LOCUS       NM_001277372            4130 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens KIAA2012 (KIAA2012), transcript variant 1, mRNA.
ACCESSION   NM_001277372 XM_011510468
VERSION     NM_001277372.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4130)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069148.6 and AC079354.4.
            
            On May 17, 2019 this sequence version replaced NM_001277372.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2158569,
                              SAMN03267765 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000498697.3/ ENSP00000419834.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               AC069148.6         41716-42172
            458-742             AC069148.6         43352-43636
            743-902             AC069148.6         59231-59390
            903-1058            AC069148.6         61491-61646
            1059-1201           AC069148.6         65896-66038
            1202-1385           AC069148.6         68074-68257
            1386-1528           AC069148.6         68768-68910
            1529-1697           AC079354.4         2234-2402
            1698-1847           AC079354.4         5049-5198
            1848-2024           AC079354.4         8901-9077
            2025-2135           AC079354.4         12624-12734
            2136-2204           AC079354.4         24502-24570
            2205-2281           AC079354.4         37720-37796
            2282-2419           AC079354.4         53961-54098
            2420-2492           AC079354.4         64572-64644
            2493-2583           AC079354.4         84041-84131
            2584-2749           AC079354.4         86221-86386
            2750-2864           AC079354.4         87440-87554
            2865-3184           AC079354.4         89462-89781
            3185-3387           AC079354.4         92589-92791
            3388-3560           AC079354.4         93478-93650
            3561-3780           AC079354.4         96088-96307
            3781-3939           AC079354.4         101717-101875
            3940-4130           AC079354.4         104286-104476
FEATURES             Location/Qualifiers
     source          1..4130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..4130
                     /gene="KIAA2012"
                     /note="KIAA2012"
                     /db_xref="GeneID:100652824"
                     /db_xref="HGNC:HGNC:51250"
     exon            1..457
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..3919
                     /gene="KIAA2012"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein KIAA2012 isoform 1"
                     /protein_id="NP_001264301.2"
                     /db_xref="CCDS:CCDS74631.2"
                     /db_xref="GeneID:100652824"
                     /db_xref="HGNC:HGNC:51250"
                     /translation="MFTLSLLSRGHGKLGQDKQKLEVYFEPEDYLNWRSPEDYVPVSK
                     PQDKNNASQHSWSLFLPKTFSTRKGALILYSEGFAISAWTPKERRKGPYCPRGPWRKL
                     DLELHTLQDLKEAILAYGRQQGEQDRAWQPYLHFRSQLESQAQRQIQPGHSAKRYLRG
                     LLRTWPPDAMYRLWCAGYIKDSVLLQDSQLNVPKKLRPQQDLSGVPPKYHLLPVFPSF
                     WIQQGKSFEQRQQGLDEGEAGAAGHVDQGPLAKNHGSQGTRLPPRRKQPWQEDETQAE
                     DTSIENHLCLYASKESYNEKTQQTSRKAFGHGRIDHSWLPSDKSHITFCGGAFPNRKA
                     DLSDKQRNVKLHKARSSHLLQVLPAERSLFPPVASATGSRIITPGEVKKKKAPKALKL
                     PPISEEPPRVLEPLKSQFKANEPPTELFILPVEIHYHTKQPPKEKAHRRGAPHPESEP
                     ESSEESTPVWRPPLKHASLETPWELTVHLPVDASRDTLSPQDDDAPPHDVAPPLDLLP
                     PIKGKKSPESQKGVDSPRTSDHNSPPSLPNMRVPRRALPAAQEDSSDPTLGHFLLGPD
                     GEKVCLSLPGHTQTEALPSGKAYESVNSNISHEEEGPSSQHFLKANTEPRANLHMNLY
