LOCUS       NM_020696               5079 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens KIAA1143 (KIAA1143), transcript variant 1, mRNA.
ACCESSION   NM_020696
VERSION     NM_020696.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5079)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5079)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA192476.1, BC008468.1, AC098649.2 and BU741967.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020696.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA443587.1, SRR1660803.152736.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMN03267771 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296121.6/ ENSP00000296121.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA192476.1         38-40
            4-789               BC008468.1         41-826
            790-4580            AC098649.2         27568-31358         c
            4581-5079           BU741967.1         17-515              c
FEATURES             Location/Qualifiers
     source          1..5079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5079
                     /gene="KIAA1143"
                     /note="KIAA1143"
                     /db_xref="GeneID:57456"
                     /db_xref="HGNC:HGNC:29198"
     exon            1..125
                     /gene="KIAA1143"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..482
                     /gene="KIAA1143"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein KIAA1143 isoform 1"
                     /protein_id="NP_065747.1"
                     /db_xref="CCDS:CCDS2721.1"
                     /db_xref="GeneID:57456"
                     /db_xref="HGNC:HGNC:29198"
                     /translation="MSKRNQVSYVRPAEPAFLARFKERVGYREGPTVETKRIQPQPPD
                     EDGDHSDKEDEQPQVVVLKKGDLSVEEVMKIKAEIKAAKADEEPTPADGRIIYRKPVK
                     HPSDEKYSGLTASSKKKKPNEDEVNQDSVKKNSQKQIKNSSLLSFDNEDENE"
     exon            126..270
                     /gene="KIAA1143"
                     /inference="alignment:Splign:2.1.0"
     exon            271..5079
                     /gene="KIAA1143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5059..5064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA1143"
                     /note="hexamer: AATAAA"
     polyA_site      5079
                     /gene="KIAA1143"
                     /note="major polyA site"
ORIGIN      
        1 ctttacccag agctaccatg agcaagcgga accaggtatc gtacgtgcgg ccagccgagc
       61 cggcgtttct ggcccgcttc aaggaacggg tcggctacag ggagggaccc accgtagaga
      121 ctaagagaat tcagcctcag cccccagatg aagatgggga tcacagtgac aaagaagatg
      181 aacagcctca agtggtggtt ttaaaaaagg gagacctgtc agttgaagaa gtcatgaaaa
      241 ttaaagcaga aataaaggct gccaaagcag atgaagaacc aactccagcc gatggaagaa
      301 tcatatatcg aaaaccagtc aagcatccct cagatgaaaa atattcaggt ttaacagcaa
      361 gctcaaaaaa gaagaagcca aatgaagatg aagtaaatca ggactcggtc aaaaagaact
      421 cacaaaaaca aattaaaaat agtagcctcc tttcttttga caacgaagat gaaaatgagt
      481 aagtgtaaat attttgaatt tagtctactt tgaaagtata tggagtgttc attaaaatca
      541 cattttttcc tattataaag atactacaag ttctttatag aaagtttagg aaatagagaa
      601 aaaaatttaa taaactacat ctattcatca atacccctct gacttaaaat gccaactcta
      661 tagaaattag ctagtattaa cattttgtta tttcccttgt gtggttgtat atatatgtaa
      721 attatatttt taagcaaaat acattttttg tgtgtaaaca aaattttata aatacaactg
      781 tattgcaaat gttctttgtc ctgcttctca cttgacattg cattacgagt attcttccag
      841 gtcagtaaat ttcaaaaacc tgacattaat agctacagat aatttcataa acatctcatt
      901 gtatcttttt cattagcaat agctccactt tgggtggggg agatgataat gtgccttgtt
      961 aaaaatacct ccccaactcc tgctaagggt ggccatgaga ctcagctctg gcaagttaag
     1021 aaatacaggt ggaattctgc ttgataaagc tgctgggttt tttgttacaa aaggacagac
     1081 ttggcaaaca tgagcctttg ctcttatctt ttcatcctac ttggagtgca gagataaaac
     1141 ctgagtacca gagccacttt taggcataag gaaggcagcc atgtgctttg ggtcatgtta
     1201 gtaaaaagac tcagagcttg gctccttgct gacatgcctg gaggagctgc tacaccagct
     1261 tggattgctg acctctgact tcttggtagt gagaagaata aacactgtgc ttaattaggc
     1321 cttggtcagg tttcttttat atgcagccaa atgcagtcct aagtaataca ataaataact
     1381 ggtcaaactg ttactggtgg agggtgtcca ggttcttggc attttggaca aataattgaa
     1441 caaaacgcac aaagcaatga atatcctcta gaggtttgcc attggttact tggcgtacac
     1501 cctgtgtaaa tgaagtagtg gcccgtgacc tgtctgattg gtgcagaaag tgaccaatca
