LOCUS       NM_001350404            6678 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens KIAA0319 (KIAA0319), transcript variant 8, mRNA.
ACCESSION   NM_001350404
VERSION     NM_001350404.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6678)
  AUTHORS   Zhao,J., Yang,Q., Cheng,C. and Wang,Z.
  TITLE     Cumulative genetic score of KIAA0319 affects reading ability in
            Chinese children: moderation by parental education and mediation by
            rapid automatized naming
  JOURNAL   Behav Brain Funct 19 (1), 10 (2023)
   PUBMED   37259151
  REMARK    GeneRIF: Cumulative genetic score of KIAA0319 affects reading
            ability in Chinese children: moderation by parental education and
            mediation by rapid automatized naming.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6678)
  AUTHORS   Diaz,R., Kronenberg,N.M., Martinelli,A., Liehm,P., Riches,A.C.,
            Gather,M.C. and Paracchini,S.
  TITLE     KIAA0319 influences cilia length, cell migration and mechanical
            cell-substrate interaction
  JOURNAL   Sci Rep 12 (1), 722 (2022)
   PUBMED   35031635
  REMARK    GeneRIF: KIAA0319 influences cilia length, cell migration and
            mechanical cell-substrate interaction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6678)
  AUTHORS   Deng,K.G., Zhao,H. and Zuo,P.X.
  TITLE     Association between KIAA0319 SNPs and risk of dyslexia: a
            meta-analysis
  JOURNAL   J Genet 98 (1) (2019)
   PUBMED   31204720
  REMARK    GeneRIF: Results indicate that the polymorphisms rs4504469,
            rs2038137, rs2179515, rs3212236, rs6935076, rs9461045, rs2143340
            and rs761100 have no association between the polymorphisms and
            dyslexia risk [Meta-analysis].
REFERENCE   4  (bases 1 to 6678)
  AUTHORS   Zhang,R., Cao,L., Cui,M., Sun,Z., Hu,M., Zhang,R., Stuart,W.,
            Zhao,X., Yang,Z., Li,X., Sun,Y., Li,S., Ding,W., Lou,Z. and Rao,Z.
  TITLE     Adeno-associated virus 2 bound to its cellular receptor AAVR
  JOURNAL   Nat Microbiol 4 (4), 675-682 (2019)
   PUBMED   30742069
  REMARK    GeneRIF: Residues in strands B and E, and the BC loop of AAVR PKD2
            interact directly with the AAV2 capsid.
REFERENCE   5  (bases 1 to 6678)
  AUTHORS   Trezzi,V., Forni,D., Giorda,R., Villa,M., Molteni,M., Marino,C. and
            Mascheretti,S.
  TITLE     The role of READ1 and KIAA0319 genetic variations in developmental
            dyslexia: testing main and interactive effects
  JOURNAL   J Hum Genet 62 (11), 949-955 (2017)
   PUBMED   29066855
  REMARK    GeneRIF: By suggesting the presence of common biological processes
            underlying reading (dis)ability, these findings represent initial
            support for a generalist effect of the non-additive interdependence
            between READ1 and the KIAA0319 risk haplotype and can help in
            clinically assessing the individual risk for Developmental
            dyslexia.
REFERENCE   6  (bases 1 to 6678)
  AUTHORS   Elbert,A., Lovett,M.W., Cate-Carter,T., Pitch,A., Kerr,E.N. and
            Barr,C.L.
  TITLE     Genetic variation in the KIAA0319 5' region as a possible
            contributor to dyslexia
  JOURNAL   Behav Genet 41 (1), 77-89 (2011)
   PUBMED   21207242
  REMARK    GeneRIF: These results support previous studies indicating the 5'
            region of the KIAA0319 gene as the location of risk alleles
            contributing to RD.
REFERENCE   7  (bases 1 to 6678)
  AUTHORS   Francks,C., Paracchini,S., Smith,S.D., Richardson,A.J.,
            Scerri,T.S., Cardon,L.R., Marlow,A.J., MacPhie,I.L., Walter,J.,
            Pennington,B.F., Fisher,S.E., Olson,R.K., DeFries,J.C., Stein,J.F.
            and Monaco,A.P.
  TITLE     A 77-kilobase region of chromosome 6p22.2 is associated with
            dyslexia in families from the United Kingdom and from the United
            States
  JOURNAL   Am J Hum Genet 75 (6), 1046-1058 (2004)
   PUBMED   15514892
REFERENCE   8  (bases 1 to 6678)
  AUTHORS   Londin,E.R., Meng,H. and Gruen,J.R.
