LOCUS       NM_001145678            7241 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens KIAA0825 (KIAA0825), transcript variant 1, mRNA.
ACCESSION   NM_001145678
VERSION     NM_001145678.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7241)
  AUTHORS   Ahmad,S., Ali,M.Z., Muzammal,M., Khan,A.U., Ikram,M., Muurinen,M.,
            Hussain,S., Loid,P., Khan,M.A. and Makitie,O.
  TITLE     Identification of GLI1 and KIAA0825 Variants in Two Families with
            Postaxial Polydactyly
  JOURNAL   Genes (Basel) 14 (4), 869 (2023)
   PUBMED   37107627
  REMARK    GeneRIF: Identification of GLI1 and KIAA0825 Variants in Two
            Families with Postaxial Polydactyly.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7241)
  AUTHORS   Yao,Y., Deng,S. and Zhu,F.
  TITLE     Prenatal Detection of Novel Compound Heterozygous Splice Site
            Variants of the KIAA0825 Gene in a Fetus with Postaxial Polydactyly
            Type A
  JOURNAL   Genes (Basel) 13 (7), 1230 (2022)
   PUBMED   35886013
  REMARK    GeneRIF: Prenatal Detection of Novel Compound Heterozygous Splice
            Site Variants of the KIAA0825 Gene in a Fetus with Postaxial
            Polydactyly Type A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7241)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 7241)
  AUTHORS   Hayat,A., Umair,M., Abbas,S., Rauf,A., Ahmad,F., Ullah,S., Ahmad,W.
            and Khan,B.
  TITLE     Identification of a novel biallelic missense variant in the
            KIAA0825 underlies postaxial polydactyly type A
  JOURNAL   Genomics 112 (4), 2729-2733 (2020)
   PUBMED   32147526
  REMARK    GeneRIF: Identification of a novel biallelic missense variant in
            the KIAA0825 underlies postaxial polydactyly type A.
REFERENCE   5  (bases 1 to 7241)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7241)
  AUTHORS   Schilit,S.L., Currall,B.B., Yao,R., Hanscom,C., Collins,R.L.,
            Pillalamarri,V., Lee,D.Y., Kammin,T., Zepeda-Mendoza,C.J.,
            Mononen,T., Nolan,L.S., Gusella,J.F., Talkowski,M.E., Shen,J. and
            Morton,C.C.
  TITLE     Estrogen-related receptor gamma implicated in a phenotype including
            hearing loss and mild developmental delay
  JOURNAL   Eur J Hum Genet 24 (11), 1622-1626 (2016)
   PUBMED   27381092
  REMARK    GeneRIF: Disruption of the orphan receptor ESRRG and disruption of
            KIAA0825 identified in a subject with hearing loss and mild
            developmental delay.
REFERENCE   7  (bases 1 to 7241)
  AUTHORS   Park,T.J., Park,J.S., Cheong,H.S., Park,B.L., Kim,L.H., Heo,J.S.,
            Kim,Y.K., Kim,K.U., Uh,S.T., Lee,H.S., Na,J.O., Seo,K.H.,
            Choi,J.S., Kim,Y.H., Kim,M.S., Park,C.S. and Shin,H.D.
  TITLE     Genome-wide association study identifies ALLC polymorphisms
            correlated with FEV change by corticosteroid
  JOURNAL   Clin Chim Acta 436, 20-26 (2014)
   PUBMED   24792382
REFERENCE   8  (bases 1 to 7241)
  AUTHORS   Cha,P.C., Zembutsu,H., Takahashi,A., Kubo,M., Kamatani,N. and
            Nakamura,Y.
  TITLE     A genome-wide association study identifies SNP in DCC is associated
            with gallbladder cancer in the Japanese population
  JOURNAL   J Hum Genet 57 (4), 235-237 (2012)
   PUBMED   22318345
REFERENCE   9  (bases 1 to 7241)
  AUTHORS   Huang,Y.C., Lin,J.M., Lin,H.J., Chen,C.C., Chen,S.Y., Tsai,C.H. and
            Tsai,F.J.
