LOCUS       NM_004523               5016 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens kinesin family member 11 (KIF11), mRNA.
ACCESSION   NM_004523
VERSION     NM_004523.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5016)
  AUTHORS   Li,G., Huang,Y., Han,W., Wei,L., Huang,H., Zhu,Y., Xiao,Q.,
            Wang,Z., Huang,W. and Duan,R.
  TITLE     Eg5 UFMylation promotes spindle organization during mitosis
  JOURNAL   Cell Death Dis 15 (7), 544 (2024)
   PUBMED   39085203
  REMARK    GeneRIF: Eg5 UFMylation promotes spindle organization during
            mitosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5016)
  AUTHORS   Meissner,L., Niese,L., Schuring,I., Mitra,A. and Diez,S.
  TITLE     Human kinesin-5 KIF11 drives the helical motion of anti-parallel
            and parallel microtubules around each other
  JOURNAL   EMBO J 43 (7), 1244-1256 (2024)
   PUBMED   38424239
  REMARK    GeneRIF: Human kinesin-5 KIF11 drives the helical motion of
            anti-parallel and parallel microtubules around each other.
REFERENCE   3  (bases 1 to 5016)
  AUTHORS   Gao,W., Lu,J., Yang,Z., Li,E., Cao,Y. and Xie,L.
  TITLE     Mitotic Functions and Characters of KIF11 in Cancers
  JOURNAL   Biomolecules 14 (4), 386 (2024)
   PUBMED   38672404
  REMARK    GeneRIF: Mitotic Functions and Characters of KIF11 in Cancers.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5016)
  AUTHORS   Qi,X., Liu,Y., Peng,Y., Fu,Y., Fu,Y., Yin,L. and Li,X.
  TITLE     UHRF1 promotes spindle assembly and chromosome congression by
            catalyzing EG5 polyubiquitination
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37728657
  REMARK    GeneRIF: UHRF1 promotes spindle assembly and chromosome congression
            by catalyzing EG5 polyubiquitination.
REFERENCE   5  (bases 1 to 5016)
  AUTHORS   Zhu,L., Chen,C., Kang,M., Ma,X., Sun,X., Xue,Y. and Fang,Y.
  TITLE     KIF11 serves as a cell cycle mediator in childhood acute
            lymphoblastic leukemia
  JOURNAL   J Cancer Res Clin Oncol 149 (17), 15609-15622 (2023)
   PUBMED   37656243
  REMARK    GeneRIF: KIF11 serves as a cell cycle mediator in childhood acute
            lymphoblastic leukemia.
REFERENCE   6  (bases 1 to 5016)
  AUTHORS   Whitehead,C.M. and Rattner,J.B.
  TITLE     Expanding the role of HsEg5 within the mitotic and post-mitotic
            phases of the cell cycle
  JOURNAL   J Cell Sci 111 (Pt 17), 2551-2561 (1998)
   PUBMED   9701554
REFERENCE   7  (bases 1 to 5016)
  AUTHORS   Blangy,A., Arnaud,L. and Nigg,E.A.
  TITLE     Phosphorylation by p34cdc2 protein kinase regulates binding of the
            kinesin-related motor HsEg5 to the dynactin subunit p150
  JOURNAL   J Biol Chem 272 (31), 19418-19424 (1997)
   PUBMED   9235942
REFERENCE   8  (bases 1 to 5016)
  AUTHORS   Blangy,A., Lane,H.A., d'Herin,P., Harper,M., Kress,M. and Nigg,E.A.
  TITLE     Phosphorylation by p34cdc2 regulates spindle association of human
            Eg5, a kinesin-related motor essential for bipolar spindle
            formation in vivo
  JOURNAL   Cell 83 (7), 1159-1169 (1995)
   PUBMED   8548803
REFERENCE   9  (bases 1 to 5016)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
REFERENCE   10 (bases 1 to 5016)
  AUTHORS   Tihy,F., Kress,M., Harper,M., Dutrillaux,B. and Lemieux,N.
