LOCUS       NM_152688               2329 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens KH RNA binding domain containing, signal transduction
            associated 2 (KHDRBS2), transcript variant 2, mRNA.
ACCESSION   NM_152688
VERSION     NM_152688.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2329)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2329)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2329)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2329)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2329)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2329)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 2329)
  AUTHORS   Stoss,O., Novoyatleva,T., Gencheva,M., Olbrich,M., Benderska,N. and
            Stamm,S.
  TITLE     p59(fyn)-mediated phosphorylation regulates the activity of the
            tissue-specific splicing factor rSLM-1
  JOURNAL   Mol Cell Neurosci 27 (1), 8-21 (2004)
   PUBMED   15345239
REFERENCE   8  (bases 1 to 2329)
  AUTHORS   Cote,J., Boisvert,F.M., Boulanger,M.C., Bedford,M.T. and Richard,S.
  TITLE     Sam68 RNA binding protein is an in vivo substrate for protein
            arginine N-methyltransferase 1
  JOURNAL   Mol Biol Cell 14 (1), 274-287 (2003)
   PUBMED   12529443
REFERENCE   9  (bases 1 to 2329)
  AUTHORS   Wang,L., Xu,J., Zeng,L., Ye,X., Wu,Q., Dai,J., Ji,C., Gu,S.,
            Zhao,C., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human STAR domain
            containing cDNA KHDRBS2
  JOURNAL   Mol Biol Rep 29 (4), 369-375 (2002)
   PUBMED   12549823
  REMARK    GeneRIF: molecular cloning and characterization
REFERENCE   10 (bases 1 to 2329)
  AUTHORS   Di Fruscio,M., Chen,T. and Richard,S.
  TITLE     Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2:
            SLM-1 is a Src substrate during mitosis
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2710-2715 (1999)
   PUBMED   10077576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034043.1, Z93021.2, AK292043.1, AY077838.1, AL049544.4 and
            D60325.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152688.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034043.1, SRR1660809.29343.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281156.5/ ENSP00000281156.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BC034043.1         3-31
            30-52               Z93021.2           56352-56374
            53-1152             AK292043.1         2-1101
            1153-1278           AY077838.1         1100-1225
            1279-1515           AK292043.1         1228-1464
            1516-1628           AY077838.1         1463-1575
            1629-1650           AL049544.4         78092-78113         c
            1651-2105           BC034043.1         1652-2106
            2106-2106           D60325.1           223-223             c
            2107-2329           BC034043.1         2107-2329
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q11.1"
     gene            1..2329
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="KH RNA binding domain containing, signal
                     transduction associated 2"
                     /db_xref="GeneID:202559"
                     /db_xref="HGNC:HGNC:18114"
                     /db_xref="MIM:610487"
     exon            1..368
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1327
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="isoform 2 is encoded by transcript variant 2; KH
                     domain-containing, RNA-binding, signal
                     transduction-associated protein 2; Sam68-like mammalian
                     protein 1; KH domain containing, RNA binding, signal
                     transduction associated 2; KHDRBS2 3'UTR overlapping
                     transcript 1"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 2 isoform 2"
                     /protein_id="NP_689901.2"
                     /db_xref="CCDS:CCDS4963.1"
                     /db_xref="GeneID:202559"
                     /db_xref="HGNC:HGNC:18114"
                     /db_xref="MIM:610487"
                     /translation="MEEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKED
