LOCUS       NM_001291415            6094 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens lysine demethylase 6A (KDM6A), transcript variant 1,
            mRNA.
ACCESSION   NM_001291415 XM_005272655
VERSION     NM_001291415.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6094)
  AUTHORS   Dupere-Richer,D., Riva,A., Barwick,B.G., Maji,S., Casellas
            Roman,H., Li,J., De,U., Sobh,A., Quickstad,G., Piper,C., Kulis,M.,
            Ezponda,T., Martin-Subero,J.I., Tonon,G., Zhang,W., Mitsiades,C.S.,
            Boise,L.H., Bennett,R.L. and Licht,J.D.
  TITLE     KDM6A regulates immune response genes in multiple myeloma
  JOURNAL   Blood 144 (14), 1508-1520 (2024)
   PUBMED   39046770
  REMARK    GeneRIF: KDM6A regulates immune response genes in multiple myeloma.
REFERENCE   2  (bases 1 to 6094)
  AUTHORS   Liang,Y. and An,Y.
  TITLE     [Clinical characteristics and genetic counseling for a
            three-generation Chinese pedigree with recurrent fetal Kabuki
            syndrome due to variant of KDM6A gene]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 41 (1), 81-85 (2024)
   PUBMED   38171564
  REMARK    GeneRIF: [Clinical characteristics and genetic counseling for a
            three-generation Chinese pedigree with recurrent fetal Kabuki
            syndrome due to variant of KDM6A gene].
REFERENCE   3  (bases 1 to 6094)
  AUTHORS   Shpargel,K.B. and Quickstad,G.
  TITLE     SETting up the genome: KMT2D and KDM6A genomic function in the
            Kabuki syndrome craniofacial developmental disorder
  JOURNAL   Birth Defects Res 115 (20), 1885-1898 (2023)
   PUBMED   37800171
  REMARK    GeneRIF: SETting up the genome: KMT2D and KDM6A genomic function in
            the Kabuki syndrome craniofacial developmental disorder.
            Review article
REFERENCE   4  (bases 1 to 6094)
  AUTHORS   Lee,M.G., Villa,R., Trojer,P., Norman,J., Yan,K.P., Reinberg,D., Di
            Croce,L. and Shiekhattar,R.
  TITLE     Demethylation of H3K27 regulates polycomb recruitment and H2A
            ubiquitination
  JOURNAL   Science 318 (5849), 447-450 (2007)
   PUBMED   17761849
  REMARK    GeneRIF: study shows that UTX is a di- and trimethyl H3K27
            demethylase; results suggest a concerted mechanism for
            transcriptional activation in which cycles of H3K4 methylation by
            MLL2/3 are linked with the demethylation of H3K27 through UTX
REFERENCE   5  (bases 1 to 6094)
  AUTHORS   Foresta,C., Ferlin,A. and Moro,E.
  TITLE     Deletion and expression analysis of AZFa genes on the human Y
            chromosome revealed a major role for DBY in male infertility
  JOURNAL   Hum Mol Genet 9 (8), 1161-1169 (2000)
   PUBMED   10767340
REFERENCE   6  (bases 1 to 6094)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y., Greenfield,A. and Stifani,S.
  TITLE     Groucho/transducin-like enhancer of split (TLE) family members
            interact with the yeast transcriptional co-repressor SSN6 and
            mammalian SSN6-related proteins: implications for evolutionary
            conservation of transcription repression mechanisms
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 13-17 (1999)
   PUBMED   9854018
REFERENCE   7  (bases 1 to 6094)
  AUTHORS   Greenfield,A., Carrel,L., Pennisi,D., Philippe,C., Quaderi,N.,
            Siggers,P., Steiner,K., Tam,P.P., Monaco,A.P., Willard,H.F. and
            Koopman,P.
  TITLE     The UTX gene escapes X inactivation in mice and humans
  JOURNAL   Hum Mol Genet 7 (4), 737-742 (1998)
   PUBMED   9499428
REFERENCE   8  (bases 1 to 6094)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
REFERENCE   9  (bases 1 to 6094)
  AUTHORS   Adam,M.P., Hudgins,L. and Hannibal,M.
  TITLE     Kabuki Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21882399
REFERENCE   10 (bases 1 to 6094)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133545.10, AL138744.41 and
            AC136488.3.
            
            On Oct 1, 2019 this sequence version replaced NM_001291415.1.
