LOCUS       NM_014809               6838 bp    mRNA    linear   PRI 05-DEC-2023
DEFINITION  Homo sapiens KIAA0319 (KIAA0319), transcript variant 1, mRNA.
ACCESSION   NM_014809 XM_376472
VERSION     NM_014809.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6838)
  AUTHORS   Zhao J, Yang Q, Cheng C and Wang Z.
  TITLE     Cumulative genetic score of KIAA0319 affects reading ability in
            Chinese children: moderation by parental education and mediation by
            rapid automatized naming
  JOURNAL   Behav Brain Funct 19 (1), 10 (2023)
   PUBMED   37259151
  REMARK    GeneRIF: Cumulative genetic score of KIAA0319 affects reading
            ability in Chinese children: moderation by parental education and
            mediation by rapid automatized naming.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6838)
  AUTHORS   Diaz R, Kronenberg NM, Martinelli A, Liehm P, Riches AC, Gather MC
            and Paracchini S.
  TITLE     KIAA0319 influences cilia length, cell migration and mechanical
            cell-substrate interaction
  JOURNAL   Sci Rep 12 (1), 722 (2022)
   PUBMED   35031635
  REMARK    GeneRIF: KIAA0319 influences cilia length, cell migration and
            mechanical cell-substrate interaction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6838)
  AUTHORS   Deng KG, Zhao H and Zuo PX.
  TITLE     Association between KIAA0319 SNPs and risk of dyslexia: a
            meta-analysis
  JOURNAL   J Genet 98 (1) (2019)
   PUBMED   31204720
  REMARK    GeneRIF: Results indicate that the polymorphisms rs4504469,
            rs2038137, rs2179515, rs3212236, rs6935076, rs9461045, rs2143340
            and rs761100 have no association between the polymorphisms and
            dyslexia risk [Meta-analysis].
REFERENCE   4  (bases 1 to 6838)
  AUTHORS   Zhang R, Cao L, Cui M, Sun Z, Hu M, Zhang R, Stuart W, Zhao X, Yang
            Z, Li X, Sun Y, Li S, Ding W, Lou Z and Rao Z.
  TITLE     Adeno-associated virus 2 bound to its cellular receptor AAVR
  JOURNAL   Nat Microbiol 4 (4), 675-682 (2019)
   PUBMED   30742069
  REMARK    GeneRIF: Residues in strands B and E, and the BC loop of AAVR PKD2
            interact directly with the AAV2 capsid.
REFERENCE   5  (bases 1 to 6838)
  AUTHORS   Trezzi V, Forni D, Giorda R, Villa M, Molteni M, Marino C and
            Mascheretti S.
  TITLE     The role of READ1 and KIAA0319 genetic variations in developmental
            dyslexia: testing main and interactive effects
  JOURNAL   J Hum Genet 62 (11), 949-955 (2017)
   PUBMED   29066855
  REMARK    GeneRIF: By suggesting the presence of common biological processes
            underlying reading (dis)ability, these findings represent initial
            support for a generalist effect of the non-additive interdependence
            between READ1 and the KIAA0319 risk haplotype and can help in
            clinically assessing the individual risk for Developmental
            dyslexia.
REFERENCE   6  (bases 1 to 6838)
  AUTHORS   Elbert A, Lovett MW, Cate-Carter T, Pitch A, Kerr EN and Barr CL.
  TITLE     Genetic variation in the KIAA0319 5' region as a possible
            contributor to dyslexia
  JOURNAL   Behav Genet 41 (1), 77-89 (2011)
   PUBMED   21207242
  REMARK    GeneRIF: These results support previous studies indicating the 5'
            region of the KIAA0319 gene as the location of risk alleles
            contributing to RD.
REFERENCE   7  (bases 1 to 6838)
  AUTHORS   Francks C, Paracchini S, Smith SD, Richardson AJ, Scerri TS, Cardon
            LR, Marlow AJ, MacPhie IL, Walter J, Pennington BF, Fisher SE,
            Olson RK, DeFries JC, Stein JF and Monaco AP.
