LOCUS       NM_020931               2789 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens KIAA1586 (KIAA1586), transcript variant 1, mRNA.
ACCESSION   NM_020931 XM_166451
VERSION     NM_020931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Eisenhardt,N., Chaugule,V.K., Koidl,S., Droescher,M., Dogan,E.,
            Rettich,J., Sutinen,P., Imanishi,S.Y., Hofmann,K., Palvimo,J.J. and
            Pichler,A.
  TITLE     A new vertebrate SUMO enzyme family reveals insights into
            SUMO-chain assembly
  JOURNAL   Nat Struct Mol Biol 22 (12), 959-967 (2015)
   PUBMED   26524493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041125.1 and CN359914.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020931.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.181122.1,
                                           SRR1660807.171359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370733.5/ ENSP00000359768.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2503              BC041125.1         108-2610
            2504-2789           CN359914.1         482-767
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..2789
                     /gene="KIAA1586"
                     /note="KIAA1586"
                     /db_xref="GeneID:57691"
                     /db_xref="HGNC:HGNC:21360"
     exon            1..84
                     /gene="KIAA1586"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2427
                     /gene="KIAA1586"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase KIAA1586 isoform a"
                     /protein_id="NP_065982.1"
                     /db_xref="CCDS:CCDS34480.1"
                     /db_xref="GeneID:57691"
                     /db_xref="HGNC:HGNC:21360"
                     /translation="MGDPGSEIIESVPPAGPEASESTTDENEDDIQFVSEGPSRPVLE
                     YIDLVCGDDENPSAYYSDILFPKMPKRQGDFLHFLNVKKVKTDTENNEVSKNHCRLSK
                     AKEPHFEYIEQPIIEEKPSLSSKKEIDNLVLPDCWNEKQAFMFTEQYKWLEIKEGKLG
                     CKDCSAVRHLGSKAEKHVHVSKEWIAYLVTPNGSNKTTRQASLRKKIREHDVSKAHGK
                     IQDLLKESTNDSICNLVHKQNNKNIDATVKVFNTVYSLVKHNRPLSDIEGARELQEKN
                     GEVNCLNTRYSATRIAEHIAKEMKMKIFKNIIEENAKICIIIDEASTVSKKTTLVIYL
                     QCTIQSAPAPVMLFVALKELVSTIAECIVNTLLTTLNDCGFTNEYLKANLIAFCSDGA
                     NTILGRKSGVATKLLENFPEIIIWNCLNHRLQLSLDDSISEIKQINHLKIFIDKIYSI
                     YHQPNKNQTKLLGTVAKELETEIIKIGRVMGPRWAACSLQAATAVWHAYPILYMHFSH
                     SYSGLAKRLANINFLQDLALMIDILEEFSVLSTALQSRSTNIKKAQKLIKRTIRALEN
                     LKIGTGKYESQIEDLIKSDKFKDIPFNKNNKFNALPRSILLDNIIQHMNLRLLSDRNH
                     EDIFNYFDLLEPSTWPYEEITSPWIAGEKTLFHLCKILKYEVDLNDFREFVNNNIKSN
                     NVSIPTTIYKAKKIVSTIAINSAEAERGFNLMNIICTRVRNSLTIDHVSDLMTINLLG
                     KELADWDATPFVKSWSNCNHRLATDTRVRQKSTKVFHENQLAIWNLK"
     exon            85..168
                     /gene="KIAA1586"
                     /inference="alignment:Splign:2.1.0"
     exon            169..249
                     /gene="KIAA1586"
                     /inference="alignment:Splign:2.1.0"
     exon            250..2789
                     /gene="KIAA1586"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1586"
                     /note="hexamer: AATAAA"
     polyA_site      2789
                     /gene="KIAA1586"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcggct gcggcagtag ggacagcagg agcagtggtg ctgtcagcgc ggccgtcgga