  TITLE     A transcription map of the 6p22.3 reading disability locus
            identifying candidate genes
  JOURNAL   BMC Genomics 4 (1), 25 (2003)
   PUBMED   12834540
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6678)
  AUTHORS   Gayan,J., Smith,S.D., Cherny,S.S., Cardon,L.R., Fulker,D.W.,
            Brower,A.M., Olson,R.K., Pennington,B.F. and DeFries,J.C.
  TITLE     Quantitative-trait locus for specific language and reading deficits
            on chromosome 6p
  JOURNAL   Am J Hum Genet 64 (1), 157-164 (1999)
   PUBMED   9915954
REFERENCE   10 (bases 1 to 6678)
  AUTHORS   Cardon,L.R., Smith,S.D., Fulker,D.W., Kimberling,W.J.,
            Pennington,B.F. and DeFries,J.C.
  TITLE     Quantitative trait locus for reading disability on chromosome 6
  JOURNAL   Science 266 (5183), 276-279 (1994)
   PUBMED   7939663
  REMARK    Erratum:[Science. 1995 Jun 16;268(5217):1553. doi:
            10.1126/science.7777847.. PMID: 7777847]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031775.1, AL512385.10 and
            AL031230.1.
            
            On May 31, 2019 this sequence version replaced NM_001350404.1.
            
            Summary: This gene encodes a transmembrane protein that contains a
            large extracellular domain with multiple polycystic kidney disease
            (PKD) domains. The encoded protein may play a role in the
            development of the cerebral cortex by regulating neuronal migration
            and cell adhesion. Single nucleotide polymorphisms in this gene are
            associated with dyslexia. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (8) encodes isoform f.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.166261.1,
                                           SRR1660809.66988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AL031775.1         67839-68294
            457-1202            AL512385.10        12636-13381         c
            1203-1395           AL512385.10        5356-5548           c
            1396-1494           AL512385.10        367-465             c
            1495-1592           AL031230.1         125902-125999       c
            1593-1680           AL031230.1         124579-124666       c
            1681-1773           AL031230.1         123511-123603       c
            1774-1906           AL031230.1         121763-121895       c
            1907-2135           AL031230.1         120021-120249       c
            2136-2259           AL031230.1         116228-116351       c
            2260-2392           AL031230.1         113556-113688       c
            2393-2541           AL031230.1         112434-112582       c
            2542-2693           AL031230.1         110250-110401       c
            2694-2832           AL031230.1         107855-107993       c
            2833-2992           AL031230.1         107012-107171       c
            2993-3135           AL031230.1         102666-102808       c
            3136-3258           AL031230.1         100260-100382       c
            3259-3349           AL031230.1         98194-98284         c
            3350-3441           AL031230.1         95087-95178         c
            3442-6678           AL031230.1         87760-90996         c
FEATURES             Location/Qualifiers
     source          1..6678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..6678
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="KIAA0319"
                     /db_xref="GeneID:9856"
                     /db_xref="HGNC:HGNC:21580"
                     /db_xref="MIM:609269"
     exon            1..456
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..3620
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="isoform f is encoded by transcript variant 8;
                     dyslexia susceptibility 2; neuronal migration"
                     /codon_start=1
                     /product="dyslexia-associated protein KIAA0319 isoform f"
                     /protein_id="NP_001337333.1"
