LOCUS       NM_006559               2713 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens KH RNA binding domain containing, signal transduction
            associated 1 (KHDRBS1), transcript variant 1, mRNA.
ACCESSION   NM_006559
VERSION     NM_006559.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Fan,R., Liu,F., Gong,Q., Liu,D., Tang,S. and Shen,D.
  TITLE     KHDRBS1 as a novel prognostic signaling biomarker influencing
            hepatocellular carcinoma cell proliferation, migration, immune
            microenvironment, and drug sensitivity
  JOURNAL   Front Immunol 15, 1393801 (2024)
   PUBMED   38660302
  REMARK    GeneRIF: KHDRBS1 as a novel prognostic signaling biomarker
            influencing hepatocellular carcinoma cell proliferation, migration,
            immune microenvironment, and drug sensitivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   da Silva,A.M., Yevdokimova,V. and Benoit,Y.D.
  TITLE     Sam68 is a druggable vulnerability point in cancer stem cells
  JOURNAL   Cancer Metastasis Rev 43 (1), 441-456 (2024)
   PUBMED   37792222
  REMARK    GeneRIF: Sam68 is a druggable vulnerability point in cancer stem
            cells.
            Review article
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Malki,I., Liepina,I., Kogelnik,N., Watmuff,H., Robinson,S.,
            Lightfoot,A., Gonchar,O., Bottrill,A., Fry,A.M. and Dominguez,C.
  TITLE     Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA
            binding, alternative splicing activity and cellular functions
  JOURNAL   Nucleic Acids Res 50 (22), 13045-13062 (2022)
   PUBMED   36537190
  REMARK    GeneRIF: Cdk1-mediated threonine phosphorylation of Sam68 modulates
            its RNA binding, alternative splicing activity and cellular
            functions.
REFERENCE   5  (bases 1 to 2713)
  AUTHORS   Barlat,I., Maurier,F., Duchesne,M., Guitard,E., Tocque,B. and
            Schweighoffer,F.
  TITLE     A role for Sam68 in cell cycle progression antagonized by a spliced
            variant within the KH domain
  JOURNAL   J Biol Chem 272 (6), 3129-3132 (1997)
   PUBMED   9013542
REFERENCE   6  (bases 1 to 2713)
  AUTHORS   Taylor,S.J., Anafi,M., Pawson,T. and Shalloway,D.
  TITLE     Functional interaction between c-Src and its mitotic target, Sam 68
  JOURNAL   J Biol Chem 270 (17), 10120-10124 (1995)
   PUBMED   7537265
REFERENCE   7  (bases 1 to 2713)
  AUTHORS   Richard,S., Yu,D., Blumer,K.J., Hausladen,D., Olszowy,M.W.,
            Connelly,P.A. and Shaw,A.S.
  TITLE     Association of p62, a multifunctional SH2- and SH3-domain-binding
            protein, with src family tyrosine kinases, Grb2, and phospholipase
            C gamma-1
  JOURNAL   Mol Cell Biol 15 (1), 186-197 (1995)
   PUBMED   7799925
REFERENCE   8  (bases 1 to 2713)
  AUTHORS   Weng,Z., Thomas,S.M., Rickles,R.J., Taylor,J.A., Brauer,A.W.,
            Seidel-Dugan,C., Michael,W.M., Dreyfuss,G. and Brugge,J.S.
  TITLE     Identification of Src, Fyn, and Lyn SH3-binding proteins:
            implications for a function of SH3 domains
  JOURNAL   Mol Cell Biol 14 (7), 4509-4521 (1994)
   PUBMED   7516469
REFERENCE   9  (bases 1 to 2713)
  AUTHORS   Wong,G., Muller,O., Clark,R., Conroy,L., Moran,M.F., Polakis,P. and
            McCormick,F.
  TITLE     Molecular cloning and nucleic acid binding properties of the
            GAP-associated tyrosine phosphoprotein p62
  JOURNAL   Cell 69 (3), 551-558 (1992)
   PUBMED   1374686
REFERENCE   10 (bases 1 to 2713)
  AUTHORS   Koch,C.A., Moran,M.F., Anderson,D., Liu,X.Q., Mbamalu,G. and
            Pawson,T.
