LOCUS       NM_020738               7348 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens kinase D interacting substrate 220 (KIDINS220),
            transcript variant 1, mRNA.
ACCESSION   NM_020738 XM_291015
VERSION     NM_020738.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7348)
  AUTHORS   Zhang,J., Zhang,Y., Shang,Q., Cheng,Y., Su,Y., Zhang,J., Wang,T.,
            Ding,J., Li,Y., Xie,Y. and Xing,Q.
  TITLE     Gain-of-Function KIDINS220 Variants Disrupt Neuronal Development
            and Cause Cerebral Palsy
  JOURNAL   Mov Disord 39 (3), 498-509 (2024)
   PUBMED   38148610
  REMARK    GeneRIF: Gain-of-Function KIDINS220 Variants Disrupt Neuronal
            Development and Cause Cerebral Palsy.
REFERENCE   2  (bases 1 to 7348)
  AUTHORS   Bondeson,D.P., Paolella,B.R., Asfaw,A., Rothberg,M.V.,
            Skipper,T.A., Langan,C., Mesa,G., Gonzalez,A., Surface,L.E.,
            Ito,K., Kazachkova,M., Colgan,W.N., Warren,A., Dempster,J.M.,
            Krill-Burger,J.M., Ericsson,M., Tang,A.A., Fung,I., Chambers,E.S.,
            Abdusamad,M., Dumont,N., Doench,J.G., Piccioni,F., Root,D.E.,
            Boehm,J., Hahn,W.C., Mannstadt,M., McFarland,J.M., Vazquez,F. and
            Golub,T.R.
  TITLE     Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a
            therapeutic vulnerability in ovarian cancer
  JOURNAL   Nat Cancer 3 (6), 681-695 (2022)
   PUBMED   35437317
  REMARK    GeneRIF: Phosphate dysregulation via the XPR1-KIDINS220 protein
            complex is a therapeutic vulnerability in ovarian cancer.
REFERENCE   3  (bases 1 to 7348)
  AUTHORS   Cai,S., Sun,Z., Sun,P.H., Gao,X., Ji,K., Tian,X., Ji,J., Hao,C.,
            Soliman,F., Liu,C., Al-Sarireh,B., Griffiths,P., Hiscox,S.,
            Jiang,W.G. and Ye,L.
  TITLE     Reduced kinase D-interacting substrate of 220 kDa (Kidins220) in
            pancreatic cancer promotes EGFR/ERK signalling and disease
            progression
  JOURNAL   Int J Oncol 58 (6) (2021)
   PUBMED   33955519
  REMARK    GeneRIF: Reduced kinase Dinteracting substrate of 220 kDa
            (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and
            disease progression.
REFERENCE   4  (bases 1 to 7348)
  AUTHORS   Jacquemin,V., Antoine,M., Duerinckx,S., Massart,A., Desir,J.,
            Perazzolo,C., Cassart,M., Thomas,D., Segers,V., Lecomte,S.,
            Abramowicz,M. and Pirson,I.
  TITLE     TrkA mediates effect of novel KIDINS220 mutation in human brain
            ventriculomegaly
  JOURNAL   Hum Mol Genet 29 (23), 3757-3764 (2021)
   PUBMED   33205811
  REMARK    GeneRIF: TrkA mediates effect of novel KIDINS220 mutation in human
            brain ventriculomegaly.
REFERENCE   5  (bases 1 to 7348)
  AUTHORS   Scholz-Starke,J. and Cesca,F.
  TITLE     Stepping Out of the Shade: Control of Neuronal Activity by the
            Scaffold Protein Kidins220/ARMS
  JOURNAL   Front Cell Neurosci 10, 68 (2016)
   PUBMED   27013979
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7348)
  AUTHORS   Arevalo,J.C., Yano,H., Teng,K.K. and Chao,M.V.
