LOCUS       NM_001366299            4276 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens KH-type splicing regulatory protein (KHSRP),
            transcript variant 2, mRNA.
ACCESSION   NM_001366299 XM_005259668
VERSION     NM_001366299.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   Yang,Y.C., Lin,Y.W., Lee,W.J., Lai,F.R., Ho,K.H., Chu,C.Y.,
            Hua,K.T., Chen,J.Q., Tung,M.C., Hsiao,M., Wen,Y.C. and Chien,M.H.
  TITLE     The RNA-binding protein KSRP aggravates malignant progression of
            clear cell renal cell carcinoma through transcriptional inhibition
            and post-transcriptional destabilization of the NEDD4L ubiquitin
            ligase
  JOURNAL   J Biomed Sci 30 (1), 68 (2023)
   PUBMED   37580757
  REMARK    GeneRIF: The RNA-binding protein KSRP aggravates malignant
            progression of clear cell renal cell carcinoma through
            transcriptional inhibition and post-transcriptional destabilization
            of the NEDD4L ubiquitin ligase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Long,F., Li,L., Xie,C., Ma,M., Wu,Z., Lu,Z., Liu,B., Yang,M.,
            Zhang,F., Ning,Z., Zhong,C., Yu,B., Liu,S., Wan,L., Tian,B.,
            Yang,K., Guo,Y., Chen,M., Chou,J., Li,X., Hu,G., Lin,C. and
            Zhang,Y.
  TITLE     Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer
            Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent
            Manner
  JOURNAL   Int J Biol Sci 19 (12), 3781-3803 (2023)
   PUBMED   37564198
  REMARK    GeneRIF: Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer
            Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent
            Manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Chen,L. and Zhao,T.
  TITLE     Identification of KHSRP-Regulated RNAs in Esophageal Cancer by
            Integrated Bioinformatics Analysis
  JOURNAL   Cancer Biother Radiopharm 36 (5), 412-424 (2021)
   PUBMED   32673063
  REMARK    GeneRIF: Identification of KHSRP-Regulated RNAs in Esophageal
            Cancer by Integrated Bioinformatics Analysis.
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Yan,M., Sun,L., Li,J., Yu,H., Lin,H., Yu,T., Zhao,F., Zhu,M.,
            Liu,L., Geng,Q., Kong,H., Pan,H. and Yao,M.
  TITLE     RNA-binding protein KHSRP promotes tumor growth and metastasis in
            non-small cell lung cancer
  JOURNAL   J Exp Clin Cancer Res 38 (1), 478 (2019)
   PUBMED   31775888
  REMARK    GeneRIF: In NSCLC cell lines, overexpression of HNRNPC
            significantly promoted lung cancer cell proliferation, migration,
            and invasion in vitro and in vivo. KHSRP and HNRNPC may induce
            human lung cancer cell invasion and metastasis by activating the
            IFN-alpha-JAK-STAT1 signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Kafer,R., Schmidtke,L., Schrick,K., Montermann,E., Bros,M.,
            Kleinert,H. and Pautz,A.
  TITLE     The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4+
            T Cells
  JOURNAL   J Immunol Res 2019, 4726532 (2019)
   PUBMED   31511826
  REMARK    GeneRIF: This is the first report demonstrating that KSRP is
            involved in the regulation of T cell responses. We present strong
            evidence that T cells derived from KSRP(-/-) mice favor Th2-driven
            immune responses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Lellek,H., Kirsten,R., Diehl,I., Apostel,F., Buck,F. and Greeve,J.
  TITLE     Purification and molecular cloning of a novel essential component
            of the apolipoprotein B mRNA editing enzyme-complex
  JOURNAL   J Biol Chem 275 (26), 19848-19856 (2000)
   PUBMED   10781591
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Nikolic,J.M., Min,H., Black,D.L. and
            Francke,U.
  TITLE     Mapping of the KHSRP gene to a region of conserved synteny on human
            chromosome 19p13.3 and mouse chromosome 17
  JOURNAL   Genomics 56 (3), 350-352 (1999)
   PUBMED   10087204
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Chou,M.Y., Rooke,N., Turck,C.W. and Black,D.L.