     1561 gaggctgaag tgaagttaca aagttatact cctgtgtaaa tgaggacttg gcctatgacc
     1621 agtctgattg gttgcaggag gggaccaatc agaggcactt tcatttttca tctgcaatgc
     1681 agaaaaggca aggggattgc aaagggagta gcctctgatc cttttgttac ttaggtatgg
     1741 agaggtgggg ttttcctttt gattcagttc taggaagtca atgtgaatca gccttaggtt
     1801 ccctgtctcc agaccctatt ctcctgcctc attttccccc tgagagacgt gatcctcgta
     1861 aatctttatg ggaggctgag agactgaggg tctttcttct gtaactgctt catgctaact
     1921 tgggacacag tccctaccta ttggagatca cgtaactctc accctgcttt gtctagggga
     1981 gacagggtag cttcttgatg gccggtggtg tcttctcctg aaactggcta gaaatcttgt
     2041 cacatgatca tctaacttgg tggtctctag gcaaaaggaa atggatttgg ttaaaagatt
     2101 taacagatat ggtccaaaaa ccaaggcaaa tataatcatt aataatgggc tggccaaggg
     2161 agggagccat gaaacccaac ttagtgccct ttaggtgccc cagctgttgt catattttag
     2221 aggcccagtc agctagtttt caggtggtgt cccttactaa tcctgattgg ttgacatcaa
     2281 aacagcattc ttcttctagg aaaatacata agccacctgt ttcagcagtt aggagatcta
     2341 gtccccttcg attttgcaaa gcgaccactg ccaaggagcc tatccgaatt tgtaaggtga
     2401 caatactttg agcaatgtta tccaggcttt ccataaaatc cttggacaag cgttggtaat
     2461 aggataggga agttgcaatc ccgctaactc ccattcctac ctctgctgtt attcctagcc
     2521 gttgtgtctg gtggttgcag ttaaaggtat aatgagggat tggttgttgg gagctatatt
     2581 aatttaggga catacaatat ttctgtctcc agtctaccac ttccaccaaa gacaaatcac
     2641 agcagaaccg acctaacttc aaaataaact gcagtcccat atactgggcc tgattaccca
     2701 cacaaagtgc aacaagaatc attgtccata tagactctcc tagattggct ttgctagaac
     2761 atttcacaag gccatttcag tcaaagtcct gagaaagtaa ccggtttcaa ttgtgcccta
     2821 ttacaaaaga aaacgtggtt attaacttta tacagacaaa tgccatgaat taagaatatt
     2881 cataaatagt ttacaaattc tggagaaatt agaatactca atacacttaa agtgtatttc
     2941 aaggctataa atagctcaaa ataaaaagat tattcagact ctgaaaaaac aaaaagaagt
     3001 agcaatattt caaacaacaa aagccataca aattatttca gtcttccatt agttcatttc
     3061 agtccatgta atcaactcct gctctacttc atattcatct ttatgaacac atcagccttt
     3121 caattagtgc cttggaagtt ttctgtctaa tccaatggca cactctccaa agttaccaga
     3181 aacctgcatt caagagttct tttcatgaac tccaaagaag taagccttgg actgtagctg
     3241 attataagtc actttttttt tttgagaagg atcagagcaa aacatcaatt atggatgaca
     3301 aaagtcttaa gacagccata aagacacagt tgacaaatgt ggctatttct gtggcttaca
     3361 acaatttaac ataatcatta caacatatat taagacatat cagaatttta gaactctcat
     3421 acaatcctgg aacacatatt aacaacaaat ctctatcagt ataacccaaa ggaagctaaa
     3481 caccacctca cacttgacaa tgtttcctgt ataattcaaa cattacaaat aagcctaata
     3541 taagcctaat atgtcactct tgaacttcag gaagcctaat atccaaaaag ttagtttaag
     3601 gtcaaaagtt tttgaattaa cttttttcca ttagtatggt catatctttc ttactaattt
     3661 gtaagttatg taatttatca attttttttt gttgttctgt ttcccaacct ctatgtcaga
     3721 taaagaatca cccaggccag acacaatggc tcatgcttgt aatcccaaca ctttgggaag
     3781 ccaaggtggg agaattgctt gaagccagga atctgagccc agcctgggcg acaaagcaat
     3841 acccctatct ctacaaaaaa taaaaaatag ccaggtgtag cgacacacac ctgtagtccc
     3901 agctgctcag gaggctaagc aggaggatgg cttgggccca ggagttcaac gctgcagtga
     3961 gctatgattg caccactgca ctccagcctg ggcaacagag taagaactgt ctcaaaaaaa
     4021 ataaaaaata gaaataaatt ttaaaaaaag aattacccat attctctttg tttttgttta
     4081 ttcacattaa cctttattct atctggaatt tattagagta tacttttttc tcaaataatc
     4141 aattgtccta gaaccatgtg tttctcattt atttgaaagg ccatctagtg agagatttct
     4201 ccaaatgttg gggtagggaa gggaggggaa gcactttaaa gtctgagcct ttagaggtga
     4261 ttcctcaaga ccctgcttaa tcctaacaat tttcctcatt agtaaaagtc agcccaaact
     4321 gggggcttgt taagatcctt accagccaca tccatctgaa attatgaatt tcaaagtatc
     4381 ttacaaattt ggtgccacat tatctttttt aagtttgttt tgttttgttt ttttgagaca
     4441 gagtctcgct ctgtcaccca ggctggagtg cagtggcgcg atctcagctc actgcaagct
     4501 ccgcctcctg ggttcacacc attctcttgc ctcagcctcc caagtatctg ggactacagt
     4561 cgcccgccac cacgcccggc taattttttt gtatttttaa tagagacggg gtttcacttt
     4621 gttagccagg atggtctcaa tctcctgacc tcatgatcca cctgcctcgg cctcccaaag
     4681 tgctgggatt acaggcagga gccaccgcgc ctgggccttt ttttaagttt taagtaccta
     4741 taaagaacac tgaaaggtga tgtgtgtgga tgagctagga agacctgaaa taggctctct
     4801 ctaaattaat caaattaatc ctgaagccat tctgcaatac tgtctttaat gtatactcac
     4861 ttgttataga agccagggtt ttttccccta atttgtatca ttgctatatg tgttattgta
     4921 ccaaactaca ctgttttaat tgctgtaaat tttaatatgt cttagtatct gggtgtggga
     4981 atcttgaaag catggagttt gtgttattca ccactgtatt ctcaaatatc agaagagtat
     5041 ctggcctact aagtgcacaa taaacatagt taaaatgaa
//
