LOCUS       NM_030647               9220 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens lysine demethylase 7A (KDM7A), mRNA.
ACCESSION   NM_030647 XM_376680 XM_379934 XM_939190
VERSION     NM_030647.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9220)
  AUTHORS   Diaz-Hernandez,M.E., Murakami,K., Murata,S., Khan,N.M.,
            Shenoy,S.P.V., Henke,K., Yamada,H. and Drissi,H.
  TITLE     Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs
  JOURNAL   Cells 13 (17), 1482 (2024)
   PUBMED   39273051
  REMARK    GeneRIF: Inhibition of KDM2/7 Promotes Notochordal Differentiation
            of hiPSCs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9220)
  AUTHORS   Ming,H., Wang,Q., Zhang,Y., Ji,L., Cheng,L., Huo,X., Yan,Z.,
            Liu,Z., Dang,Y. and Wen,B.
  TITLE     The nuclear bodies formed by histone demethylase KDM7A
  JOURNAL   Protein Cell 12 (4), 297-304 (2021)
   PUBMED   32935279
  REMARK    GeneRIF: The nuclear bodies formed by histone demethylase KDM7A.
REFERENCE   3  (bases 1 to 9220)
  AUTHORS   Wu,M., Liu,Y., Pu,Y.S., Ma,Y., Wang,J.H. and Liu,E.Q.
  TITLE     JHDM1D-AS1 aggravates the development of gastric cancer through
            miR-450a-2-3p-PRAF2 axis
  JOURNAL   Life Sci 265, 118805 (2021)
   PUBMED   33245963
  REMARK    GeneRIF: JHDM1D-AS1 aggravates the development of gastric cancer
            through miR-450a-2-3p-PRAF2 axis.
REFERENCE   4  (bases 1 to 9220)
  AUTHORS   Lee,K.H., Kim,B.C., Jeong,S.H., Jeong,C.W., Ku,J.H., Kim,H.H. and
            Kwak,C.
  TITLE     Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and
            Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in
            Bladder Cancer Cells
  JOURNAL   Int J Mol Sci 21 (16), 5658 (2020)
   PUBMED   32781788
  REMARK    GeneRIF: Histone Demethylase KDM7A Regulates Androgen Receptor
            Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes
            Cisplatin-Resistance in Bladder Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9220)
  AUTHORS   Higashijima,Y., Matsui,Y., Shimamura,T., Nakaki,R., Nagai,N.,
            Tsutsumi,S., Abe,Y., Link,V.M., Osaka,M., Yoshida,M., Watanabe,R.,
            Tanaka,T., Taguchi,A., Miura,M., Ruan,X., Li,G., Inoue,T.,
            Nangaku,M., Kimura,H., Furukawa,T., Aburatani,H., Wada,Y., Ruan,Y.,
            Glass,C.K. and Kanki,Y.
  TITLE     Coordinated demethylation of H3K9 and H3K27 is required for rapid
            inflammatory responses of endothelial cells
  JOURNAL   EMBO J 39 (7), e103949 (2020)
   PUBMED   32125007
  REMARK    GeneRIF: Coordinated demethylation of H3K9 and H3K27 is required
            for rapid inflammatory responses of endothelial cells.
REFERENCE   6  (bases 1 to 9220)
  AUTHORS   Osawa,T., Muramatsu,M., Wang,F., Tsuchida,R., Kodama,T., Minami,T.
            and Shibuya,M.
  TITLE     Increased expression of histone demethylase JHDM1D under nutrient
            starvation suppresses tumor growth via down-regulating angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 108 (51), 20725-20729 (2011)
   PUBMED   22143793
  REMARK    GeneRIF: increased JHDM1D expression suppresses tumor growth by
            down-regulating angiogenesis under nutrient starvation
REFERENCE   7  (bases 1 to 9220)
  AUTHORS   Qi,H.H., Sarkissian,M., Hu,G.Q., Wang,Z., Bhattacharjee,A.,
            Gordon,D.B., Gonzales,M., Lan,F., Ongusaha,P.P., Huarte,M.,
            Yaghi,N.K., Lim,H., Garcia,B.A., Brizuela,L., Zhao,K., Roberts,T.M.
            and Shi,Y.