  TITLE     hnRNP H is a component of a splicing enhancer complex that
            activates a c-src alternative exon in neuronal cells
  JOURNAL   Mol Cell Biol 19 (1), 69-77 (1999)
   PUBMED   9858532
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Min,H., Turck,C.W., Nikolic,J.M. and Black,D.L.
  TITLE     A new regulatory protein, KSRP, mediates exon inclusion through an
            intronic splicing enhancer
  JOURNAL   Genes Dev 11 (8), 1023-1036 (1997)
   PUBMED   9136930
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Davis-Smyth,T., Duncan,R.C., Zheng,T., Michelotti,G. and Levens,D.
  TITLE     The far upstream element-binding proteins comprise an ancient
            family of single-strand DNA-binding transactivators
  JOURNAL   J Biol Chem 271 (49), 31679-31687 (1996)
   PUBMED   8940189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011539.7 and AC011491.7.
            
            On Sep 28, 2018 this sequence version replaced XM_005259668.5.
            
            Summary: The KHSRP gene encodes a multifunctional RNA-binding
            protein implicated in a variety of cellular processes, including
            transcription, alternative pre-mRNA splicing, and mRNA localization
            (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed
            15175153]).[supplied by OMIM, Apr 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1862665.1,
                                           SRR1163657.378655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600480.2/ ENSP00000471146.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC011539.7         9994-10352          c
            360-456             AC011539.7         7881-7977           c
            457-495             AC011539.7         7191-7229           c
            496-535             AC011539.7         6819-6858           c
            536-585             AC011539.7         5963-6012           c
            586-657             AC011539.7         5614-5685           c
            658-715             AC011539.7         4744-4801           c
            716-890             AC011539.7         4243-4417           c
            891-989             AC011539.7         4024-4122           c
            990-1088            AC011539.7         3522-3620           c
            1089-1191           AC011539.7         3280-3382           c
            1192-1292           AC011491.7         118505-118605       c
            1293-1437           AC011491.7         118256-118400       c
            1438-1598           AC011491.7         118008-118168       c
            1599-1708           AC011491.7         117816-117925       c
            1709-1797           AC011491.7         117326-117414       c
            1798-1998           AC011491.7         117052-117252       c
            1999-2076           AC011491.7         116898-116975       c
            2077-4276           AC011491.7         114620-116819       c
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4276
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /note="KH-type splicing regulatory protein"
                     /db_xref="GeneID:8570"
                     /db_xref="HGNC:HGNC:6316"
                     /db_xref="MIM:603445"
     exon            1..359
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2354
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /note="isoform 2 is encoded by transcript variant 2; far
                     upstream element-binding protein 2; FUSE-binding protein
                     2; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="far upstream element-binding protein 2 isoform
                     2"
                     /protein_id="NP_001353228.1"
                     /db_xref="CCDS:CCDS92499.1"
                     /db_xref="GeneID:8570"
                     /db_xref="HGNC:HGNC:6316"
                     /db_xref="MIM:603445"
                     /translation="MSDYSTGGPPPGPPPPAGGGGGAGGAGGGPPPGPPGAGDRGGGG