  TITLE     A unique pathway for sustained neurotrophin signaling through an
            ankyrin-rich membrane-spanning protein
  JOURNAL   EMBO J 23 (12), 2358-2368 (2004)
   PUBMED   15167895
REFERENCE   7  (bases 1 to 7348)
  AUTHORS   Riol-Blanco,L., Iglesias,T., Sanchez-Sanchez,N., de la Rosa,G.,
            Sanchez-Ruiloba,L., Cabrera-Poch,N., Torres,A., Longo,I.,
            Garcia-Bordas,J., Longo,N., Tejedor,A., Sanchez-Mateos,P. and
            Rodriguez-Fernandez,J.L.
  TITLE     The neuronal protein Kidins220 localizes in a raft compartment at
            the leading edge of motile immature dendritic cells
  JOURNAL   Eur J Immunol 34 (1), 108-118 (2004)
   PUBMED   14971036
REFERENCE   8  (bases 1 to 7348)
  AUTHORS   Kong,H., Boulter,J., Weber,J.L., Lai,C. and Chao,M.V.
  TITLE     An evolutionarily conserved transmembrane protein that is a novel
            downstream target of neurotrophin and ephrin receptors
  JOURNAL   J Neurosci 21 (1), 176-185 (2001)
   PUBMED   11150334
REFERENCE   9  (bases 1 to 7348)
  AUTHORS   Iglesias,T., Cabrera-Poch,N., Mitchell,M.P., Naven,T.J.,
            Rozengurt,E. and Schiavo,G.
  TITLE     Identification and cloning of Kidins220, a novel neuronal substrate
            of protein kinase D
  JOURNAL   J Biol Chem 275 (51), 40048-40056 (2000)
   PUBMED   10998417
REFERENCE   10 (bases 1 to 7348)
  AUTHORS   Kaplan,D.R. and Miller,F.D.
  TITLE     Signal transduction by the neurotrophin receptors
  JOURNAL   Curr Opin Cell Biol 9 (2), 213-221 (1997)
   PUBMED   9069267
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012495.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_020738.3.
            
            Summary: This gene encodes a transmembrane protein that is
            preferentially expressed in the nervous system where it controls
            neuronal cell survival, differentiation into exons and dendrites,
            and synaptic plasticity. The encoded protein interacts with
            membrane receptors, cytosolic signaling components, and
            cytoskeletal proteins, serving as a scaffold that mediates
            crosstalk between the neurotrophin pathway and several other
            intracellular signaling pathways. Aberrant expression of this gene
            is associated with the onset of various neuropsychiatric disorders
            and neurodegenerative diseases, including Alzheimer's disease.
            Naturally occurring mutations in this gene are associated with a
            syndrome characterized by spastic paraplegia, intellectual
            disability, nystagmus and obesity. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033076.2, SRR1660807.41152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256707.8/ ENSP00000256707.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC012495.9         113692-113825       c
            135-278             AC012495.9         103198-103341       c
            279-377             AC012495.9         94907-95005         c
            378-476             AC012495.9         93830-93928         c
            477-575             AC012495.9         89449-89547         c
            576-674             AC012495.9         88607-88705         c
            675-773             AC012495.9         82483-82581         c
            774-971             AC012495.9         79142-79339         c
            972-1070            AC012495.9         76612-76710         c
            1071-1169           AC012495.9         74414-74512         c
            1170-1268           AC012495.9         72983-73081         c
            1269-1446           AC012495.9         70022-70199         c
            1447-1611           AC012495.9         67272-67436         c
            1612-1791           AC012495.9         66092-66271         c
            1792-1957           AC012495.9         64859-65024         c
            1958-2109           AC012495.9         62418-62569         c
            2110-2399           AC012495.9         61953-62242         c
