LOCUS       NM_001348716            6728 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens lysine demethylase 6B (KDM6B), transcript variant 2,
            mRNA.
ACCESSION   NM_001348716 XM_017024381
VERSION     NM_001348716.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6728)
  AUTHORS   Zhu,H., Lu,J., Fu,M., Chen,P., Yu,Y., Chen,M., Zhao,Q., Wu,M. and
            Ye,M.
  TITLE     YAP represses intestinal inflammation through epigenetic silencing
            of JMJD3
  JOURNAL   Clin Epigenetics 16 (1), 14 (2024)
   PUBMED   38245781
  REMARK    GeneRIF: YAP represses intestinal inflammation through epigenetic
            silencing of JMJD3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6728)
  AUTHORS   Wu,S., Xu,X., Gao,S., Huo,S., Wan,M., Zhou,X., Zhou,X., Zheng,L.
            and Zhou,Y.
  TITLE     MicroRNA-93-5p regulates odontogenic differentiation and dentin
            formation via KDM6B
  JOURNAL   J Transl Med 22 (1), 54 (2024)
   PUBMED   38218880
  REMARK    GeneRIF: MicroRNA-93-5p regulates odontogenic differentiation and
            dentin formation via KDM6B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6728)
  AUTHORS   Ge,G., Zhang,P., Sui,P., Chen,S., Yang,H., Guo,Y., Rubalcava,I.P.,
            Noor,A., Delma,C.R., Agosto-Pena,J., Geng,H., Medina,E.A.,
            Liang,Y., Nimer,S.D., Mesa,R., Abdel-Wahab,O., Xu,M. and Yang,F.C.
  TITLE     Targeting lysine demethylase 6B ameliorates ASXL1
            truncation-mediated myeloid malignancies in preclinical models
  JOURNAL   J Clin Invest 134 (1), e163964 (2024)
   PUBMED   37917239
  REMARK    GeneRIF: Targeting lysine demethylase 6B ameliorates ASXL1
            truncation-mediated myeloid malignancies in preclinical models.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6728)
  AUTHORS   Sylvestre,M., Barbier,N., Sibut,V., Nayar,S., Monvoisin,C.,
            Leonard,S., Saint-Vanne,J., Martin,A., Guirriec,M., Latour,M.,
            Jouan,F., Baulande,S., Bohec,M., Verdiere,L., Mechta-Grigoriou,F.,
            Mourcin,F., Bertheuil,N., Barone,F., Tarte,K. and Roulois,D.
  TITLE     KDM6B drives epigenetic reprogramming associated with lymphoid
            stromal cell early commitment and immune properties
  JOURNAL   Sci Adv 9 (48), eadh2708 (2023)
   PUBMED   38019914
  REMARK    GeneRIF: KDM6B drives epigenetic reprogramming associated with
            lymphoid stromal cell early commitment and immune properties.
REFERENCE   5  (bases 1 to 6728)
  AUTHORS   Lin,R., Wang,X., Ni,C., Fu,C., Yang,C., Dong,D., Wu,X., Chen,X.,
            Wang,L. and Hou,J.
  TITLE     Echinococcus granulosus cyst fluid inhibits KDM6B-mediated
            demethylation of trimethylated histone H3 lysine 27 and
            interleukin-1beta production in macrophages
  JOURNAL   Parasit Vectors 16 (1), 422 (2023)
   PUBMED   37974225
  REMARK    GeneRIF: Echinococcus granulosus cyst fluid inhibits KDM6B-mediated
            demethylation of trimethylated histone H3 lysine 27 and
            interleukin-1beta production in macrophages.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6728)
  AUTHORS   Sen,G.L., Webster,D.E., Barragan,D.I., Chang,H.Y. and Khavari,P.A.
  TITLE     Control of differentiation in a self-renewing mammalian tissue by
            the histone demethylase JMJD3
  JOURNAL   Genes Dev 22 (14), 1865-1870 (2008)
   PUBMED   18628393
  REMARK    GeneRIF: These results indicate that epigenetic derepression by
            JMJD3 controls mammalian epidermal differentiation.
