LOCUS       NM_015254               8743 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens kinesin family member 13B (KIF13B), mRNA.
ACCESSION   NM_015254
VERSION     NM_015254.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8743)
  AUTHORS   Cho,H.D., Nhan,N.T.T., Zhou,C., Tu,K., Nguyen,T., Sarich,N.A. and
            Yamada,K.H.
  TITLE     KIF13B mediates VEGFR2 recycling to modulate vascular permeability
  JOURNAL   Cell Mol Life Sci 80 (4), 91 (2023)
   PUBMED   36928770
  REMARK    GeneRIF: KIF13B mediates VEGFR2 recycling to modulate vascular
            permeability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8743)
  AUTHORS   Juhl,A.D., Anvarian,Z., Kuhns,S., Berges,J., Andersen,J.S.,
            Wustner,D. and Pedersen,L.B.
  TITLE     Transient accumulation and bidirectional movement of KIF13B in
            primary cilia
  JOURNAL   J Cell Sci 136 (5) (2023)
   PUBMED   35403186
  REMARK    GeneRIF: Transient accumulation and bidirectional movement of
            KIF13B in primary cilia.
REFERENCE   3  (bases 1 to 8743)
  AUTHORS   Drabik,A., Ner-Kluza,J., Hartman,K., Mayer,G. and Silberring,J.
  TITLE     Changes in Protein Glycosylation as a Result of Aptamer
            Interactions with Cancer Cells
  JOURNAL   Proteomics Clin Appl 14 (1), e1800186 (2020)
   PUBMED   31550741
  REMARK    GeneRIF: Changes in Protein Glycosylation as a Result of Aptamer
            Interactions with Cancer Cells.
REFERENCE   4  (bases 1 to 8743)
  AUTHORS   Schou,K.B., Mogensen,J.B., Morthorst,S.K., Nielsen,B.S.,
            Aleliunaite,A., Serra-Marques,A., Furstenberg,N., Saunier,S.,
            Bizet,A.A., Veland,I.R., Akhmanova,A., Christensen,S.T. and
            Pedersen,L.B.
  TITLE     KIF13B establishes a CAV1-enriched microdomain at the ciliary
            transition zone to promote Sonic hedgehog signalling
  JOURNAL   Nat Commun 8, 14177 (2017)
   PUBMED   28134340
  REMARK    GeneRIF: Study provides evidence that KIF13B and NPHP4 are both
            required for establishment of a specialized caveolin-1 membrane
            microdomain at the ciliary transition zone, which is essential for
            Shh-induced accumulation of SMO in the primary cilium as well as
            for activation of GLI-mediated target gene expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8743)
  AUTHORS   Zhu,J., Shang,Y., Xia,Y., Zhang,R. and Zhang,M.
  TITLE     An Atypical MAGUK GK Target Recognition Mode Revealed by the
            Interaction between DLG and KIF13B
  JOURNAL   Structure 24 (11), 1876-1885 (2016)
   PUBMED   27642159
  REMARK    GeneRIF: Findings show that the high-affinity binding of KIF13B to
            DLG guanylate kinase (GK) domain does not require phosphorylation
            of KIF13B and that DLG binds to an unphosphorylated and
            autonomously folded domain within its stalk region (MAGUK binding
            stalk [MBS] domain) with high specificity and affinity.
REFERENCE   6  (bases 1 to 8743)
  AUTHORS   Yoshimura,Y., Terabayashi,T. and Miki,H.
  TITLE     Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B
            to regulate axon formation
  JOURNAL   Mol Cell Biol 30 (9), 2206-2219 (2010)
   PUBMED   20194617
  REMARK    GeneRIF: These results reveal that GAKIN/KIF13B is a key
            intermediate linking Par1b to the regulation of axon formation.
REFERENCE   7  (bases 1 to 8743)
  AUTHORS   Yamada,K.H., Hanada,T. and Chishti,A.H.
  TITLE     The effector domain of human Dlg tumor suppressor acts as a switch
            that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B
  JOURNAL   Biochemistry 46 (35), 10039-10045 (2007)
   PUBMED   17696365
  REMARK    GeneRIF: Binding of the SH3-I3-GUK module of hDlg to GAKIN
            activates the microtubule-stimulated ATPase activity of GAKIN by
            approximately 10-fold. We propose: the cargo-mediated regulation of
            motor activity is a general paradigm for the activation of
            kinesins.