  TITLE     Localization of the human kinesin-related gene to band 10q24 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 13 (4), 1371-1372 (1992)
   PUBMED   1505978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB078134.1, BC136474.1,
            CU446438.1, BM742618.1 and AA504625.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004523.3.
            
            Summary: This gene encodes a motor protein that belongs to the
            kinesin-like protein family. Members of this protein family are
            known to be involved in various kinds of spindle dynamics. The
            function of this gene product includes chromosome positioning,
            centrosome separation and establishing a bipolar spindle during
            cell mitosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.219550.1, U37426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260731.5/ ENSP00000260731.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               DB078134.1         63-579
            518-4126            BC136474.1         379-3987
            4127-4411           CU446438.1         19-303              c
            4412-4877           BM742618.1         151-616
            4878-5016           AA504625.1         24-162              c
FEATURES             Location/Qualifiers
     source          1..5016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..5016
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="kinesin family member 11"
                     /db_xref="GeneID:3832"
                     /db_xref="HGNC:HGNC:6388"
                     /db_xref="MIM:148760"
     exon            1..323
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..3417
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="TRIP-5; kinesin-like protein 1; TR-interacting
                     protein 5; kinesin-like spindle protein HKSP;
                     kinesin-related motor protein Eg5; thyroid
                     receptor-interacting protein 5"
                     /codon_start=1
                     /product="kinesin-like protein KIF11"
                     /protein_id="NP_004514.2"
                     /db_xref="CCDS:CCDS7422.1"
                     /db_xref="GeneID:3832"
                     /db_xref="HGNC:HGNC:6388"
                     /db_xref="MIM:148760"
                     /translation="MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECD
                     PVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIF
                     AYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSL
                     LEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGA
                     AKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSG
                     AVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIA
                     TISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAA
                     REKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQC
                     KSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTK
                     DVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTL
                     FGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQEL
                     INVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSIL
                     CNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKC
                     ENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESV
                     KHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCE
                     ASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLE
                     QDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEET
                     IPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTL
                     ERSKVEETTEHLVTKSRLPLRAQINL"
     exon            324..456
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            457..554
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            555..633
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            634..819