  TITLE     Genome-wide association study of diabetic retinopathy in a
            Taiwanese population
  JOURNAL   Ophthalmology 118 (4), 642-648 (2011)
   PUBMED   21310492
REFERENCE   10 (bases 1 to 7241)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025766.4, AC093311.2, AC117521.2 and AC104127.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001145678.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968540, SAMEA1968968
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682413.1/ ENSP00000506760.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC025766.4         49498-49602
            106-256             AC093311.2         152934-153084       c
            257-388             AC093311.2         107497-107628       c
            389-557             AC093311.2         94431-94599         c
            558-1227            AC093311.2         90749-91418         c
            1228-1389           AC093311.2         55270-55431         c
            1390-1484           AC117521.2         778-872
            1485-1712           AC117521.2         4464-4691
            1713-1978           AC117521.2         6252-6517
            1979-2129           AC117521.2         7872-8022
            2130-2320           AC117521.2         12924-13114
            2321-2503           AC117521.2         15414-15596
            2504-2614           AC117521.2         24914-25024
            2615-2754           AC117521.2         37862-38001
            2755-2919           AC117521.2         60618-60782
            2920-3144           AC117521.2         74190-74414
            3145-3553           AC117521.2         81474-81882
            3554-3713           AC117521.2         86289-86448
            3714-3876           AC117521.2         91579-91741
            3877-3967           AC117521.2         93525-93615
            3968-7241           AC104127.2         151631-154904
FEATURES             Location/Qualifiers
     source          1..7241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..7241
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="KIAA0825"
                     /db_xref="GeneID:285600"
                     /db_xref="HGNC:HGNC:28532"
                     /db_xref="MIM:617266"
     exon            1..105
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            106..256
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            257..388
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..4085
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="uncharacterized protein KIAA0825 isoform 1"
                     /protein_id="NP_001139150.1"
                     /db_xref="CCDS:CCDS93745.1"
                     /db_xref="GeneID:285600"
                     /db_xref="HGNC:HGNC:28532"
                     /db_xref="MIM:617266"
                     /translation="MDWDDEYSHNSFDLHCLLNSFPGDLEFEQIFSDIDEKIEQNAAS
                     IKHCIKEIQSEINKQCPGVQLQTTTDCFEWLTNYNYSTSESSFISHGDLIKFFKTLQD
                     LLKNEQNQEEMTLDLLWDLSCHSSVSFPSTLSGTSFHFLSRTSLHSVEDNSSMDVKSM
