LOCUS       NM_019590               7407 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KIAA1217 (KIAA1217), transcript variant 1, mRNA.
ACCESSION   NM_019590 XM_166112
VERSION     NM_019590.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7407)
  AUTHORS   Dai,J., Jiang,H., Cheng,Z., Li,Y. and Tang,X.
  TITLE     Genetic polymorphism of KIAA1217 is functionally associated with
            lumbar disc herniation in the Chinese population
  JOURNAL   Neurochirurgie 70 (2), 101538 (2024)
   PUBMED   38311218
  REMARK    GeneRIF: Genetic polymorphism of KIAA1217 is functionally
            associated with lumbar disc herniation in the Chinese population.
REFERENCE   2  (bases 1 to 7407)
  AUTHORS   Wang,Y., Li,N., Zheng,Y., Wang,A., Yu,C., Song,Z., Wang,S., Sun,Y.,
            Zheng,L., Wang,G., Liu,L., Yi,J., Huang,Y., Zhang,M., Bao,Y. and
            Sun,L.
  TITLE     KIAA1217 Promotes Epithelial-Mesenchymal Transition and
            Hepatocellular Carcinoma Metastasis by Interacting with and
            Activating STAT3
  JOURNAL   Int J Mol Sci 23 (1), 104 (2021)
   PUBMED   35008530
  REMARK    GeneRIF: KIAA1217 Promotes Epithelial-Mesenchymal Transition and
            Hepatocellular Carcinoma Metastasis by Interacting with and
            Activating STAT3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7407)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7407)
  AUTHORS   Al Dhaheri,N., Wu,N., Zhao,S., Wu,Z., Blank,R.D., Zhang,J.,
            Raggio,C., Halanski,M., Shen,J., Noonan,K., Qiu,G., Nemeth,B.,
            Sund,S., Dunwoodie,S.L., Chapman,G., Glurich,I., Steiner,R.D.,
            Wohler,E., Martin,R., Sobreira,N.L. and Giampietro,P.F.
  TITLE     KIAA1217: A novel candidate gene associated with isolated and
            syndromic vertebral malformations
  JOURNAL   Am J Med Genet A 182 (7), 1664-1672 (2020)
   PUBMED   32369272
  REMARK    GeneRIF: KIAA1217: A novel candidate gene associated with isolated
            and syndromic vertebral malformations.
REFERENCE   5  (bases 1 to 7407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7407)
  AUTHORS   Wheeler,E., Huang,N., Bochukova,E.G., Keogh,J.M., Lindsay,S.,
            Garg,S., Henning,E., Blackburn,H., Loos,R.J., Wareham,N.J.,
            O'Rahilly,S., Hurles,M.E., Barroso,I. and Farooqi,I.S.
  TITLE     Genome-wide SNP and CNV analysis identifies common and
            low-frequency variants associated with severe early-onset obesity
  JOURNAL   Nat Genet 45 (5), 513-517 (2013)
   PUBMED   23563609
REFERENCE   7  (bases 1 to 7407)
  AUTHORS   Kelempisioti,A., Eskola,P.J., Okuloff,A., Karjalainen,U.,
            Takatalo,J., Daavittila,I., Niinimaki,J., Sequeiros,R.B.,
            Tervonen,O., Solovieva,S., Kao,P.Y., Song,Y.Q., Cheung,K.M.,
            Chan,D., Ala-Kokko,L., Jarvelin,M.R., Karppinen,J. and Mannikko,M.
  TITLE     Genetic susceptibility of intervertebral disc degeneration among
            young Finnish adults
  JOURNAL   BMC Med Genet 12, 153 (2011)
   PUBMED   22107760
  REMARK    GeneRIF: SKT is involved in the etiology of intervertebral disc
            degeneration among young adults.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7407)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   9  (bases 1 to 7407)
  AUTHORS   Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B.,
            Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
  TITLE     Web-based, participant-driven studies yield novel genetic
            associations for common traits
  JOURNAL   PLoS Genet 6 (6), e1000993 (2010)
   PUBMED   20585627
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7407)
  AUTHORS   Karasugi,T., Semba,K., Hirose,Y., Kelempisioti,A., Nakajima,M.,
            Miyake,A., Furuichi,T., Kawaguchi,Y., Mikami,Y., Chiba,K.,
            Kamata,M., Ozaki,K., Takahashi,A., Makela,P., Karppinen,J.,
            Kimura,T., Kubo,T., Toyama,Y., Yamamura,K., Mannikko,M., Mizuta,H.
            and Ikegawa,S.
