LOCUS       NM_015299               6778 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens KH and NYN domain containing (KHNYN), transcript
            variant 1, mRNA.
ACCESSION   NM_015299 XM_377338
VERSION     NM_015299.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6778)
  AUTHORS   Hong,S. and Choe,J.
  TITLE     Crystallization and biochemical studies of the NYN domain of human
            KHNYN
  JOURNAL   Acta Crystallogr F Struct Biol Commun 80 (Pt 3), 67-72 (2024)
   PUBMED   38376822
  REMARK    GeneRIF: Crystallization and biochemical studies of the NYN domain
            of human KHNYN.
REFERENCE   2  (bases 1 to 6778)
  AUTHORS   Nchioua,R., Kmiec,D., Muller,J.A., Conzelmann,C., Gross,R.,
            Swanson,C.M., Neil,S.J.D., Stenger,S., Sauter,D., Munch,J.,
            Sparrer,K.M.J. and Kirchhoff,F.
  TITLE     SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite
            Preadaptation to the Low-CpG Environment in Humans
  JOURNAL   mBio 11 (5), e01930-20 (2020)
   PUBMED   33067384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6778)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6778)
  AUTHORS   Ficarelli,M., Wilson,H., Pedro Galao,R., Mazzon,M.,
            Antzin-Anduetza,I., Marsh,M., Neil,S.J. and Swanson,C.M.
  TITLE     KHNYN is essential for the zinc finger antiviral protein (ZAP) to
            restrict HIV-1 containing clustered CpG dinucleotides
  JOURNAL   Elife 8, e46767 (2019)
   PUBMED   31284899
  REMARK    GeneRIF: KHNYN as a novel cofactor for ZAP to target CpG-containing
            retroviral RNA for degradation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6778)
  AUTHORS   Castagnoli,L., Mandaliti,W., Nepravishta,R., Valentini,E.,
            Mattioni,A., Procopio,R., Iannuccelli,M., Polo,S., Paci,M.,
            Cesareni,G. and Santonico,E.
  TITLE     Selectivity of the CUBAN domain in the recognition of ubiquitin and
            NEDD8
  JOURNAL   FEBS J 286 (4), 653-677 (2019)
   PUBMED   30659753
REFERENCE   6  (bases 1 to 6778)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6778)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   8  (bases 1 to 6778)
  AUTHORS   Marco,A. and Marin,I.
  TITLE     CGIN1: a retroviral contribution to mammalian genomes
  JOURNAL   Mol Biol Evol 26 (10), 2167-2170 (2009)
   PUBMED   19561090
REFERENCE   9  (bases 1 to 6778)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   10 (bases 1 to 6778)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA674601.1, BX161465.1, BC015780.1, AL132800.4 and CB115247.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015299.2.
            
            Summary: The protein encoded by this gene contains a ribonuclease
            NYN domain and belongs to the N4BP1 family. The protein is a
            cofactor for the zinc finger antiviral protein (ZAP protein) which
            targets viral RNA for degradation and restricts SARS-CoV-2
            infection. [provided by RefSeq, Sep 2021].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1. Variants 1 and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042554.1, SRR1803614.114901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553935.6/ ENSP00000450799.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA674601.1         20-53
            35-2364             BX161465.1         27-2356
            2365-3016           BC015780.1         1407-2058
            3017-6058           AL132800.4         126618-129659       c
            6059-6277           CB115247.1         6-224               c
            6278-6778           AL132800.4         125898-126398       c
FEATURES             Location/Qualifiers
     source          1..6778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..6778