                     EEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSIL
                     GKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLV
                     PDYNDEIRQEQLRELSYLNGSEDSGRGRGIRGRGIRIAPTAPSRGRGGAIPPPPPPGR
                     GVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGY
                     GGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQ
                     RSARGGYREHPYGRY"
     exon            369..496
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..613
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..760
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..888
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1087
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1170
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1229
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2329
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="hexamer: AATAAA"
     polyA_site      2056
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="major polyA site"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="KHDRBS2"
                     /gene_synonym="KHDRBS2-OT; KHDRBS2-OT1; SLM-1; SLM1"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgttcc cgcctctcca gttaaggccg ctggtgtgag ccggggctct gcgcgagcga
       61 gggacgacgg aagggacggg caggtgtggg cgcggggcca cgcagcccga cggcgggagt
      121 cgcaggtgct gggtgcatgg gccagtgagg acgcacagag atccctcgcc gcgcggagga
      181 ggagcagcgc gggagccagg cgctgcccca agaccctgcc tgcgtccgag cgagcggaac
      241 ctcgcgcttc gcccggggac aatccgaagt ccgcgctatg gaagaggaga aatatttgcc
      301 tgagctgatg gcagagaaag atagcctgga tccatctttt gtgcatgcgt cgcgcctttt
      361 ggcagaagaa attgaaaagt ttcaaggttc tgatggaaaa aaggaagacg aagaaaagaa
      421 gtatcttgat gtcatcagca acaaaaacat aaagctctca gaaagagtac tgattcctgt
      481 caagcagtat ccaaagttca attttgtggg gaaattgctt ggaccaagag gaaactcctt
      541 gaagaggcta caggaagaaa caggtgctaa aatgtctatc ctgggcaaag gatcaatgag
      601 agataaagct aaggaagaag aactaaggaa gagtggggaa gccaaatatg cccacttgag
      661 tgatgagctt catgtattaa ttgaagtgtt tgctccacct ggggaagctt attcacgtat
      721 gagtcatgca ttggaagaga ttaaaaaatt cctggttcct gactacaatg atgaaattcg
      781 tcaggaacaa ctacgtgaat tatcttactt aaatggctca gaggactctg gtcgtggcag
      841 aggtattaga ggcagaggga tcagaatagc tcccacagct ccttcaaggg gccgtggggg
      901 tgccattcct cctcccccac cacctggacg aggtgttctc acccctcggg gaagcactgt
      961 aacccgtgga gcgcttccag tgccacctgt agcaagaggt gtccctaccc ctcgagcccg
     1021 gggggcacca acagtgccag gatacagggc acctcctcct ccagcccatg aagcttatga
     1081 agaatatggt tatgatgatg gctacggggg tgaatatgat gaccagacct atgagactta
     1141 tgataacagc tatgcgaccc aaacacaaag tgtgcctgaa tactatgact acggtcatgg
     1201 agtaagtgag gatgcctatg acagctacgc accagaagaa tgggccacaa cccgctctag
     1261 cttgaaggca ccaccgcaaa ggtcagccag agggggatac agggaacacc cctatggtag
     1321 atattgaagg tccttcccac ctgtgacctc acctcaaaga caattcatag cctgtggtct
     1381 ccacataaac agcaacaaga caagtaatag tccttttttt gtttgtttgt ttctattcta
     1441 gggataactg ctcatgatta ctcccatata tttctagtat ttccctctgt actgttggcg
     1501 tgacattgac actagtatta ttttacaaaa cagactgaaa aagacattag caagcatagt
     1561 ctataaacct ttcagtagga tgatattctc ttggttgttt ttcattgttg tgtgtaatct
     1621 tttttttttc tttttctttt tttttttttt gaggaaaagc atgaatttgt taacagattt
     1681 tgagtctcaa ccaactagca gaaactttgt ttagggttgc taaaagactg taatatgatt
     1741 tttgaactag ctgataataa agttgtagat aagatgtttt aacctgtctt ttaatatctg
     1801 ttagttagac aaagatgttt gatattaagt ttgtaaattt aattttaatg ctgttttaat
     1861 ggggttgaaa acaagcagct actgtatgta tgtagctaac tgaatttgtt cagtgtttta
     1921 acctgtattt gttaaaaaag aaaaaaaaac acacataaag ttccatgtgt aagcttctct
     1981 aaataggaaa ccacaatttg tcaaatatgt ttgccataat ttgtcaataa agctgaaaac
     2041 ttttgtaaaa attaaatttg gaattacttg ttttctagct ttaaatgcct gctttatttc
     2101 ttcttcaaga gatgcctaaa atgttttcta tttaaaaatt acaaaaatga acccaagtct
     2161 gttttaagat atttgtgtaa tacttaaaaa tgtattaata acttatggtt gttaaataat
     2221 ttaaaagtta acaaactaaa ctgttacatg aatcatggtt agtaaacact aatgtataac
     2281 atgttaatgg aaaaaaatgg atttagaata ataaatggat tttaaacta
//
