,F.A.
  TITLE     KIF14 and citron kinase act together to promote efficient
            cytokinesis
  JOURNAL   J Cell Biol 172 (3), 363-372 (2006)
   PUBMED   16431929
  REMARK    GeneRIF: During cytokinesis, the localization of KIF14 and citron
            kinase to the central spindle and midbody is codependent, and they
            form a complex depending on the activation state of citron kinase.
REFERENCE   8  (bases 1 to 7291)
  AUTHORS   Corson,T.W., Huang,A., Tsao,M.S. and Gallie,B.L.
  TITLE     KIF14 is a candidate oncogene in the 1q minimal region of genomic
            gain in multiple cancers
  JOURNAL   Oncogene 24 (30), 4741-4753 (2005)
   PUBMED   15897902
  REMARK    GeneRIF: Primary non-small-cell lung carcinoma overexpressing KIF14
            showed a trend toward decreased survival.
            GeneRIF: Overexpressed in primary retinoblastoma and lung cancer,
            and in medulloblastoma and breast cancer cell lines. Low expression
            in normal adult tissue; highly expressed in fetal liver and thymus.
REFERENCE   9  (bases 1 to 7291)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   10 (bases 1 to 7291)
  AUTHORS   Nakagawa,T., Tanaka,Y., Matsuoka,E., Kondo,S., Okada,Y., Noda,Y.,
            Kanai,Y. and Hirokawa,N.
  TITLE     Identification and classification of 16 new kinesin superfamily
            (KIF) proteins in mouse genome
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9654-9659 (1997)
   PUBMED   9275178
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4214]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445483.13, D26361.1 and
            BC098582.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014875.2.
            
            Summary: This gene encodes a member of the kinesin-3 superfamily of
            microtubule motor proteins. These proteins are involved in numerous
            processes including vesicle transport, chromosome segregation,
            mitotic spindle formation, and cytokinesis. In human HeLa-S3 and
            293T cells, this protein is localized to the cytoplasm during
            interphase, to the spindle poles and spindle microtubules during
            mitosis, and to the midbody during cytokinesis. An internal motor
            domain displays microtubule-dependent ATPase activity, consistent
            with its function as a microtubule motor protein. Knockdown of this
            gene results in failed cytokinesis with endoreplication, which
            results in multinucleated cells. This gene has been identified as a
            likely oncogene in breast, lung and ovarian cancers, as well as
            retinoblastomas and gliomas. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26361.1, SRR14038197.2500244.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367350.5/ ENSP00000356319.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL445483.13        75807-75823         c
            18-3551             D26361.1           1-3534
            3552-3570           AL445483.13        44289-44307         c
            3571-5649           D26361.1           3554-5632
            5650-6788           AL445483.13        7075-8213           c
            6789-7291           BC098582.1         4346-4848
FEATURES             Location/Qualifiers
     source          1..7291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..7291
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /note="kinesin family member 14"
                     /db_xref="GeneID:9928"
                     /db_xref="HGNC:HGNC:19181"
                     /db_xref="MIM:611279"
     exon            1..341
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            342..1568
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..5403
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF14; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="kinesin-like protein KIF14 isoform 1"
                     /protein_id="NP_055690.1"
                     /db_xref="CCDS:CCDS30963.1"
                     /db_xref="GeneID:9928"
                     /db_xref="HGNC:HGNC:19181"
                     /db_xref="MIM:611279"
                     /translation="MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDM
                     SECENDDPLLRSAGKVRDINRTYVISASRKTADMPLTPNPVGRLALQRRTTRNKESSL
                     LVSELEDTTEKTAETRLTLQRRAKTDSAEKWKTAEIDSVKMTLNVGGETENNGVSKES