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            820..944
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1035
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1278
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1374
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1463
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1551
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1740
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1948
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2121
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2247
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2406
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2513
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2793
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3016
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3168
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3285
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..5016
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3461..3466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="hexamer: AATAAA"
     polyA_site      3479
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="major polyA site"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="hexamer: TATAAA"
     polyA_site      3971
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
     regulatory      4994..4999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="hexamer: AATAAA"
     polyA_site      5016
                     /gene="KIF11"
                     /gene_synonym="EG5; HKSP; KNSL1; MCLMR; TRIP5"
                     /note="major polyA site"
ORIGIN      
        1 agtttctggg gattcgggcg gagacgagat tagtgatttg gcggctccga ctggcgcggg
       61 acaaacgcca cggccagagt accgggtaga gagcggggac gccgacctgc gtgcgtcggt
      121 cctccaggcc acgccagcgc ccgagaggga ccagggagac tccggcccct gtcggccgcc
      181 aagcccctcc gcccctcaca gcgcccaggt ccgcggccgg gccttgattt tttggcgggg
      241 accgtcatgg cgtcgcagcc aaattcgtct gcgaagaaga aagaggagaa ggggaagaac
      301 atccaggtgg tggtgagatg cagaccattt aatttggcag agcggaaagc tagcgcccat
      361 tcaatagtag aatgtgatcc tgtacgaaaa gaagttagtg tacgaactgg aggattggct
      421 gacaagagct caaggaaaac atacactttt gatatggtgt ttggagcatc tactaaacag
      481 attgatgttt accgaagtgt tgtttgtcca attctggatg aagttattat gggctataat
      541 tgcactatct ttgcgtatgg ccaaactggc actggaaaaa cttttacaat ggaaggtgaa
      601 aggtcaccta atgaagagta tacctgggaa gaggatccct tggctggtat aattccacgt
      661 acccttcatc aaatttttga gaaacttact gataatggta ctgaattttc agtcaaagtg
      721 tctctgttgg agatctataa tgaagagctt tttgatcttc ttaatccatc atctgatgtt
      781 tctgagagac tacagatgtt tgatgatccc cgtaacaaga gaggagtgat aattaaaggt
      841 ttagaagaaa ttacagtaca caacaaggat gaagtctatc aaattttaga aaagggggca
      901 gcaaaaagga caactgcagc tactctgatg aatgcatact ctagtcgttc ccactcagtt
      961 ttctctgtta caatacatat gaaagaaact acgattgatg gagaagagct tgttaaaatc
     1021 ggaaagttga acttggttga tcttgcagga agtgaaaaca ttggccgttc tggagctgtt
     1081 gataagagag ctcgggaagc tggaaatata aatcaatccc tgttgacttt gggaagggtc
     1141 attactgccc ttgtagaaag aacacctcat gttccttatc gagaatctaa actaactaga
     1201 atcctccagg attctcttgg agggcgtaca agaacatcta taattgcaac aatttctcct
     1261 gcatctctca atcttgagga aactctgagt acattggaat atgctcatag agcaaagaac
     1321 atattgaata agcctgaagt gaatcagaaa ctcaccaaaa aagctcttat taaggagtat
     1381 acggaggaga tagaacgttt aaaacgagat cttgctgcag cccgtgagaa aaatggagtg
     1441 tatatttctg aagaaaattt tagagtcatg agtggaaaat taactgttca agaagagcag
     1501 attgtagaat tgattgaaaa aattggtgct gttgaggagg agctgaatag ggttacagag
     1561 ttgtttatgg ataataaaaa tgaacttgac cagtgtaaat ctgacctgca aaataaaaca
     1621 caagaacttg aaaccactca aaaacatttg caagaaacta aattacaact tgttaaagaa
     1681 gaatatatca catcagcttt ggaaagtact gaggagaaac ttcatgatgc tgccagcaag
     1741 ctgcttaaca cagttgaaga aactacaaaa gatgtatctg gtctccattc caaactggat
     1801 cgtaagaagg cagttgacca acacaatgca gaagctcagg atatttttgg caaaaacctg