                     PGGGGPGGGSAGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNSTPD
                     FGFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLII
                     GRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGG
                     PPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQN
                     TNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSV
                     GVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQS
                     LRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAI
                     NQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGG
                     PGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPSKAA
                     AAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEE
                     YYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYY
                     RQQAAYYGQTPGPGGPQPPPTQQGQQQASGNCHPPPPPFSFQPPATVHPALVGSAGNP
                     FPCGVCP"
     exon            360..456
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            457..495
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            496..535
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            536..585
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            586..657
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            658..715
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            716..890
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            891..989
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1088
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1191
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1292
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1437
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1598
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1708
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1797
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1998
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2076
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..4276
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4010..4015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /note="hexamer: AATAAA"
     polyA_site      4028
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /note="major polyA site"
     regulatory      4250..4255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
                     /note="hexamer: AATAAA"
     polyA_site      4276
                     /gene="KHSRP"
                     /gene_synonym="FBP2; FUBP2; KSRP; p75"
ORIGIN      
        1 agagtgctcc gcggccgtgt ggagcgaggc cttgttcccg cgttgagccg ccgccgccgc
       61 cgccgcctcc tcagcttcag cctccgcgcc aggcccggcc ccgccgcgcc atgtcggact
      121 acagcacggg aggacccccg cccgggccgc cgccgcccgc cggcgggggc gggggagccg
      181 gaggcgccgg gggaggccct ccgccgggcc cgccaggcgc gggggaccgg ggcggcggcg
      241 gtcccggcgg cggcggcccg ggcggggggt cggccggggg cccctctcag ccacccggcg
      301 gaggcggccc gggaatccgc aaggacgctt tcgccgacgc cgtgcagcgg gcccgccaga
      361 ttgcagccaa aattggaggc gatgctgcca cgacagtgaa taacagcact cctgattttg
      421 gttttggggg ccaaaagaga cagttggaag atggagatca accggagagc aagaagctgg
      481 cttcccaggg agactcaatc agttctcaac ttggacccat ccatcctccc ccaaggactt
      541 caatgacaga agagtacagg gtcccagacg gcatggtggg cctgatcatt ggcagaggag
      601 gtgaacaaat taacaaaatc caacaggatt caggctgcaa agtacagatt tctccagaca
      661 gcggtggcct acccgagcgc agtgtgtcct tgacaggagc cccagaatct gtccagaaag
      721 ccaagatgat gctggatgac attgtgtctc ggggtcgtgg gggcccccca ggacagttcc
      781 acgacaacgc caacgggggc cagaacggca ccgtgcagga gatcatgatc cccgcgggca
      841 aggccggcct ggtcattggc aagggcgggg agaccattaa gcagctgcag gaacgcgctg
      901 gagtgaagat gatcttaatt caggacggat ctcagaatac gaatgtggac aaacctctcc
      961 gcatcattgg ggatccttac aaagtgcagc aagcctgtga gatggtgatg gacatcctcc
     1021 gggaacgtga ccaaggcggc tttggggacc ggaatgagta cggatctcgg attggcggag
     1081 gcatcgatgt gccagtgccc aggcattctg ttggcgtggt cattggccgg agtggagaga