                     /db_xref="GeneID:9856"
                     /db_xref="HGNC:HGNC:21580"
                     /db_xref="MIM:609269"
                     /translation="MGRASVSPAVTTGCARKQCSEGRTYSNAVISPNLETTRIMRVSH
                     TFPVVDCTAACCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQ
                     RPAQLLDYGDMMLNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKD
                     LLQPSGKQEPRGSAEYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESAST
                     PAPKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLEL
                     SSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAG
                     DNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQL
                     SVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDG
                     SQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNS
                     TTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSLGPGSEG
                     KHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNRPPVAVAG
                     PDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVTGLQVGT
                     YHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNSITLDGSRSTDD
                     QRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGASDTDTA
                     TVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQKIRAHSD
                     LSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLLKCSGH
                     GHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTWLCI
                     CCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDSD
                     QDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR"
     exon            457..1202
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1395
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1494
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1592
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1680
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1773
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1906
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2135
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2259
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2392
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2541
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2693
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2832
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2992
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3135
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3258
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3349
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3441
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..6678
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3825..3830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      3852
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="major polyA site"
     regulatory      6409..6414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATATA"
     polyA_site      6428
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="major polyA site"
     regulatory      6604..6609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      6628
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
     regulatory      6657..6662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
                     /note="hexamer: AATAAA"
     polyA_site      6678
                     /gene="KIAA0319"
                     /gene_synonym="DYLX2; DYX2; NMIG"
ORIGIN      
        1 gaatcactgg cgcgcgcttt ccccgagcct gcagaagctg ccgcgggcgg tgggcgggga
       61 tcccccgggg gtgcaacctt gctccacctg tgctgccctc ggcgggcctg gctggccccg
      121 cgcagagcgg cggcggcgct cgctgtcact gccggaggtg agagcgcagc agtagcttca
      181 gcctgtcttg ggcttggtcc agattcgctc ctctggggct acgtcccggg gaagaggaag
      241 cgaggatttt gctggggtgg ggctgtacct cttaacagca ggtgcgcgcg cgagggtgtg
      301 aacgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taagacctgc