  TITLE     Multiple SH2-mediated interactions in v-src-transformed cells
  JOURNAL   Mol Cell Biol 12 (3), 1366-1374 (1992)
   PUBMED   1545818
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN345570.1, M88108.1 and
            CA442272.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006559.2.
            
            Summary: This gene encodes a member of the K homology
            domain-containing, RNA-binding, signal transduction-associated
            protein family. The encoded protein appears to have many functions
            and may be involved in a variety of cellular processes, including
            alternative splicing, cell cycle regulation, RNA 3'-end formation,
            tumorigenesis, and regulation of human immunodeficiency virus gene
            expression. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.23040.1, M88108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327300.12/ ENSP00000313829.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CN345570.1         165-186
            23-2707             M88108.1           1-2685
            2708-2713           CA442272.1         21-26               c
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2713
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="KH RNA binding domain containing, signal
                     transduction associated 1"
                     /db_xref="GeneID:10657"
                     /db_xref="HGNC:HGNC:18116"
                     /db_xref="MIM:602489"
     exon            1..510
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1460
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GAP-associated tyrosine phosphoprotein p62 (Sam68);
                     src-associated in mitosis 68 kDa protein; p21 Ras
                     GTPase-activating protein-associated p62; KH domain
                     containing, RNA binding, signal transduction associated 1"
                     /codon_start=1
                     /product="KH domain-containing, RNA-binding, signal
                     transduction-associated protein 1 isoform 1"
                     /protein_id="NP_006550.1"
                     /db_xref="CCDS:CCDS350.1"
                     /db_xref="GeneID:10657"
                     /db_xref="HGNC:HGNC:18116"
                     /db_xref="MIM:602489"
                     /translation="MQRRDDPAARMSRSSGRSGSMDPSGAHPSVRQTPSRQPPLPHRS
                     RGGGGGSRGGARASPATQPPPLLPPSATGPDATVGGPAPTPLLPPSATASVKMEPENK
                     YLPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKNMKLKERV
                     LIPVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDP
                     KYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNG
                     VPEPSRGRGVPVRGRGAAPPPPPVPRGRGVGPPRGALVRGTPVRGAITRGATVTRGVP
                     PPPTVRGAPAPRARTAGIQRIPLPPPPAPETYEEYGYDDTYAEQSYEGYEGYYSQSQG
                     DSEYYDYGHGEVQDSYEAYGQDDWNGTRPSLKAPPARPVKGAYREHPYGRY"
     exon            511..635
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            636..752
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            753..899
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1033
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1235
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1303
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1362
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..2713
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="KHDRBS1"