  TITLE     Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and
            craniofacial development
  JOURNAL   Nature 466 (7305), 503-507 (2010)
   PUBMED   20622853
REFERENCE   8  (bases 1 to 9220)
  AUTHORS   Tsukada,Y., Ishitani,T. and Nakayama,K.I.
  TITLE     KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and
            functions in brain development
  JOURNAL   Genes Dev 24 (5), 432-437 (2010)
   PUBMED   20194436
REFERENCE   9  (bases 1 to 9220)
  AUTHORS   Huang,C., Xiang,Y., Wang,Y., Li,X., Xu,L., Zhu,Z., Zhang,T.,
            Zhu,Q., Zhang,K., Jing,N. and Chen,C.D.
  TITLE     Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates
            neural differentiation through FGF4
  JOURNAL   Cell Res 20 (2), 154-165 (2010)
   PUBMED   20084082
  REMARK    GeneRIF: KIAA1718 is a dual-specificity histone demethylase that
            regulates neural differentiation through FGF4.
REFERENCE   10 (bases 1 to 9220)
  AUTHORS   Horton,J.R., Upadhyay,A.K., Qi,H.H., Zhang,X., Shi,Y. and Cheng,X.
  TITLE     Enzymatic and structural insights for substrate specificity of a
            family of jumonji histone lysine demethylases
  JOURNAL   Nat Struct Mol Biol 17 (1), 38-43 (2010)
   PUBMED   20023638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004849.1, AK131497.1 and AB051505.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131497.1, DRR138518.375958.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397560.7/ ENSP00000380692.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC004849.1         10072-10113
            43-2748             AK131497.1         2-2707
            2749-5912           AB051505.1         1012-4175
            5913-9220           AC004849.1         99002-102309
FEATURES             Location/Qualifiers
     source          1..9220
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..9220
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /note="lysine demethylase 7A"
                     /db_xref="GeneID:80853"
                     /db_xref="HGNC:HGNC:22224"
                     /db_xref="MIM:619640"
     exon            1..240
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2872
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /EC_number="1.14.11.65"
                     /note="histone lysine demethylase JHDM1D; lysine-specific
                     demethylase 7; jmjC domain-containing histone
                     demethylation protein 1D; jumonji C domain containing
                     histone demethylase 1 homolog D; lysine (K)-specific
                     demethylase 7A; [histone H3]-dimethyl-L-lysine9
                     demethylase 7A"
                     /codon_start=1
                     /product="lysine-specific demethylase 7A"
                     /protein_id="NP_085150.1"
                     /db_xref="CCDS:CCDS43658.1"
                     /db_xref="GeneID:80853"
                     /db_xref="HGNC:HGNC:22224"
                     /db_xref="MIM:619640"
                     /translation="MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQ
                     PYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHR
                     HDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPI
                     MVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPN
                     RPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQD
                     SYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDK
                     CYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPD
                     LFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE
                     HAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSR
                     RKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDILSSKLNGKFNKHLQPSST
                     VPEWRAKDNDLRLLLTNGRIIKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESS
                     GVEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESEDSGPECTALKSIFTTEESE
                     SSGDEKKQEITSNFKEESNVMRNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLS
                     MAGLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVRQLYRYDKPVECGYHVKTE
                     DPDLRTSSWIKQFDTSRFHPQDLSRSQKCIRKEGSSEISQRVQSRNYVDSSGSSLQNG
                     KYMQNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPASNPPPISNQATKGKRP
                     KKGMATAKQRLGKILKLNRNGHARFFV"
     exon            241..326
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            327..444
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            445..605
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            606..747
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            748..934
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1097
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1185
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1292
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1384
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1474
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1684
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1809
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1964
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2062
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2211
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2420
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2503
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2777
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..9220
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9085..9090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /note="hexamer: ATTAAA"
     polyA_site      9111
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /note="major polyA site"
     regulatory      9192..9197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /note="hexamer: AAGAAA"
     polyA_site      9220
                     /gene="KDM7A"
                     /gene_synonym="JHDM1D"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcgag cggagtagcg agcgagcgtg tgtgtgtttt ttaaagatgg ccggagcggc
       61 ggcggcggtg gccgcgggag cagcagctgg agccgccgcg gcagccgtgt cggtggcggc
      121 tcccggccgg gcctcggcgc ctccgccgcc cccgcccgtg tactgtgtgt gccggcagcc
      181 gtacgacgtg aaccgcttca tgatcgagtg cgatatctgc aaggactggt tccacggcag
      241 ctgtgttgga gtagaagaac atcatgctgt tgacattgac ctgtatcact gtcccaactg
      301 tgcagtttta catggttcct ccttgatgaa aaaaaggagg aactggcaca gacatgacta
      361 cacagaaatt gatgatggtt ccaaaccagt gcaagctgga actagaactt tcattaagga
      421 attacgctct cgagtcttcc caagtgccga tgaaataatt ataaagatgc atggcagcca
      481 gctgacacaa agatatctgg agaaacatgg atttgatgtc cctattatgg tcccaaaatt
      541 agatgatcta ggactcaggc tcccttcacc tacattttct gtgatggatg tggaacgtta
      601 tgtaggtggt gacaaagtga tagatgtcat tgatgtggcg aggcaggcag acagcaaaat
      661 gacacttcac aattatgtta aatacttcat gaatcctaac agaccaaaag tgttaaatgt
      721 gatcagcctt gaattttcag atacaaagat gtctgaattg gtggaggtcc ctgatatagc
      781 caaaaaactt tcctgggtgg aaaattattg gccagatgat tcagtctttc ccaagccatt