            2400-2540           AC012495.9         55886-56026         c
            2541-2784           AC012495.9         55108-55351         c
            2785-2873           AC012495.9         54851-54939         c
            2874-3018           AC012495.9         52960-53104         c
            3019-3181           AC012495.9         46882-47044         c
            3182-3360           AC012495.9         27678-27856         c
            3361-3584           AC012495.9         26324-26547         c
            3585-3698           AC012495.9         24099-24212         c
            3699-3755           AC012495.9         23357-23413         c
            3756-3887           AC012495.9         13080-13211         c
            3888-3986           AC012495.9         10867-10965         c
            3987-4223           AC012495.9         9656-9892           c
            4224-7348           AC012495.9         5070-8194           c
FEATURES             Location/Qualifiers
     source          1..7348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..7348
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /note="kinase D interacting substrate 220"
                     /db_xref="GeneID:57498"
                     /db_xref="HGNC:HGNC:29508"
                     /db_xref="MIM:615759"
     exon            1..134
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            135..278
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..5486
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat-rich membrane-spanning protein; kinase
                     D-interacting substrate 220kDa"
                     /codon_start=1
                     /product="kinase D-interacting substrate of 220 kDa
                     isoform 1"
                     /protein_id="NP_065789.1"
                     /db_xref="CCDS:CCDS42650.1"
                     /db_xref="GeneID:57498"
                     /db_xref="HGNC:HGNC:29508"
                     /db_xref="MIM:615759"
                     /translation="MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMI
                     AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDM
                     GGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG
                     AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS
                     VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA
                     VRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD
                     GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPK
                     DGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADI
                     LSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLL
                     CGGLGLLFAFTVHPNLGIAVSLSFLALLYIFFIVIYFGGRREGESWNWAWVLSTRLAR
                     HIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDA
                     CEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRV
                     DPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLNSQRKRLHNAASKLHKLKSEG
                     FMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKG
                     PFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFL
                     VTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTIT
                     RQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLT
                     EQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEV
                     FLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYPPLPLHEGP
                     PRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPFFAPYLY
                     TPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPAPGPV
                     VLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMNMN
                     FGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS
                     QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDK
                     VQAEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKG
                     KDSEPKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGK
                     KSSERSSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERV
                     PKSPEHSAEPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLE
                     KANLIELEDDSHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWP
                     ACQKAYNLNRTPSTVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQN
                     ENLKSMTHKRSQRSSYTRLSKDPPELHAAASSESTGFGEERESIL"
     exon            279..377
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            378..476
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            477..575
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            576..674
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            675..773
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            774..971
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1070
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1169
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1268
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1446
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1611
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1791
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1957
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2109
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2399
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2540
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2784
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2873
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3018
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3181
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3360
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3584
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3698
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3755
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3887
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..3986
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4223
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..7348
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7259..7264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /note="hexamer: AATAAA"
     polyA_site      7277
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /note="major polyA site"
     regulatory      7328..7333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
                     /note="hexamer: AATAAA"
     polyA_site      7348
                     /gene="KIDINS220"
                     /gene_synonym="ARMS; SINO; VENARG"
ORIGIN      
        1 agttcgcgga gagggaagaa tatggccgcc gggtgtggtg agggcgacgc gcttgcagtc
       61 gccgtctctt gcttccccgt cctctgacat cgcctgcagc cgagcgggcc cgttccgccg
      121 gagctgagga ccaggtattc aaataaagtt aattgcagct ttctgtgaaa atgtcagttt
      181 tgatatcaca gagcgtcata aattatgtag aggaagaaaa cattcctgct ctgaaagctc
      241 ttcttgaaaa atgcaaagat gtagatgaga gaaatgagtg tggccagact ccactgatga
      301 tagctgccga acaaggcaat ctggaaatag tgaaggaatt aattaagaat ggagctaact
      361 gcaatctgga agatttggat aattggacag cacttatatc tgcatcgaaa gaagggcatg
      421 tgcacatcgt agaggaacta ctgaaatgtg gggttaactt ggagcaccgt gatatgggag
      481 gatggacagc tcttatgtgg gcatgttaca aaggccgtac tgacgtagta gagttgcttc
      541 tttctcatgg tgccaatcca agtgtcactg gtctgtacag tgtttaccca atcatttggg
      601 cagcagggag aggccatgca gatatagttc atcttttact gcaaaatggt gctaaagtca
      661 actgctctga taagtatgga accacccctt tagtttgggc tgcacgaaag ggtcatttgg
      721 aatgtgtgaa acatttattg gccatgggag ctgatgtgga tcaagaagga gctaattcaa
      781 tgactgcact tattgtggca gtgaaaggag gttacacaca gtcagtaaaa gaaattttga
      841 agaggaatcc aaatgtaaac ttaacagata aagatggaaa tacagctttg atgattgcat
      901 caaaggaggg acatacggag attgtgcagg atctgctcga cgctggaaca tatgtgaaca
      961 tacctgacag gagtggggat actgtgttga ttggcgctgt cagaggtggt catgttgaaa