  TITLE     A 77-kilobase region of chromosome 6p22.2 is associated with
            dyslexia in families from the United Kingdom and from the United
            States
  JOURNAL   Am J Hum Genet 75 (6), 1046-1058 (2004)
   PUBMED   15514892
REFERENCE   8  (bases 1 to 6838)
  AUTHORS   Londin ER, Meng H and Gruen JR.
  TITLE     A transcription map of the 6p22.3 reading disability locus
            identifying candidate genes
  JOURNAL   BMC Genomics 4 (1), 25 (2003)
   PUBMED   12834540
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6838)
  AUTHORS   Gayan J, Smith SD, Cherny SS, Cardon LR, Fulker DW, Brower AM,
            Olson RK, Pennington BF and DeFries JC.
  TITLE     Quantitative-trait locus for specific language and reading deficits
            on chromosome 6p
  JOURNAL   Am J Hum Genet 64 (1), 157-164 (1999)
   PUBMED   9915954
REFERENCE   10 (bases 1 to 6838)
  AUTHORS   Cardon LR, Smith SD, Fulker DW, Kimberling WJ, Pennington BF and
            DeFries JC.
  TITLE     Quantitative trait locus for reading disability on chromosome 6
  JOURNAL   Science 266 (5183), 276-279 (1994)
   PUBMED   7939663
  REMARK    Erratum:[Science. 1995 Jun 16;268(5217):1553. PMID: 7777847]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031775.1, AB002317.1,
            AL512385.10 and AL031230.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014809.3.
            
            Summary: This gene encodes a transmembrane protein that contains a
            large extracellular domain with multiple polycystic kidney disease
            (PKD) domains. The encoded protein may play a role in the
            development of the cerebral cortex by regulating neuronal migration
            and cell adhesion. Single nucleotide polymorphisms in this gene are
            associated with dyslexia. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2, and 7 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript matching the
            genomic sequence was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.114266.1, BC152460.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378214.8/ ENSP00000367459.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL031775.1         67839-67874
            37-321              AB002317.1         1-285
            322-351             AL031775.1         68160-68189
            352-984             AB002317.1         302-934
            985-1030            AL512385.10        12968-13013         c
            1031-2396           AB002317.1         981-2346
            2397-2397           AL031230.1         116250-116250       c
            2398-4145           AB002317.1         2348-4095
            4146-6838           AL031230.1         87760-90452         c
FEATURES             Location/Qualifiers
     source          1..6838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..6838
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="KIAA0319"
                     /db_xref="GeneID:9856"
                     /db_xref="HGNC:HGNC:21580"
                     /db_xref="MIM:609269"
     exon            1..456
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            457..616
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..3780
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; dyslexia susceptibility 2; neuronal migration"
                     /codon_start=1
                     /product="dyslexia-associated protein KIAA0319 isoform a
                     precursor"
                     /protein_id="NP_055624.2"
                     /db_xref="CCDS:CCDS34348.1"
                     /db_xref="GeneID:9856"
                     /db_xref="HGNC:HGNC:21580"
                     /db_xref="MIM:609269"
                     /translation="MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTR
                     IMRVSHTFPVVDCTAACCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTF
                     VLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDY
                     RELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYL
                     NESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLP
                     PASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSESTPSELPISPTTAPRTVKE
                     LTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQT
                     LNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPVAVVSPQLQELTLPLT
                     SALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDS
                     DGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSL
                     GPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNRP
                     PVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVT
                     GLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNSITLDG
                     SRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGA
                     SDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQK
                     IRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCL
                     LKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGG
                     FTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSE
                     SEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR"
     exon            617..1362
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1555
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1654
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1752
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1840
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1933
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2066
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2295
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2419
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2552
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2701
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2853
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2992
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3152
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3295
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3418
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3509
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3601
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..6838
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3985..3990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      4012
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="major polyA site"
     regulatory      6569..6574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATATA"
     polyA_site      6588
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="major polyA site"
     regulatory      6764..6769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      6788
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
     regulatory      6817..6822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      6838
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
ORIGIN      
        1 gaatcactgg cgcgcgcttt ccccgagcct gcagaagctg ccgcgggcgg tgggcgggga
       61 tcccccgggg gtgcaacctt gctccacctg tgctgccctc ggcgggcctg gctggccccg
      121 cgcagagcgg cggcggcgct cgctgtcact gccggaggtg agagcgcagc agtagcttca
      181 gcctgtcttg ggcttggtcc agattcgctc ctctggggct acgtcccggg gaagaggaag
      241 cgaggatttt gctggggtgg ggctgtacct cttaacagca ggtgcgcgcg cgagggtgtg
      301 aacgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taagacctgc
      361 gatgacgacg aggaggaaca agtgggacgg cgagtgatgc tcagggccag cagcaacgca
      421 tggggcgagc ttcagtgtcg ccagcagtga ccacagttct tgaggccaaa tctggctcct
      481 aaaaaacatc aaaggaagct tgcaccaaac tctcttcagg gccgcctcag aagcctgcca
      541 tcacccactg tgtggtgcac aatggcgccc cccacaggtg tgctctcttc attgctgctg
      601 ctggtgacaa ttgcaggttg tgcccgtaag cagtgcagcg aggggaggac atattccaat