REFERENCE   7  (bases 1 to 6728)
  AUTHORS   Hong,S., Cho,Y.W., Yu,L.R., Yu,H., Veenstra,T.D. and Ge,K.
  TITLE     Identification of JmjC domain-containing UTX and JMJD3 as histone
            H3 lysine 27 demethylases
  JOURNAL   Proc Natl Acad Sci U S A 104 (47), 18439-18444 (2007)
   PUBMED   18003914
  REMARK    GeneRIF: JMJD3 demethylates di- and trimethylated lysine 27 of
            histone H3 in vitro and in cells.
REFERENCE   8  (bases 1 to 6728)
  AUTHORS   Agger,K., Cloos,P.A., Christensen,J., Pasini,D., Rose,S.,
            Rappsilber,J., Issaeva,I., Canaani,E., Salcini,A.E. and Helin,K.
  TITLE     UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene
            regulation and development
  JOURNAL   Nature 449 (7163), 731-734 (2007)
   PUBMED   17713478
  REMARK    GeneRIF: the human JmjC-domain-containing proteins UTX and JMJD3
            demethylate tri-methylated Lys 27 on histone H3
REFERENCE   9  (bases 1 to 6728)
  AUTHORS   Xiang,Y., Zhu,Z., Han,G., Lin,H., Xu,L. and Chen,C.D.
  TITLE     JMJD3 is a histone H3K27 demethylase
  JOURNAL   Cell Res 17 (10), 850-857 (2007)
   PUBMED   17923864
  REMARK    GeneRIF: JMJD3 was identified as a demethylase capable of removing
            the trimethyl group from histone H3 lysine 27 and upregulated in
            prostate cancer.
REFERENCE   10 (bases 1 to 6728)
  AUTHORS   De Santa,F., Totaro,M.G., Prosperini,E., Notarbartolo,S., Testa,G.
            and Natoli,G.
  TITLE     The histone H3 lysine-27 demethylase Jmjd3 links inflammation to
            inhibition of polycomb-mediated gene silencing
  JOURNAL   Cell 130 (6), 1083-1094 (2007)
   PUBMED   17825402
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025335.25 and AC104581.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2020 this sequence version replaced NM_001348716.1.
            
            Summary: The protein encoded by this gene is a lysine-specific
            demethylase that specifically demethylates di- or tri-methylated
            lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27
            trimethylation is a repressive epigenetic mark controlling
            chromatin organization and gene silencing. This protein can also
            demethylate non-histone proteins such as retinoblastoma protein.
            Through its demethylation actvity this gene influences cellular
            differentiation and development, tumorigenesis, inflammatory
            diseases, and neurodegenerative diseases. This protein has two
            classical nuclear localization signals at its N-terminus.
            Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (2) encodes the shorter isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1621255.1,
                                           SRR14038194.2153157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448097.7/ ENSP00000412513.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC025335.25        114577-114710
            135-253             AC104581.22        3143-3261
            254-373             AC104581.22        8138-8257
            374-516             AC104581.22        8551-8693
            517-658             AC104581.22        8787-8928
            659-757             AC104581.22        9109-9207
            758-977             AC104581.22        9315-9534
            978-1070            AC104581.22        9637-9729
            1071-1232           AC104581.22        9816-9977
            1233-1430           AC104581.22        10056-10253
            1431-1778           AC104581.22        10342-10689
            1779-3961           AC104581.22        10783-12965
            3962-4088           AC104581.22        13058-13184
            4089-4194           AC104581.22        13309-13414
            4195-4400           AC104581.22        14258-14463
            4401-4465           AC104581.22        14567-14631
            4466-4537           AC104581.22        14715-14786
            4538-4686           AC104581.22        14885-15033
            4687-4801           AC104581.22        15188-15302
            4802-4989           AC104581.22        15386-15573
            4990-5131           AC104581.22        15732-15873
            5132-5258           AC104581.22        16237-16363
            5259-5429           AC104581.22        16447-16617
            5430-6728           AC104581.22        16735-18033
FEATURES             Location/Qualifiers
     source          1..6728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6728
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="lysine demethylase 6B"
                     /db_xref="GeneID:23135"
                     /db_xref="HGNC:HGNC:29012"
                     /db_xref="MIM:611577"
     exon            1..134
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            135..253
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            254..373
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            374..516
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            517..658
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..5453
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /EC_number="1.14.11.68"
                     /note="isoform 2 is encoded by transcript variant 2;
                     jumonji domain containing 3, histone lysine demethylase;
                     lysine (K)-specific demethylase 6B; lysine-specific
                     demethylase 6B; jmjC domain-containing protein 3; jumonji
                     domain-containing protein 3; [histone
                     H3]-trimethyl-L-lysine(27) demethylase 6B"
                     /codon_start=1
                     /product="lysine-specific demethylase 6B isoform 2"
                     /protein_id="NP_001335645.1"
                     /db_xref="CCDS:CCDS86569.1"
                     /db_xref="GeneID:23135"
                     /db_xref="HGNC:HGNC:29012"
                     /db_xref="MIM:611577"
                     /translation="MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPG
                     GRCSASIGQPPLPAPLPPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLR
                     EPAQPGLWEQLGQLYESEHDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHT
                     GSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPS
                     GEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQL
                     TKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAP
                     PGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPG
                     LPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFL
                     GAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGT
                     EGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPA
                     GPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRR
                     PESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQF
                     EEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDT
                     APTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPP
                     SPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPS
                     AQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVL
                     EEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSC
                     KRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQG
                     REKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRAD
                     MLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRAS
                     RNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQF
                     CTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGT
                     RQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDP
                     KNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQL
                     YMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGS
                     WWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQ
                     LALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRE
                     SLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRS
                     AGLQGVVVLEQYRTEELAQAYDAFTLAPASTSR"
     exon            659..757
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            758..977
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1070
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1232
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1430
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1778
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..3961
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4088
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4194
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4400
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4465
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4466..4537
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4538..4686
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4801
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..4989
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5131
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5258
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5429
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     exon            5430..6728
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6346..6351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="hexamer: AATAAA"
     regulatory      6355..6360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="hexamer: AATAAA"
     regulatory      6364..6369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="hexamer: ATTAAA"
     polyA_site      6364
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="major polyA site"
     polyA_site      6378
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
     polyA_site      6385
                     /gene="KDM6B"
                     /gene_synonym="JMJD3; NEDCFSA; NEDSST"
                     /note="major polyA site"
ORIGIN      
        1 gtttgtgttg gaaaatccaa ctgcgccact gggcggagcg gcccccccag ccccggcctg
       61 ggagaagggg gggccgctcg accccctggg ataccttggg gagcctgaac acctgggacc
      121 ccccccagaa ccaggttccc cccagggcaa catgccagcc ccgtagcact gcccacccca
      181 cccactgtgg tctgttgtac cccactgctg gggtggtggt tccaatgaga cagggcacac
      241 caaactccat ctggctgtta ctgaggcgga gacacgggtg atgattggct ttctggggag
      301 agaggaagtc ctgtgattgg ccagatctct ggagcttgcc gacgcggtgt gaggacgctc
      361 ccacggaggc cggaattggc tgtgaaagga ctgaggcagc catctggggg tagcgggcac
