LOCUS       NM_014804               4647 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens KIAA0753 (KIAA0753), transcript variant 1, mRNA.
ACCESSION   NM_014804 XM_375397
VERSION     NM_014804.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4647)
  AUTHORS   Inskeep,K.A., Zarate,Y.A., Monteil,D., Spranger,J., Doherty,D.,
            Stottmann,R.W. and Weaver,K.N.
  TITLE     Genetic and phenotypic heterogeneity in KIAA0753-related
            ciliopathies
  JOURNAL   Am J Med Genet A 188 (1), 104-115 (2022)
   PUBMED   34523780
  REMARK    GeneRIF: Genetic and phenotypic heterogeneity in KIAA0753-related
            ciliopathies.
REFERENCE   2  (bases 1 to 4647)
  AUTHORS   Chang,C.H., Chen,T.Y., Lu,I.L., Li,R.B., Tsai,J.J., Lin,P.Y. and
            Tang,T.K.
  TITLE     CEP120-mediated KIAA0753 recruitment onto centrioles is required
            for timely neuronal differentiation and germinal zone exit in the
            developing cerebellum
  JOURNAL   Genes Dev 35 (21-22), 1445-1460 (2021)
   PUBMED   34711653
  REMARK    GeneRIF: CEP120-mediated KIAA0753 recruitment onto centrioles is
            required for timely neuronal differentiation and germinal zone exit
            in the developing cerebellum.
REFERENCE   3  (bases 1 to 4647)
  AUTHORS   Kumar,D., Rains,A., Herranz-Perez,V., Lu,Q., Shi,X., Swaney,D.L.,
            Stevenson,E., Krogan,N.J., Huang,B., Westlake,C.,
            Garcia-Verdugo,J.M., Yoder,B.K. and Reiter,J.F.
  TITLE     A ciliopathy complex builds distal appendages to initiate
            ciliogenesis
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34241634
  REMARK    GeneRIF: A ciliopathy complex builds distal appendages to initiate
            ciliogenesis.
REFERENCE   4  (bases 1 to 4647)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4647)
  AUTHORS   Hammarsjo,A., Wang,Z., Vaz,R., Taylan,F., Sedghi,M., Girisha,K.M.,
            Chitayat,D., Neethukrishna,K., Shannon,P., Godoy,R.,
            Gowrishankar,K., Lindstrand,A., Nasiri,J., Baktashian,M.,
            Newton,P.T., Guo,L., Hofmeister,W., Pettersson,M., Chagin,A.S.,
            Nishimura,G., Yan,L., Matsumoto,N., Nordgren,A., Miyake,N.,
            Grigelioniene,G. and Ikegawa,S.
  TITLE     Novel KIAA0753 mutations extend the phenotype of skeletal
            ciliopathies
  JOURNAL   Sci Rep 7 (1), 15585 (2017)
   PUBMED   29138412
  REMARK    GeneRIF: We demonstrate that KIAA0753 is expressed in normal fetal
            human growth plate and show that the affected fetus, with a
            compound heterozygous frameshift and a nonsense mutation in
            KIAA0753, has an abnormal proliferative zone and a broad
            hypertrophic zone.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4647)
  AUTHORS   Chevrier,V., Bruel,A.L., Van Dam,T.J., Franco,B., Lo Scalzo,M.,
            Lembo,F., Audebert,S., Baudelet,E., Isnardon,D., Bole,A.,
            Borg,J.P., Kuentz,P., Thevenon,J., Burglen,L., Faivre,L.,
            Riviere,J.B., Huynen,M.A., Birnbaum,D., Rosnet,O. and
            Thauvin-Robinet,C.
  TITLE     OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar
            satellites and centrosomes and is mutated in one individual with
            oral-facial-digital syndrome
  JOURNAL   Hum Mol Genet 25 (3), 497-513 (2016)
   PUBMED   26643951
REFERENCE   7  (bases 1 to 4647)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   8  (bases 1 to 4647)
  AUTHORS   Kodani,A., Yu,T.W., Johnson,J.R., Jayaraman,D., Johnson,T.L.,
            Al-Gazali,L., Sztriha,L., Partlow,J.N., Kim,H., Krup,A.L.,
            Dammermann,A., Krogan,N.J., Walsh,C.A. and Reiter,J.F.