      661 gcagtcattt cacctaactt ggaaaccacc agaatcatgc gggtgtctca caccttccct
      721 gtcgtagact gcacggccgc ttgctgtgac ctgtccagct gtgacctggc ctggtggttc
      781 gagggccgct gctacctggt gagctgcccc cacaaagaga actgtgagcc caagaagatg
      841 ggccccatca ggtcttatct cacttttgtg ctccggcctg ttcagaggcc tgcacagctg
      901 ctggactatg gggacatgat gctgaacagg ggctccccct cggggatctg gggggactca
      961 cctgaggata tcagaaagga cttgaccttt ctaggcaaag attggggcct agaggagatg
     1021 tctgagtact cagatgacta ccgggagctg gagaaggacc tcttgcaacc cagtggcaag
     1081 caggagccca gagggagtgc cgagtacacg gactggggcc tactgccggg cagcgagggg
     1141 gccttcaact cctctgttgg agacagtcct gcggtgccag cggagacgca gcaggaccct
     1201 gagctccatt acctgaatga gtcggcttca acccctgccc caaaactccc tgagagaagt
     1261 gtgttgcttc ccttgccgac tactccatct tcaggagagg tgttggagaa agaaaaggct
     1321 tctcagctcc aggaacaatc cagcaacagc tctggaaaag aggttctaat gccttcccat
     1381 agtcttcctc cggcaagcct ggagctcagc tcagtcaccg tggagaaaag cccagtgctc
     1441 acagtcaccc cggggagtac agagcacagc atcccaacac ctcccactag cgcagccccc
     1501 tctgagtcca ccccatctga gctacccata tctcctacca ctgctcccag gacagtgaaa
     1561 gaacttacgg tatcggctgg agataaccta attataactt tacccgacaa tgaagttgaa
     1621 ctgaaggcct ttgttgcgcc agcgccacct gtagaaacaa cctacaacta tgaatggaat
     1681 ttaataagcc accccacaga ctaccaaggt gaaataaaac aaggacacaa gcaaactctt
     1741 aacctctctc aattgtccgt cggactttat gtcttcaaag tcactgtttc tagtgaaaac
     1801 gcctttggag aaggatttgt caatgtcact gttaagcctg ccagaagagt caacctgcca
     1861 cctgtagcag ttgtttctcc ccaactgcaa gagctcactt tgcctttgac gtcagccctc
     1921 attgatggca gccaaagtac agatgatact gaaatagtga gttatcattg ggaagaaata
     1981 aacgggccct tcatagaaga gaagacttca gttgactctc ccgtcttacg cttgtctaac
     2041 cttgatcctg gtaactatag tttcaggttg actgttacag actcggacgg agccactaac
     2101 tctacaactg cagccctaat agtgaacaat gctgtggact acccaccagt tgctaatgca
     2161 ggaccaaatc acaccataac tttgccccaa aactccatca ctttgaatgg aaaccagagc
     2221 agtgacgatc accagattgt cctctatgag tggtccctgg gtcctgggag tgagggcaaa
     2281 catgtggtca tgcagggagt acagacgcca taccttcatt tatctgcaat gcaggaagga
     2341 gattatacat ttcagctgaa ggtgacagat tcttcaaggc aacagtctac tgctgtggtg
     2401 actgtgattg tccagcctga aaacaataga cctccagtgg ctgtggccgg ccctgataaa
     2461 gagctgatct tcccagtgga aagtgctacc ctggatggga gcagcagcag cgatgaccac
     2521 ggcattgtct tctaccactg ggagcacgtc agaggcccca gtgcagtgga gatggaaaat
     2581 attgacaaag caatagccac tgtgactggt ctccaggtgg ggacctacca cttccgtttg
     2641 acagtgaaag accagcaggg actgagcagc acgtccaccc tcactgtggc tgtgaagaag
     2701 gaaaataata gtcctcccag agcccgggct ggtggcagac atgttcttgt gcttcccaat
     2761 aattccatta ctttggatgg ttcaaggtct actgatgacc aaagaattgt gtcctatctg
     2821 tggatccggg atggccagag tccagcagct ggagatgtca tcgatggctc tgaccacagt
     2881 gtggctctgc agcttacgaa tctggtggag ggggtgtaca ctttccactt gcgagtcacc
     2941 gacagtcagg gggcctcgga cacagacact gccactgtgg aagtgcagcc agaccctagg
     3001 aagagtggcc tggtggagct gaccctgcag gttggtgttg ggcagctgac agagcagcgg
     3061 aaggacaccc ttgtgaggca gctggctgtg ctgctgaacg tgctggactc ggacattaag
     3121 gtccagaaga ttcgggccca ctcggatctc agcaccgtga ttgtgtttta tgtacagagc
     3181 aggccgcctt tcaaggttct caaagctgct gaagtggccc gaaatctgca catgcggctc
     3241 tcaaaggaga aggctgactt cttgcttttc aaggtcttga gggttgatac agcaggttgc
     3301 cttctgaagt gttctggcca tggtcactgc gaccccctca caaagcgctg catttgctct
     3361 cacttatgga tggagaacct tatacagcgt tatatctggg atggagagag caactgtgag
     3421 tggagtatat tctatgtgac agtgttggct tttactctta ttgtgctaac aggaggtttc
     3481 acttggcttt gcatctgctg ctgcaaaaga caaaaaagga ctaaaatcag gaaaaaaaca
     3541 aagtacacca tcctggataa catggatgaa caggaaagaa tggaactgag gcccaaatat
     3601 ggtatcaagc accgaagcac agagcacaac tccagcctga tggtatccga gtctgagttt
     3661 gacagtgacc aggacacaat cttcagccga gaaaagatgg agagagggaa tccaaaggtt
