LOCUS       NM_006558               1978 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens KH RNA binding domain containing, signal transduction
            associated 3 (KHDRBS3), mRNA.
ACCESSION   NM_006558
VERSION     NM_006558.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Wu,X., Qiu,L., Feng,H., Zhang,H., Yu,H., Du,Y., Wu,H., Zhu,S.,
            Ruan,Y. and Jiang,H.
  TITLE     KHDRBS3 promotes paclitaxel resistance and induces glycolysis
            through modulated MIR17HG/CLDN6 signaling in epithelial ovarian
            cancer
  JOURNAL   Life Sci 293, 120328 (2022)
   PUBMED   35051418
  REMARK    GeneRIF: KHDRBS3 promotes paclitaxel resistance and induces
            glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial
            ovarian cancer.
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Boeckel,J.N., Mobius-Winkler,M., Muller,M., Rebs,S., Eger,N.,
            Schoppe,L., Tappu,R., Kokot,K.E., Kneuer,J.M., Gaul,S.,
            Bordalo,D.M., Lai,A., Haas,J., Ghanbari,M., Drewe-Boss,P., Liss,M.,
            Katus,H.A., Ohler,U., Gotthardt,M., Laufs,U., Streckfuss-Bomeke,K.
            and Meder,B.
  TITLE     SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure
            due to Dilated Cardiomyopathy
  JOURNAL   Genomics Proteomics Bioinformatics 20 (1), 129-146 (2022)
   PUBMED   34273561
  REMARK    GeneRIF: SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart
            Failure due to Dilated Cardiomyopathy.
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Ukai,S., Sakamoto,N., Taniyama,D., Harada,K., Honma,R.,
            Maruyama,R., Naka,K., Hinoi,T., Takakura,Y., Shimizu,W., Ohdan,H.
            and Yasui,W.
  TITLE     KHDRBS3 promotes multi-drug resistance and anchorage-independent
            growth in colorectal cancer
  JOURNAL   Cancer Sci 112 (3), 1196-1208 (2021)
   PUBMED   33423358
  REMARK    GeneRIF: KHDRBS3 promotes multi-drug resistance and
            anchorage-independent growth in colorectal cancer.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Ukai,S., Honma,R., Sakamoto,N., Yamamoto,Y., Pham,Q.T., Harada,K.,
            Takashima,T., Taniyama,D., Asai,R., Fukada,K., Naka,K., Tanabe,K.,
            Ohdan,H. and Yasui,W.
  TITLE     Molecular biological analysis of 5-FU-resistant gastric cancer
            organoids; KHDRBS3 contributes to the attainment of features of
            cancer stem cell
  JOURNAL   Oncogene 39 (50), 7265-7278 (2020)
   PUBMED   33046798
  REMARK    GeneRIF: Molecular biological analysis of 5-FU-resistant gastric
            cancer organoids; KHDRBS3 contributes to the attainment of features
            of cancer stem cell.
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Lee,J. and Burr,J.G.
  TITLE     Salpalpha and Salpbeta, growth-arresting homologs of Sam68
  JOURNAL   Gene 240 (1), 133-147 (1999)
   PUBMED   10564820
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum Mol Genet 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Di Fruscio,M., Chen,T. and Richard,S.