     1021 ttgttcgagc gcttctccaa aaatatgctg atatagacat tagaggacag gataataaaa
     1081 ctgctttgta ttgggctgtt gagaaaggaa atgcaacaat ggtgagagat atcttacagt
     1141 gcaatcctga cactgaaata tgcacaaagg atggtgaaac gccacttata aaggctacca
     1201 agatgagaaa cattgaagtg gtggagctgc tgctagataa aggtgctaaa gtgtctgctg
     1261 tagataagaa aggagatact cccttgcata ttgctattcg tggaaggagc cggaaactgg
     1321 cagaactgct tttaagaaat cccaaagatg ggcgattact ttataggccc aacaaagcag
     1381 gcgagactcc ttataatatt gactgtagcc atcagaagag tattttaact caaatatttg
     1441 gagccagaca cttgtctcct actgaaacag acggtgacat gcttggatat gatttatata
     1501 gcagtgccct ggcagatatt ctcagtgagc ctaccatgca gccacccatt tgtgtggggt
     1561 tatatgcaca gtggggaagt gggaaatctt tcttactcaa gaaactagaa gacgaaatga
     1621 aaaccttcgc cggacaacag attgagcctc tctttcagtt ctcatggctc atagtgtttc
     1681 ttaccctgct actttgtgga gggcttggtt tattgtttgc cttcacggtc cacccaaatc
     1741 ttggaatagc agtgtcactg agcttcttgg ctctcttata tatattcttt attgtcattt
     1801 actttggtgg acgaagagaa ggagagagtt ggaattgggc ctgggtcctc agcactagat
     1861 tggcaagaca tattggatat ttggaactcc tccttaaatt gatgtttgtg aatccacctg
     1921 agttgccaga gcagactact aaagctttac ctgtgaggtt tttgtttaca gattacaata
     1981 gactgtccag tgtaggtgga gaaacttctc tggctgaaat gattgcaacc ctctcggatg
     2041 cttgtgaaag agagtttggc tttttggcaa ccaggctttt tcgagtattc aagactgaag
     2101 atactcaggg taaaaagaaa tggaaaaaaa catgttgtct cccatctttt gtcatcttcc
     2161 tttttatcat tggctgcatt atatctggaa ttactcttct ggctatattt agagttgacc
     2221 caaagcatct gactgtaaat gctgtcctca tatcaatcgc atctgtagtg ggattggcct
     2281 ttgtgttgaa ctgtcgtaca tggtggcaag tgctggactc gctcctgaat tcccaaagaa
     2341 aacgcctcca taatgcagcc tccaaactgc acaaattgaa aagtgaagga ttcatgaaag
     2401 ttcttaaatg tgaagtggaa ttgatggcca ggatggcaaa aaccattgac agcttcactc
     2461 agaatcagac aaggctggtg gtcatcatcg atggattaga tgcctgtgag caggacaaag
     2521 tccttcagat gctggacact gtccgagttc tgttttcaaa aggcccgttc attgccattt
     2581 ttgcaagtga tccacatatt atcataaagg caattaacca gaacctcaat agtgtgcttc
     2641 gggattcaaa tataaatggc catgactaca tgcgcaacat agtccacttg cctgtgttcc
     2701 ttaatagtcg tggactaagc aatgcaagaa aatttctcgt aacttcagca acaaatggag
     2761 acgttccatg ctcagatact acagggatac aggaagatgc tgacagaaga gtttcacaga
     2821 acagccttgg ggagatgaca aaacttggta gcaagacagc cctcaataga cgggacactt
     2881 accgaagaag gcagatgcag aggaccatca ctcgccagat gtcctttgat cttacaaaac
     2941 tgctggttac cgaggactgg ttcagtgaca tcagtcccca gaccatgaga agattactta
     3001 atattgtttc tgtgacagga cgattactga gagccaatca gattagtttc aactgggaca
     3061 ggcttgctag ctggatcaac cttactgagc agtggccata ccggacttca tggctcatat
     3121 tatatttgga agagactgaa ggtattccag atcaaatgac attaaaaacc atctacgaaa
     3181 gaatatcaaa gaatattcca acaactaagg atgttgagcc acttcttgaa attgatggag
     3241 atataagaaa ttttgaagtg tttttgtctt caaggacccc agttcttgtg gctcgagatg
     3301 taaaagtctt tttgccatgc actgtaaacc tagatcccaa actacgggaa attattgcag
     3361 atgttcgtgc tgccagagag cagatcagta ttggaggact ggcgtacccc ccgctccctc
     3421 tacatgaggg tcctcctagg gcgccatcag ggtacagcca gcccccatcc gtgtgctctt
     3481 ccacgtcctt caatgggccc ttcgcaggtg gagtggtgtc accacagcct cacagcagct
     3541 attacagcgg catgacgggc cctcagcatc ccttctacaa caggccattc tttgccccat
     3601 acctttacac gccaaggtat taccctggcg gctcccaaca tctcatctca cgtccatcag
     3661 taaaaacgag tttgcccaga gatcagaaca atggcctaga agttatcaag gaggatgctg
     3721 ctgaggggct ttcttcaccc acagactcct cgagggggtc aggcccagcc ccaggcccag
     3781 tggtattact gaattcactg aatgtggatg cagtatgtga gaagctgaaa caaatagaag
     3841 ggctggacca gagtatgctg cctcagtatt gtaccacgat caaaaaggca aacataaatg
     3901 gccgtgtgtt agctcagtgt aacattgatg agctgaagaa agagatgaat atgaattttg
     3961 gagactggca ccttttcaga agcacagtac tagaaatgag aaacgcagaa agccacgtgg
     4021 tccctgaaga cccacgtttc ctcagtgaga gcagcagtgg cccagccccg cacggtgagc
     4081 ctgctcgccg cgcttcccac aacgagctgc ctcacaccga gctctccagc cagacgccct
     4141 acacactcaa cttcagcttc gaagagctga acacgcttgg cctggatgaa ggtgcccctc