  TITLE     Centriolar satellites assemble centrosomal microcephaly proteins to
            recruit CDK2 and promote centriole duplication
  JOURNAL   Elife 4, e07519 (2015)
   PUBMED   26297806
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4647)
  AUTHORS   Firat-Karalar,E.N., Rauniyar,N., Yates,J.R. 3rd and Stearns,T.
  TITLE     Proximity interactions among centrosome components identify
            regulators of centriole duplication
  JOURNAL   Curr Biol 24 (6), 664-670 (2014)
   PUBMED   24613305
REFERENCE   10 (bases 1 to 4647)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB075150.1, BC113016.1,
            AB018296.1, AL080108.1 and AC015916.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014804.2.
            
            Summary: This gene encodes a subunit of a protein complex that
            regulates ciliogenesis and cilia maintenance. The encoded protein
            has also been shown to regulate centriolar duplication. Mutations
            in this gene cause an orofaciodigital syndrome and a form of
            Joubert syndrome in human patients. [provided by RefSeq, May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018296.1, AK292876.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361413.8/ ENSP00000355250.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                DB075150.1         217-285
            70-649              BC113016.1         1-580
            650-2603            AB018296.1         611-2564
            2604-2829           BC113016.1         2535-2760
            2830-4463           AB018296.1         2791-4424
            4464-4469           AL080108.1         3113-3118
            4470-4647           AC015916.13        50693-50870
FEATURES             Location/Qualifiers
     source          1..4647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..4647
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="KIAA0753"
                     /db_xref="GeneID:9851"
                     /db_xref="HGNC:HGNC:29110"
                     /db_xref="MIM:617112"
     exon            1..75
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            76..236
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3047
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein moonraker; OFD1 and FOPNL interacting protein;
                     OFD1 and FOR20 interacting protein"
                     /codon_start=1
                     /product="protein moonraker isoform 1"
                     /protein_id="NP_055619.2"
                     /db_xref="CCDS:CCDS42247.1"
                     /db_xref="GeneID:9851"
                     /db_xref="HGNC:HGNC:29110"
                     /db_xref="MIM:617112"
                     /translation="MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHS
                     SNLAIRYSCPHAIRIEKLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVH
                     LARRDVKRRQFEKHIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQ
                     PSKVEISSSGAKVYLYSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLE
                     VQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQV
                     KEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCK
                     ELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRS
                     RFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPET
                     QRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDT
                     LAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPP
                     ASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKE
                     LEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEE
                     AVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDD
                     FLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNK
                     IAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSL
                     DESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRIIS
                     HEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTSEFLEAAT"
     exon            237..861
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            862..968
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1031
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1247
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1458
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1688
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1855
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1972
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2062
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2152
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2231
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2315
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2501
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2583
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2704
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2929
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..4647
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4447..4452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="hexamer: AATAAA"
     polyA_site      4469
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="major polyA site"
     regulatory      4619..4624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="hexamer: AATAAA"
     polyA_site      4647
                     /gene="KIAA0753"
                     /gene_synonym="JBTS38; MNR; OFIP; SRTD21"
                     /note="major polyA site"
ORIGIN      
        1 aggcggccgg aagcgcggcc ttgttggggg cccccgttgc ccgcctccca gtagccgcgc
       61 ctcaccctag gccaggaatg gttttaggga agactgttgc cggatgacaa ggctgtcact
      121 attgttctgt actacctgac attatgggac caggccagcc agcttcaacc tgtgttcatc
      181 tagcacctag gacccaactt gatgggagga gcgaccccaa agtacttcag acccagaacc
      241 agctgcagtt taataggaat gttcctacac attcaagcaa cttggcgatc cgatattctt
      301 gcccacatgc cattagaatt gaaaaactga agcactcata caatgaatca taccattgta
      361 aagatgcaga ttgtagagtt ggtcctgacc tgggcagttc tgtttcattt tccgtcatat
      421 cccaagagag acttagctat gctgtccacc tagccagaag agatgtgaaa cgaagacaat
      481 ttgaaaaaca tataaaagaa catcatctca gaagtcagcc tcaaagctct cagaagtgtg
      541 gacatactaa gtataaaata cccgaccaca gggtggaaag gaaggaatca aagagtcaag
      601 cagcctgtca gtgtagccac cagccatcca aagtagaaat ctccagctct ggtgccaaag
      661 tataccttta ctcatctcat ccaggccagt cagatcttac tgtgccaaat tcgccaccca
      721 cccatgatcc gggacttcag cctcatccca ggataggtga ccacaaaaac ataagtgaac
      781 agaaaagcct gctagaagtc cagcgactcc agaaagaact gagcagttgt atccacaaaa
      841 ttgaagaggt aactaaaaaa gatagactag aagaagcttt ggatccagat gaagaacgtc
      901 gaatccgtat caggagacag gagcaagctg ctcgctctgc ccgaatgctc tacgtcctcc
      961 agcagcaggt aaaagaaatc caggaagaat tggataaatt gagtccacat aaaattaaac
     1021 acactaagaa gtcatgggca atgtctaagc tggcggctgc ccatcgagga gccattcggg
     1081 ccttacagat gtttgtcact cagtttactg accgagggga gcatccactt cctgctcggt
     1141 gtaaggaact gggcagcctt attcgccagc tttcactttg ttctgtcaag ctggatgcag
     1201 acccttctgt tcctgatgtg gttatagata ttctgcaaca aattgaggct ttggaatctc
     1261 tcctggaaaa gaaactgtca ccaaaaaagg tgaaaaaatg tttcagtgaa attcggagca
     1321 gatttcctat cggtagccaa aaggccttgg agagatggcc aagtacatca ccaaagggtg
     1381 agaggaggcc cctcacagca aaggacacat tcccacagga aacaagtcga ccttctgtag
     1441 caaagcagct tcttgccgat aagtatcagc ccgatacgga gcttccggag acccagaggt
     1501 tgcagagtga gcttgatgta ttagatgcgg atatagttct ggaagaagga ccatttattc
     1561 tagaccaaag tgcaagcttc aaagacgagg tgttagccgt ggcaaaaaca aaagcaggga