      841 tgttcagaaa tattgcttaa tgggagttca agacagctat acagatttcc acattgactt
      901 cggtggaact tcagtctggt accatgtcct ctggggtgag aagatttttt atttaataaa
      961 gccaacagat gaaaatttgg cacgttatga atcttggagt tcatctgtga cccagagtga
     1021 ggtgttcttt ggagataagg tggataaatg ctacaaatgt gtggtaaagc agggacatac
     1081 cttatttgtt cctacagggt ggatccatgc tgtgctcact tctcaggact gtatggcttt
     1141 tggggggaac ttcctgcaca accttaacat tggcatgcag ctcaggtgtt atgagatgga
     1201 gaaaaggcta aaaacaccag atcttttcaa attccctttc tttgaagcca tatgttggtt
     1261 tgtagccaaa aacttgctgg aaaccctgaa agaactgaga gaagatggtt tccagcctca
     1321 aacttaccta gtacagggag tgaaagcact gcatactgct ttaaaattat ggatgaaaaa
     1381 agaacttgta tctgaacatg cctttgaaat tccagacaat gttagacctg gacaccttat
     1441 taaagaactt tctaaagtaa ttcgagcaat agaggaggaa aacggcaaac cagttaaatc
     1501 tcagggaatt cctattgtgt gtccagtttc acgatcctca aatgaagcaa cttccccata
     1561 ccattcccga agaaagatga ggaaacttcg agatcataat gtccgaactc cttctaacct
     1621 agacatccta gagctccaca caagggaggt cctcaaaaga ttagagatgt gtccatggga
     1681 agaggacatc ttgagctcta aactgaatgg aaaattcaac aaacatctcc aaccatcctc
     1741 cacagtacct gaatggagag cgaaagataa tgatctacga ttactgctga caaatggaag
     1801 aataattaaa gatgaaaggc agccctttgc agatcaaagt ctttatacag cagatagtga
     1861 aaatgaagag gataaaagaa ggacaaaaaa ggcaaaaatg aagatagaag agagttcagg
     1921 agtagaggga gtggaacatg aagaatctca aaaaccactg aatgggtttt ttacacgtgt
     1981 gaaatcagaa ctcaggagta gatcatcagg atattctgat atttctgagt cagaagactc
     2041 cggacccgag tgcactgcac tgaaaagtat ctttaccact gaagagtctg aaagttcagg
     2101 tgatgaaaag aaacaagaaa taacatccaa ctttaaggag gaatctaatg tgatgaggaa
     2161 cttccttcaa aagagccaga agccatctag aagtgaaatt ccaattaaaa gggaatgtcc
     2221 tacctcgacg agcacagagg aagaagctat tcagggcatg ctgtctatgg cagggttgca
     2281 ctattccacg tgtttacaaa ggcaaataca aagcacagac tgcagtggtg aaagaaactc
     2341 tctccaggat cccagcagct gccatggcag taaccatgag gttaggcagt tgtatcgcta
     2401 tgataaacca gtggaatgtg gataccatgt caagactgaa gatccagact tgaggacttc
     2461 ctcctggatt aaacagtttg atacttccag atttcatcct caggatctaa gtagaagcca
     2521 gaaatgcatc agaaaggaag gttcatcaga aattagtcag agggtacaaa gtaggaatta
     2581 tgtggacagc agcggctcaa gccttcagaa tggaaagtat atgcagaatt caaacctgac
     2641 ttcgggggcg tgccagataa gtaatggcag tctaagccca gaaaggccag ttggtgaaac
     2701 ttccttctcg gtgccccttc accccaccaa gagaccggca tcaaatccac cacctatcag
     2761 caaccaggca acaaaaggta aacgtccaaa aaaaggaatg gcaacagcca aacaacgtct
     2821 tgggaagatc cttaagttga acagaaatgg ccatgcacgt ttctttgtgt gacagagctg
     2881 ctgttgcagc cattcttccc tttggagacc agtctagggg tgcaggagcc tggagcttcc
     2941 gctgtccccc tgcctggagc agtttgtgtg tatagtaaga acactgcccg aagaacagaa
     3001 tgaacctgat gctgcatttt cactgtgcca cacccactca gcaataacca ttttggacct
     3061 ggtgggggag aggaagaagg agggtagaac cttaaaaaga gaccttgaac tggaaagggt
     3121 ctcttgtcag ggcttgaatt ttattttgtt gttggtagtg tcttgatgta ttttcagtgg
     3181 tagggtaaag aattatcaat aatttattta acagattttt ttttaaagtt aacagctttt
     3241 aaattctttt tttaaagcta tttatttgga agatttctgg agaaatatct cactaattta
     3301 gatgtaagaa tgtgaaggtt tttaaattat ttttgatagt gtgtgtgtta catgtgggga
     3361 agggccacag taacagtaac tagtctggac tcttaaattt gatattcagg ttaaagtctt
     3421 aaacagggat ttgatgcatt aattatttta aattaagatg tatatgaaaa tcattttatt
     3481 ttatatattt catgtgtttt ttataagcta ttagcttcgc ttttgctaac atccaaggtg
     3541 catactgtta tccaggttga ttaccttata tcccaccttc cctctgcact ccccatcatt