                     RTNVRIVNNAKNSFVASSVPLDEDPQVIEMMADKKYKETFSAPSRANENVALKYSSNR
                     PPIASLSQTEVVRSGHLTTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTSNKFGSLEKR
                     TPTKCTTEHKLTTKCSLPQLKSPAPSILKNRMSNLQVKQRPKSSFLANKQERSAENTI
                     LPEEETVVQNTSAGKDPLKVENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEH
                     PDTKQVYNFIYDVSFWSFDECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTG
                     SGKSYTMMGFSEEPGIIPRFCEDLFSQVARKQTQEVSYHIEMSFFEVYNEKIHDLLVC
                     KDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDK
                     SSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGV
                     SINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPAA
                     SNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPER
                     YRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDN
                     HLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFG
                     GTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRD
                     TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQ
                     KAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLE
                     METLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSM
                     KLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESK
                     LAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLH
                     DIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERT
                     IADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFEQLVVL
                     MKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIV
                     QQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKA
                     KELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFK
                     RMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVP
                     STSVGSYESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKS
                     SGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV"
     exon            1569..1823
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1911
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2010
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2063
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2094
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2202
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2319
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2435
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2608
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2756
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2820
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3005
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3108
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3269
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3417
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3570
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3697
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3791
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3921
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4022
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4117
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4342
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4527
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4686
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4809
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4810..4884
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            4885..5023
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..7291
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7269..7274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /note="hexamer: AATAAA"
     polyA_site      7291
                     /gene="KIF14"
                     /gene_synonym="MCPH20; MKS12"
                     /note="major polyA site"
ORIGIN      
        1 attcaaattg cggccttctg gggagccggc gctggaggtg gtgagtggcg tggggactgt
       61 gtcgaggggg tccccaaggt gccggaccct gcggaggggc gaagtttcgg cactggggag
      121 ggcgtgcgga cgctttccct acaggcgacc actgctctgc gggcgggtgg tcttagctcc
      181 agtcccccat tcagttcctc agcattccag gtcggcggcg aaggggtccc cgaacgaagg
      241 gcgcaaggca gcgtctctgc tgggaccggg aagccggact tcagggcctc tcggcccgtg