                     ETSPLTQTTEKQGAQQSLEAAAQKTGEPQSCINKALICSNRKEFYTRKLHIDMTPFLK
                     ESGNALDYQEEAGRPLRETHHNDQDPEPRSMTLDSPRASRTEHIQTPEADIVQKVGRD
                     YDVHHLHRGLLGYGPESPERLSAVYTSLLPREREGKAEPRLFSQETSANISHERDLIN
                     EAKRKEKPKKDKTKGPKSEREGKVYGQAEAAIGKSKDSKAKKKLEKKTRPQRKRTQKE
                     RNLEIAAELSGPDVSYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSP
                     SQIATVTGNMESKEERRCEDPSKALLTKREQEKASWDRLRAERAEMRWLEVEKKRREQ
                     EEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQQRQEEEERKQQLRLK
                     AAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAE
                     EERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQARQKAALEKHFH
                     FYQELHKEASGLQWTQNISRPWVYSYFQFLQIPRP"
     exon            458..742
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            743..902
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1058
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1201
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1385
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1528
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1697
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1847
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2024
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2135
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2204
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2281
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2419
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2492
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2583
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2749
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2864
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3184
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3387
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3560
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3780
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3939
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4130
                     /gene="KIAA2012"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacaagaag gatggtgctg tggccgagat ctgtagatgc acacggctgg taacagagca
       61 accgggacca agggacaaca agagctcagg agaaggggag agacaggtcg cccagagagt
      121 agacaatcca gggcttgagg aggctggctg tgcggtttat tttttctctc cacaaagaca
      181 cacactgtct aaactgtgtg gctggttgtt actaagaagc tgctgcgaga gggaaaaatg
      241 tatttaataa aaggccctgt gtttgtggtc ttcttgggct tgctgtgagc tctggaaatc
      301 ttgaggtgtg accagatttc agccttcaaa accaagatgg actgcccttg agaaggggtg
      361 gtcagaggga aacatgttca cgctctccct cctgagccgg ggccacggga agctgggcca
      421 ggacaaacag aagttagaag tctactttga accagaggat tacttgaact ggaggtcccc
      481 agaagactat gttcctgtca gcaaacctca agataagaac aatgccagtc agcactcctg
      541 gagcctcttt ctccctaaaa ctttcagtac tagaaagggt gccctgatcc tgtactcaga
      601 aggttttgcc atttcggcat ggacacccaa agagaggaga aaaggcccct actgccccag
      661 aggtccctgg aggaagctgg atcttgaact gcacacactt caagacctca aagaagccat
      721 cctggcatat ggaaggcagc agggagagca ggacagagcc tggcaaccat acctccactt
      781 ccgaagccag ctggagagcc aggcccaacg gcagatccag ccagggcatt cagccaagag
      841 atacctccga ggcctcctgc ggacttggcc cccagacgcc atgtataggc tctggtgcgc
      901 aggatacatc aaggattctg tgctactcca ggacagtcaa cttaatgtac caaagaagct
      961 caggccacaa caagatcttt caggtgtacc cccaaaatac catctcctgc ctgtcttccc
     1021 ttcattttgg attcaacaag gaaaatcttt tgaacaacgt caacagggcc tggatgaagg
     1081 ggaagctgga gctgctggac acgtggacca gggccctcta gccaagaacc atggcagtca
     1141 ggggactcgc ttgccaccac gcaggaagca gccctggcag gaagatgaaa cgcaggcaga