     3601 ttgtgatgac ccagtaagac tcttctcttt gcagggaaac actttcgtag ccaatgtgta
     3661 agaactccat gaaagatccc tcatttctca tttcgtttga cattgtgatt ttcttctcaa
     3721 cattaaaaaa aataggcttt tgcattttca tttctgctga tgatatctgg gtcccaaaga
     3781 gagcagcttt aatatatttt tcctacttgt gggaaaagta ttataagttt ggttaaattg
     3841 tcatgtttat agtttttcca agtacatttg taactacagc aggccttctt cgtactgctg
     3901 ctgttggaca acaggactgg cacctgctgc agaggttata ccttatgata cttttatgct
     3961 ccatacctga tttgttggga aatgttattt aggatattca aatctgcatc ataagccgta
     4021 atataatagg attaatacta cattaagttg tatagaagca agcatgttgg aatagatctt
     4081 ttgtgtgtat ttactttttt tatttcttaa ttttctaaag aattacttaa gatatggatt
     4141 tggagtaaaa tgggtgcttt tggcagtttc ttccatctat cctaacctga ccagtacata
     4201 ttgaggttaa gtatctggtt aaactttaag gtattcattt atctccttta tgtatgattt
     4261 ttactaaatg ccagttttca tttgcttata gtagcttcta ttttcccttt tttccatcca
     4321 tggcataaaa ataagtgatt tctgggggtg gggcagaaat gttcccaagt ctgacaatag
     4381 agcattttac aaattcctac aaagaaaata taggcaaata gataaaattt atttttatgg
     4441 agaagaaata tggccatatt atggatttgt ctttttttta ctcagcaaga tagcaggact
     4501 tacccttctc tattaagtat cacttgaatt gctaagaaga aaaaagtctg taccatcatc
     4561 tttcatggtt gcattcaaat gtatattttc aaagagaaat acttcttgtg tccccattcc
     4621 aaaatgtcat gggataaata tgaaatagtt tatgaagtag cctttctggt tcagagtgac
     4681 tggaccaaag tctgaatctt atctgggtat caggaaaaag aatttttatg gaaatcctta
     4741 gtgtctataa acaacccgtg taaaccctgt ctacactatg ccaaaaccag tggaaagatg
     4801 ggtagagtca tcttatctca ggatgtcaaa aatctgggtt tgactgattc ccctaccttc
     4861 ccacacagta tattcttgtg atttttgctt ttctgtagat cctgagtcgg tgttacaata
     4921 gtcatgtttt tattttgggt taagaaatac gaggtgtaag agctataatt tccttttcgt
     4981 gttatatcat gatctgggtt ttcttttttc ctttacgttt ttcacagctc ttgagtattt
     5041 tctatttttt tctttagtca caaaaattaa aattaaactt tatttttatg aattaaaatg
     5101 aaatttaatt tatttttatg aattaaaatt gtggccagta tccactgtgt ccttaggctg
     5161 agaagtacta atttggagta gcccgtgtgt ggaattctaa agtgaaggta ctgtggattc
     5221 atttttagta gttttagccc cttaataagt ggctaagtta gaaaactttc agcgaggtaa
     5281 tagaaccact tgaatagaat ccatgtgtct ttttctgaat tggtgaaaat tcggccactg
     5341 atccagtgac tcctggtcaa acgtcttata acattactgg ccataatgca tccctttatc
     5401 tcatggaaat ggctgaactt tgtggtagct gctgcgagta cctgggctta acagtaatag
     5461 agaacctcat ttataccata cagacacagc aacttaggaa gacagcactg atagcattta
     5521 gctagttgta accaaataca aatatgtaaa attgagaatt atgattaaca tatgcaactt
     5581 tagtaatagg aatagatgat aattttcctg tattgtttca aataagtgac tgttcagctg
     5641 ggatccattg gattataatt tacaatgtca cataatatta tgcttttcaa tattgatgag
     5701 tgatgtaaac aatataaagt tggcagtttg tagtagttca gtatcctaga aatacattga
     5761 acttcataag tatcagttca tttttaagca tacagaattg aagattctga ctgaaatcat
     5821 aaactcagag gaaacaagcc catctttatc actaattact tagcttgaat acttttctat
     5881 ttttaaataa tcctaattat tgccttttca attatagtct actgtattta tttatatggg
     5941 atcaacaggt atttatcaaa catctactgt gtgcccagca ctacctagta ctgttgggga
     6001 acatcaattt gcagttgtgg tctctgccct tgaaggtatc ttctccagga aattagcagt
     6061 attattttca cttctaagca aacatgagca aaagaggacc tgttcattaa aaaacatgct
     6121 gactttttta gtttcaactg agatatgcca ctgtagaagt gaaagtaatt tcacaattaa
     6181 agaaatgctt caacttggta attaatatgg tcatacaggg acttggtgta gcatgcaagg
     6241 aagcagaaga cctgggcttt tgtcgaagtt ctgccattta ggtatcagct gtgtaacctt
     6301 gaataagtca cttaactctt tctcttagtt ttctcatttg taaatttgga ttaaagtgtt
     6361 tattatgata atcaattaag aaaatctctt aacacttcat acatacagag aacttatcat