      361 gatgacgacg aggaggaaca agtgggacgg cgagtgatgc tcagggccag cagcaacgca
      421 tggggcgagc ttcagtgtcg ccagcagtga ccacaggttg tgcccgtaag cagtgcagcg
      481 aggggaggac atattccaat gcagtcattt cacctaactt ggaaaccacc agaatcatgc
      541 gggtgtctca caccttccct gtcgtagact gcacggccgc ttgctgtgac ctgtccagct
      601 gtgacctggc ctggtggttc gagggccgct gctacctggt gagctgcccc cacaaagaga
      661 actgtgagcc caagaagatg ggccccatca ggtcttatct cacttttgtg ctccggcctg
      721 ttcagaggcc tgcacagctg ctggactatg gggacatgat gctgaacagg ggctccccct
      781 cggggatctg gggggactca cctgaggata tcagaaagga cttgaccttt ctaggcaaag
      841 attggggcct agaggagatg tctgagtact cagatgacta ccgggagctg gagaaggacc
      901 tcttgcaacc cagtggcaag caggagccca gagggagtgc cgagtacacg gactggggcc
      961 tactgccggg cagcgagggg gccttcaact cctctgttgg agacagtcct gcggtgccag
     1021 cggagacgca gcaggaccct gagctccatt acctgaatga gtcggcttca acccctgccc
     1081 caaaactccc tgagagaagt gtgttgcttc ccttgccgac tactccatct tcaggagagg
     1141 tgttggagaa agaaaaggct tctcagctcc aggaacaatc cagcaacagc tctggaaaag
     1201 aggttctaat gccttcccat agtcttcctc cggcaagcct ggagctcagc tcagtcaccg
     1261 tggagaaaag cccagtgctc acagtcaccc cggggagtac agagcacagc atcccaacac
     1321 ctcccactag cgcagccccc tctgagtcca ccccatctga gctacccata tctcctacca
     1381 ctgctcccag gacagtgaaa gaacttacgg tatcggctgg agataaccta attataactt
     1441 tacccgacaa tgaagttgaa ctgaaggcct ttgttgcgcc agcgccacct gtagaaacaa
     1501 cctacaacta tgaatggaat ttaataagcc accccacaga ctaccaaggt gaaataaaac
     1561 aaggacacaa gcaaactctt aacctctctc aattgtccgt cggactttat gtcttcaaag
     1621 tcactgtttc tagtgaaaac gcctttggag aaggatttgt caatgtcact gttaagcctg
     1681 ccagaagagt caacctgcca cctgtagcag ttgtttctcc ccaactgcaa gagctcactt
     1741 tgcctttgac gtcagccctc attgatggca gccaaagtac agatgatact gaaatagtga
     1801 gttatcattg ggaagaaata aacgggccct tcatagaaga gaagacttca gttgactctc
     1861 ccgtcttacg cttgtctaac cttgatcctg gtaactatag tttcaggttg actgttacag
     1921 actcggacgg agccactaac tctacaactg cagccctaat agtgaacaat gctgtggact
     1981 acccaccagt tgctaatgca ggaccaaatc acaccataac tttgccccaa aactccatca
     2041 ctttgaatgg aaaccagagc agtgacgatc accagattgt cctctatgag tggtccctgg
     2101 gtcctgggag tgagggcaaa catgtggtca tgcagggagt acagacgcca taccttcatt
     2161 tatctgcaat gcaggaagga gattatacat ttcagctgaa ggtgacagat tcttcaaggc
     2221 aacagtctac tgctgtggtg actgtgattg tccagcctga aaacaataga cctccagtgg
     2281 ctgtggccgg ccctgataaa gagctgatct tcccagtgga aagtgctacc ctggatggga
     2341 gcagcagcag cgatgaccac ggcattgtct tctaccactg ggagcacgtc agaggcccca
     2401 gtgcagtgga gatggaaaat attgacaaag caatagccac tgtgactggt ctccaggtgg
     2461 ggacctacca cttccgtttg acagtgaaag accagcaggg actgagcagc acgtccaccc
     2521 tcactgtggc tgtgaagaag gaaaataata gtcctcccag agcccgggct ggtggcagac
     2581 atgttcttgt gcttcccaat aattccatta ctttggatgg ttcaaggtct actgatgacc
     2641 aaagaattgt gtcctatctg tggatccggg atggccagag tccagcagct ggagatgtca
     2701 tcgatggctc tgaccacagt gtggctctgc agcttacgaa tctggtggag ggggtgtaca
     2761 ctttccactt gcgagtcacc gacagtcagg gggcctcgga cacagacact gccactgtgg
     2821 aagtgcagcc agaccctagg aagagtggcc tggtggagct gaccctgcag gttggtgttg
     2881 ggcagctgac agagcagcgg aaggacaccc ttgtgaggca gctggctgtg ctgctgaacg
     2941 tgctggactc ggacattaag gtccagaaga ttcgggccca ctcggatctc agcaccgtga
     3001 ttgtgtttta tgtacagagc aggccgcctt tcaaggttct caaagctgct gaagtggccc
     3061 gaaatctgca catgcggctc tcaaaggaga aggctgactt cttgcttttc aaggtcttga
     3121 gggttgatac agcaggttgc cttctgaagt gttctggcca tggtcactgc gaccccctca
     3181 caaagcgctg catttgctct cacttatgga tggagaacct tatacagcgt tatatctggg
     3241 atggagagag caactgtgag tggagtatat tctatgtgac agtgttggct tttactctta
     3301 ttgtgctaac aggaggtttc acttggcttt gcatctgctg ctgcaaaaga caaaaaagga
     3361 ctaaaatcag gaaaaaaaca aagtacacca tcctggataa catggatgaa caggaaagaa
     3421 tggaactgag gcccaaatat ggtatcaagc accgaagcac agagcacaac tccagcctga
     3481 tggtatccga gtctgagttt gacagtgacc aggacacaat cttcagccga gaaaagatgg