                     WDDIRLHLRRFLVSKLQSHNEINNSQQKILLKKQCLQQLLFLYPESEVIIKYQNIQNK
                     LLANLLWNCFPSYNRDSNLDVIAHGYQSTMLKLYSVIKEDFNTLCEILAPSSMVKFIK
                     ETYLDTVTEEMAKFLENFCELQFRENAVRVVKTSKSSSKHRGAVHALVTTECPQKGRN
                     FSLPLDKVEFLSQLIKSFMKLEKGVQELFDEILLSLKITRDTSGILEKSDREVVMEKP
                     RANETNIPSEQSLPGKEATLLDFGWRSAFKEVSLPMAHCVVTAIEGFSTKILQQEQNE
                     RSSAVSYAMNLVNVQQVWQDSHMFPEEEQPKKIGKFCSDIMEKLDTMLPLALACRDDS
                     FQEIRANLVEACCKVATAVLQRLQERAKEVPSKAPLKNLHTYLSTAVYVFQHFKRYDN
                     LMKEMTKKPIFLVLVQRYQEFINTLQFQVTNYCVRVCATSILQDAESHHWDDYKAFYE
                     GERCSFSIQMWHYFCWSLHYDLWTILPPKLAQEILVEVLEKSLSLLASRYARAHPSRK
                     RTPQLRLDVTTILICTENMLWSVCTSVQKLLNPHQHTDDKIFKIHTHCNNLFTTLVIL
                     TSPLTELYKTFQHGLDESASDSLKSFFKQPLYWVSCISHFYPSLLRTPSAGGLKAEGQ
                     LKLLLSQPRCNWNLLLETLLHHDGLLLRILLKSSKQVSDTENNLNQGPSLMEAIFKIL
                     YHCSFSPQTFANVFVSYMEEEQLWDFLYNIPVSTCVEYELEVIRCLRLALTDAIKDTV
                     QQIVSVMSSRRNCETNLNKHIVPDCLLESMPKEWNYSPKETNRKESCKSFTRLTAQAV
                     SIVISKLPTVIACLPPPVKYFFFLSERKMSKKFVELKKAGLLVWNLIVIICRIFEDGN
                     TVELLTGASLDRWSKEKLGLICMCLKSIMGDQTSIHNQMIQKVIQSIEQQKPNWIERQ
                     LLKARKLSTECAFMTIEKSTALQEGDVALELTEQKINTMVLDLCHKPGGREYLRQIYH
                     IMQLNEEYLKEQLFSMNSSEEKPLPIRPLKTTLRSIEDQPSAFNPFHVYKAFSENMLD
                     QVSITKWNWNWAKLLPNYLRLDKMTFSVLLKNRWEMKKDETLEEEEKAILEHLKQICT
                     PQNSSASDNIEEQ"
     exon            389..557
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            558..1227
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1389
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1484
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1712
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1978
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2129
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2320
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2503
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2614
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2754
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2919
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3144
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3553
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3713
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3876
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3967
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..7241
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7212..7217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="hexamer: AATAAA"
     regulatory      7219..7224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="hexamer: TATAAA"
     polyA_site      7236
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="major polyA site"
     polyA_site      7241
                     /gene="KIAA0825"
                     /gene_synonym="C5orf36; PAPA10"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgctc cggagccgtc gccagggtgg taatacctgg tgcagagctt gagtctggcc