     4201 gtcacagtaa tctaagttgg cagtcacaaa ctcgcagaac cccaagtctt tcgagtctca
     4261 attcccagga ttccagtatt gaaatttcaa agcttactga taaggtgcag gccgagtata
     4321 gagatgccta tagagaatac attgctcaga tgtcccagtt agaagggggc cccgggtcta
     4381 caaccattag tggcagatct tctccacata gcacatatta catgggtcag agttcatcag
     4441 ggggctctat tcattcaaac ctagagcaag aaaaggggaa ggatagtgaa ccaaagcccg
     4501 atgatgggag gaagtccttt ctaatgaaga ggggagatgt tatcgattat tcatcatcag
     4561 gggtttccac caacgatgct tcccccctgg atcctatcac tgaagaagat gaaaaatcag
     4621 atcagtcagg cagtaagctt ctcccaggca agaaatcttc cgaaaggtca agcctcttcc
     4681 agacagattt gaagcttaag ggaagtgggc tgcgctatca aaaactccca agtgacgagg
     4741 atgaatctgg cacagaagaa tcagataaca ctccactgct caaagatgac aaagacagaa
     4801 aagccgaagg gaaagtagag agagtgccga agtctccaga acacagtgct gagccgatca
     4861 gaaccttcat taaagccaaa gagtatttat cggatgcgct ccttgacaaa aaggattcat
     4921 cggattcagg agtgagatcc agtgaaagtt ctcccaatca ctctctgcac aatgaagtgg
     4981 cggatgactc ccagcttgaa aaggcaaatc tcatagagct ggaagatgac agtcacagcg
     5041 gaaagcgggg aatcccacat agcctgagtg gcctgcaaga tccaattata gctcggatgt
     5101 ccatttgttc agaagacaag aaaagccctt ccgaatgcag cttgatagcc agcagccctg
     5161 aagaaaactg gcctgcatgc cagaaagcct acaacctgaa ccgaactccc agcaccgtga
     5221 ctctgaacaa caatagtgct ccagccaaca gagccaatca aaatttcgat gagatggagg
     5281 gaattaggga gacttctcaa gtcattttga ggcctagttc cagtcccaac ccaaccacta
     5341 ttcagaatga gaatctaaaa agcatgacac ataagcgaag ccaacgttca agttacacaa
     5401 ggctctccaa agatcctccg gagctccatg cagcagcctc ttctgagagc acaggctttg
     5461 gagaagaaag agaaagcatt ctttgagaaa aacaagcaaa ggagaagagt gttactgtac
     5521 ctttatgaca gaattgtcct ggattttgac tccatccacg cccatcacct ttctacattt
     5581 tgctgacaga taactaaccg atgatgaggc cgaggtaaaa gagacatctg cagtgtgaca
     5641 gaagggagca tgagaagcat ggctcaccag ccagcctctg tggtctttgt aattagaagc
     5701 ttcagaactc actaatacta ctgtaccttt cattggcgca ttaccccata aaactttttg
     5761 agacgaggtg agatctgagt ataaagatag gtcagaagta ttttaaaggg cttaatgtgc
     5821 caaaaagaaa aaaagctaga gacccttttt gcaaacattt ggtgaccaca catttgaggg
     5881 aagacgtggc gttaggtgaa gcagaagcaa accctgctct taggggctca cctaggtgag
     5941 tgcacagcct gtgacgctac agggagaggc tgagtaaacc gagatccagc gttctgtatg
     6001 gcaggggtat tgcttatcac agaggttctg aagagtagga agtacataat gaagagggct
     6061 ttaaaaattg ccaacaaagt gagtcaccag ggctggcagt agtgtgacgg ggctgtcctg
     6121 agctgttagg agagtagatg cggggagggc tggtgacctc cgtgggttta tatgtcggaa
     6181 actcttctct ccaaatccca ggcctggctt ccagcaccat ccagctgtgc ccaagaagcc
     6241 accctggtct gttctccaac tcttttaaat ggtgcccaac ttttctaagt gagcttagca
     6301 atgagaagaa aaaaaaacat gaattctttt tctggaaaat cagggagaca tgggtaataa
     6361 taggtactaa taaatattta tagatgagtg aatgaggaaa taattacatc aaaaaggtca
     6421 gtgacaattg ataaatgaca aggaaatatt taattaggta aaactaaatc attgctctct
     6481 atactaggat agactttatc tacttcatct gttcctaagt cagcatgtta gttctgggga
     6541 aggatcataa gaaaggaaat actttttaaa aaaaaatttg gaaacatgta acaaagcaag
     6601 ggtaaaatat atatatatat ctatataagt gctgtgactg taaaagtgta ctttccatta
     6661 attattagcc gagttaagag aatggtcaca ttgaagtact gtgtggacta gaaatgtacc
     6721 ctgtcatcat gcaatgaaat attgttatcg ttttaacata gctcatttat gtagaatgaa
     6781 ttctggtggt ttaccccaag tcacagttag gacggtagat ggtgagatcg cagatgcgct
     6841 attatctaga ttcagtgtta cattttcgat gtttatcact cagtgggttt ttattaatat
     6901 gctgattaag ttatttactg ggccagtcat tgtgctaaat agttgctctt ttgtgtttca
     6961 ttgccttgat gtttgagtgt aatctagcat tttaatacag tgtttatttt gcatgatctt
     7021 taacaaatgt tttaagcaat tttaaaaagg caggatgtta ttgacattat acactgaagt
     7081 cttaacattt taacatttat agtgcttatt tgcaaaattg tataattagg aattatttca
     7141 gagacaatgt tttctttttc aggtgagtag ttgccgcgta atatcattgg agtacattct
     7201 ttatactgtt tgtgaaatta atactagcat attaagtgta caaatagatt tagaaaacaa
     7261 taaaaaattg catgctattc tgactcatga atttttattc actatgatga ttcacatttt
     7321 gattaaaaat aaaagtagtt tgtgtgtt
//