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="KH and NYN domain containing"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
     exon            1..166
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            167..384
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2220
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein KHNYN"
                     /codon_start=1
                     /product="protein KHNYN isoform 1"
                     /protein_id="NP_056114.1"
                     /db_xref="CCDS:CCDS32058.1"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
                     /translation="MPTWGARPASPDRFAVSAEAENKVREQQPHVERIFSVGVSVLPK
                     DCPDNPHIWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFFLDC
                     LAWSTSAHLVPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQCTGV
                     LRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGALASWEGRSSALLG
                     AQCQGVRAPPSDGRESLDTGSMGPGDCRGARGDTYAVEKEGGKQGGPREMDWGWKELP
                     GEEAWEREVALRPQSVGGGARESAPLKGKALGKEEIALGGGGFCVHREPPGAHGSCHR
                     AAQSRGASLLQRLHNGNASPPRVPSPPPAPEPPWHCGDRGDCGDRGDVGDRGDKQQGM
                     ARGRGPQWKRGARGGNLVTGTQRFKEALQDPFTLCLANVPGQPDLRHIVIDGSNVAMV
                     HGLQHYFSSRGIAIAVQYFWDRGHRDITVFVPQWRFSKDAKVRESHFLQKLYSLSLLS
                     LTPSRVMDGKRISSYDDRFMVKLAEETDGIIVSNDQFRDLAEESEKWMAIIRERLLPF
                     TFVGNLFMVPDDPLGRNGPTLDEFLKKPARTQGSSKAQHPSRGFAEHGKQQQGREEEK
                     GSGGIRKTRETERLRRQLLEVFWGQDHKVDFILQREPYCRDINQLSEALLSLNF"
     exon            385..1532
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1663
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1760
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1868
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1970
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..6778
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="hexamer: CATAAA"
     polyA_site      3338
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="major polyA site"
     regulatory      6246..6251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="hexamer: AATAAA"
     regulatory      6262..6267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="hexamer: CATAAA"
     polyA_site      6270
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="major polyA site"
     polyA_site      6277
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="major polyA site"
     regulatory      6750..6755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /note="hexamer: AATAAA"
     polyA_site      6778
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
ORIGIN      
        1 agtttgcgtg cgatgtggac aagagaggtc cccgctgggt gaggaacccg ggaaggcccg
       61 cccagattcg ggccccctgc ccttgtcccc tgggctgggg gcgcgggcaa agcgggggcc
      121 tggcgggcgc tgagaggacc tgaagccggc gcgggcggcg gaggcgggct gggggcagca
      181 gccatgccta cctggggggc ccgccccgcg tccccagatc gctttgcggt gtctgcggag
      241 gctgagaaca aggttcggga acagcagccc catgtggagc gcatcttcag cgtgggggtg
      301 agcgtccttc cgaaggactg tccggacaac ccccacatct ggctgcagct ggagggcccc
      361 aaggaaaacg ccagcagagc caaggagtac ctgaagggcc tctgcagccc agaactgcag
      421 gatgaaatcc actacccgcc caaactgcac tgcatctttc tgggagccca gggcttcttc
      481 cttgactgcc tggcctggag cacgtcagcc catctggtgc ccagggcgcc aggctcactg
      541 atgatcagtg gcctgactga agcctttgtc atggctcaga gccgggtaga agagctggca
      601 gagcggctga gctgggactt cacgccagga ccatcttccg gagcctctca gtgtactgga
      661 gtgctgagag acttctctgc cctgctgcag tccccggggg atgcccatag agaggctctg
      721 ttgcagttgc ccctggctgt ccaggaggag ctgctgagtc tggtgcagga ggcgtctagt
      781 gggcaggggc caggagcact ggcttcttgg gaggggcgga gctcagcctt gctgggtgct