       61 agcgggtcag gctcttgcta gatcagcacc ggaggtggaa gactggtaca ttttacatac
      121 tttgggaaaa aaaaacgttg ctgaagttac tagaaaagag acagttcttc tgctgacaac
      181 tcttcaggaa ataattttct acctccttag gattcgaaga ccagttcatt cttagtgtct
      241 tctgaaataa aattagaatg gattgggatg atgaatattc tcataattct tttgacctac
      301 attgtttgtt aaactcattt cctggagact tggagtttga gcagatcttc agtgacattg
      361 atgaaaagat tgaacaaaat gctgcaagca taaaacattg cattaaagag atacagtccg
      421 aaattaacaa acaatgtcca ggtgtgcagc tgcaaacaac aactgactgc tttgaatggc
      481 taactaacta taattacagt acatctgaat catctttcat ttctcatgga gacttgataa
      541 aatttttcaa aacactgcaa gatttgttga agaatgaaca aaatcaagaa gaaatgacat
      601 tggatttact ttgggacctc tcctgccaca gcagcgtttc attcccatca accctaagtg
      661 gaacatcttt ccatttcctc tctaggacgt ctcttcattc tgttgaagat aattcctcta
      721 tggatgtcaa gtctatgtgg gatgatataa gactgcatct tcgacgcttc ttagtgagca
      781 aattacaaag ccataatgaa ataaacaatt cacagcaaaa aattttattg aaaaagcagt
      841 gcttacaaca actcttgttt ctttatccag aatcagaagt tataatcaaa taccaaaaca
      901 tacagaataa actgttggct aatcttctgt ggaactgctt tccttcttac aacagagatt
      961 caaatttaga tgtaatagct catggatatc aaagtacaat gcttaagtta tactcagtaa
     1021 taaaagagga ttttaacaca ctatgtgaaa ttttagctcc atcttcaatg gtgaaattca
     1081 ttaaagaaac ttacctggat actgttacag aagaaatggc aaaatttctt gaaaattttt
     1141 gtgagctgca gttcagagaa aatgctgttc gtgtggttaa aacaagcaag agctccagca
     1201 agcatagagg agcagtgcat gctttggtta ctactgaatg cccacagaaa ggaagaaact
     1261 tctctctccc tttagacaaa gtcgaattct tatcgcagct cataaaatcc tttatgaaac
     1321 tggaaaaagg tgttcaagaa ttgtttgacg aaatactttt atcactcaag ataaccaggg
     1381 atacttcagg aattttggag aaatccgata gagaggttgt aatggaaaaa cctagagcaa
     1441 acgaaaccaa tattccttcc gagcaatcac taccaggaaa agaggctacc ttactagatt
     1501 ttggctggag aagtgcattt aaagaagtgt ctcttcccat ggcgcactgc gtagtaactg
     1561 caattgaagg tttttccaca aaaattctcc aacaggaaca gaatgaaagg tcttcagctg
     1621 tgagctatgc tatgaacctt gtaaatgtcc agcaagtttg gcaagacagc catatgtttc
     1681 ctgaggagga acaaccaaag aaaattggaa aattttgttc tgacatcatg gaaaaacttg
     1741 acacaatgct tccactggct ctggcatgca gagatgattc ttttcaggaa attagagcaa
     1801 acttggtgga ggcctgttgt aaagtggcaa cagctgtcct gcagagactg caagagagag
     1861 ccaaggaggt tccttccaaa gcacccctga aaaacttgca cacatacctc tccacagcgg
     1921 tgtatgtctt ccagcatttc aagcgatatg ataatttgat gaaggaaatg actaaaaaac
     1981 ccatattcct ggtgcttgtc caacgatatc aggaattcat caacactcta cagtttcagg
     2041 ttacgaacta ctgcgtcaga gtttgtgcta caagcatttt acaggatgct gagagccacc
     2101 actgggatga ctacaaagct ttttatgagg gggaaagatg ttccttctcg atccagatgt
     2161 ggcattattt ctgctggtct cttcattacg atctctggac cattctgcct cctaagttag
     2221 cccaggagat tctagtggaa gtgctggaga aatctttgag tctactggcc tccagatacg
     2281 ctcgggccca ccccagccgt aaaagaactc cacagttaag acttgatgtc acaacaattt
     2341 tgatatgcac tgagaacatg ttatggtcag tttgtacatc tgtacagaaa cttttgaatc