  TITLE     Association of the tag SNPs in the human SKT gene (KIAA1217) with
            lumbar disc herniation
  JOURNAL   J Bone Miner Res 24 (9), 1537-1543 (2009)
   PUBMED   19338451
  REMARK    GeneRIF: Using tag SNPs, we examined the association in two
            independent Japanese case-control populations and found a
            significant association of lumbar herniation with SKT rs16924573 in
            the allele frequency model
            GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091142.1, AL833280.1, AB033043.2, DB164876.1 and AB291616.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019590.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833280.1, SRR14372079.3488401.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376454.8/ ENSP00000365637.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK091142.1         348-373
            27-1547             AL833280.1         1-1521
            1548-2092           AB033043.2         2061-2605
            2093-2982           AL833280.1         2067-2956
            2983-3971           AL833280.1         2958-3946
            3972-3972           DB164876.1         78-78
            3973-5283           AL833280.1         3948-5258
            5284-6636           AB033043.2         4000-5352
            6637-7407           AB291616.1         4728-5498
FEATURES             Location/Qualifiers
     source          1..7407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2-p12.1"
     gene            1..7407
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="KIAA1217"
                     /db_xref="GeneID:56243"
                     /db_xref="HGNC:HGNC:25428"
                     /db_xref="MIM:617367"
     exon            1..126
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..5888
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sickle tail protein homolog; likely orthologue of Mus
                     musculus enhancer trap locus 4"
                     /codon_start=1
                     /product="sickle tail protein homolog isoform 1"
                     /protein_id="NP_062536.2"
                     /db_xref="CCDS:CCDS31165.1"
                     /db_xref="GeneID:56243"
                     /db_xref="HGNC:HGNC:25428"
                     /db_xref="MIM:617367"
                     /translation="MEENESQKCEPCLPYSADRRQMQEQGKGNLHVTSPEDAECRRTK
                     ERLSNGNSRGSVSKSSRNIPRRHTLGGPRSSKEILGMQTSEMDRKREAFLEHLKQKYP
                     HHASAIMGHQERLRDQTRSPKLSHSPQPPSLGDPVEHLSETSADSLEAMSEGDAPTPF
                     SRGSRTRASLPVVRSTNQTKERSLGVLYLQYGDETKQLRMPNEITSADTIRALFVSAF
                     PQQLTMKMLESPSVAIYIKDESRNVYYELNDVRNIQDRSLLKVYNKDPAHAFNHTPKT
                     MNGDMRMQRELVYARGDGPGAPRPGSTAHPPHAIPNSPPSTPVPHSMPPSPSRIPYGG
                     TRSMVVPGNATIPRDRISSLPVSRPISPSPSAILERRDVKPDEDMSGKNIAMYRNEGF
                     YADPYLYHEGRMSIASSHGGHPLDVPDHIIAYHRTAIRSASAYCNPSMQAEMHMEQSL
                     YRQKSRKYPDSHLPTLGSKTPPASPHRVSDLRMIDMHAHYNAHGPPHTMQPDRASPSR
                     QAFKKEPGTLVYIEKPRSAAGLSSLVDLGPPLMEKQVFAYSTATIPKDRETRERMQAM
                     EKQIASLTGLVQSALFKGPITSYSKDASSEKMMKTTANRNHTDSAGTPHVSGGKMLSA
                     LESTVPPSQPPPVGTSAIHMSLLEMRRSVAELRLQLQQMRQLQLQNQELLRAMMKKAE