     1861 aatagtctgt ttaataatat ggaagaatta attaaggatg gcagctcaaa gcaaaaggcc
     1921 atgctagaag tacataagac cttatttggt aatctgctgt cttccagtgt ctctgcatta
     1981 gataccatta ctacagtagc acttggatct ctcacatcta ttccagaaaa tgtgtctact
     2041 catgtttctc agatttttaa tatgatacta aaagaacaat cattagcagc agaaagtaaa
     2101 actgtactac aggaattgat taatgtactc aagactgatc ttctaagttc actggaaatg
     2161 attttatccc caactgtggt gtctatactg aaaatcaata gtcaactaaa gcatattttc
     2221 aagacttcat tgacagtggc cgataagata gaagatcaaa aaaaggaact agatggcttt
     2281 ctcagtatac tgtgtaacaa tctacatgaa ctacaagaaa ataccatttg ttccttggtt
     2341 gagtcacaaa agcaatgtgg aaacctaact gaagacctga agacaataaa gcagacccat
     2401 tcccaggaac tttgcaagtt aatgaatctt tggacagaga gattctgtgc tttggaggaa
     2461 aagtgtgaaa atatacagaa accacttagt agtgtccagg aaaatataca gcagaaatct
     2521 aaggatatag tcaacaaaat gacttttcac agtcaaaaat tttgtgctga ttctgatggc
     2581 ttctcacagg aactcagaaa ttttaaccaa gaaggtacaa aattggttga agaatctgtg
     2641 aaacactctg ataaactcaa tggcaacctg gaaaaaatat ctcaagagac tgaacagaga
     2701 tgtgaatctc tgaacacaag aacagtttat ttttctgaac agtgggtatc ttccttaaat
     2761 gaaagggaac aggaacttca caacttattg gaggttgtaa gccaatgttg tgaggcttca
     2821 agttcagaca tcactgagaa atcagatgga cgtaaggcag ctcatgagaa acagcataac
     2881 atttttcttg atcagatgac tattgatgaa gataaattga tagcacaaaa tctagaactt
     2941 aatgaaacca taaaaattgg tttgactaag cttaattgct ttctggaaca ggatctgaaa
     3001 ctggatatcc caacaggtac gacaccacag aggaaaagtt atttataccc atcaacactg
     3061 gtaagaactg aaccacgtga acatctcctt gatcagctga aaaggaaaca gcctgagctg
     3121 ttaatgatgc taaactgttc agaaaacaac aaagaagaga caattccgga tgtggatgta
     3181 gaagaggcag ttctggggca gtatactgaa gaacctctaa gtcaagagcc atctgtagat
     3241 gctggtgtgg attgttcatc aattggcggg gttccatttt tccagcataa aaaatcacat
     3301 ggaaaagaca aagaaaacag aggcattaac acactggaga ggtctaaagt ggaagaaact
     3361 acagagcact tggttacaaa gagcagatta cctctgcgag cccagatcaa cctttaattc
     3421 acttgggggt tggcaatttt atttttaaag aaaacttaaa aataaaacct gaaaccccag
     3481 aacttgagcc ttgtgtatag attttaaaag aatatatata tcagccgggc gcggtggctc
     3541 atgcctgtaa tcccagcact ttgggaggct gaggcgggtg gattgcttga gcccaggagt
     3601 ttgagaccag cctggccaac gtggcaaaac ctcgtctctg ttaaaaatta gccgggcgtg
     3661 gtggcacact cctgtaatcc cagctactgg ggaggctgag gcacgagaat cacttgaacc
     3721 caggaagcgg ggttgcagtg agccaaaggt acaccactac actccagcct gggcaacaga
     3781 gcaagactcg gtctcaaaaa caaaatttaa aaaagatata aggcagtact gtaaattcag
     3841 ttgaattttg atatctaccc atttttctgt catccctata gttcactttg tattaaattg
     3901 ggtttcattt gggatttgca atgtaaatac gtatttctag ttttcatata aagtagttct
     3961 tttataacaa atgaaaagta tttttcttgt atattattaa gtaatgaata tataagaact
     4021 gtactcttct cagcttgagc ttacataggt aaatatcacc aacatctgtc cttagaaagg
     4081 accatctcat gttttttttc ttgctatgac ttgtgtattt tcttgcatcc tccctagact
     4141 tccctatttc gctttctcct cggctcactt tctccctttt tatttttcac caaaccattt
     4201 gtagagctac aaaaggtatc ctttcttatt ttcagtagtc agaattttat ctagaaatct
     4261 tttaacacct ttttagtggt tatttctaaa atcactgtca acaataaatc taaccctagt
     4321 tgtatccctc ctttcagtat ttttcacttg ttgccccaaa tgtgaaagca tttcattcct
     4381 ttaagaggcc taactcattc accctgacag agttcacaaa aagcccactt aagagtatac
     4441 attgctatta tgggagacca cccagacatc tgactaatgg ctctgtgccc acactccaag
     4501 acctgtgcct tttagagaag ctcacaatga tttaaggact gtttgaaact tccaattatg
     4561 tctataattt atattctttt gtttacatga tgaaactttt tgttgttgct tgtttgtata
     4621 taatacaatg tgtacatgta tctttttctc gattcaaatc ttaaccctta ggactctggt
     4681 atttttgatc tggcaaccat atttctggaa gttgagatgt ttcagcttga agaaccaaaa
     4741 cagaaggaat atgtacaaag aataaatttt ctgctcacga tgagtttagt gtgtaaagtt
     4801 tagagacatc tgactttgat agctaaatta aaccaaaccc tattgaagaa ttgaatatat
     4861 gctacttcaa gaaactaaat tgatctcgta gaattatctt aataaaataa tggctataat
     4921 ttctctgcaa aatcagatgt cagcataagc gatggataat acctaataaa ctgccctcag
     4981 taaatccatg gttaataaat gtggtttcta cattaa
//