  TITLE     Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2:
            SLM-1 is a Src substrate during mitosis
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2710-2715 (1999)
   PUBMED   10077576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040914.5, BC032606.2, AF051321.1, BC106028.1 and CB155439.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006558.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.222284.1, AF051321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355849.10/ ENSP00000348108.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC040914.5         68527-68535
            10-17               BC032606.2         10-17
            18-1550             AF051321.1         1-1533
            1551-1628           BC106028.1         1501-1578
            1629-1974           AF051321.1         1612-1957
            1975-1978           CB155439.1         353-356
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.23"
     gene            1..1978
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /note="KH RNA binding domain containing, signal
                     transduction associated 3"
                     /db_xref="GeneID:10656"
                     /db_xref="HGNC:HGNC:18117"
                     /db_xref="MIM:610421"
     exon            1..499
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1452
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /note="Sam68-like phosphotyrosine protein, T-STAR;
                     RNA-binding protein T-Star; sam68-like mammalian protein
                     2; KH domain containing, RNA binding, signal transduction
                     associated 3"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 3"
                     /protein_id="NP_006549.1"
                     /db_xref="CCDS:CCDS6374.1"
                     /db_xref="GeneID:10656"
                     /db_xref="HGNC:HGNC:18117"
                     /db_xref="MIM:610421"
                     /translation="MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGKDEEK
                     YIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGS
                     MRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYN
                     DEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAPAITRGRGGVTARPVGVVV
                     PRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYG
                     TAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKAPSARTA
                     KGVYRDQPYGRY"
     exon            500..618
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            619..735
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            736..882
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1022
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1218
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1301
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1360
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1978
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /note="hexamer: AATAAA"
     polyA_site      1978
                     /gene="KHDRBS3"
                     /gene_synonym="Etle; etoile; SALP; SLM-2; SLM2; T-STAR;
                     TSTAR"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcgcg gggcggcgcg cggcgtgcag gtcgcagctg tggctcgggt gctggcaggt
       61 gctggcggga ctggcgggga tcgccgtgga ctgcctcagg ggcgccgcag cccgctcggc
      121 ccgagggccc gcctaaccgc gccgcccgcg cccgctcctc ctcggcccgc gcccggagcg
      181 cgggggccgc cggcgctggg tactcggcgg ccaccgggga tcggggctga gcggtcggtt
      241 cccgcccccg tgccgccgcc gccgccttcc ggccgaccgc ccggcttggc cgctgctgcc
      301 gcgtctggcc cccgggtccc cgccgctggg ggcgcgggcg gggtcggggg ttgccgggcg
      361 ccgccccccg tgcgcctgga gtccacatcc cgggcccggc ggccggcgag catggaggag
      421 aagtacctgc ccgagctgat ggcggagaag gactccctgg acccctcctt cacgcacgcc
      481 ctgcgcctgg tgaaccaaga aatagaaaag tttcaaaaag gagaaggcaa ggatgaagaa
      541 aagtacatcg atgtggtgat taataagaac atgaagctgg gacagaaagt gttaattccc
      601 gtaaaacagt tccctaagtt caactttgtg gggaaacttt tgggtccacg tggcaattct
      661 ctgaagcgtt tacaagaaga aaccttgaca aaaatgtcca tccttgggaa aggttccatg
      721 agagacaagg ccaaggaaga agagttgagg aaaagtggag aagcgaagta cttccatctc
      781 aatgatgatc tccatgttct cattgaagtg tttgccccac ctgcagaagc ttatgccagg
      841 atgggacatg ctttggaaga aatcaaaaag ttcctcatcc ctgattataa tgatgagatc
      901 aggcaagcac agctccagga gttaacatat ttgaatggtg gttcagaaaa tgcagatgtt
      961 ccagtggttc gagggaaacc caccttgcgt acaagaggtg taccagcccc agcaataacc
     1021 aggggaaggg gaggagttac agcccggcca gttggagttg tagtaccacg agggacgcca
     1081 actcccagag gagtcctgtc cacccgaggg ccagtgagtc ggggaagagg acttctcact
     1141 cccagagcaa gaggagtccc cccaactggg tacagacctc caccgccacc cccgacacaa
     1201 gagacttatg gagaatatga ctatgatgat ggatatggca ctgcttatga tgaacagagt
     1261 tatgattcct atgataacag ctatagcacc ccagcccaaa gtggtgctga ttactatgat
     1321 tacggacatg gactcagtga ggagacttat gattcctacg ggcaagaaga gtggactaac
     1381 tcaagacaca aggcaccttc agcgaggaca gcaaagggcg tctacagaga ccagccatat
     1441 ggcagatact gattgtactg tctgatgttg tgaaatagcc aatctccacc agtcctgtat
     1501 actgttcaaa gtaatttttt tctatgaaca atcccttttt aaataaatca gaatgcttaa
     1561 aatctgaatg gatggaactt aaaactactt tgttgaaaca tcaacctggg cagaaaaaaa
     1621 aaaaaaaaga catgtaaaat tttgttattt ccagtctgta tatgaaaaaa taggtcatca
     1681 aaaggaaaaa aaataacttt gattaactag tgttaaacaa aaaataggtt tactaaatat
     1741 gttaatctat tcttttaaca taagcctcac ctttcatttt aaaggtttcc atagaattta
     1801 gttattttat ctttcagcca tatgctagtt tttttttctc ttgccaacat gcgtaaaaag
     1861 ggaagccaat tacaagtgca aataatgtgg tattcttttg taactcaagt cttgaaatgt
     1921 tctgtagtgt taagcaaagt ctcctcttgc ttgatactaa ataaactttt gaaagaaa
//