                     LEISGKVMETMKRLEDPVQRQRVLVEQERQKYLHEEEKIVKKLCELEDFVEDLKKDST
                     AASRLVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAILRIEVEAVRFLKEEPH
                     KLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDAAQAAQYMAMEKATAAEVLKSQEEAA
                     HTSGQPFHSTGAPGDAKSEVVPLSGMMVRHAQSSPVVIQPSQHSVALLNPAQNLPHVA
                     SSPAVPQEATSTLQMSQAPQSPQIPMNGSAMQSLFIEEIHSVSAKNRAVSIEKAEKKW
                     EEKRQNLDHYNGKEFEKLLEEAQANIMKSIPNLEMPPATGPLPRGDAPVDKVELSEDS
                     PNSEQDLEKLGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRKENITAKASSEDA
                     GPSPQTRATKYPAEEPASAWTPSPPPVTTSSSKDEEEEEEEGDKIMAELQAFQKCSFM
                     DVNSNSHAEPSRADSHVKDTRSGATVPPKEKKNLEFFHEDVRKSDVEYENGPQMEFQK
                     VTTGAVRPSDPPKWERGMENSISDASRTSEYKTEIIMKENSISNMSLLRDSRNYSQET
                     VPKASFGFSGISPLEDEINKGSKISGLQYSIPDTENQTLNYGKTKEMEKQNTDKCHVS
                     SHTRLTESSVHDFKTEDQEVITTDFGQVVLRPKEARHANVNPNEDGESSSSSPTEENA
                     ATDNIAFMITETTVQVLSSGEVHDIVSQKGEDIQTVNIDARKEMTPRQEGTDNEDPVV
                     CLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMMMEEKIEEEEEEENGDSVVQ
                     NNNTSQMSHKKVAPGNLRTGQQVETKSQPHSLATETRNPGGQEMNRTELNKFSHVDSP
                     NSECKGEDATDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEE
                     DGTLKQHKEAKRFEIARSQPEDTPENTVRRQEQPSIESTSPISRTDEIRKNTYRTLDS
                     LEQTIKQLENTISEMSPKALVDTSCSSNRDSVASSSHIAQEASPRPLLVPDEGPTALE
                     PPTSIPSASRKGSSGAPQTSRMPVPMSAKNRPGTLDKPGKQSKLQDPRQYRQANGSAK
                     KSGGDFKPTSPSLPASKIPALSPSSGKSSSLPSSSGDSSNLPNPPATKPSIASNPLSP
                     QTGPPAHSASLIPSVSNGSLKFQSLTHTGKGHHLSFSPQSQNGRAPPPLSFSSSPPSP
                     ASSVSLNQGAKGTRTIHTPSLTSYKAQNGSSSKATPSTAKETS"
     exon            127..410
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            411..609
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            610..808
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            809..902
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1735
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1840
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1890
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2057
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2233
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2364
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2512
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2954
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3138
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3302
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3470
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3590
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3668
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..5267
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            5268..5390
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..7407
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7030..7035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="hexamer: AATAAA"
     polyA_site      7052
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="major polyA site"