REFERENCE   8  (bases 1 to 8743)
  AUTHORS   Horiguchi,K., Hanada,T., Fukui,Y. and Chishti,A.H.
  TITLE     Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates
            neuronal cell polarity
  JOURNAL   J Cell Biol 174 (3), 425-436 (2006)
   PUBMED   16864656
  REMARK    GeneRIF: These results suggest that, in neurons, the GAKIN-PIP3BP
            complex transports PIP3 to the neurite ends and regulates neuronal
            polarity formation.
REFERENCE   9  (bases 1 to 8743)
  AUTHORS   Asaba,N., Hanada,T., Takeuchi,A. and Chishti,A.H.
  TITLE     Direct interaction with a kinesin-related motor mediates transport
            of mammalian discs large tumor suppressor homologue in epithelial
            cells
  JOURNAL   J Biol Chem 278 (10), 8395-8400 (2003)
   PUBMED   12496241
REFERENCE   10 (bases 1 to 8743)
  AUTHORS   Hanada,T., Lin,L., Tibaldi,E.V., Reinherz,E.L. and Chishti,A.H.
  TITLE     GAKIN, a novel kinesin-like protein associates with the human
            homologue of the Drosophila discs large tumor suppressor in T
            lymphocytes
  JOURNAL   J Biol Chem 275 (37), 28774-28784 (2000)
   PUBMED   10859302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA068190.1, AB014539.3, AC108449.5, DA437040.1 and AI760125.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015254.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279865.1, AB014539.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524189.6/ ENSP00000427900.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-547               DA068190.1         24-570
            548-1875            AB014539.3         541-1868
            1876-1876           AC108449.5         149513-149513       c
            1877-5732           AB014539.3         1870-5725
            5733-6105           DA437040.1         196-568
            6106-8742           AB014539.3         6099-8735
            8743-8743           AI760125.1         9-9                 c
FEATURES             Location/Qualifiers
     source          1..8743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..8743
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /note="kinesin family member 13B"
                     /db_xref="GeneID:23303"
                     /db_xref="HGNC:HGNC:14405"
                     /db_xref="MIM:607350"
     exon            1..91
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..5517
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /note="kinesin 13B; guanylate kinase associated kinesin;
                     kinesin-like protein GAKIN"
                     /codon_start=1
                     /product="kinesin-like protein KIF13B"
                     /protein_id="NP_056069.2"
                     /db_xref="CCDS:CCDS55217.1"
                     /db_xref="GeneID:23303"
                     /db_xref="HGNC:HGNC:14405"
                     /db_xref="MIM:607350"
                     /translation="MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNL
                     SKGDARGQPKVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAY
                     GQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRD
                     LLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEE
                     SSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNI
                     NKSLTTLGLVISALADQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAA
                     DNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEAMKSPE
                     LKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFL
                     VNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQ
                     KNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDQDPSMKNEN
                     SSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRS
                     ALERQRLMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPSAQQRLRQWAEEREATLNNS
                     LMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIPASSLDANRKRGSLLSEPAIQ
                     VRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYFKRADPFYDEQENHS
                     LIGVANVFLESLFYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGDVGERIAGGDEVAE
                     VSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEPVIVAPEVDTSSSSV
                     SKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQ
                     AKTRSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQGQSRR
                     VQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRAPRTHETFHEEEEDMDSYQDRDL
                     ERLRRKWLNALTKRQEYLDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEERNAVMV
                     PSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGGWDATLTGEE
                     EEEFFELQIVKQHDGEVKAEASWDSAVHGCPQLSRGTPVDERLFLIVRVTVQLSHPAD
                     MQLVLRKRICVNVHGRQGFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREA
                     LARMAANVENPASADSEAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRR
                     SISSPNVNRLSGSRQDLIPSYSLGSNKGRWESQQDVSQTTVSRGIAPAPALSVSPQNN
                     HSPDPGLSNLAASYLNPVKSFVPQMPKLLKSLFPVRDEKRGKRPSPLAHQPVPRIMVQ
                     SASPDIRVTRMEEAQPEMGPDVLVQTMGAPALKICDKPAKVPSPPPVIAVTAVTPAPE
                     AQDGPPSPLSEASSGYFSHSVSTATLSDALGPGLDAAAPPGSMPTAPEAEPEAPISHP
                     PPPTAVPAEEPPGPQQLVSPGRERPDLEAPAPGSPFRVRRVRASELRSFSRMLAGDPG
                     CSPGAEGNAPAPGAGGQALASDSEEADEVPEWLREGEFVTVGAHKTGVVRYVGPADFQ
                     EGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGLLVRPSRVRRATGPVRRRSTGLRLG
                     APEARRSATLSGSATNLASLTAALAKADRSHKNPENRKSWAS"
     exon            92..185
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            186..198
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            199..259
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            260..352
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            353..533
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            534..621
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            622..756
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            757..869
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            870..981
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1194
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1305
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1440
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1571
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1658
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1849
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2060
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2223
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2370
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2520
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2649
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2820
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2978
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3111
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3258
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3288
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3388
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3515
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..3571
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3696
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3873
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3966
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4119
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4197
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4251