                     /gene_synonym="p62; p68; Sam68"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgctgg gtcgctcggg tcggcttcgg tcgctaccgc tcccgctctg ccacccccgc
       61 caaccgccgc tcgggcctcc gtcgctgccg cgtcgctttc tcgctccttg gatcgcacat
      121 cctcccagat gcagcgccgg gacgaccccg ccgcgcgcat gagccggtct tcgggccgta
      181 gcggctccat ggacccctcc ggtgcccacc cctcggtgcg tcagacgccg tctcggcagc
      241 cgccgctgcc tcaccggtcc cggggaggcg gagggggatc ccgcgggggc gcccgggcct
      301 cgcccgccac gcagccgcca ccgctgctgc cgccctcggc cacgggtccc gacgcgacag
      361 tgggcgggcc agcgccgacc ccgctgctgc ccccctcggc cacagcctcg gtcaagatgg
      421 agccagagaa caagtacctg cccgaactca tggccgagaa ggactcgctc gacccgtcct
      481 tcactcacgc catgcagctg ctgacggcag aaattgagaa gattcagaaa ggagactcaa
      541 aaaaggatga tgaggagaat tacttggatt tattttctca taagaacatg aaactgaaag
      601 agcgagtgct gatacctgtc aagcagtatc ccaagttcaa ttttgtgggg aagattcttg
      661 gaccacaagg gaatacaatc aaaagactgc aggaagagac tggtgcaaag atctctgtat
      721 tgggaaaggg ctcaatgaga gacaaagcca aggaggaaga gctgcgcaaa ggtggagacc
      781 ccaaatatgc ccacttgaat atggatctgc atgtcttcat tgaagtcttt ggacccccat
      841 gtgaggctta tgctcttatg gcccatgcca tggaggaagt caagaaattt ctagtaccgg
      901 atatgatgga tgatatctgt caggagcaat ttctagagct gtcctacttg aatggagtac
      961 ctgaaccctc tcgtggacgt ggggtgccag tgagaggccg gggagctgca cctcctccac
     1021 cacctgttcc caggggccgt ggtgttggac cacctcgggg ggctttggta cgtggtacac
     1081 cagtaagggg agccatcacc agaggtgcca ctgtgactcg aggcgtgcca cccccaccta
     1141 ctgtgagggg tgctccagca ccaagagcac ggacagcggg catccagagg atacctttgc
     1201 ctccacctcc tgcaccagaa acatatgaag aatatggata tgatgataca tacgcagaac
     1261 aaagttacga aggctacgaa ggctattaca gccagagtca aggggactca gaatattatg
     1321 actatggaca tggggaggtt caagattctt atgaagctta tggccaggac gactggaatg
     1381 ggaccaggcc gtcgctgaag gcccctcctg ctaggccagt gaagggagca tacagagagc
     1441 acccatatgg acgttattaa aaacaaacat gaggggaaaa tatcagttat gagcaaagtt
     1501 gttactgatt tcttgtatct cccaggattc ctgttgcttt acccacaaca gacaagtaat
     1561 tgtctaagtg tttttcttcg tggtcccctt cttctcccca ccttattcca ttcttaactc
     1621 tgcattctgg cttctgtatg tagtatttta aaatgagtta aaatagattt aggaatattg
     1681 aattaatttt ttaagtgtgt agatgctttt ttctttgttg tttaaatata aacagaagtg
     1741 taccttttat aataaaaaaa agaagttgag taaaaaaaaa aaacacacaa acctgttagt
     1801 ttcaaaaatg acattgcttg cttaaaggtt ctgaagtaaa ggcttgttaa gtttctctta
     1861 gttttgattt gaggcatccc gtaaagttgt agttgcagaa tcccaaacta ggctacattt
     1921 caaaattcag ggctgtttaa gatttaaaat cacaaacatt aacggcagta ggcaccacca
     1981 tgtaaaagtg agctcagacg tctctaaaaa atgtttcctt tataaaagca catggcggtt
     2041 gaatcttaag gttaaatttt aatatgaaag atcctcatga attaaatagt tgatgcaatt
     2101 tttaacgtta attgatataa aaaaaaaaac aacaaaatta ggcttgtaaa actgactttt
     2161 tcattacgtg ggttttgaaa tctagcccca gacatactgt gttgagagat acttagaggg
     2221 agggagtagg ttttgaagag gttgatggtg gtggggaggg aaggcctcct gaattgagtt
     2281 tgatgcagag ctttttagcc atgaagaatc tttcagtcat agtactaata attaaatttt
     2341 cagtatttaa aaagacaaag tattttgtcc atttgagatt ctgcactcca tgaaaagttc
     2401 acttggacgc tggggccaaa agctgttgat tttcttaagt tgacggttgt caatatatcg
     2461 aactgttccc aagttagtca agtatgtctc aacactagca tgatataaaa agggacactg
     2521 cagctgaatg aaaaaggaat caaaatccac tttgtacata agttaaagtc ctaattggat
     2581 ttgtaccgtc ctcccatttt gttctcggaa gattaaatgc tacatgtgta agtctgccta
     2641 aataggtagc ttaaacttat gtcaaaatgt ctgcagcagt ttgtcaataa agtttagtcc
     2701 ttttttaatc aaa
//