     1141 tgatcaagaa gatccagaat gatgctggcg tgcggataca gttcaagcaa gatgacggga
     1201 cagggcccga gaagattgct catataatgg ggcccccaga caggtgcgag cacgcagccc
     1261 ggatcatcaa cgacctcctc cagagcctca ggagtggtcc cccaggtcct ccagggggtc
     1321 caggcatgcc cccggggggc cgaggccgag gaagaggcca aggcaattgg ggtccccctg
     1381 gcggggagat gaccttctcc atccccactc acaagtgtgg gctggtcatc ggccgaggtg
     1441 gcgagaatgt gaaagccata aaccagcaga cgggagcctt cgtagagatc tcccggcagc
     1501 tgccacccaa cggggacccc aacttcaagt tgttcatcat ccggggttca ccccagcaga
     1561 ttgaccacgc caagcagctt atcgaggaaa agatcgaggg tcctctctgc ccagttggac
     1621 caggcccagg tggcccaggc cctgctggcc caatggggcc cttcaatcct gggcccttca
     1681 accaggggcc acccggggct cccccacatg ccggggggcc ccctcctcac cagtacccac
     1741 cccagggctg gggcaatacc tacccccagt ggcagccgcc tgctcctcat gacccaagca
     1801 aagcagctgc agcggccgcg gaccccaacg ccgcgtgggc cgcctactac tcacactact
     1861 accagcagcc cccgggcccc gtccccggcc ccgcaccggc ccctgcggcc ccaccggctc
     1921 agggtgagcc ccctcagccc ccacccaccg gccagtcgga ctacactaag gcctgggaag
     1981 agtattacaa aaagatcggc cagcagcccc agcagcccgg agcaccccca cagcaggact
     2041 acacgaaggc ttgggaggag tactacaaga agcaagcgca agtggccacc ggagggggtc
     2101 caggagctcc cccaggctcc cagccagact acagtgccgc ctgggcggaa tattacagac
     2161 agcaggccgc ttactacgga cagaccccag gtcctggcgg cccccagccg ccgcccacgc
     2221 agcagggaca gcagcaggca agtgggaatt gccaccctcc tcctcctcct ttctccttcc
     2281 aacccccggc caccgtccat cctgccttag tgggtagcgc cggaaacccc ttcccctgcg
     2341 gggtgtgccc ttgatgcctg cagcgggggc cgtgtggccg gaggtctccg ggagtcccca
     2401 cgcaccgcca gggaagcatt cgctgggtcc agaggttaaa cgaagaggcc tccctgcgcc
     2461 ggctgcttgt tcctgtgtgc cgctgtcgtg atgctgggga gcgctgagac tcgcaggcgg
     2521 gacttctgaa ctgctgggga gtcggggggc aggcagacag cgcggacggt gggcaccggc
     2581 ccggccgcca ccacctcgct cacaatctgg ccacttggga agaaaacgtc tattttttcc
     2641 ccttctctgc atcacttttt tggtttttgt tctttttatt cttttatttt ttaaacccat
     2701 gatctttttt cctgtgtcca agtgactgtg ttgcaggcgg cctggctctg gcagggactg
     2761 gtggggacgc ggggagcggc ccaggcccct gccccgccgg gctcagcctc ccatgcgctc
     2821 gcgcttgcct gtgtcccggg cttgtctgtg aagtgggcgt gaagatcgtt gccaccttcc
     2881 aacctacctc acaggggtgt tgtggggaca ccatgatctc tggattgttc atgtcgtcgt
     2941 gctgcgccgg gagccaccgc cctccggaga cagggcagct cccctacgac cctagcgcct
     3001 ccgccctccg cggcccctct cctctcttcc tgctctgtcc ctccttctcc atcagggagc
     3061 agcgtgactt cagcgagtcc cgcgagcacc tggctagaca gttaacaagc acgtccttcc
     3121 agcctgagcc agcgcaggtt tgggaggggg cttcctggcc ccccccacgg tgttccagcc
     3181 cctcctctct tccgccccct agtctcccac ccttccctcc ccgtagtgac caattcctat
     3241 ctcttccctc tccgcaggct caatgaatcg aatgaatgtg aacttcttca tctgtgaaaa
     3301 atcttttttt tttccatttt gttctgtttg ggggcttctg ttttgtttgg cgagagagcg
     3361 atggctgccg tggggagtac tggggagccc tcgcggcaag cagggtgggg gggacttggg
     3421 ggcatgccgg gccctcactc tctcgcctgt tctgtgtctc acatgctttt tctttcaaaa
     3481 ttgggatcct tccatgttga gccagccaga gaagatagcg agatctaaat ctctgccaaa
     3541 aaaaaaaaaa aacttaaaaa ttaaaaacac aaagagcaaa gcagaactta taaaattata
     3601 tatatatata ttaaaaagtc tctattcttc accccccagc cttcctgaac ctgcctctct
     3661 gaggataaag caattcattt tctcccaccc tcggccctct tgtttttaaa ataaactttt
     3721 aaaaaggaaa aaaaaaagtc actcttgcta tttctttttt ttagttagag gtggaacatt
     3781 ccttggacca ggtgttgtat tgcaggaccc cttcccccag cagccaagcc ccctcttctc
     3841 tccctcccgc cctggctcag ctcccgcggc cccgcccgtc ccccctccca ggactggtct
     3901 gttgtctttt catctgttca agaggagatt gaaactgaaa acaaaatgag aacaacaaaa
     3961 aaaattgtat ggcagttttt actttttatc gctcgttttt aacttcacaa ataaatgata
     4021 acaaaacctc cccgtctgcg ggtgctgtct gtctcccccc ctttccttcc ctccctgtag
     4081 ttttgaagcg gatgtttgtt ctttatagat gttgtttaaa aagcctgata atggtgattg
     4141 aaatttacaa actttgtgtt tttttttttt taagaaaaat ataaaatagt tttcttcagg
     4201 ctcaatgtgc tttcctaacc gtgccccccc cccttttttt tttttgttaa ataaagtgct
     4261 ttttgtttaa aaaaga
//