     regulatory      7208..7213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="hexamer: AATAAA"
     polyA_site      7238
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="major polyA site"
     regulatory      7390..7395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
                     /note="hexamer: AATAAA"
     polyA_site      7407
                     /gene="KIAA1217"
                     /gene_synonym="ETL4; SKT"
ORIGIN      
        1 agaactgcgc tctgaagttt ccagagagcg aggagctttt gcggcaggca gagacaatgg
       61 aagaaaatga aagccagaaa tgtgagccgt gccttcctta ctcagcagac agaagacaga
      121 tgcaggaaca aggcaaaggc aatctgcatg taacatcacc agaagatgca gaatgccgca
      181 gaaccaagga acgcctttct aatggaaaca gtcgtggttc agtttccaag tcttcccgca
      241 atatcccaag gagacacacc ctaggggggc cccgaagttc caaggaaata ctgggaatgc
      301 aaacatctga gatggatcgg aagagagaag cgttcctaga acatctgaag cagaagtacc
      361 cccaccacgc ctctgcaatc atgggtcacc aagagaggct gagagaccag acaaggagcc
      421 ccaaactgtc tcacagtcct caaccaccca gtctgggtga cccggtcgag catttatcag
      481 agacgtccgc tgattctttg gaagccatgt ctgaggggga tgctccaacc cctttttcca
      541 gaggcagccg gactcgtgcg agccttcctg tggtgaggtc aaccaaccag acgaaagaaa
      601 gatctctggg ggttctctat ctccagtatg gagatgaaac caagcagctc aggatgccga
      661 atgaaatcac aagtgcagac acaatccgtg ctctcttcgt aagtgccttt ccacagcagc
      721 tcaccatgaa aatgctggaa tcgcccagtg tcgccattta catcaaagat gaaagcagaa
      781 atgtctatta tgaattaaat gatgtaagga acattcaaga cagatcactc ctcaaagtgt
      841 acaacaagga tcctgcacat gcgtttaatc acacaccaaa aactatgaat ggagacatga
      901 ggatgcagag agaacttgtt tatgcaagag gagatggccc tggggcccct cgccccggat
      961 ctactgctca tccaccccat gcgattccaa attccccacc gtctactcca gtgccccatt
     1021 ccatgccccc ctccccgtcc agaattcctt atgggggcac ccgctccatg gttgttcctg
     1081 gcaatgccac catccccagg gacagaatct ccagcctgcc agtctccaga cccatctctc
     1141 caagcccaag cgccatttta gaaagaagag atgtcaagcc tgatgaagac atgagtggca
     1201 aaaacattgc aatgtacaga aatgagggtt tctatgctga tccttacctt tatcacgagg
     1261 gacggatgag catagcctca tcccatggtg gacacccact ggatgtcccc gaccacatca
     1321 ttgcatatca ccgcaccgcc atccggtcag cgagtgctta ttgtaacccc tcaatgcaag
     1381 cggaaatgca tatggaacaa tcactgtaca gacagaaatc aaggaaatat ccggatagcc
     1441 atttgcctac actgggctcc aaaacacccc ctgcctctcc tcacagagtc agtgacctga
     1501 ggatgataga catgcacgct cactataatg cccacggccc ccctcacacc atgcagccag
     1561 accgggcctc tccgagccgc caggccttta aaaaggagcc aggcaccttg gtgtatatag
     1621 aaaagccacg gagcgctgca ggattatcca gccttgtaga cctcggccct cctctaatgg
     1681 agaagcaagt ttttgcctac agcacggcga caatacccaa agacagagag accagagaga
     1741 ggatgcaagc catggagaaa cagattgcca gtttaactgg ccttgttcag tctgcgcttt
     1801 ttaaagggcc cattacaagt tatagcaaag atgcgtctag cgagaaaatg atgaaaacca
     1861 cagccaacag gaaccacaca gatagtgcag gaacgcccca tgtgtctggt gggaagatgc
     1921 tcagtgctct ggagtccacg gtgcctccca gccagcctcc acctgtgggc acctcagcca
     1981 tccacatgag cctgcttgag atgaggcgga gcgtggcgga actcaggctc cagctccagc
     2041 agatgcggca gctccagctg cagaaccagg agttgctgag ggcaatgatg aagaaggccg
     2101 agctggaaat cagtggcaaa gtgatggaaa caatgaagag actggaggat cccgtgcagc
     2161 gacagcgcgt cctagtggag caagagagac aaaaatatct tcatgaggaa gagaagatcg