     2401 ctcatcagca tacagatgat aaaattttta aaattcacac tcattgtaat aatctgttta
     2461 caacattagt cattttgact tcaccattaa cagaattata taagactttt cagcatggcc
     2521 tggatgagtc tgcttcagat tccttaaaat cattttttaa gcaaccatta tattgggttt
     2581 cttgcatatc acatttctac ccttctttac tcaggactcc atcagctgga ggactgaaag
     2641 ccgagggtca gttgaaactg ctcttatccc agccacgttg taactggaac ttgcttctgg
     2701 aaaccctact gcatcatgat ggacttttac tgagaatctt gctgaagagc tcaaaacaag
     2761 tttccgacac agaaaataac ctgaaccaag gacccagctt gatggaagcc atctttaaaa
     2821 tattgtacca ttgcagtttt tctccacaaa catttgcaaa cgtttttgtg agctacatgg
     2881 aagaagagca attatgggac tttttatata acatcccagt ctcaacgtgc gtggagtacg
     2941 agctagaggt catccgatgc ttgagactgg cactgaccga tgccatcaag gacactgtac
     3001 agcagatagt atctgtaatg agttctagga gaaactgtga gacaaaccta aacaagcaca
     3061 ttgttcctga ttgtttgctt gagagcatgc caaaggaatg gaattatagt ccaaaagaaa
     3121 ctaacaggaa agaatcatgc aaaagcttca caaggcttac tgctcaggca gtatctattg
     3181 taatcagcaa gttacctacg gtgattgcat gtttgcctcc cccagttaaa tacttctttt
     3241 ttctgtctga gagaaaaatg tcaaaaaaat ttgttgaatt gaagaaagct ggcctgcttg
     3301 tctggaactt gattgtaatt atatgtcgga tatttgagga cggaaacact gtggaacttt
     3361 taacaggtgc ctctcttgac agatggagta aagaaaaatt gggtttaatt tgtatgtgtt
     3421 tgaaaagcat catgggagac cagacaagta tccataatca aatgatccaa aaggtcatac
     3481 agagcattga gcagcagaag cccaactgga ttgaacgtca attgttgaaa gcaaggaaac
     3541 tgagcactga atgtgcattt atgacaatag agaaaagcac ggccttacaa gaaggagatg
     3601 ttgctcttga actgactgag cagaaaataa acacgatggt cctggatctc tgccacaaac
     3661 caggtggcag ggagtacctg aggcaaattt atcacatcat gcagctcaat gaggaatatt
     3721 taaaagaaca gctgttttct atgaatagtt cagaggaaaa gccattaccc atccgacctt
     3781 taaagacgac cttgaggagt atagaagatc agccttctgc ctttaaccct ttccatgtgt
     3841 ataaggcgtt tagtgaaaac atgctagatc aggtatccat cacaaaatgg aactggaatt
     3901 gggcaaagtt gctgccaaat tatctgagac tggataagat gaccttcagt gtgctgctca
     3961 aaaacaggtg ggaaatgaag aaggatgaaa cactagaaga ggaagaaaaa gcaatactgg
     4021 agcacttaaa acaaatttgc accccacaga actcttctgc ctcagataac atagaggaac
     4081 agtaatctgc agaaaacagc aacagcttta ttttaggaaa caatcccatg taatggagta
     4141 ggatttttta ccatagtcag aatgaacctc atatgtgctg tgaagcatga aaccaatgac
     4201 tgagtaatct ctgtactgaa aaggaataca gcacataaag gataaggtgc tacatatttt
     4261 tttattttaa aaataatttc aaatgttttt ctttccccaa tctttctctt tatatgatat
     4321 aactgctgcc atctcgtgtt ccctttgaat tatttttttc tcctttcagt cttgaagtat
     4381 ctatgacaac aggaagaaat gttcagaaat tttttaaagg attttttaaa tacaacattt
     4441 ggatgttaag ttgagtggag tcacatagcc ccaggaggtc atctgaaatt tttaatttaa
     4501 ttttgttgta gctgtagccc aagtcccaat tttaattgcc tttactatcc acaattgtgt
     4561 caactttcct cattcaattt atctaattat agtcaaaaaa aagcattctc ctgaactata
     4621 actttagtca cacctctgct tgtagtggtt ttcagtcttc ctcctaaacc agaatcaaat
     4681 ttctactcat acatattcag gtcctatacc aaatggctcc atgttcagac aattgcttgc
     4741 catcctcttg gttcaagtca catgcttgcc atgttttccc aatcagaatc catctttctt