      421 tcttatcaga gcggctggag ccggaccatc gtcccagaga gctggggcag ggggccgtgc
      481 ccaatctcca gggctcctgg ggccactgct gacctggctg gatgcatcgg gcagtggacc
      541 ctccaggggc ccgcgctgca cgggaagcct ttgcccttgg gggcctgagc tgtgctgggg
      601 cctggagctc ctgcccgcct catccccctc ctcgtagcgc atggctgcct ggaggcagat
      661 gctcagccag cattgggcag cccccgcttc ctgctcccct acccccttca catggcagta
      721 gttctgggca ccccagcaaa ccatattatg ctccaggggc gcccactcca agacccctcc
      781 atgggaagct ggaatccctg catggctgtg tgcaggcatt gctccgggag ccagcccagc
      841 cagggctttg ggaacagctt gggcaactgt acgagtcaga gcacgatagt gaggaggcca
      901 cacgctgcta ccacagcgcc cttcgatacg gaggaagctt cgctgagctg gggccccgca
      961 ttggccgact gcagcaggcc cagctctgga actttcatac tggctcctgc cagcaccgag
     1021 ccaaggtcct gcccccactg gagcaagtgt ggaacttgct acaccttgag cacaaacgga
     1081 actatggagc caagcgggga ggtcccccgg tgaagcgagc tgctgaaccc ccagtggtgc
     1141 agcctgtgcc tcctgcagca ctctcaggcc cctcagggga ggagggcctc agccctggag
     1201 gcaagcgaag gagaggctgc aactctgaac agactggcct tcccccaggg ctgccactgc
     1261 ctccaccacc attaccacca ccaccaccac caccaccacc accaccacca cccctgcctg
     1321 gcctggctac cagcccccca tttcagctaa ccaagccagg gctgtggagt accctgcatg
     1381 gagatgcctg gggcccagag cgcaagggtt cagcaccccc agagcgccag gagcagcggc
     1441 actcgctgcc tcacccatat ccatacccag ctccagcgta caccgcgcac ccccctggcc
     1501 accggctggt cccggctgct cccccaggcc caggcccccg ccccccagga gcagagagcc
     1561 atggctgcct gcctgccacc cgtccccccg gaagtgacct tagagagagc agagttcaga
     1621 ggtcgcggat ggactccagc gtttcaccag cagcaaccac cgcctgcgtg ccttacgccc
     1681 cttcccggcc ccctggcctc cccggcacca ccaccagcag cagcagtagc agcagcagca
     1741 acactggtct ccggggcgtg gagccgaacc caggcattcc cggcgctgac cattaccaaa
     1801 ctcccgcgct ggaggtctct caccatggcc gcctggggcc ctcggcacac agcagtcgga
     1861 aaccgttctt gggggctccc gctgccactc cccacctatc cctgccacct ggaccttcct
     1921 caccccctcc acccccctgt ccccgcctct tacgcccccc accaccccct gcctggttga
     1981 agggtccggc ctgccgggca gcccgagagg atggagagat cttagaagag ctcttctttg
     2041 ggactgaggg acccccccgc cctgccccac cacccctccc ccatcgcgag ggcttcttgg
     2101 ggcctccggc ctcccgcttt tctgtgggca ctcaggattc tcacacccct cccactcccc
     2161 caaccccaac caccagcagt agcaacagca acagtggcag ccacagcagc agccctgctg
     2221 ggcctgtgtc ctttccccca ccaccctatc tggccagaag tatagacccc cttccccggc
     2281 ctcccagccc agcacagaac ccccaggacc cacctcttgt acccctgact cttgccctgc
     2341 ctccagcccc tccttcctcc tgccaccaaa atacctcagg aagcttcagg cgcccggaga
     2401 gcccccggcc cagggtctcc ttcccaaaga cccccgaggt ggggccgggg ccacccccag
     2461 gccccctgag taaagccccc cagcctgtgc cgcccggggt tggggagctg cctgcccgag
     2521 gccctcgact ctttgatttt ccccccactc cgctggagga ccagtttgag gagccagccg
     2581 aattcaagat cctacctgat gggctggcca acatcatgaa gatgctggac gaatccattc
     2641 gcaaggaaga ggaacagcaa caacacgaag caggcgtggc cccccaaccc ccgctgaagg
     2701 agccctttgc atctctgcag tctcctttcc ccaccgacac agcccccacc actactgctc
     2761 ctgctgtcgc cgtcaccacc accaccacca ccaccaccac caccacggcc acccaggaag
     2821 aggagaagaa gccaccacca gccctaccac caccaccgcc tctagccaag ttccctccac
     2881 cctctcagcc acagccacca ccacccccac cccccagccc ggccagcctg ctcaaatcct
     2941 tggcctccgt gctggaggga caaaagtact gttatcgggg gactggagca gctgtttcca
     3001 cccggcctgg gcccttgccc accactcagt attcccctgg ccccccatca ggtgctaccg
     3061 ccctgccgcc cacctcagcg gcccctagcg cccagggctc cccacagccc tctgcttcct
     3121 cgtcatctca gttctctacc tcaggcgggc cctgggcccg ggagcgcagg gcgggcgaag
     3181 agccagtccc gggccccatg acccccaccc aaccgccccc acccctatct ctgccccctg
     3241 ctcgctctga gtctgaggtg ctagaagaga tcagccgggc ttgcgagacc cttgtggagc
     3301 gggtgggccg gagtgccact gacccagccg acccagtgga cacagcagag ccagcggaca
     3361 gtgggactga gcgactgctg ccccccgcac aggccaagga ggaggctggc ggggtggcgg
     3421 cagtgtcagg cagctgtaag cggcgacaga aggagcatca gaaggagcat cggcggcaca
     3481 ggcgggcctg taaggacagt gtgggtcgtc ggccccgtga gggcagggca aaggccaagg