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4252..4360
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4494
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4557
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..5254
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..8743
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8716..8721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /note="hexamer: AATAAA"
     polyA_site      8743
                     /gene="KIF13B"
                     /gene_synonym="GAKIN"
                     /note="major polyA site"
ORIGIN      
        1 agacggaagc cgaacgagtt cctcggcggc tgcaggatgg gggactccaa agtgaaagtg
       61 gcggtgcgga tacgacccat gaaccggcga gagactgact tgcataccaa atgtgtggtg
      121 gatgtggatg caaacaaggt tattcttaat cctgtaaata cgaatctttc caaaggagat
      181 gcccggggcc agccgaaggt gtttgcttat gatcattgtt tctggtctat ggatgaatct
      241 gtcaaagaaa agtatgcagg tcaagatatt gttttcaagt gccttggaga gaatatcctg
      301 cagaatgctt ttgatggcta caatgcatgt atctttgcct atggacagac tggctctgga
      361 aaatcttata ccatgatggg cacagctgac caacctggat taatcccaag actttgcagt
      421 ggactctttg aacgaactca gaaagaggaa aatgaagaac agagttttaa agtagaagtg
      481 tcctacatgg aaatttataa tgaaaaagtt cgagaccttc ttgatcccaa aggaagccgt
      541 cagacgttga aagtcagaga gcatagtgtg ttgggacctt atgtcgacgg actttctaaa
      601 ctggctgtca caagctacaa ggatattgag tcgttgatgt ctgagggtaa caaatctcgc
      661 acagttgctg caaccaacat gaacgaggag agtagccgat cccatgcagt tttcaaaatc
      721 accctcacac atactctcta cgatgtgaag tctgggacat ctggagagaa agtgggcaaa
      781 ctcagcctgg tggatttagc tggcagtgaa cgagcaacga agacaggcgc tgcaggggac
      841 aggctgaagg aagggagcaa cattaacaag tccctcacaa ccctcggtct ggttatctca
      901 gctcttgcag atcagagtgc tggcaaaaac aagaataaat ttgttccata tcgtgactca
      961 gttctcactt ggctgctcaa agacagcctc gggggtaaca gcaagaccgc catggtggct
     1021 actgtgagtc ctgcagctga taactatgat gaaaccctct caactctgcg gtatgcagat
     1081 cgagccaagc acattgtaaa ccacgctgtg gtgaatgagg accctaatgc ccgaattatc
     1141 cgggatctcc gggaagaagt tgagaaactc cgggagcagc tgaccaaagc agaggcaatg
     1201 aaatctccag agctaaagga ccggctggaa gaatctgaga agctaatcca ggaaatgact
     1261 gtgacctggg aggagaaatt aaggaaaacg gaggagattg cacaggaacg acagaaacag
     1321 cttgagagtc ttggaatatc tcttcagtct tcgggaatca aagttgggga tgataaatgc
     1381 ttccttgtga atctgaatgc tgacccagct ctgaatgagc ttctggtgta ctatttaaag
     1441 gaacatacat tgatagggtc agcaaattcc caagatatcc aactgtgcgg catgggaatt
     1501 cttcctgaac actgtattat agacatcacg tcagaaggcc aggttatgct gactcctcag
     1561 aagaacacca gaacatttgt aaatgggtca tctgtctcca gtccaataca gctacaccat
     1621 ggggacagga tattatgggg aaacaatcat ttcttcagac tcaatttgcc taaaaagaaa
     1681 aagaaagcag aacgagagga tgaggaccag gatccctcca tgaagaacga gaatagttct
     1741 gagcagctgg atgtagacgg agactcctcc agcgaggtgt ccagtgaagt taactttaat
     1801 tacgaatacg cacagatgga ggtcaccatg aaggccctgg gcagcaatga tccgatgcag
     1861 tccatattaa acagcttaga acaacagcat gaagaagaaa aacgatctgc actggagcgc
     1921 cagaggctta tgtatgagca cgaattggag cagctccgga gaaggctgtc tcctgagaag
     1981 cagaactgcc ggagcatgga caggttttct ttccactcgc ccagcgctca gcaacgctta
     2041 agacagtggg ctgaggagag agaagcaacg ttgaataaca gcctgatgag gctgagggaa
     2101 caaattgtta aggccaatct attggtgaga gaagctaatt acattgctga ggagctggat
     2161 aaaagaacag aatacaaagt taccctacag attccagcct ccagcctgga tgccaacagg
     2221 aagcgaggct ctcttcttag tgagcctgca atccaggtga gaagaaaagg aaaaggaaag
     2281 cagatttggt ctttggaaaa actggacaac aggctgttgg atatgagaga cctttatcag
     2341 gagtggaaag agtgtgaaga agataaccca gtaatacgat catacttcaa acgtgctgat
     2401 ccattctatg atgagcagga aaatcacagt ctcattgggg tggccaatgt cttcctcgag
     2461 tcacttttct atgatgtgaa gttacaatac gctgttccca tcatcaacca gaaaggagag
     2521 gtggcaggtc ggctgcacgt ggaggtgatg cgactcagtg gtgatgttgg ggagaggatc
     2581 gcaggaggcg atgaggtggc agaggtctcc tttgagaagg agacccagga gaacaaactg