     1621 aaaagaagcc tgtgactgag aatgtgccgt ttaggaagaa agatactctg gcgccagcaa
     1681 gacagcaagg actccgcaaa gctgaaagag gtagacaaag ccaacctcac agtaaaagca
     1741 gagtgcagca gacaacagtt tcatccagat taaaaatgaa ccggcagcct gtgaaagacc
     1801 gcaaggcacc atggataccc ccaaacccca catccccacc agcgtctcct aaatgtgctg
     1861 catggctaaa ggtgaaaact agccccagag atgccacaaa agagcctctc cagcaagaag
     1921 atcctcaaga ggaaagtcac ctgacaggtg ctgttgagca tgaagcagcc aggctcgctt
     1981 ggcttgatgc tgaaacttcc aaaagattga aggaactaga agagttaaaa gccaaggaaa
     2041 ttgacagcat gcaaaaacag aggcttgatt ggcttgatgc tgaaacttct agaagaacaa
     2101 aggaactgaa tgagctcaaa gctgaagaaa tgtatagact ccaacaattg agtgtttctg
     2161 ccacccactt agcagacaag gtagaggagg cagttctgga tcgtttgaag cctctcttgg
     2221 tcaaggccca gagagtcaat tctactacag aagcaaatat tcatttgaaa gatggctcgt
     2281 cagtaaacac agcgaaagcc cagcctgcac aggaggttgc agctgttgat tttgaatcca
     2341 acaacattcg tcagcttgat gattttttgg aagattgtgc cagtgagctc tgggctgtga
     2401 ctcatgctaa gatcttgggg tctgaaacct tagccaccgt tgaggacagc aaggatagcc
     2461 cagatctgga gatcatgatg cgccgaatgg aagagatgga aaaataccag gagtctgttc
     2521 gtcaaagata taataaaatc gcatatgctg atcctcgact ttggatgcag gaagaaaaca
     2581 atgaccaaaa aatctcagca ataagtgaaa agcctctatc tcctcatcca atcagaatca
     2641 cgaagacagt ggatcgcaag gatccagccg tgaacatcat gttagaaagg ccctgtaatg
     2701 gcaattccct ggatgaaagt gtgggaacag aggaaggatc agagaaaaga gaggcccctc
     2761 ttctctccct agccgaagat tctcaacaga aagaaggccg agctcccctc tttgtcccac
     2821 cgggtatgca gcacagcatc ggtgactact gtagtcgttt tgagcagtac cttcggatca
     2881 tatctcatga ggctgtaggc tccttcaacc cgtggctgat agctgaaagc ttttcagaag
     2941 agctggtaga tgaagctctg ggtgctgtgg ctgctgaact tcaggatatg tgcgaagatt
     3001 atgcagaagc tgtgttcacc tcagaattct tagaggctgc tacataaagg ctctctgagg
     3061 cgaggccatt tgtgtcacac tggagaaggg atggcaccac cctttgtttt ggcccacagg
     3121 aaattttcat cctcagctgt ccatccaggc ccagaaggtg ctgcccactg aaaggaaggc
     3181 agtgccgggg aggtcatcct cactttgcat tttcttttgt catggcaatg gttctggaaa
     3241 tgtatgatgc aatgtatcac acttatcagt gcccaggcaa cacaacttga ttatggcaat
     3301 attttcagaa tgtgtacttt tcctattgaa ataccatgtt cattcctctg gctcagtttg
     3361 gtgatgaaaa tgttttgaaa gataatcgat acgtatattt cacacaagga ttcaggttgc
     3421 tgttgaaccc ttgctggcat tgataccaac acaagtgcgg ctactagctg gtcccatcac
     3481 ggggcccctg ttttgcatct ttggcgattt cctgtcagga cctctggccc tactaggctg
     3541 tagactcagg gagagcacag tctggctgtg ctgccaaacc tctcctctgc tgcagtttat
     3601 tccaaacagg agccccctgg ctgtcagtgc acaataatag acacacattt cttcaacgtt
     3661 ccattcctag gtgattttca catttttagt tcctcagcat attttattgc tgtgtgttga
     3721 cacaatctgg tataaaaaac tttctctgga ttcagaggaa gtttgaggaa tcaggagagg
     3781 accaggcctt ctcctgtgcc tgggtgaagg tacagacctc gctgtgtctc cgatgaggtc
     3841 agaagtgtct ctatttcata ccacaaagga acccaagtgg gagtagggaa cagatggatg
     3901 gcgcgaagac ctctgtgtct ccccagagaa aggaagaaac ttaagaacca tcatagcctg
     3961 gtcctccaac atcttacaga tcatgttttc caagagaaaa gcctgtgttt tcagaaactc
     4021 tgaattcaga aaaagaaacg gaatgtgcgt aagaatcagg ccactgcctg gaaagacttt
     4081 ctctcaattc gtagcctgag gctcagtgaa ggaaacatgc agaaagaatg cctgagacgc
     4141 ccccagggaa taagggaact ctttataacc tgtccagtgc cgtcatctgg gatttttctc
     4201 tgaagtacaa gaatttcagg tgatttaagc tgcttgatca cacttatttg tgcaaaattg
     4261 attttcattt aatgttaatg ttttcctgct taattttata taacttcaga atgtaaagag
     4321 cttcaaggta aattacaggg tgtttaacct ggggagttaa atgtgtacac ttgaattaat
     4381 aggagcaccg gttgttgcta gtataaagta atttgtgtgg cagtttgtac tgtgctgagt
     4441 ttttaaaata aacccaatat tttaaagtat gtgcctattt taaataactt acatctcctt
     4501 tttttcccac aggcaaagtg aaatgtgatt tacagaaacc actgagaata cttttatatg
     4561 tgatatgact atagtggatt atttgccacc ccttcccccc gagaaaaaaa ttagtgacaa
     4621 taaaagctaa catttattga gcaccta
//