     1201 ggacacgtca atagagaatc acctttgttt atatgcttca aaggagagct acaatgaaaa
     1261 gacacagcaa acctccagga aggcctttgg gcatggccgc atcgatcact cttggctccc
     1321 aagtgacaaa tcccacatta cattctgtgg aggcgccttc cctaatagga aggcagatct
     1381 cagcgataaa caaaggaacg tgaaactcca caaggccaga agcagccact tgttacaggt
     1441 gcttcctgct gaaagaagcc tcttccctcc tgtagcatct gccactggct ccagaataat
     1501 cacccctggg gaagtgaaga agaaaaaggc accaaaggct ttgaaattac ctcctatctc
     1561 agaagaacca cccagagtct tggagcccct gaagagccaa tttaaagcca atgagccccc
     1621 aacagagctc ttcatcttac cggtggagat tcattaccac accaaacaac ccccaaaaga
     1681 gaaagcccac agaagaggtg ctccacaccc tgagtcagaa ccagaaagca gcgaagaatc
     1741 cacacctgtg tggagacctc ccctgaagca tgcgtcctta gaaacaccat gggagttaac
     1801 agtgcatctc ccagtggacg cgagcaggga cacactctca cctcaagatg atgatgcccc
     1861 acctcacgat gtggccccac cattggatct tctacccccg attaaaggaa aaaaaagtcc
     1921 tgagagccag aagggcgtgg acagccctag gacatcagac cacaacagcc ccccaagtct
     1981 cccgaacatg agagtgccca ggagggcact gccagcagct caagaagatt ccagcgaccc
     2041 tacactggga cacttcttgc tgggtccaga tggagaaaaa gtctgcctgt ccctcccagg
     2101 gcatacccaa accgaggcgc ttccatcggg taaagcctat gaatctgtca attcaaatat
     2161 cagccatgaa gaggaagggc ctagtagtca gcatttccta aaagcaaaca ctgaacctag
     2221 agccaatctt cacatgaacc tttatgaaac ctcaccgttg acccaaacaa cagagaagca
     2281 gggagcccag cagtccttgg aggcagcagc tcagaagaca ggagagcctc aaagttgtat
     2341 aaataaagcg ctgatatgtt caaacagaaa agaattttac acgcgcaagc tgcacatcga
     2401 catgacgccg ttcctgaagg aaagtggaaa tgcactggac tatcaggaag aagcagggag
     2461 acccctcaga gaaactcacc acaacgacca agacccagag ccaaggagta tgacccttga
     2521 ctctcccagg gcttcccgga ctgagcacat ccagacccca gaagcagata ttgtgcaaaa
     2581 agtgggcaga gattatgatg tacaccacct acacagagga cttctgggat acgggcctga
     2641 gtcacccgag aggttgagtg ctgtgtatac atctcttctt ccaagagaaa gagaagggaa
     2701 ggctgaacca agactgttta gccaggagac atcagccaac atcagtcatg agagggattt
     2761 gattaacgag gccaagagaa aggaaaaacc caagaaagac aaaaccaaag gacccaaaag
     2821 cgagagagaa ggaaaggtct acgggcaagc agaggctgcc attggaaagt caaaggactc
     2881 aaaggctaaa aaaaaattag aaaaaaaaac aagaccccaa aggaaaagga cacagaagga
     2941 aagaaatctg gagatagcgg cagagctgag cgggcctgat gtcagctatg aggaaacaga
     3001 agacacctca aatagaggtt cctttgcctc agactccttt gtagaggacc cttggctttc
     3061 tcccaaatat gatgcccagg aaagccaagt ttctctagat ggaagatcat caccctctca
     3121 gattgcaact gtcactggca acatggaatc taaagaagag agaagatgtg aggacccttc
     3181 caaggccctc ctcactaaga gggagcagga gaaggcttcc tgggacaggc ttcgagcaga
     3241 aagagccgag atgaggtggc tggaggtgga gaagaagaga agggagcagg aagagcaaag
     3301 gcagctccag caggagcagc tggagagagc aaaaaagatg gaggaggagc tggagctgga
     3361 gcagcagaga cgtacagaag agatccgctt gaggaaacag agactccaag aagaacagca
     3421 gcggcaggag gaggaggaga gaaagcagca gctccggttg aaagcagccc aggagagagc
     3481 ccggcaacag caagaggagt ttcggaggaa actgcgagaa ctacagagaa aaaagcagca
     3541 ggaggaagcc gagagggccg aggcagagaa gcaaaggcaa gaggaattgg aaatgcagtt
     3601 agaagaagaa caaaaacacc tgatggaaat ggctgaagag gaacgactgg agtaccagcg
     3661 gcggaaacag gaagcagaag agaaggctcg gctggaggca gaggagagga ggcaaaaaga
     3721 agaggaagca gcaagactgg ctctggaaga agccacgaaa caagcccagg aacaagccag
     3781 gcaaaaagct gctttggaga aacattttca tttctatcaa gaactccata aggaagccag
     3841 tggcctgcag tggacacaga acatttccag accatgggtt tactcttatt tccagttcct
     3901 acaaataccc aggccttaag gctagaagaa aactaaaaaa tttaggatgt tgcagtcaag
     3961 caccagataa gagtgacttc cctaaatgtt attcaaggtc ccttcagaaa tctgataatc
     4021 tgttaaaatt tttgttgtga aatgcctatt ttatcagcac tgctaaccag ataagcacac
     4081 atttaagtta accatatcag agtgcaatgc atttcgaaaa atccaaaaaa
//