       61 gacatgggag acccggggtc ggaaataata gaatctgtcc ctccagctgg ccctgaggca
      121 tctgagtcaa caacggatga aaatgaagac gacattcagt ttgtcagtga aggaccatcg
      181 agacctgttc ttgaatacat cgatctggtc tgtggtgatg atgaaaaccc tagcgcctat
      241 tatagtgata ttctgtttcc taaaatgcca aaacgacagg gtgatttttt gcatttttta
      301 aatgtgaaga aggtgaaaac agacacagaa aataatgaag tgagcaaaaa tcactgcaga
      361 ttgtctaagg caaaggaacc acatttcgag tatattgaac aaccaatcat tgaagaaaag
      421 ccatcacttt catcaaagaa agaaatagat aatcttgtgc ttccagattg ttggaatgaa
      481 aaacaagcat ttatgtttac agaacaatac aaatggcttg aaataaaaga aggtaaatta
      541 ggatgtaagg attgttcagc agttcggcat ttgggatcga aagcagaaaa gcatgtccat
      601 gtgtccaagg aatggattgc atatttagta acccctaatg gcagtaataa aactactagg
      661 caagcttctc tacgaaaaaa aattagggaa catgatgttt ctaaagccca tggtaaaatt
      721 caggatttgt taaaggaatc aactaatgat tcaatttgta atttagtgca taaacaaaat
      781 aataaaaata ttgatgctac tgtaaaagtt ttcaatactg tttacagttt agtaaaacat
      841 aacagacctt tatctgatat tgagggggca agagaattac aggaaaaaaa tggagaggta
      901 aattgtttaa atacacgtta cagtgcaaca agaatagcag aacatattgc aaaagaaatg
      961 aagatgaaga tatttaagaa tattatagaa gagaatgcca aaatctgtat cataattgat
     1021 gaggcatcta cagtttcaaa gaaaaccacc ctagtgattt atctccagtg cacaattcag
     1081 tcagctcctg cacctgttat gttatttgtg gctttaaaag aattggtgtc aactatagca
     1141 gagtgtattg tcaatacatt attgactact ttaaatgatt gtggttttac aaatgaatat
     1201 ttgaaagcaa atttaattgc attttgttct gatggtgcta atacaatcct gggaagaaag
     1261 tctggagtag ctacaaaatt gttagaaaat tttcctgaaa tcatcatttg gaactgttta
     1321 aatcatcgat tacaattgtc acttgatgat tctatatccg aaataaaaca aattaatcat
     1381 ttaaaaatat ttattgataa aatttattct atttatcatc aacctaataa aaatcaaacc
     1441 aagcttctag gaactgtagc taaagaactt gaaactgaaa ttattaaaat tggtcgagta
     1501 atgggaccaa gatgggcggc atgtagttta caagctgcta ctgctgtatg gcatgcatat
     1561 cctatattat atatgcattt ttctcattct tactctggtt tggcgaagag attagctaac
     1621 attaatttct tacaagacct tgctttaatg attgacattc ttgaagaatt ttcagtactt
     1681 tcaactgcat tacagtcaag atcaactaat attaagaaag cacaaaaatt gatcaaacgt
     1741 accataagag ctttggaaaa tttaaaaatt ggtactggaa agtatgaatc tcaaattgaa
     1801 gatttgatca agtcagataa gtttaaagat attccattta ataaaaacaa taaatttaat
     1861 gctcttccta ggagtatatt actagacaat ataattcagc acatgaacct acgcctttta
     1921 tctgacagaa accatgaaga tatttttaat tactttgatt tgctggaacc ttccacatgg
     1981 ccttatgaag aaataacttc accatggata gctggtgaaa aaacattatt tcatttgtgt
     2041 aaaattttaa aatatgaagt tgatttgaat gattttcggg aatttgtaaa taataatata
     2101 aaatcaaaca atgtttcaat tcctacaact atatacaaag ctaaaaagat agttagcacc
     2161 attgcaatca atagtgctga agctgaaagg ggtttcaatt taatgaacat aatttgtaca
     2221 agggtgagaa atagtttaac aatagatcat gtatcagatt taatgacaat aaatttactg
     2281 gggaaagaat tagcagattg ggatgcaaca ccgtttgtaa aatcttggtc aaattgcaac
     2341 cacaggttgg ctacagatac aagagttcgg caaaagtcaa caaaagtctt ccatgagaat
     2401 caattggcta tatggaactt aaaatagaat attgtatacg ttttttgtca tctgtaaatt
     2461 atgtactaca catcctttat atacataaag gtcttttttt tttttggaaa gccagttaaa
     2521 cttttatcag catgttgctg tttaaaaggc gttctttaag aagataatct tgaagattgg
     2581 ttttagaagc tatagttttt tagagattgg cccatgtttg ctagagtggg tcataataca
     2641 tattccatga agttctgtac agaacaaaca ccgtttataa ttttgtactg ttttacttta
     2701 agtaaggatg caaaaaatag caggactcag ctaagttcta agccctggag gttatattaa
     2761 ataaaagaga aatggaataa aaactgtaa
//