     6421 taagttaaaa ctggcaatta atgcaccttt atatatattt ttaaatgaaa actaatacta
     6481 ttcatgatgt ttattttata tcaaatatat gcccagggca tgctacttta aaaatccgag
     6541 gaatctccaa caaggtgctg gattaaaatc agatttcgtg cttgaagtgg aagaaaaatg
     6601 aagttgttta tggataagag agtgagaatg tgtatcctca agtacgttaa gatgatttaa
     6661 ctgaaagatg gctttaggtt tttcttgaag aattaggaaa gtaccatccc cacagattca
     6721 gcatactctt caggtactag ataaaggtga aggaagtcat ggaattaaaa tgacttagca
     6781 actccccagg gaacttgtgg ggagaatgag gtggttagaa aggtgagaat gcacaaagac
     6841 agctctgggt tgggtaccaa cagtttgctt ggtagaaaga aaccagtgta ggaaaggaga
     6901 cgccaccaga catcttcaac agacaagatt ctttctgcct ttttcaaaag atgctctctg
     6961 cagcagtaag actatagata gagttgattg gaatatcatg tgacccagta tgctactgct
     7021 aggcataatt atcaaaaatt catttttctc attaaatatt gttaattgct cgccacataa
     7081 agagaagcta gagctcacca gtcttggtgg tgtcctagac cttcctctaa agcagtcttg
     7141 ggaagctgga tcatcagatc tttagcctag acagagtgtc gctggtaaat aaaggagaca
     7201 caggtaaccc agagtggaca gtgatttgcg tggggagaca cagtggatct ggggcctctg
     7261 atactttgct tcctaaaaca gcccccagtt ttcggcttgc cctatgagat gatgttcatg
     7321 tgcttccttg aaaccaggtg gaaagaaagg ggaagaatta attttctcat tctgttgctg
     7381 ttgaacgtaa tgtaatctta atactgtagc cttcctagaa gcccttccct ctttttcatg
     7441 ctgtaaagtc aaatatttga tatccttaac ataaatttta aaaattaagg tcattaggaa
     7501 gcaaatgtct atttccaaag caatgagctt gttgtgactg tgattttatt cttctatagt
     7561 atttttttcc tcattttaac tgagaggaga aaataatact cttttgcaat atccttaggt
     7621 tctccccttc cccctggtgc cccttctagt gtcttaagac tttgtcttaa caagtataac
     7681 attacatttt gttgttaaaa cctttcgaaa ctgtattcag tgattcttcc aagtttatct
     7741 gctctgcact atttcactaa taaaccctgg ctaccacgta gcccttgatc tccaagtagt
     7801 ttacctatgc aagacctgtg acactctgaa ttcacttctc tttctttcag aaagtagtca
     7861 taaatggagc ttaattataa aggtaaaact tgtctccaac cagtttcatt ttggccattt
     7921 ctttttcaaa atgtcagctg ttttcctcca agatttttca ccaaaacaat gatcataagt
     7981 gctggaatat ataatacttt gcaggcataa aataacccag acatactctc atatttcttt
     8041 ggtgtatttt ggttggtaaa acttaccagc attaaatgta aaatataatg aggagttaat
     8101 tccttaccta gaactatttc ttccttttaa gattcataag taacctttta tttttacaga
     8161 gctacgtata acttccacat tacagtcagg gacctgaggt gtaacttact aagtgaaccc
     8221 caaggttatt ttatcttgca aaagaaacct aaaccaaact aagggcctta cagtttatgg
     8281 ttagactgaa tcaaaagcta taacctcaat ttttccaaaa acagcttctg actgcaaaag
     8341 caagtcatac agttgttagg tatgaaatag cactgatcag gaaatgcatc ttcgcagatg
     8401 gtatttcctt cagaaaagac ttttctactt ttaatataaa ttaagccata acagtttcat
     8461 gctgtggaaa gagggtgaaa aggttcattt taagagatta tataatatga actttcacat
     8521 ttactgtgaa atgtctaact ttgccagtgc ttcagcaagt ttttttgggg ggtgatgggg
     8581 aggggtagta ttggttttag aggtttcaaa tctgtgaact ttggagaggg gacagttgtt
     8641 ggctctggta tttactagtt ttgtagtaac gttttgctag cctgactgac ttttcttact
     8701 ggtttttatg cccacggtcc gaggggactg ttcttcttgt tgggggtgtc tgcggaatag
     8761 cgtctcgtct tgtttgtata ggcagtcaat gtgtgtgaca tgtgtgtcct ttcagtccgg
     8821 aagcccactg tgtgacaatg gcgtggggtg tggctgggag gtggggtgct gaagcttgaa
     8881 gagcatttct ttgctgattc ataacagtat ttcccatctt ttgcctgcag gcagggaaag
     8941 tgtacagtat ttattttgtt tctgttttac tttaaatttg taagtcttta agtagcttac
     9001 attgattatt ataggggagg acaagtgact tgtttaaagt tgtatttagt attctttcca
     9061 atttctgtat tttaaaatat tgaaattaaa attgtattac ttctgttttg atttttttag
     9121 cacttagtgt attttttgct cattttgttt gaaagtataa atgttgaaaa ttgtataaaa
     9181 tgcgtccttg aaagaaaaag aatctgaatt ctatatccaa
//
