LOCUS       NM_020776               4853 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens KIAA1328 (KIAA1328), transcript variant 1, mRNA.
ACCESSION   NM_020776 XM_029429
VERSION     NM_020776.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Drew,K., Lee,C., Huizar,R.L., Tu,F., Borgeson,B., McWhite,C.D.,
            Ma,Y., Wallingford,J.B. and Marcotte,E.M.
  TITLE     Integration of over 9,000 mass spectrometry experiments builds a
            global map of human protein complexes
  JOURNAL   Mol Syst Biol 13 (6), 932 (2017)
   PUBMED   28596423
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Barone,R., Fichera,M., De Grandi,M., Battaglia,M., Lo Faro,V.,
            Mattina,T. and Rizzo,R.
  TITLE     Familial 18q12.2 deletion supports the role of RNA-binding protein
            CELF4 in autism spectrum disorders
  JOURNAL   Am J Med Genet A 173 (6), 1649-1655 (2017)
   PUBMED   28407444
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Shaffer,J.R., Polk,D.E., Wang,X., Feingold,E., Weeks,D.E.,
            Lee,M.K., Cuenco,K.T., Weyant,R.J., Crout,R.J., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association study of periodontal health measured by
            probing depth in adults ages 18-49 years
  JOURNAL   G3 (Bethesda) 4 (2), 307-314 (2014)
   PUBMED   24347629
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Patel,C.A. and Ghiselli,G.
  TITLE     Hinderin, a five-domains protein including coiled-coil motifs that
            binds to SMC3
  JOURNAL   BMC Cell Biol 6 (1), 3 (2005)
   PUBMED   15656913
  REMARK    GeneRIF: Hinderin is a novel binding partner of SMC3. Based on its
            ability to modulate SMC1/SMC3 interaction we postulate that
            Hinderin affects the availability of SMC3 to engage in the
            formation of multimeric protein complexes.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832625.2, BC045585.1, BC008670.1, BC037903.1, BX648875.1,
            AB037749.2 and AC015961.16.
            
            On Nov 24, 2018 this sequence version replaced NM_020776.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832625.2, SRR1660803.30522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280020.10/ ENSP00000280020.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL832625.2         12-207
            197-460             BC045585.1         195-458
            461-911             AL832625.2         472-922
            912-1244            BC008670.1         348-680
            1245-1535           BC037903.1         1187-1477
            1536-1824           BC037903.1         1582-1870
            1825-1828           BX648875.1         1835-1838
            1829-1963           AL832625.2         1840-1974
            1964-3089           AB037749.2         2366-3491
            3090-4669           AB037749.2         3493-5072
            4670-4749           AL832625.2         4678-4757
            4750-4802           AB037749.2         5151-5203
            4803-4844           AL832625.2         4811-4852
            4845-4853           AC015961.16        134072-134080
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..4853
                     /gene="KIAA1328"
                     /note="KIAA1328"
                     /db_xref="GeneID:57536"
                     /db_xref="HGNC:HGNC:29248"
                     /db_xref="MIM:616480"
     exon            1..70
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1746
                     /gene="KIAA1328"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hinderin; protein hinderin"
                     /codon_start=1
                     /product="protein hinderin isoform 1"
                     /protein_id="NP_065827.1"
                     /db_xref="CCDS:CCDS45855.1"
                     /db_xref="GeneID:57536"
                     /db_xref="HGNC:HGNC:29248"
                     /db_xref="MIM:616480"