      841 cagtgccaag gagtgagagc tccccctagt gacggcaggg agtccctgga cactggatct
      901 atgggacccg gagattgcag gggagcaagg ggagacactt acgctgtgga gaaggaggga
      961 gggaaacagg gtggtcccag ggagatggat tgggggtgga aggagttgcc tggggaagag
     1021 gcgtgggaga gagaagtggc cctcaggcca cagtcagtgg gtggaggggc aagggagtca
     1081 gcacccctga aagggaaggc cctggggaag gaggagatag ctctgggagg aggagggttc
     1141 tgtgtccacc gtgagcctcc cggtgcccat ggctcctgtc acagggcagc tcagtcccga
     1201 ggagcctccc tcctccagcg gctccacaat gggaatgcct ctcctccgag ggtgcccagc
     1261 cctccacctg caccggaacc cccatggcac tgtggagacc ggggtgactg cggagaccgg
     1321 ggagacgtgg gggacagggg agacaagcag cagggcatgg cacggggtcg ggggcctcaa
     1381 tggaaacgag gcgcccgagg gggcaacttg gtgactggca cacagcgttt caaggaggcc
     1441 ctgcaggatc ctttcaccct gtgccttgcc aatgtgcctg gccagccaga cctccgccat
     1501 attgtcattg acggcagcaa cgtggccatg gtgcatggcc tccagcacta cttctccagc
     1561 cggggcattg ccattgctgt gcagtacttc tgggaccgtg gtcaccgtga cataactgtc
     1621 tttgtgcctc agtggcgctt cagtaaggat gccaaagtca gagagagtca cttcctgcaa
     1681 aagctgtatt ccctcagcct gctctccctc acaccctcac gagtcatgga tggcaagagg
     1741 atctcctcct atgatgacag gttcatggtg aagctggctg aagagacaga tgggataatt
     1801 gtctccaatg accagttccg ggacctggcg gaggagtctg agaagtggat ggcaatcatc
     1861 agagaacgcc tgctgccctt tacctttgtg ggaaacctct tcatggtacc tgatgaccca
     1921 ctggggcgaa acggccccac cctggatgaa tttctgaaga agccagccag gacacagggg
     1981 tcttctaagg ctcagcatcc ttccaggggc tttgcagaac atggtaaaca gcagcagggg
     2041 agagaagagg aaaaaggtag tggtggcatt cggaagaccc gggaaacaga gcggctccgg
     2101 cggcagctgc tggaggtgtt ttggggtcag gatcacaaag tggacttcat cctgcagcgg
     2161 gagccatact gccgggacat caaccaactg tctgaggccc tgctcagtct taacttttga
     2221 gcctcacctg cttgagtggc tgccgccctg tcagctccag ccgcctccag ctcagccctt
     2281 tctgtgagag tccctctgct gctcactctg atccagaggc accctgagtt ggtgctttgg
     2341 atcagggaag ccactttggg acaggtccat aaagtgaact gatcttaccg agtcaggacc
     2401 tcagccagct ctcaagaggt tctgctcagc cttaacttct caactttgcc ttagcacagg
     2461 gtttctgtag ggagtggggg ctgctagagg ggattagttc cggagactga gactgttggc
     2521 tccacctcca agctgagcta gggtggaggg cagggtgggc aggaagtgac aggaagttaa
     2581 gctgttcctc tccctggctg ctgctctgga tggccagaga acaagatgct cccttgctga
     2641 gctcctggga gcgtggaagg agatgctagg ccctggcaca gtgttatgtg gactgggcca
     2701 cgatagggtg gagtgagcta gtgaagaagg cagagggaga cttggcttct ggtctcagct
     2761 atgcctgttt tgtgaccttg attgagttgc ttgggcttta cttctgccta caaatcaggg
     2821 gtaaaaatac ctgttgggag gagaaatgag aacatagagg aaagcctctt ggaggaaagg
     2881 tgcttggacc aagtctcagg tgtgtctgcc tgtggctgca caggctctct aaccgaaacc
     2941 tcactttcag agagatgtgg gtcctttgtc tccaggatcc acaccctaga ttttaacact
     3001 gcattctcac tataacgtgc cctataatgg ctgcatccct tttgagcaac ctccaaaatc
     3061 tacatttaca cagtaggtaa attagggatg actgcattat caaaatactc tcagggttcc
     3121 tataaatggc agctctcctg ttgtattcag gtgttgttta cagactaaca aatgtgttgg
     3181 caaatccctg gttagatgca cttcctggtg ttgagatgaa cacgtcgatt tttcaccaat
     3241 cgatgaagcc atgctctgca atgacaatat taatgtgatc cgaccctaac attttctcta
     3301 tggaagacgt atgttgcata aagcaaggca cacttctgct ttatgtgtgt gtgtatgggg
     3361 atgggaggac ttaacggaag ttgaaccagt tggttctaga tgaaccaatt atctggaaaa
     3421 tgaaagaacc agagttggaa ggcacttgac tggccaccag accaactctg ctgttactga
     3481 catgctttct tcaccctgat tcctagaggt cattgccctg gatctgcttg aagtcctcct
     3541 gtgccaggga atttactatc tccagggtag cacattccct gtgtagacgg tattaatcag
     3601 tactccttac tttagtgcag cctaaagtat gcttttctgt tacatccacc tttgaggctg
     3661 gtcatacctc caggaacaat acagagccag tcaacttcct ggaatccaag accagataaa
     3721 gaagtaggac aggtgcccct gggttctgtt ctgtgtgggc ctgtggggag tctctagaca