     3541 agagagggaa tccaaaggtt tccatgaatg gttccatcag aaatggagct tccttcagtt
     3601 attgctcaaa ggacagataa tggcgcagtt cattgtaaag tggaaggacc ccttgaatcc
     3661 aagaccagtc agtgggagtt acagcacaaa acccactctt ttagaatagt tcattgacct
     3721 tcttccccag tgggttagat gtgtatcccc acgtactaaa agaccggttt ttgaaggcac
     3781 aaaacaaaaa ctttgctctt ttaactgaga tgcttgttaa tagaaataaa ggctgggtaa
     3841 aactctaagg tatatactta aaagagtttt gagtttttgt agctggcaca atctcatatt
     3901 aaagatgaac aacgatttct atctgtagaa ccttagagaa ggtgaatgaa acaaggtttt
     3961 aaaaagggat gatttctgtc ttagctgctg tgattgcctc taaggaacag cattctaaac
     4021 acggtttctc ttgtaggacc tgcagtcaga tggctgtgta tgttaaaata gcttgtctaa
     4081 gaggcacggg ccatctgtgg aggtacggag tcttgcatgt agcaagcttt ctgtgctgac
     4141 ggcaacactc gcacagtgcc aagccctcct ggtttttaat tctgtgctat gtcaatggca
     4201 gttttcatct ctctcaagaa agcagctgtt ggccattcaa gagctaagga agaatcgtat
     4261 tctaaggact gaggcaatag aaaggggagg aggagcttaa tgccgtgcag gttgaaggta
     4321 gcattgtaac attatctttt ctttctctaa gaaaaactac actgactcct ctcggtgttg
     4381 tttagcagta tagttctcta atgtaaacgg atccccagtt tacattaaat gcaatagaag
     4441 tgattaattc attaagcatt tattatgttc tgtaggctgt gcgtttggac tgccatagat
     4501 agggataacg actcagcaat tgtgtatata ttccaaaact ctgaaataca gtcagtctta
     4561 acttggatgg cgtggttatg atactctggt ccccgacagg tactttccaa aataacttga
     4621 catagatgta ttcacttcat atgtttaaaa atacatttaa gtttttctac cgaataaatc
     4681 ttatttcaaa catgaaagac aattaaaaca ttcccaccca caaagcagta ctcccgagca
     4741 attaactgga gttaattgta gcctgctacg ttgactggtt cagggtagtt ccccatccac
     4801 ccttggtcct gaggctggtg gccttggtgg tgcccttggc attttttgtg ggaagattag
     4861 aatgagagat agaaccagtg ttgtggtacc aagtgtgagc acacctaaac aatatcctgt
     4921 tgcacaatgc ttttttaaca catgggaaaa ctaggaatgc attgctgatg aagaagcaag
     4981 gtatttaaac accagggcag gagtgccaga gaaaatgttt ccccatgggt tcttaaaaaa
     5041 aattcagctt ttaggtgctt ttgtcatctc ccgcagtatt catcctcatg ggaccatctt
     5101 atttttactt attgtaattt actggggaaa ggcagaacta aaaagtgtgt cattttattt
     5161 ttaaaataat tgctttgctt atgcctacac tttctgtata actagccaat tcaatactgt
     5221 ctatagtgtt agaaggaaaa tgtgattttt ttttttaacc agtattgagc ttcataagcc
     5281 tagaatctgc cttatcaggt gaccagggtt atggttgttt gcatgcaaat gtgaatttct
     5341 ggcatagggg acagcagccc aaatgtaaag tcatcgggcg taatgaggaa gaagggagtg
     5401 aacatttacc gctttatgta cataacatat gcagtttaca tactcatttg atccttataa
     5461 tcaaccttga agaggagata ctatcattct tatgttgcag atagccctct gaaggcccag
     5521 agaggttaaa taacttccca gaggtcatgg ccaagaagta gtggctccaa gaactgaatg
     5581 caaatttttt aaactgtaga gttctgcttt ccactaaaca aagaactcct gccttgatgg
     5641 atggagggca aattctggtg gaacttttgg gccacctgaa agttctattc ccaggactaa
     5701 gaggaatttc ttttaatgga tccagagagc caaggtcaga gggagagatg gcctgcatag
     5761 tctcctgtgg atcacacccg ggccacccct ccctctaggt ttacagtgga cttcttctgc
     5821 ccctcctcct tttctgtcct tggccatctc agcctggcct ctctgatcct tccatcacag
     5881 aaggatcttg aatctctggg aaatcaaaca tcacagtagt gatcagaaag tgagtcctgt
     5941 cttgtcaccc catttctcat cagaacaaag cacgagatgg aatgaccaac cagcattctt
     6001 catggtggac tgcttatcat tgaggatctt tgggagataa agcacgctaa gagctctgga
     6061 cagagaaaaa caggccctag aatatgggag tgggtgtttg tagggctcac aggctaacaa
     6121 gcactttagt tgctggttta cattcaatga aggaggattc atacccatgg cattacaagg
     6181 ctaagcatgt gtatgactaa ggaactatct gaaaaacatg cagcaaggta agaaaatgta
     6241 ccactcaaca agccagtgat gccacctttt gtgcgcgggg aggagagtga ctaccattgt
     6301 tttttgtgtg acaaagctat catggactat tttaatcttg gttttattgc ttaaaatata
     6361 ttatttttcc ctatgtgttg acaaggtatt tctaatatca cactattaaa tatatgcact
     6421 aatctaaata aaggtgtctg tattttctgt aatgcttatt tttaggggga aatttgtttt
     6481 ctttatgctt cagggtagag ggatttccct tgagtatagg tcagcaaact gtggcctaca
     6541 gcctgtgtgt gcacgcccca tgagccgaaa agtgggtctt atgttttcaa atggttaaaa
     6601 ataaataaaa aaatttgaaa catgtgaact atatgacatt cagatttgtg ttcataaata
     6661 aagttttatt ggaacata
//