     4801 ccaaaattag gctcaaaact aattccagca atctttaccc caaagctcat tagctcatat
     4861 aatgtgttac tttaaaattt tttcattgta ttgatacaca cacacaaaat aagaaaacag
     4921 aacatgctct agtaccctct ctgccaagga caattataga tatttattat ttccttccta
     4981 tcactgcctg atattagatt ataaagacat tgaagatatt atgatataat atgaagtctc
     5041 cctttataac tccctgtatg cctactacag tgttatttca tcaagtggac agttaacgaa
     5101 cacaattgat taaatagctg ccaatgaaag aaaaagacaa caaagagaat tgcatggttg
     5161 ggcagtctaa gaacgtctgg gagaaaccat atatatatat atatatatat atatatatat
     5221 atatatatat atataatttt tttttttttt tttttttttt tttttttttt cattttagaa
     5281 acagggtctt gctctgttgc ctggaatgta gtgcagtggc atgatcatag ttcaatgtaa
     5341 cctcaaactc ataggctcaa gcaatactcc cacctcagcc tcctgagtag ctagaactac
     5401 aggtgcatgc caccacacct ggttaatttt ttttaatttt tttgtaaaga tgaggtctca
     5461 ctatgttgcc caggctggac ttgaactcct tgtctcaagt gattctccca cctagctaga
     5521 actacagttg tgtgccacca cacctggtta atttttaaaa tgtttttgta gagatggggt
     5581 ctcactatgt tgcccaggct ggacttgaac tccctacctc aagtgatctt cccctctctg
     5641 tctctcaaag ccctggaact ataggcataa gccaccacac caggcccaga agccttacat
     5701 catgggctat tttagaccat atgacatcaa acttcatgtt ttctgatgtt ctcagatata
     5761 taataaattg tccatactcc cacattctgt gatttttata aaatatgtgt aggctacatg
     5821 atttccaaag gaaagtactc atgcattttt caaagagtaa aagcttgggg tgcagaggag
     5881 gccacattag gaaatctctt acattttttc tttaaataaa aatacataaa tggccatgta
     5941 gacagctgcc tgccaaataa cacattttat ttttaaaaaa tgtactttag ttggccagta
     6001 taatcataaa ccaagtgttt ttaagatttg gttgaagtaa tttctaaaaa ttctatgaag
     6061 accatttaga aaatggtagg aaaattttat gagaactgga cattccatct aatctgatct
     6121 ttaaacaggt tactataaca atcaacataa ggcaacagtt gactttattc cttcagctaa
     6181 gtggtggtct gtgtactaaa tctgcataac tgtgcttcat tagacaagat gcaaaaatgg
     6241 aaagttaaaa ataaattaat ccaataaact agatacaaca tcttataaaa ttacaggatt
     6301 tcacatttgg attgtcttct aatatatcta aacgtcatct tttaaagcta ttattattga
     6361 attcgtatat tcctgtatta atcctgggaa gtaattttgc tcctccagaa aaaatctttt
     6421 ctgtggctcc cttttgaaag aaaggaagta tagtaagggg aaaatgggat gagtttaaag
     6481 gaagataaaa gtaggagaga aagaggcctt gcagttgaat tctattctgt gcttgttcag
     6541 tgaaattatt atagccataa gtgcaataaa gtttataatt gagagtatta ggtgacaagt
     6601 cattgattta tcagattatt ttgactttat actcaatatg tttttttttt tttttttttt
     6661 ttttttttga gacggagtct cgctctgtcg cccaggccgg actgcggact gcagtggcgc
     6721 aatctcggct cactgcaagc tccgcttccc gggttcacgc cattctcctg cctcagcctc
     6781 ccgagtagct gggactacag gcgcccgcca ccgcgcccgg ctactttttt gtatttttag
     6841 tagagacggg gtttcacctt gttagccagg atggtctcga tctcctgacc tcatgatcca
     6901 cccgcctcgg cctcccaaag tgctgggatt acaggcgtga gccaccgcgc ccggccatgt
     6961 ttttttaagt ataataagaa gtggtatttc aaagcagttt ttgtttctca catttgtgtg
     7021 agttaacaac aggaatgaag cctaacagtt tatatctccc catatgctta ttacaaaaat
     7081 attatcttcc tataaagtat gatcttcctt ctgtgttctg cttaattgta tttttatgta
     7141 attatataga gatatctatt ttattattgg tttagcagtt actatgtgaa aacagtatga
     7201 aataattttt aaataaatta taaagaatat tgtctatttc a
//