                     /translation="MADVAGPSRPSAAAFWSRDFSDEEQSVVYVPGISAEGNVRSRHK
                     LMSPKADVKLKTSRVTDASISMESLKGTGDSVDEQNSCRGEIKSASLKDLCLEDKRRI
                     ANLIKELARVSEEKEVTEERLKAEQESFEKKIRQLEEQNELIIKEREALQLQYRECQE
                     LLSLYQKYLSEQQEKLTMSLSELGAARMQEQQVSSRKSTLQCSSVELDGSYLSIARPQ
                     TYYQTKQRPKSAVQDSASESLIAFRNNSLKPVTLHHPKDDLDKIPSETTTCNCESPGR
                     KPAVPTEKMPQEELHMKECPHLKPTPSQCCGHRLAADRVHDSHPTNMTPQHPKTHPES
                     CSYCRLSWASLVHGGGALQPIETLKKQISEDRKQQLMLQKMELEIEKERLQHLLAQQE
                     TKLLLKQQQLHQSRLDYNCLLKSNCDGWLLGTSSSIKKHQDPPNSGENRKERKTVGFH
                     SHMKDDAQWSCQKKDTCRPQRGTVTGVRKDASTSPMPTGSLKDFVTTASPSLQHTTSR
                     YETSLLDLVQSLSPNSAPKPQRYPSREAGAWNHGTFRLSPLKSTRKKMGMHRTPEELE
                     ENQILEDIFFI"
     exon            71..106
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            107..249
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            250..344
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            345..460
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            461..588
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1244
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1426
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1535
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..4853
                     /gene="KIAA1328"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4824..4829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1328"
                     /note="hexamer: AATAAA"
     polyA_site      4853
                     /gene="KIAA1328"
                     /note="major polyA site"
ORIGIN      
        1 ggttgtttca agatggcgga cgtggcgggc ccctcccgcc ccagtgccgc ggcgttctgg
       61 agccgggact tttctgatga agaacaatca gtagtatacg ttccaggaat ttctgctgaa
      121 ggaaatgtca gatcaagaca caagctgatg agtccaaaag ctgatgttaa acttaagact
      181 tccagggtga ctgatgcttc aatctccatg gagtccttaa aaggcacagg agattcagta
      241 gatgaacaga attcctgcag gggagaaata aagagtgcat cattgaagga tttatgtctt
      301 gaagacaaaa gacgcattgc aaacttaatt aaagaactgg ccagagtaag tgaggaaaag
      361 gaagtgacag aggaaagact gaaagctgag caggagtcat ttgagaagaa gatcaggcag
      421 ttggaagaac agaatgaact gatcatcaaa gaaagggaag ctcttcagct acagtataga
      481 gaatgccaag aacttctaag cctgtatcag aaatatttat cagaacaaca ggagaagctc
      541 accatgtctc tctcagaact tggtgctgct agaatgcagg aacagcaggt atccagtaga
      601 aaaagcactc tccagtgttc atctgtggaa ctggatggtt cctacttgag catagccaga
      661 ccacagacct actatcaaac caagcaaaga cctaagtctg cagtccagga ttcagcttca
      721 gaatccctta tagcatttag gaataattct ttgaaaccag taacccttca tcatcccaaa
      781 gatgatctag ataagatacc atcagagacc acaacatgta attgtgaatc tccagggaga
      841 aaacctgcag tcccaacaga gaaaatgcca caagaagaat tgcacatgaa ggaatgtcca
      901 catcttaagc ctactcctag tcaatgctgt ggtcatagac ttgctgcaga tcgtgttcat
      961 gacagccatc ctacaaacat gacccctcaa catcctaaga cacatccaga atcatgcagt
     1021 tattgtcggc tttcttgggc atctctggtg catggtggtg gggcactgca acccattgaa
     1081 actttgaaaa agcagatctc agaagataga aagcagcaac tgatgcttca gaaaatggaa
     1141 ctggaaattg aaaaggagcg ccttcagcat ctgctggccc agcaggagac aaagcttctt
     1201 ctaaaacagc agcagcttca ccagtctcga ctggattaca attgtttatt gaagtcaaac
     1261 tgtgatggct ggctgcttgg aacatcatca tctattaaaa agcaccaaga ccccccaaac
     1321 agtggagaga ataggaagga gaggaagaca gttgggtttc attcgcatat gaaagatgat
     1381 gcccagtggt catgtcaaaa gaaagataca tgtagacccc aaagagggac agtgacagga
     1441 gttagaaaag atgcgtctac atctcctatg ccaacaggaa gcctaaagga ttttgtcacc
     1501 acagcctcac catcattaca gcacaccacc tcccggtatg agacatcttt gttggatttg
     1561 gttcagtctc tgagcccaaa ctctgcgccc aaacctcagc gctatccctc cagagaagct
     1621 ggggcctgga atcatggtac tttccgactc agtcctctaa aatcaacccg gaagaagatg
     1681 gggatgcaca gaacccctga agagttggag gagaatcaga ttctggaaga tatatttttc