     2641 gtgtgcatgg ttaaaatcct gcaagctact gggttgccac agcatctgtc ccactttgtg
     2701 ttctgcaaat acagcttctg ggatcaacag gagccggtga ttgtcgctcc tgaagtggac
     2761 acctcctcct cttccgtcag caaggagccg cactgcatgg ttgtctttga tcattgcaat
     2821 gagttttctg ttaacatcac cgaagacttt atcgagcatc tttccgaagg agcattggca
     2881 attgaagtat atggacataa aataaacgat ccccggaaaa accccgccct gtgggatttg
     2941 ggaatcatcc aagcaaagac acgtagtctt cgggacagat ggagtgaagt gaccaggaaa
     3001 ttggaattct gggttcaaat cttggaacag aatgagaatg gtgaatactg ccctgtagaa
     3061 gtgatttctg caaaggatgt cccaacagga ggaatcttcc agctccggca ggggcagtcc
     3121 cggagagttc aagtcgaagt gaagtcagtg caggaatctg ggactttacc actgatggaa
     3181 gaatgtatac tgtctgttgg cattggatgt gtcaaagtta gaccgctcag agcccccaga
     3241 acacatgaga ccttccatga ggaagaggaa gacatggaca gctaccagga tcgagattta
     3301 gagagacttc gtagaaaatg gctaaatgca ttaacaaaac gtcaggagta cttggatcaa
     3361 caattgcaaa agcttgtcag taaacgtgat aaaacagagg atgatgctga ccgtgaagcg
     3421 cagcttctgg agatgcggtt gaccctaact gaggagagga acgcggtgat ggtcccctct
     3481 gctggcagtg gtattccagg ggccccagca gaatggaccc cagtacctgg gatggagaca
     3541 cacattcctg ttatattcct ggacttaaat gctgatgatt tcagctctca ggataatctt
     3601 gatgacccag aagctggtgg atgggatgcg accttgactg gggaagaaga agaggagttc
     3661 tttgaattgc agattgtgaa gcagcatgat ggggaggtga aagcagaagc ctcctgggac
     3721 tccgcggtgc atggctgccc tcagctcagc aggggcacgc ccgtggacga gcggttgttc
     3781 ctgatcgtgc gcgtgacggt ccagctcagc caccctgctg acatgcaact ggtgttacgc
     3841 aagagaatct gtgtcaatgt tcacggccgc cagggttttg cacagagtct cctaaaaaag
     3901 atgtctcatc gaagttctat tcctggctgt ggagtgactt ttgaaattgt ctccaatatt
     3961 ccagaggatg cccagggagt ggaagaacgg gaagcattag caagaatggc agccaatgtt
     4021 gaaaacccag cttctgctga ctcggaggct tatattgaaa agtacctcag gagcgtgctg
     4081 gctgtagaaa acctcctgac tttagatcgt ctgcgccagg aagttgcagt gaaggaacag
     4141 ttaacaggaa aaggaaagtt gagcaggagg agtatcagtt ctccaaatgt gaacagattg
     4201 tctggaagcc gacaagatct cattccatca tacagtctag gcagcaacaa gggccggtgg
     4261 gaaagtcagc aggatgtatc ccaaaccaca gtttccagag gaatagctcc tgcccccgcc
     4321 ctctctgttt ctccccaaaa taaccattct ccagatccag gactcagtaa ccttgcagca
     4381 tcctacttga atcctgtcaa atccttcgtg ccgcaaatgc caaagctcct caagtctctc
     4441 tttcccgtcc gcgatgagaa gaggggcaag cggccgtctc ccctcgcaca ccagcccgtg
     4501 ccccgcatca tggtgcagtc agccagcccg gacatcaggg tgaccaggat ggaggaggct
     4561 cagccggaga tgggccctga cgtgctggtg cagacgatgg gggccccggc cttgaagatc
     4621 tgcgacaaac ctgccaaagt gccttcccca ccgcctgtca tagctgtcac agcggtcacc
     4681 ccggctccgg aggcacagga cgggcccccc agccccctga gtgaagcctc tagcgggtac
     4741 ttctcccaca gcgtctccac cgcgaccctg tcggacgccc tgggccccgg cctggacgct
     4801 gcggccccgc cggggtccat gcccaccgcc cctgaggccg agcccgaggc gcccatcagc
     4861 caccccccac cgcccacggc cgtccccgcc gaggagcccc ctggccccca gcagctcgtg
     4921 agccccggtc gggagcgccc cgacctcgag gccccggcgc ccggctcccc gttccgcgtc
     4981 cggagggtgc gggcctcgga gttgcgctcc ttctcgcgca tgctggctgg ggaccccggc
     5041 tgctccccgg gggccgaggg gaatgcgccg gccccgggcg ccgggggaca ggccctggcc
     5101 tctgattccg aggaagctga cgaggtcccg gagtggctcc gagagggcga gttcgtcacc
     5161 gtgggcgccc acaaaacggg cgtggtgaga tacgtggggc ctgccgactt ccaagagggc
     5221 acgtgggtcg gcgtggagct cgacctgccc tcaggtaaga atgacggttc catcggcggg
     5281 aagcagtact tcaggtgtaa ccctggctac gggctgctgg tcaggcccag ccgggtccgc
     5341 agggccacgg gccctgtgcg gcggcgcagc acaggactcc ggctgggtgc ccccgaggcc
     5401 cgccggagcg ccaccctctc gggctccgcc accaacctgg cctcgctgac agctgccctg
     5461 gccaaggccg acaggagcca caagaaccct gagaaccgga aatcctgggc cagctgagcc
     5521 gctgccttag ggcgaacttt tctgggggtg cccggcccct tttgagccct gccagtgaca
     5581 gccctgagga gccaggagcc cggtggcccc ttccccaggg gcagggcgat gaatgctttt
     5641 tgcacgacac agggctggtg acctccctgg gcctctggaa gctttgtttc ttctgtaccc