      301 ggcttctccc cgagtctccc cgagtcggtt ggcattaaga gtttagcaga tactttcaga
      361 aatggataca taagaaatgg ctggaaatca aatgaatgtc caaagaagag cttagggtct
      421 tagtaacatt cttttttaaa ataactgtct gccaaaatgt cattacacag tactcataat
      481 agaaataaca gcggtgatat tcttgatatt ccttcttccc aaaatagttc atcactgaat
      541 gccctcaccc acagtagccg acttaagctg catttgaagt cggatatgtc agaatgtgaa
      601 aatgatgatc cattattgag atctgcaggt aaagtcagag acataaatag aacttatgtt
      661 atttctgcca gtagaaaaac agcagacatg ccccttaccc ctaatcctgt aggtagattg
      721 gcacttcaga ggagaactac aaggaacaaa gaatcatctt tgcttgttag tgagttggaa
      781 gacacaactg aaaaaacagc agaaacacgt cttacattac aacgtcgtgc taaaacagat
      841 tctgcagaaa agtggaaaac agctgaaata gattctgtca aaatgacact gaatgtggga
      901 ggtgaaacag aaaataatgg tgtttctaag gaaagtagaa caaatgtaag gattgtaaat
      961 aatgctaaaa actcttttgt tgcctcttct gtacctttag atgaagatcc acaggtcatt
     1021 gaaatgatgg ctgataagaa atacaaagaa acattttctg cccccagtag agcaaatgaa
     1081 aatgttgcac ttaagtactc aagtaataga ccacccattg cttccctgag tcagactgaa
     1141 gttgttagat caggacactt gacaacgaaa cctactcaga gcaagttgga tatcaaagtg
     1201 ttgggaacag gaaacttgta tcatagaagt attgggaagg aaattgcaaa aacttcaaat
     1261 aaatttggga gcttagaaaa aagaacacct acaaaatgta caacagaaca caaactgaca
     1321 acaaagtgca gcctgcctca gcttaagagc ccagctccat caatactgaa gaatagaatg
     1381 tctaaccttc aagttaaaca aagaccaaaa agttcctttc ttgcaaataa acaggaaaga
     1441 tccgcagaaa atacaattct tcccgaagaa gaaactgtag ttcagaacac ctctgcagga
     1501 aaagacccct taaaagtaga gaatagtcaa gtgacagtgg cagtacgcgt aagacctttc
     1561 accaagagag agaagattga aaaagcatcc caggtagtct tcatgagtgg gaaagaaata
     1621 actgtggaac accctgacac gaaacaagtt tataatttta tttatgatgt ttcattctgg
     1681 tcttttgatg aatgtcatcc tcactacgct agccagacaa ctgtctatga gaagctagca
     1741 gcaccactcc tagaaagagc cttcgaaggc ttcaatacct gtctttttgc ttatggtcag
     1801 actggctctg gaaaatcata tacgatgatg ggatttagtg aagaaccagg aataattcca
     1861 agattttgtg aagatctttt ttctcaagta gccagaaaac aaacccaaga ggtcagctat
     1921 cacattgaaa tgagcttctt tgaagtatat aatgaaaaaa ttcacgacct tctggtttgt
     1981 aaagatgaaa atgggcagag aaagcaacca ctgagagtga gggaacatcc tgtttatgga
     2041 ccatatgttg aagcactgtc aatgaacatt gtcagttctt acgctgatat ccagagttgg
     2101 ctagaattgg gaaataaaca aagagctact gctgctactg gtatgaatga taaaagttcc
     2161 cgatctcatt cagttttcac cctggtgatg acccagacca agacagaatt tgtggaaggg
     2221 gaagaacacg atcacagaat aacaagtcga attaacctaa tagatctggc aggcagtgag
     2281 cgctgctcta cggctcacac taatggagat cgactaaagg aaggtgtgag tattaataag
     2341 tccttgctaa ctttgggaaa agttatatct gcactttcgg aacaagcaaa ccaaaggagt
     2401 gtttttattc cttatcgtga atctgttctt acatggctgt taaaagaaag tctgggtgga
     2461 aattcaaaaa ctgcaatgat tgctacgatt agtcccgctg ccagcaacat agaagaaaca
     2521 ttaagcacac ttagatatgc taaccaagcc cgtttaatag tcaacattgc taaagtaaat
     2581 gaagatatga acgctaagtt aattagagaa ttgaaggcag aaattgcaaa gctaaaagct
     2641 gctcagagaa acagtcggaa tattgaccct gaacgataca ggctctgtcg gcaagaaata
     2701 acatccttaa gaatgaaact gcatcaacag gagagagaca tggcagaaat gcaaagagtg
     2761 tggaaagaaa agtttgaaca agctgaaaaa agaaaacttc aagaaacaaa agagttacag
     2821 aaagcaggaa ttatgtttca aatggacaat catttaccaa accttgttaa tctgaatgaa
     2881 gatccacaac tatctgagat gctgctatat atgataaaag aaggaacaac tacagttgga
     2941 aagtataaac caaactcaag ccatgatatt cagttatctg gggtgctgat tgctgatgat
     3001 cattgtacta tcaaaaattt tggtgggaca gtgagtatta tcccagttgg ggaagcaaag
     3061 acatatgtaa atggaaaaca tattttggaa atcacagtat tacgtcatgg tgatcgagtg
     3121 attcttggtg gagatcatta ttttagattt aatcatccag tagaagtcca gaaaggaaaa
     3181 aggccatctg gaagagatac tcctataagt gagggtccaa aagactttga atttgcaaaa
     3241 aatgagttgc tcatggcaca gagatcacaa cttgaagcag aaataaaaga ggctcagttg
     3301 aaggcaaagg aagaaatgat gcaaggaatc cagattgcaa aagaaatggc tcagcaagag
     3361 ctttcttctc aaaaagctgc atatgaaagc aaaataaaag cactggaagc agaactgaga
     3421 gaagagtctc aaaggaaaaa aatgcaggaa ataaataacc agaaggctaa tcacaaaatt
     3481 gaggaattag aaaaggcaaa gcagcatctt gaacaggaaa tatatgtcaa caaaaagcga
     3541 ttagaaatgg aaacattggc tacaaaacag gctttagaag accatagcat ccgccatgca
     3601 agaattctgg aagctttaga aactgaaaag caaaaaattg ctaaagaagt acaaattcta
     3661 cagcagaatc ggaataatag ggataaaact tttacagtgc agacaacttg gagctctatg
     3721 aaactctcaa tgatgattca ggaagccaat gctatcagca gcaaattgaa aacatactat