     2221 tcaagaagtt gtgcgagttg gaagactttg ttgaagactt gaagaaggac tccacggcag
     2281 ccagccgatt ggttactctg aaagacgtgg aagacggggc tttcctcctg cgtcaagtgg
     2341 gagaggctgt agctaccctg aaaggagaat ttccaacctt acaaaacaag atgcgagcca
     2401 tcctgcgcat agaagtggag gccgtgcggt ttctgaagga ggagccacac aagctggaca
     2461 gtctcctgaa gcgtgtgcgc agcatgacag acgtcctgac catgctgcgg agacatgtca
     2521 ctgatgggct cctgaaaggc acggacgcag cccaagccgc acagtacatg gctatggaaa
     2581 aggccacagc cgcagaagtc ctgaagagtc aggaggaggc agcccacacc tccggccagc
     2641 ccttccacag cacaggtgcc cctggcgatg cgaagtcgga agtggtgcct ttgtccggca
     2701 tgatggttcg ccacgcgcag agctcccctg tggtcatcca gccctcccag cactccgtgg
     2761 ccctgctgaa ccctgctcag aacttgcctc acgtggccag ctccccagcc gtcccccagg
     2821 aagcaacctc cactctgcag atgtcgcagg ctccgcagtc cccacagata cccatgaatg
     2881 ggtctgccat gcagagcttg ttcattgaag aaatccacag tgtgagtgcc aagaacaggg
     2941 cagtgtctat cgagaaagca gaaaagaaat gggaggaaaa aaggcaaaat ctggatcact
     3001 ataatgggaa agagtttgag aagctcctag aagaagctca ggccaatatc atgaagtcaa
     3061 taccaaatct ggagatgccg ccagccacag gcccactgcc aaggggagat gccccagtgg
     3121 acaaggtgga actttcagaa gattctccaa attcggaaca ggacttggaa aagctggggg
     3181 gaaagtcgcc ccctcctcct ccgccacctc ctcgtcgaag ctacctgcca ggatcgggac
     3241 tcaccaccac gaggtcaggc gatgtggtct acaccggcag aaaggagaac atcaccgcta
     3301 aggcaagcag tgaagatgct ggaccaagcc cacagaccag agctacaaaa tatccagcag
     3361 aggagcctgc ttcagcctgg accccatccc caccgcctgt caccacctcc tcctcaaagg
     3421 atgaggagga agaagaagaa gaaggagaca aaataatggc agaactccag gcattccaga
     3481 agtgttcctt tatggatgta aattcaaaca gtcatgctga gccatcccgg gctgacagtc
     3541 acgttaaaga cactaggtcg ggcgccacag tgccacccaa ggagaagaag aatttggaat
     3601 ttttccatga agatgtacgg aaatctgatg ttgaatatga aaatggcccc caaatggaat
     3661 tccaaaaggt taccacaggg gctgtaagac ctagtgaccc tcctaagtgg gaaagaggaa
     3721 tggagaatag tatttctgat gcatcaagaa catcagaata taaaactgag atcataatga
     3781 aggaaaattc catatccaat atgagtttac tcagagacag tagaaactat tcccaggaaa
     3841 ctgtgcctaa ggccagtttc ggtttctctg gcattagtcc attagaagat gaaataaaca
     3901 aagggtctaa aatctcaggc ctgcaatact ctatacctga caccgagaac cagacgctga
     3961 attacggaaa gacaaaggag atggaaaagc aaaatacgga taagtgtcac gtttcctctc
     4021 acactagact aacagaatca agcgtgcatg attttaaaac agaagatcaa gaggttatca
     4081 cgacagattt tggccaagtt gttctaagac ccaaggaggc aaggcatgct aacgtgaacc
     4141 ctaatgagga tggagaatca agttcaagtt ctcccactga agaaaatgca gccactgaca
     4201 atattgcctt catgattacc gaaaccactg tccaggttct ttccagtggg gaggtgcatg
     4261 atattgttag ccaaaaggga gaagacatac agacggttaa tatcgatgcc agaaaagaga
     4321 tgaccccccg acaagaaggg actgacaatg aggatccagt cgtgtgcctg gacaagaaac
     4381 cagtgatcat cattttcgat gagcccatgg acatccggtc tgcctataag agactttcaa
     4441 ctatctttga ggaatgtgat gaggaattag agagaatgat gatggaggaa aagatagagg
     4501 aggaggaaga ggaggaaaat ggggattctg tagtccagaa taataacact tcccagatgt
     4561 ctcataagaa ggtggcccca ggcaatctta gaaccggaca acaggtggaa acaaagtcac
     4621 agccacactc cctggccaca gagaccagaa acccaggagg acaggaaatg aacagaacgg
     4681 agctgaacaa gttcagccac gtggattctc caaattcgga atgcaagggt gaggacgcga
     4741 ccgatgacca gtttgaaagc cccaagaaaa agtttaaatt caaattccct aagaagcaac