     3541 ccaaggtccc caaagaaaag agccgccggg tgctggggaa cctggacctg cagagcgagg
     3601 agatccaggg tcgtgagaag tcccggcccg atcttggcgg ggcctccaag gccaagccac
     3661 ccacagctcc agcccctcca tcagctcctg caccttctgc ccagcccaca cccccgtcag
     3721 cctctgtccc tggaaagaag gctcgggagg aagccccagg gccaccgggt gtcagccggg
     3781 ccgacatgct gaagctgcgc tcacttagtg aggggccccc caaggagctg aagatccggc
     3841 tcatcaaggt agagagtggt gacaaggaga cctttatcgc ctctgaggtg gaagagcggc
     3901 ggctgcgcat ggcagacctc accatcagcc actgtgctgc tgacgtcgtg cgcgccagca
     3961 ggaatgccaa ggtgaaaggg aagtttcgag agtcctacct ttcccctgcc cagtctgtga
     4021 aaccgaagat caacactgag gagaagctgc cccgggaaaa actcaacccc cctacaccca
     4081 gcatctatct ggagagcaaa cgggatgcct tctcacctgt cctgctgcag ttctgtacag
     4141 accctcgaaa tcccatcaca gtgatccggg gcctggcggg ctccctgcgg ctcaacttgg
     4201 gcctcttctc caccaagacc ctggtggaag cgagtggcga acacaccgtg gaagttcgca
     4261 cccaggtgca gcagccctca gatgagaact gggatctgac aggcactcgg cagatctggc
     4321 cttgtgagag ctcccgttcc cacaccacca ttgccaagta cgcacagtac caggcctcat
     4381 ccttccagga gtctctgcag gaggagaagg agagtgagga tgaggagtca gaggagccag
     4441 acagcaccac tggaacccct cctagcagcg caccagaccc gaagaaccat cacatcatca
     4501 agtttggcac caacatcgac ttgtctgatg ctaagcggtg gaagccccag ctgcaggagc
     4561 tgctgaagct gcccgccttc atgcgggtaa catccacggg caacatgctg agccacgtgg
     4621 gccacaccat cctgggcatg aacacggtgc agctgtacat gaaggtgccc ggcagccgaa
     4681 cgccaggcca ccaggagaat aacaacttct gctccgtcaa catcaacatt ggcccaggcg
     4741 actgcgagtg gttcgcggtg cacgagcact actgggagac catcagcgct ttctgtgatc
     4801 ggcacggcgt ggactacttg acgggttcct ggtggccaat cctggatgat ctctatgcat
     4861 ccaatattcc tgtgtaccgc ttcgtgcagc gacccggaga cctcgtgtgg attaatgcgg
     4921 ggactgtgca ctgggtgcag gccaccggct ggtgcaacaa cattgcctgg aacgtggggc
     4981 ccctcaccgc ctatcagtac cagctggccc tggaacgata cgagtggaat gaggtgaaga
     5041 acgtcaaatc catcgtgccc atgattcacg tgtcatggaa cgtggctcgc acggtcaaaa
     5101 tcagcgaccc cgacttgttc aagatgatca agttctgcct gctgcagtcc atgaagcact
     5161 gccaggtgca acgcgagagc ctggtgcggg cagggaagaa aatcgcttac cagggccgtg
     5221 tcaaggacga gccagcctac tactgcaacg agtgcgatgt ggaggtgttt aacatcctgt
     5281 tcgtgacaag tgagaatggc agccgcaaca cgtacctggt acactgcgag ggctgtgccc
     5341 ggcgccgcag cgcaggcctg cagggcgtgg tggtgctgga gcagtaccgc actgaggagc
     5401 tggctcaggc ctacgacgcc ttcacgctgg ccccagccag cacgtcgcga tgaggccgga
     5461 cgccccgccc gcctgcctgc ccgcgcaagg cgccgcgggg ccaccagcac atgcctgggc
     5521 tggacctagg tcccgcctgt ggccgagaag ggggtcgggc ccagcccttc caccccattg
     5581 gcagctcccc tcacttaatt tattaagaaa aacttttttt ttttttttag caaatatgag
     5641 gaaaaaagga aaaaaaatgg gagacggggg agggggctgg cagcccctcg cccaccagcg
     5701 cctcccctca ccgactttgg cctttttagc aacagacaca aggaccaggc tccggcggcg
     5761 gcgggggtca catacgggtt ccctcaccct gccagccgcc cgcccgcccg gcgcagatgc
     5821 acgcggctcg tgtatgtaca tagacgttac ggcagccgag gtttttaatg agattctttc
     5881 tatgggcttt acccctcccc cggaacctcc ttttttactt ccaatgctag ctgtgacccc
     5941 tgtacatgtc tctttattca cttggttatg atttgtattt tttgttcttt tcttgttttt
     6001 ttgtttttaa tttataacag tcccactcac ctctatttat tcatttttgg gaaaacccga
     6061 cctcccacac ccccaagcca tcctgcccgc ccctccaggg accgcccgtc gccgggctct
     6121 ccccgcgccc cagtgtgtgt ccgggcccgg cccgaccgtc tccacccgtc cgcccgcggc
     6181 tccagccggg ttctcatggt gctcaaaccc gctcccctcc cctacgtcct gcactttctc
     6241 ggaccagtcc ccccactccc gacccgaccc cagccccacc tgagggtgag caactcctgt
     6301 actgtagggg aagaagtggg aactgaaatg gtattttgta aaaaaaataa ataaaataaa
     6361 aaaattaaag gttttaaaga aagaactatg aggaaaagga accccgtcct tcccagcccc
     6421 ggccaacttt aaaaaacaca gaccttcacc cccaccccct tttcttttta agtgtgaaac
     6481 aacccagggc cagggcctca ctggggcagg gacaccccgg ggtgagtttc tctggggctt
     6541 tattttcgtt ttgttggttg ttttttctcc acgctggggc tgcggagggg tggggggttt
     6601 acagtcccgc accctcgcac tgcactgtct ctctgcccca ggggcagagg ggtcttccca
     6661 accctacccc tattttcggt gatttttgtg tgagaatatt aatattaaaa ataaacggag
     6721 aaaaaaaa
//