     3781 gtttttggca gacatgatat atcagataaa agtagttctg acacttctat tcgggttcgt
     3841 aacctgaaac taggaatctc aacattctgg agtctggaaa agtttgaatc taaacttgca
     3901 gcaatgaaag aactttatga gagtaatggt agtaacaggg gtgaagatgc cttttgtgat
     3961 cctgaagatg aatgggaacc cgacattaca gatgcaccag tttcttcact ttctagaagg
     4021 aggagtagga gtttgatgaa gaacagaaga atttctggtt gtttacatga catacaagtc
     4081 catccaatta agaatttgca ttcttcacat tcatcaggtt taatggacaa atcaagcact
     4141 atttactcaa attcagcaga gtcctttctt cctggaattt gcaaagaatt gattggttct
     4201 tcgttagatt tttttggaca gagttatgat gaagaaagaa ctatagcaga cagcctaatt
     4261 aatagttttc ttaaaattta taatgggcta tttgccattt ccaaggctca tgaagaacaa
     4321 gatgaagaaa gtcaagataa cttgttttct tctgatcgag caatccagtc acttactatt
     4381 cagactgcat gtgcttttga gcagctagta gtgctaatga aacactggct gagtgattta
     4441 ctgccttgta ccaacatagc aagacttgag gatgagttga gacaagaagt taaaaaactg
     4501 ggaggctact tacagttatt tttgcaggga tgctgtttgg atatttcatc aatgataaaa
     4561 gaggctcaaa agaatgcaat ccaaattgta caacaagctg taaagtatgt ggggcagtta
     4621 gcagttctga aagggagcaa gctacatttt ctagaaaacg gtaacaataa agctgccagt
     4681 gtccaggagg aattcatgga tgctgtttgt gatggtgtag gcttaggaat gaagatttta
     4741 ttagattctg gactggaaaa agcaaaagaa cttcagcatg aactctttag gcagtgtaca
     4801 aaaaatgagg ttaccaaaga aatgaaaact aatgccatgg gattgattag atctcttgaa
     4861 aacatctttg ctgaatcgaa aattaaaagt ttcagaaggc aagtacaaga agaaaacttt
     4921 gaataccaag atttcaagag gatggttaat cgtgctccag aattcttaaa gttaaaacat
     4981 tgcttagaga aagctattga aattattatt tctgcactga aaggatgcca tagtgatata
     5041 aatcttctcc agacttgtgt tgaaagtatt cgcaacttgg ccagtgattt ttacagtgac
     5101 ttcagtgtgc cttctacttc tgttggcagc tatgagagta gagtaactca cattgtccac
     5161 caggaactag aatctctagc taagtctctc ctcttttgtt ttgaatctga agaaagccct
     5221 gatttgttga aaccctggga aacttataat caaaatacca aagaagaaca ccaacaatct
     5281 aaatcaagcg ggattgacgg cagtaagaat aaaggtgtac caaagcgtgt ctatgagctc
     5341 catggctcat ccccagcagt gagctcagag gaatgcacac ccagtaggat tcagtgggtg
     5401 tgaatactga tgtgtaggca cttttatgac cacccatgaa agaaaaagaa cacttgctcg
     5461 gtaattttct ttatgcagga gagtttaaga gaaatcagca cagatatttc aaaaaagtcc
     5521 atgtcttttt atctttaaaa tatctattta tcaaaggcca gacacagtgg ctcacgcctg
     5581 taatcccagc actttgggag gcgggcagat cacaaggtca ggagtttgag accggcctgg
     5641 ccaacatggc gaaaccccgt ctctactaaa aatacaaaaa tttgctgggc atggtggcgc
     5701 gtgcctgtaa tcccagctac taggggggct gaggcaggag gatcgcttga acctgagagg
     5761 cagaggttgc agtgagccaa gatcatgcca ctttactcca gtctgagcaa cagaacgaga
     5821 cttagtcaaa ataaataaat aaataaataa ataaataaat aaataaataa ataaaatata
     5881 tttttatctt taaagtgttt aacattggta tactgtctgt agttggttca ttagtcgttt
     5941 ataaagggtt attttctcat gagtggaaac ctgaacaatc agttaccttt gtgcctatgc
     6001 cttctctctc ctcagacagc tgggatgttt atggtgaaat ggcctgtaca agtttaacta
     6061 agacaactta acttgcattg ttaatcaaaa attcttttct caaagggtta actggttgcc
     6121 attttgaata gtatgttcaa gggtgtagct tcctgtttct ttccaaatta taagtagcta
     6181 cctaaatata gtataattat atattaataa tatggcttgc tggcacagta gtttaccctg
     6241 ttatctgtgt ttcataatgg gggctgtatg aatattattt aaaactaata aaatgttgcc
     6301 agaattatac taaactgttg gatgagatta ggagatcaga ggctggacct tctcttgata
     6361 atgcttgttt tgttaaaggt ataatgaaat aatttgtata tgatttgatg aagattaaag
     6421 acccttattt tccacagctt taaaaaaaaa cctttattta tgatcaagta ataaagataa
     6481 tattctactt gtgggatctt acattacgga aatagtttga cgtttttgac ctcaagagta
     6541 tgtataattt gaagagatac tttgtaacta tgcttgggtg atattgagca gttcctaaag
     6601 aataattcat ttaaaaaaaa agaagaaaaa aaaagaagaa ttcatttaaa taacctgatc
     6661 ctttcatttg cccttttcga atttacagat actacttgta catttggcat aactagttga
     6721 aattggccat tcgtaccatg aataaatctg atagtttcct tgttaggaag agattgtaag
     6781 taaatacagt cattgcagtc agaacagtat tagtgaacct tgtgtggtgt tttcaagctc
     6841 tttaaaatgg tacaatgtag cacatttgct ttcatttctt tttttatttt tggcatttga
     6901 ccttgtattc tttctgaagc tctatatgtg tttttattag tcaataatct ggcaagtagc
     6961 actttgcctg tgcagtttgc tggagtgtag atgtacatat gaggatttcc cgggaggtgc
     7021 acttctttga agaacttcct aaagtacctg tatagtagtt ttcatcttaa tattcagtat
     7081 ttaatcttca gtttgtgctt tgtaaactca tgacttaatt ggtcagaaac tttttagtgt
     7141 ctttataaaa ttttgtatac atatttatac taaacacatt gtgatactgt atttgaatga
     7201 atggtgaaaa aatatttgct attggaatta tgtgcactga caagaaatgt tataaagaga
     7261 atgcctttaa taaatctttt cagcattaga a
//
