LOCUS       NM_020444               2786 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KIAA1191 (KIAA1191), transcript variant 1, mRNA.
ACCESSION   NM_020444
VERSION     NM_020444.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Xu,Z., Sun,Y., Jiang,J. and Liu,P.
  TITLE     The role of KIAA1191 in the necroptotic pathway of multiple myeloma
  JOURNAL   Ann Hematol 101 (2), 359-367 (2022)
   PUBMED   34989828
  REMARK    GeneRIF: The role of KIAA1191 in the necroptotic pathway of
            multiple myeloma.
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Mishra,M., Inoue,N. and Heese,K.
  TITLE     Characterizing the novel protein p33MONOX
  JOURNAL   Mol Cell Biochem 350 (1-2), 127-134 (2011)
   PUBMED   21153684
  REMARK    GeneRIF: p33MONOX might regulate pre- and post-transcriptional
            control of dynamic processes related to growth cone guidance.
REFERENCE   4  (bases 1 to 2786)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 2786)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   6  (bases 1 to 2786)
  AUTHORS   Yokota,T., Mishra,M., Akatsu,H., Tani,Y., Miyauchi,T., Yamamoto,T.,
            Kosaka,K., Nagai,Y., Sawada,T. and Heese,K.
  TITLE     Brain site-specific gene expression analysis in Alzheimer's disease
            patients
  JOURNAL   Eur J Clin Invest 36 (11), 820-830 (2006)
   PUBMED   17032350
REFERENCE   7  (bases 1 to 2786)
  AUTHORS   Zuhlke,C., Kiehl,R., Johannsmeyer,A., Grzeschik,K.H. and
            Schwinger,E.
  TITLE     Isolation and characterization of novel CAG repeat containing genes
            expressed in human brain
  JOURNAL   DNA Seq 10 (1), 1-6 (1999)
   PUBMED   10565538
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648859.1 and AA569811.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020444.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017097.1, BX648859.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298569.9/ ENSP00000298569.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2563              BX648859.1         43-2605
            2564-2786           AA569811.1         20-242              c
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..2786
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /note="KIAA1191"
                     /db_xref="GeneID:57179"
                     /db_xref="HGNC:HGNC:29209"
     exon            1..163
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            164..271
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            272..358
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1248
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /note="isoform a is encoded by transcript variant 1;
                     brain-derived rescue factor p60MONOX; flavine
                     monooxygenase motif-containing protein of 33 kDa; putative
                     monooxygenase p33MONOX; flavin monooxygenase
                     motif-containing protein of 33 kDa; p60MONOX brain-derived
                     rescue factor"
                     /codon_start=1
                     /product="putative monooxygenase p33MONOX isoform a"
                     /protein_id="NP_065177.2"
                     /db_xref="CCDS:CCDS4399.1"
                     /db_xref="GeneID:57179"
                     /db_xref="HGNC:HGNC:29209"
                     /translation="MASRQPEVPALEASAPLGKMSLPIGIYRRAVSYDDTLEDPAPMT
                     PPPSDMGSVPWKPVIPERKYQHLAKVEEGEASLPSPAMTLSSAIDSVDKVPVVKAKAT
                     HVIMNSLITKQTQESIQHFERQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSG
                     EVTKEERQPASAQSTPSTTPHSSPKQRPRGWFTSGSSTALPGPNPSTMDSGSGDKDRN
                     LSDKWSLFGPRSLQKYDSGSFATQAYRGAQKPSPLELIRAQANRMAEDPAALKPPKMD
                     IPVMEGKKQPPRAHNLKPRDLNVLTPTGF"
     exon            359..537
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            538..664
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            665..789