     5701 gggtaaagtg ggggcctcaa ctgtgcctcc tcaggtggat ggaaggttct gggtgcccgc
     5761 aggggctggg ggatgctagg actgagaccc tgggtggtgc agcgcctggt gatcttgctg
     5821 tgtgcctgtg cctggggcct tatgttgctc tttctatcat ttccattctg gtggccccac
     5881 taatgtctta acctaaacca taattgtaac cagtgccttt cctccccact ggagggcaag
     5941 cccccccacc cacccaggat gtcctggctc actccgcaag ccccccagcc tcccaccctg
     6001 gtcccagttt cccgcaaagt gcctctgggg gaccccccag cctcccaccc tggtcccagg
     6061 ttccacaagt gcctctggag ggccctgggc tctggcagat ggtcctggtg ccccagacgg
     6121 gggccgaggg cctgagcccc cccatccctc ctctgccagg gtttcttagc ggtttctctg
     6181 tggatgtttt ggcatcttta gacacctgga aagtctctta tgtttgccgt ttattccctt
     6241 cacagaaggc ttggaatgta tttatttata tttatttttt caaaatccga aatcatttgc
     6301 gagccgcaat cgtcgtctgc ctgtgtgggg gggcccaggg cctgccttgc acgttgcagc
     6361 ctctctggcc attgcagagc tgctggcctc ctgcccaggt ggagggtcct ggggacggca
     6421 gaggataaag ccccctcctc acatccctct attgcggatc cacagtggcc ttactcttaa
     6481 cttggatgag agcaaaaacc tgggagaatg atgtgcttct gtagtcggtg acaaaggaag
     6541 aggcattgct actttatttg gtgcactttt ggtttctagg aaggtctttg ggtcatttta
     6601 acttctcggc aactcccaga ctctcagagt gtggggctgg ggcctggcgg ctgggctggt
     6661 gcagggagtg tgctggttag tctccagacc ctcacagcag ccacgccccc aggcccaccg
     6721 tgcatggtgt gggcgggaca gccggaagct tccggggtgg cctccacctc ctggctgggg
     6781 cacttatgct cccagagcct ttggtgccag gtttgtggga tgggggttag cgtctatgtg
     6841 tggaaggcca ccaatctagg gacaggagtc ctgggtcaag attcacacag ccacccttgg
     6901 agctggtttc tagttctcac atttagtcaa catctagaaa gcgctgcgga aggctctggt
     6961 tctctaggga cttgaaggcg ccaacagagt agtctccatg gtgggcctgt cccagccctg
     7021 gctgcgagga caggttgtct ttctctcccc agttggcgag ggacacgaag gctgcggccg
     7081 ggctggcaga gggcccggcc cctgggggga ggcactcctc cagggctctc cctgtcctta
     7141 gccgattttg agggaaccct gtggcacctg tccctggatg aagagctgtc acctctgcct
     7201 tgccctttaa ctcaacccgc ttcccagcac agcggctttc tttttaaaac ctgtttcact
     7261 gagaagtttg tttttgggtc cgctggtgtc actatggcct gggtgagagg ccagcactgc
     7321 tgctgccctg aggggaaacg cctgggccgt gtagtgggga cgctctggga atggtggcgg
     7381 acgggcagcg tgggtgggac ctggcacttc gtggtggctg agccatccac ccagcagcgg
     7441 cctcctgtag caccatcttg ggaaagtcct gggggacgtg tgtgtcgtgc tttttaccat
     7501 cggtttgact tacagtggag tagaacgagc cagagttcct gacttgagca ggtggatttg
     7561 ggcccaggcc ctgttcactc ttgcttctcg gtgcggacta atgtcagctt gtggctggga
     7621 aagagggatg tgcagtgacg tggtcaccaa ggcagtgagc cccgctgacc ccgggccagc
     7681 acttggcagg caggaggtgc ggtctccaga gtggtgggcc agggcgggct ggcctccgtc
     7741 ttctatcttc ttttcttgcc tccctgacca gcagactcac ctcccaagaa cgcctgcccg
     7801 cccacccgcc ttaggactcc cgatgcgctc ctggaaggcc ccaggagtgg caccttagtg
     7861 tgggtcggcc cgcagatggc acccaaggcc gggaagggca gtaactgcac acgcggcgct
     7921 gtcagagatg ggggtggggg atgcttctgg gggccctgcc tccccattgt gtgcccagaa
     7981 catccctggc cccaccccgc cacttccctc gggcccttat gaaggactga ggctccaggg
     8041 tgagaaggct cacttctgcc ccgggcactg cgtccagcag cagaggggac agggggcagg
     8101 tgtgtgactg ggttcctggg tacccaggcc tgaccagagg gagcgggagg gcagaggtga
     8161 ggagggggaa gatgtttctg ggcctaccaa ggttcaacaa gagaacggag ctgggaatgt
     8221 gactgctgga gcctgagagg tggaggagtt ctgatccccc gttacttcct agcattttct
     8281 cctcttgcct taaaagttcc ctgtatgtga aacgggaagt cctgagagtg tgtgttggtg
     8341 gctgtgcgca cgcacacaag acgggagtca ccctgtgctt cctgcccaag atactgaccc
     8401 attgaacccc caaagcatct ttctctccac aaagtccgtg gtgccttcct ggtgggctgc
     8461 agacactaat ggtgttgggg ggtcttggaa cagcttctct atgtgtggat tcgtgtaaat
     8521 gcgaagagtt cacatataaa gaagtgactt tgattctgtg attatattga tttggtacac
     8581 agtaaatggg agtttaaaaa atccaaagac tctaatgact tgtaaagact ctaatgattt
     8641 gtatcatgta atgaactaaa ccacctgtaa ttttgtaccg tatgtgtctt tccatcaaat
     8701 gaccaacagc ttctcaataa aaccagacca tttctcacct gca
//