     3721 tccatgaatg gttccatcag aaatggagct tccttcagtt attgctcaaa ggacagataa
     3781 tggcgcagtt cattgtaaag tggaaggacc ccttgaatcc aagaccagtc agtgggagtt
     3841 acagcacaaa acccactctt ttagaatagt tcattgacct tcttccccag tgggttagat
     3901 gtgtatcccc acgtactaaa agaccggttt ttgaaggcac aaaacaaaaa ctttgctctt
     3961 ttaactgaga tgcttgttaa tagaaataaa ggctgggtaa aactctaagg tatatactta
     4021 aaagagtttt gagtttttgt agctggcaca atctcatatt aaagatgaac aacgatttct
     4081 atctgtagaa ccttagagaa ggtgaatgaa acaaggtttt aaaaagggat gatttctgtc
     4141 ttagctgctg tgattgcctc taaggaacag cattctaaac acggtttctc ttgtaggacc
     4201 tgcagtcaga tggctgtgta tgttaaaata gcttgtctaa gaggcacggg ccatctgtgg
     4261 aggtacggag tcttgcatgt agcaagcttt ctgtgctgac ggcaacactc gcacagtgcc
     4321 aagccctcct ggtttttaat tctgtgctat gtcaatggca gttttcatct ctctcaagaa
     4381 agcagctgtt ggccattcaa gagctaagga agaatcgtat tctaaggact gaggcaatag
     4441 aaaggggagg aggagcttaa tgccgtgcag gttgaaggta gcattgtaac attatctttt
     4501 ctttctctaa gaaaaactac actgactcct ctcggtgttg tttagcagta tagttctcta
     4561 atgtaaacgg atccccagtt tacattaaat gcaatagaag tgattaattc attaagcatt
     4621 tattatgttc tgtaggctgt gcgtttggac tgccatagat agggataacg actcagcaat
     4681 tgtgtatata ttccaaaact ctgaaataca gtcagtctta acttggatgg cgtggttatg
     4741 atactctggt ccccgacagg tactttccaa aataacttga catagatgta ttcacttcat
     4801 atgtttaaaa atacatttaa gtttttctac cgaataaatc ttatttcaaa catgaaagac
     4861 aattaaaaca ttcccaccca caaagcagta ctcccgagca attaactgga gttaattgta
     4921 gcctgctacg ttgactggtt cagggtagtt ccccatccac ccttggtcct gaggctggtg
     4981 gccttggtgg tgcccttggc attttttgtg ggaagattag aatgagagat agaaccagtg
     5041 ttgtggtacc aagtgtgagc acacctaaac aatatcctgt tgcacaatgc ttttttaaca
     5101 catgggaaaa ctaggaatgc attgctgatg aagaagcaag gtatttaaac accagggcag
     5161 gagtgccaga gaaaatgttt ccccatgggt tcttaaaaaa aattcagctt ttaggtgctt
     5221 ttgtcatctc ccgcagtatt catcctcatg ggaccatctt atttttactt attgtaattt
     5281 actggggaaa ggcagaacta aaaagtgtgt cattttattt ttaaaataat tgctttgctt
     5341 atgcctacac tttctgtata actagccaat tcaatactgt ctatagtgtt agaaggaaaa
     5401 tgtgattttt ttttttaacc agtattgagc ttcataagcc tagaatctgc cttatcaggt
     5461 gaccagggtt atggttgttt gcatgcaaat gtgaatttct ggcatagggg acagcagccc
     5521 aaatgtaaag tcatcgggcg taatgaggaa gaagggagtg aacatttacc gctttatgta
     5581 cataacatat gcagtttaca tactcatttg atccttataa tcaaccttga agaggagata
     5641 ctatcattct tatgttgcag atagccctct gaaggcccag agaggttaaa taacttccca
     5701 gaggtcatgg ccaagaagta gtggctccaa gaactgaatg caaatttttt aaactgtaga
     5761 gttctgcttt ccactaaaca aagaactcct gccttgatgg atggagggca aattctggtg
     5821 gaacttttgg gccacctgaa agttctattc ccaggactaa gaggaatttc ttttaatgga
     5881 tccagagagc caaggtcaga gggagagatg gcctgcatag tctcctgtgg atcacacccg
     5941 ggccacccct ccctctaggt ttacagtgga cttcttctgc ccctcctcct tttctgtcct
     6001 tggccatctc agcctggcct ctctgatcct tccatcacag aaggatcttg aatctctggg
     6061 aaatcaaaca tcacagtagt gatcagaaag tgagtcctgt cttgtcaccc catttctcat
     6121 cagaacaaag cacgagatgg aatgaccaac cagcattctt catggtggac tgcttatcat
     6181 tgaggatctt tgggagataa agcacgctaa gagctctgga cagagaaaaa caggccctag
     6241 aatatgggag tgggtgtttg tagggctcac aggctaacaa gcactttagt tgctggttta
     6301 cattcaatga aggaggattc atacccatgg cattacaagg ctaagcatgt gtatgactaa
     6361 ggaactatct gaaaaacatg cagcaaggta agaaaatgta ccactcaaca agccagtgat
     6421 gccacctttt gtgcgcgggg aggagagtga ctaccattgt tttttgtgtg acaaagctat
     6481 catggactat tttaatcttg gttttattgc ttaaaatata ttatttttcc ctatgtgttg
     6541 acaaggtatt tctaatatca cactattaaa tatatgcact aatctaaata aaggtgtctg
     6601 tattttctgt aatgcttatt tttaggggga aatttgtttt ctttatgctt cagggtagag
     6661 ggatttccct tgagtatagg tcagcaaact gtggcctaca gcctgtgtgt gcacgcccca
     6721 tgagccgaaa agtgggtctt atgttttcaa atggttaaaa ataaataaaa aaatttgaaa
     6781 catgtgaact atatgacatt cagatttgtg ttcataaata aagttttatt ggaacata
//