     3781 agatcttttc caggccctga cttctgcctc cctctgagtg gcacagggag ttgaatactg
     3841 catggcgagt gtaatgatga tggggagggt ccttgtgtcc tcaccccttc ctttttggtg
     3901 atttacacca ctgtaccata ctgacccagg ctgggggcag gtgtgttgga gacaggctgg
     3961 tcaaagaggt gacaatgatt aagagataac ccagcggtcc ctgagaagag attggttagt
     4021 atggcctgaa ctggtggctg ggggaactgt gtctggtcaa gttatggcag atgtcacagc
     4081 tttaggtagg taaaaagggt cctagatgaa aaccttggag tttttttttt tcctgatagg
     4141 gttgtttata cttcttgatt ggtttcttgc cattttcact ttcagtgatg gtgggtgtgc
     4201 agtagaccaa aagtgtcttc tgcccttttg tgctaagggc cctggttgac tgagtggccc
     4261 cagtcagatg agaggcaagt cctaagcttc ttatagacag ggatgttgac tttgttctgc
     4321 tgcagcctga taaactggga ccactgtgtg gttagtaatg cacttgccat ttggtgacac
     4381 agactgaagg ctatcctaca cctgggcctt acctcttcct ctactggcat cctaatggca
     4441 ctctgacagc atccagggtg actacagggc ccattggaaa tggatcatca ttctctcttc
     4501 tagtgtctat ctttatcata acctgatgtc ccaaacttgt gacaagttct tttggcaact
     4561 gaaggaccaa gaagggaaac ggtgatgaga gagactgctc attgtaactt tcaaaacccc
     4621 gtctttgggg aagaatcatc tagggtgaca ttccttgaag taaatcccag gagaatctag
     4681 gccaaagaga tgagccaagg ttagtgagac aatttatttt tattgcctaa actgcagagc
     4741 attctctaca cagcgtaaag gagaagtggg gcagctgcag gacatgtaga gaaaccaaac
     4801 tgggaaatct tacaaggagt tgaaaagatt aatgtcccaa cctgatgaga ttacggcctt
     4861 gagacaataa ggtggagcaa cagaacaatg ggaaagagga ctgggagagg aatctaagaa
     4921 ccagatggct tcagctctct agaggagctg agcctattca cagtgcctaa cctggaagcc
     4981 tgtgaggaac aggcctcagg cccttgccac gacctactta ggctacaatt tcctttaagg
     5041 cagcccctag ctctgggaag gaatactggt agccagtggc cagtgttcgc tgtgggatca
     5101 ccttctggcc ctccagcagc atgatggcac gctgtcgccc aaagacagct tgcaccacag
     5161 cgctggggag agggatgaag gctcggcggc ccagggcagc acccaaggtc tgggcaaact
     5221 cagcattagt ggcggaggat ggagccactc cattcaggac cccgtgcacg tggtttgctt
     5281 caagggcatg ggtcaggatt cctgccaggt ccccgatgtg tatccagggg aagaattggt
     5341 ggcctgagcc gatggggccc cccaggccca ggcgaaaggg cagcagcatg tggcccatgg
     5401 caccaccccc acggcccagc acaaccccta gagcaggaaa gagggaaggt acaggggtcc
     5461 tctcagcctt gaaggagccc actgctcctc ctggtttctg tttccccttc ctcactctcc
     5521 ccatgctgac ttggctctgt aacagaagtg agcagtatgg ctgtctttaa gacctcacac
     5581 cttctcatct gcaggttggc tagaagtggt ggcatcctct cactctgtaa ttgtaatctc
     5641 agctctccta atcccatcac ttccccagcc cagagaagac attccaaccc tgtctgatac
     5701 ccaggcccgt ttctcacctg agcgcaccac cacctggcgt gtagaatctc caggaagcct
     5761 ggctgcagct tcccatttgg ttacgaggtt ggagaaaaag tcaaagtccc ctcctgggct
     5821 gtcttcatca tactccgcag tcagactggg ctggtagtaa gctgccggtg gaacacaatc
     5881 atttgccctg ggtgtccttg gtcctgcctg gctctctgta gtggaggctc cccttggcct
     5941 caccttctct ggcccttagg atctccccat ttggagacag agccatttgg atattttccc
     6001 cttgaacttc tccatgacct gaagcgttcc ttccctggag gaactctggt tgcagggcta
     6061 aacttagagg ctgctagagt gtagtggtta agaacaggaa cttgggtacc aggcgcctga
     6121 attttaatca gctccctcat ttattaactc tctgacttga tgcaagttac ttaacctctc
     6181 tgtatagaat tttcacatct ttaaaatggg aataatagta cctacctcat agggttgttg
     6241 taaggaataa atgataataa gcataaaaca cttcaaatag tggctggtgt gtataattgt
     6301 ttgcaattac ttggtcccaa aggtgaccag gaactctgtt cctaaagaac tatggtgtga
     6361 gaagtaaggg actttgggat aggtggactt ttccctggca ttgagtgatg ccactcccca
     6421 ctgttttttc agggtctcaa tttcttagtg aaagtacaca aaggttagga gaaacatgca
     6481 tggatcaagg gcctaggaag tcattttgcc tggaaaagac cagtgctctg gtgtgtgcat
     6541 agctacagag gtctgagtta ccccgttccc ctggcgaata taaggggctg gtgatttggg
     6601 gggcgtacct acacctgtga ctaagaccca ggccttgggg ggttgtgggg ctttggtgat
     6661 ggctttagcc agcaattggg tggtctctag gcggctgccg attacctctt tttggaaggt
     6721 ttcattccat ctgcaggaga aacatgggaa ataaaaagcc actaaataca taagtgca
//