     4801 tcgccgctct cactcaagcc attcgcaccg gaactaaaac agggaagaag actttgcaag
     4861 tggtagtcta tgaagaagag gaagaggatg gcaccctgaa acagcacaaa gaagccaagc
     4921 gcttcgaaat cgctaggtct caacctgaag acacccctga aaacacagtg aggaggcaag
     4981 agcagcccag catcgagagt acatctccga tttcaagaac tgatgaaatt agaaaaaaca
     5041 cctacagaac attggatagc ctggagcaga ccattaaaca gctcgaaaat acaatcagtg
     5101 aaatgagtcc caaagcccta gttgatacct catgttcttc caacagagat tctgttgcaa
     5161 gttcatccca catagcccaa gaggcctctc cccgaccctt gctagttccg gatgaaggtc
     5221 ccactgccct agagccccct acgtcgatac cttcagcttc acgtaagggc tccagcgggg
     5281 ccccacagac gagcaggatg cctgtcccca tgagtgccaa gaacagaccc ggaaccctgg
     5341 acaaacccgg caagcagtcc aaactgcagg atccccgcca atatcgtcag gctaatggaa
     5401 gtgctaagaa atctggtggg gactttaagc ctacttcccc ctccttacct gcttctaaga
     5461 ttccagccct ttctcccagc tctgggaaaa gcagttctct gccctcttct agtggtgaca
     5521 gctctaacct ccctaatcca cctgctacta aaccatcgat tgcttctaac cctctcagcc
     5581 cccaaacagg accacctgct cactctgcct ccctcatccc ttctgtctct aatggctctt
     5641 tgaagtttca gagcctcact catacaggta aaggtcacca tctttcattc tcaccgcaga
     5701 gtcaaaatgg ccgagcaccc cctcctttgt cattttcctc ctcccctcct tctcctgcct
     5761 cctccgtctc actgaatcaa ggtgccaagg gcaccaggac catccatact cccagcctca
     5821 ccagctacaa ggcacagaat ggaagttcaa gcaaagccac cccatccaca gcaaaagaaa
     5881 cctcttaaag gtcaaatcct attaggcaca agtcggagtt acatttaaaa aaaattaaca
     5941 gtctacaaca actgttttca caagagaatg taacatattg ctgtatcgtt tgaggcttaa
     6001 tgctaaatat gtgctaaata ctggattaat agatttcagt aaagctcgtt cgttttgttt
     6061 ggttttcttt ttacctagtt gctatagtgt ctacagtcta tactcaatac ctataaaatg
     6121 cagtaagcat gtgttacaga aagaggttct ggtgggagag aaaggtgcgt gtgagacagg
     6181 agaattgtct taagcatata aaacatgtat gattccagaa ttttagtatg ttttgtataa
     6241 aactattttt cattacggag actagaagtg aacagagaat tacacaagtg tgactataca
     6301 aattgtaaaa cagatactat aatatttcct tttattttag tgttatttag ctttattaca
     6361 gatttctatt tttgtcaaaa cttcatggtt cctttcaaga tcttttttgc caaaacattt
     6421 tgatactata gcattgtaca tttgaaagta gtgttctaga ctataaaacc aatgaacttc
     6481 tacatgagcc ctacagacag gcatgtgtag aaggcaattt atcaaaccta ttgcactgcc
     6541 atgaaaagtg tgtataataa tttgctagcc caagcaagct agttttcttt gcttgcttct
     6601 tttctttctt ttttccttcc tttttttttt ttttttcttt tttaacatgt tgagattctc
     6661 tagttgtttt ctttggcgta tctaacccct tcttttgttt tctgagacct ggtaacccac
     6721 gctcttgcat tgtggatttt aaaatgtata ctctgtacgg ttctgtaaac cgaaaaactt
     6781 ttgtaaatat ataaatatac atagacataa aaatactgta tgtgacagca catagagtag
     6841 ttttcccaca ccaaagttaa tttttatgca tgctttaaaa gtatatatcg ggaccggcag
     6901 aaatggaagt atccatacat ttttaaaaag caacaagttt gcacagctag agtgtttttg
     6961 taaataaatg tatttgtata acacagtcat gtaatataca gaactataag cagagacttt
     7021 gcaaaactaa ataaagggct gcatgcttat tattttttgt accttgtcac tataactact
     7081 tcctagtcaa agaacgaaat gtaactgtta ccgagttaaa tgtttttccg ctttgaggga
     7141 tgtaaccaca tccactcaga ggacactact tttctgaaag ctctggggtg actaatgatg
     7201 agttcctaat aaattaattg caagtgtggt gccttggatg tggcctgttg gctcgctttc
     7261 ttctctgtgg cttatcaagg tgtagatgac agaaagcaaa cctggataca gagtttccac
     7321 cctcagttcc tggaggggct cttattattt tctctctttt taaaaaactt ccagtagaag
     7381 taaagtggaa ataaaatgtc tttatca
//