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            790..896
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1039
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..2786
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /note="hexamer: AATAAA"
     polyA_site      2786
                     /gene="KIAA1191"
                     /gene_synonym="p33MONOX; p60MONOX"
                     /note="major polyA site"
ORIGIN      
        1 ggtactgcta cctagtgggt cttggggacc ttcgaaatcg ccgccgctct cacaatggct
       61 tgggtccaga ctgcgccaca gcctctcggg agacgtgggc cctcggaacc tttttagtgc
      121 cggactccgg gccgcaggca gtcccgcggc agcaggatca cagaacctct ggatggactc
      181 ttcctgggaa gctttgctac tttgcagcag ctggaccatg ttcctcatta acatctgtct
      241 gtccgcttag tcatcacatc atttcactgt ggtggcaggg actcagctcg gaattctgta
      301 tagaaaaagc acctggatcc cagtctttca atggcttcaa gacaaccaga agtgcctgct
      361 cttgaggcta gtgcgcctct aggcaagatg tccctgccca tcgggatata ccgccgggca
      421 gtcagctatg atgataccct cgaggaccct gcgcccatga ctcctcctcc atcggacatg
      481 ggcagcgtcc cttggaagcc agtgattcca gagcgcaagt atcagcacct cgccaaggtg
      541 gaggaaggag aggccagtct accctcccct gccatgaccc tgtcatcagc cattgacagt
      601 gtggacaagg tcccagtggt gaaggctaaa gctacccatg tcatcatgaa ttctctgatc
      661 acaaaacaga cccaggaaag cattcagcat tttgagcgac aggcagggct gagagatgct
      721 ggctacacac cccacaaggg cctcaccacc gaggagacca agtaccttcg agtggccgaa
      781 gcactccaca aactaaagtt acagagtgga gaggtaacaa aagaagagag gcagcctgca
      841 tcagcccagt ccaccccaag caccactccg cactcttcac ctaagcagag gcccaggggc
      901 tggttcactt ctggttcttc cacagcctta cctggcccaa atcctagcac catggactct
      961 ggaagtgggg ataaggacag aaacttgtca gataagtgga gcctctttgg accgagatcc
     1021 cttcagaagt acgattctgg aagttttgcc acccaggcct accgaggagc ccagaagccc
     1081 tctccattgg aactgatacg tgcccaggcc aaccgaatgg ctgaagatcc agcagccttg
     1141 aagcccccca agatggacat cccagtgatg gaaggaaaga aacagccacc acgggcccat
     1201 aacctcaaac cccgtgacct gaatgtgctc acacccactg gcttctagag ccctctttcc
     1261 agggattctg gtaaaggtgg tttcttgcat cccactcccc ttttaccttg gctttgacat
     1321 aggaaaggta tatttaaaaa cttaatcagc tgggcgtggt ggctcacgcc tgtaatccca
     1381 gcactttggg aggccaaggt aggtggatac ctgaggtcag gagttcaaga ccagcctggc
     1441 caacatggtg aaaccccgtc tctactaaaa atacaaaaat tagctgggcg tggtggtggg
     1501 cgcctgtagt cccagctact tgggaggctg aggcaggaga atcgcctgaa cccaggaagc
     1561 agatgttgta ccgagctgag atcatgccat tacactccag cctgggcgac agaacgagac
     1621 gccatcaata aataaataaa taaagtaaag taaaaaacct attaaattga ggctagagct
     1681 ggagatgtaa ttggtttttg agaaacatta gtataaagct tgcccttgtt gtgtggaaga
     1741 agccattttg tactgcttta aagttagact aatattctca gcacgggtgt atggggacct
     1801 cattacctat ttttttcatc atttacccta ggtaagaact ttgatcactg cttactaggt
     1861 aaagaatgtt tgtactgttc caaaacccag gcttctttat tcctttacca ctatccatgt
     1921 gagcattgac aaatcatggc ttagaggtgc tcactgactc gctaagacga ctttggccct
     1981 gttgatgact ggtgctgtgc tccagcctta tcagttaggg gacccaaggt ttgtttggga
     2041 cctgggtaca ggtaaaagcc agacttggca gggacccctc tttctaggct gaaccttgag
     2101 tccccctgct ttttggcaga cctaatggat cactgtcttg cagctagttc ttcatgtggg
     2161 gcctcttagg ccagtgccgg aggaggcatg ctcctctttc tatgccacag aacaaacact
     2221 actctagcag agcctttctt gcactttaaa gtgagattaa tttagctgta atttggttaa
     2281 aaacttccta agagagaaaa ttaagtctac tgatttggta taggtaaatg gacattaaac
     2341 ttttttaaag taaaggagat ggtagatacc gttagattat agtcttgagg ttcatgtgaa
     2401 gccagtggtg ttaacttact ttgatttcct tgttcaggtc agggcctgga acgcctgtgc
     2461 ggggaggtca ctcaattcaa aattttctgt atgaaagcat ttttcaccaa aatgagcctc
     2521 atccctttat gcaacacata accttactga gggagggaaa tacagaagcc acctttttat
     2581 ttctcttcac tgtgtacaag ttcacttgtt gtcttgaaca ctgtctcaaa tacctgcttt
     2641 ttgttttgga tagtaccttg tctgtataag aagctggcct ttccatagag aggccctgga
     2701 gtctaaaatt atgagaacaa ttaatttatt tgtgtcttct attatgatct cgttttgaca
     2761 ataaaaatcc ttactacttt ctcaaa
//