     1741 atttgacata ttgcaaaatt ttcttaggaa atttgtgggt ttcctcacat actgatctag
     1801 gattttaaat tatttcattg caaagtaatt gtgtctctcc tttcacgggg acttgtctca
     1861 ctagcatcct gttacgtatt gaatatagaa atcattctaa caacccaggt tattttcaat
     1921 cagaccaggc attcgataac acactaaggg ggtaggaatg gaagatggta tcttttatat
     1981 gctaaacaga ttagaaaatt aacataggat actttctgcg tggtggaaac cattgcatat
     2041 tcagcctcat ttcaagagtg tttccttctc aaacttctgc tagaaaatgc tgactcactt
     2101 ttatatacaa gaaaaacctt tccactgaaa aatccctctg atttaaaagt aacccctttg
     2161 aaacataagc agtttcagaa aggcagactc tctcatcttt ctcatcctgt tctctcacta
     2221 ctacatttct gtaagtggtc ctttaattct gaagttggag ttggtgcccc tgccatcaca
     2281 aacaacacga gagccaattg tgagtcagtc tcagtagcca tcagcctggc agctgcccat
     2341 cccataacca aagagctcaa tgggctggag ggtgagaccc agccaatcct tgggagcaag
     2401 cagcactaaa tcacatcagg gagtgattag tcctggggaa attcagtgga ggcacaagcc
     2461 tgaagcactc ttctaccaat gtttgggtga ccacccctcc aatatcccag aatgaataag
     2521 aacaatccct aggtattttt atttacccaa gtgttcagct tattcacccc acccccccac
     2581 cccccatcac acgtgctcct gtgaactttc catggttatg tctacggaaa atgccactag
     2641 agagagagtg atgcaagctg ctgcaaagct gatgggcttc ctctggccct cccttttcct
     2701 ccacgaggat taaaggatac aagctgacca ggcctcacag gtgctctgct cgtggcccca
     2761 aagaaccatc tctacttgcc agagtatgtt ccaccaccca agcagggtct ccctactttt
     2821 tctcactggc ctcgttttga cccagagaaa gcctatggaa gttatgcagt gcagacctca
     2881 tcctgtctgc tgtcttttct cccacagagc tcttgagatg ggtccttcag cttgcagtgg
     2941 tccctagtag cctctcaagc taatggggat gatgatcctg gtttagccag agttcaaaac
     3001 tctccagtca ttgaaagcaa ggggagggtg tgttcccaga tgtgtattac ttgggaattt
     3061 tatttgatct ggagggtgtg gctttttttc tctccttttt accaacccca actaaactgg
     3121 gagtaagact tagtcagtgt tggtagacaa agtcatacca cccagggcag cctgcatgca
     3181 gcgagtctgc gtggcttccc tgaattactc ttttaattaa aactagatta tttcaatcta
     3241 gaaaagcctt gttgagcagc ctccttatcc agatagatcc aaagctcatg tctcttcagg
     3301 ctgagactgg cgctgtcacc tccacccagc cttctttcac ttggggtttt ttattctttg
     3361 gagtagaaaa gaatggagcc cactaatatt atatttttct tctgaaataa atataaagtc
     3421 aagactaact agttataatc attcccttaa aaagttggaa aatcattaca gattaaaatt
     3481 tctttataaa gttcacctct gagagtaacc aaatcggttt catcccatat caaaaagcct
     3541 ttggagtgtg gagctttctg tggtatggca gaaatgggtg gatggcaaac taagagccct
     3601 cagccatttt ttcagttaaa gttaggttgc cagaactttc ttttccttgc cccctgtgtc
     3661 atgactagct taagtgtact tgactcccat agactactcc catgcccaca gtcacccatt
     3721 ccagactcca gtgtccttaa aactctggag tgagaggatg ccagaggatc aagaaaagga
     3781 tcacagtttc ttgaagaagc ttgtttgcct ttagaagaat cgtaaacaga gtctaaacta
     3841 aaggcttttt gggggtcaca gccacagagt ggagttttat tgcttctttg cctctccatg
     3901 aatggccaat ttggaaaagc agagatgggc tttcagcaga atatcaacca atacattttt
     3961 cacatgcaaa actcatcacc agttgccttt ttctaactta atggacattt tgttggtgtt
     4021 ggtgcaaggg caataggatg taaatttgta tataatctaa tgtcttcatt attaattgaa
     4081 tagtacatgt taacatttta atctatttaa atttactttg aaatatatac atacatatga
     4141 atgaaaggtt gttacagagc ctcaaagctg ttgcagacta tcccaagaga aaggatctgg
     4201 cacaaaggaa tctgcctttc ctccgtctca agtctcccac ccttgactgg ttgggatttg
     4261 ctcgtccagc ctctagacac ttcccaaagc aagactggac acatgccgag ggcgttgcgg
     4321 atagtgcctc accattgccc accctgctgc ccaactcctg tgagagaaaa accaatcaat
     4381 gtttacaaaa tggaaaagga cacagcatgt cctttgaact ccctaagtaa ggcccacagt
     4441 tcttgatgca gagaaccaaa gtgaatcata gaaaagcttt tgctaacagt ccgctttcca
     4501 ggaggcaaac ttgtgtttat ccaaacctga tccccatgat ggggactttt ctagagcacc
     4561 ccaaatgtca tggggagaga gggactcttt ctgctccctc agagctactc ttcacttgtc
     4621 cctgcttccg gcaccaagtt cataatagag atcttctggc cagagaatca ggggagagga
     4681 gaggcctgat ggggcagagc tggacgaagt ctgctaagag agatggaggc tgtggcggac
     4741 tccttccaac tcacgattta tcctcagctc agagtgtatt ttgaatatga gcaaatgttt
     4801 atgtacgtat gagatttcaa gttaataaat catctctatg gctattttcc cca
//