            
            Summary: This gene is located on the X chromosome and is the
            corresponding locus to a Y-linked gene which encodes a
            tetratricopeptide repeat (TPR) protein. The encoded protein of this
            gene contains a JmjC-domain and catalyzes the demethylation of
            tri/dimethylated histone H3. Multiple alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143277.1, SRR11853567.31827.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611820.5/ ENSP00000483595.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AL133545.10        69542-70066
            526-589             AL133545.10        70278-70341
            590-698             AL138744.41        18920-19028
            699-748             AL138744.41        32302-32351
            749-807             AC136488.3         15256-15314
            808-928             AC136488.3         24905-25025
            929-983             AC136488.3         39226-39280
            984-1018            AC136488.3         41950-41984
            1019-1112           AC136488.3         56004-56097
            1113-1239           AC136488.3         58124-58250
            1240-1338           AC136488.3         63301-63399
            1339-1558           AC136488.3         63542-63761
            1559-1693           AC136488.3         64317-64451
            1694-1849           AC136488.3         64904-65059
            1850-1945           AC136488.3         65619-65714
            1946-2047           AC136488.3         66942-67043
            2048-2443           AC136488.3         67717-68112
            2444-3222           AC136488.3         73874-74652
            3223-3352           AC136488.3         80992-81121
            3353-3458           AC136488.3         82695-82800
            3459-3664           AC136488.3         83441-83646
            3665-3729           AC136488.3         86871-86935
            3730-3804           AC136488.3         87010-87084
            3805-3953           AC136488.3         87755-87903
            3954-4068           AC136488.3         90160-90274
            4069-4256           AC136488.3         94038-94225
            4257-4398           AC136488.3         95018-95159
            4399-4525           AC136488.3         111705-111831
            4526-4696           AC136488.3         114374-114544
            4697-6094           AC136488.3         115677-117074
FEATURES             Location/Qualifiers
     source          1..6094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..6094
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="lysine demethylase 6A"
                     /db_xref="GeneID:7403"
                     /db_xref="HGNC:HGNC:12637"
                     /db_xref="MIM:300128"
     exon            1..525
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..4726
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /EC_number="1.14.11.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitously-transcribed TPR gene on the X chromosome;
                     ubiquitously transcribed tetratricopeptide repeat protein
                     X-linked; lysine (K)-specific demethylase 6A; bA386N14.2
                     (ubiquitously transcribed X chromosome tetratricopeptide
                     repeat protein (UTX)); histone demethylase UTX; [histone
                     H3]-trimethyl-L-lysine(27) demethylase 6A"
                     /codon_start=1
                     /product="lysine-specific demethylase 6A isoform 1"
                     /protein_id="NP_001278344.1"
                     /db_xref="CCDS:CCDS94599.1"
                     /db_xref="GeneID:7403"
                     /db_xref="HGNC:HGNC:12637"
                     /db_xref="MIM:300128"
                     /translation="MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAE
                     EREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHF
                     NLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVD
                     PSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQ
                     RKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKS
                     LEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQP
                     MDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKSCSNTSALAA
                     RIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQACKPHHP
                     NTEPVLGLSQTPISQQSLPLHMIPSSQVDDLSSPAKRKRTSSPTKNTSDNWSGGHAVS
                     HPPVQQQAHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTG
                     VAQVRSTGIPNGPTADSSLPTNSVSGQQPQLALTRVPSVSQPGVRPACPGQPLANGPF
                     SAGHVPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQRNALTLPHNRTNLTSSAEE
                     PWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSN
                     SVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNSTASVEG
                     LPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGTGTCDKVNNIH
                     PAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEES
                     QSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPP
                     PRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALK
                     LDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYA
                     QYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDK
                     KWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNF
                     CSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRF
                     IQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIV
                     PMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEE
                     PAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLM
                     QVYDQFTLAPPLPSASS"
     exon            526..589
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            590..698
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            699..748
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            749..807
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            808..928
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            929..983
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1018
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1112
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1239
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1338
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1558
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1693
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1849
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1945
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2047
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2443
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..3222
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3352
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3458
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3664
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3729
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3804
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3953
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4068
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4256
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4398
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4525
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4696
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..6094
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5543..5548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="hexamer: ATTAAA"
     polyA_site      5565
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="major polyA site"
     regulatory      5817..5822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="hexamer: AATATA"
     polyA_site      5842
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
     regulatory      5897..5902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="hexamer: AATAAA"
     polyA_site      5921
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
     regulatory      6064..6069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
                     /note="hexamer: AATAAA"
     polyA_site      6094
                     /gene="KDM6A"
                     /gene_synonym="bA386N14.2; KABUK2; UTX"
ORIGIN      
        1 acaacaactt tgtgctggtg ccggggaagt ttgtgtctcc aacgaatccc ctcagtgctc
       61 cccagccccg cgcgctccgg ccgttcccgc cgtccccgcc tgtggctgcc ccctgcccaa
      121 ccccgcgatg tgaccctaca gccgaaagcc gccgctgccg acccgggggc tccgcagccc
      181 ctgccgccgc cgccgccgcc ttcaccgccg ccgcgttggg atttttcgtc gccgccgccc
      241 gcggcggagg aggaggcggc gataaagttg gtgtgctggt cccgcgcgca gattgggggc
      301 gtcactgcgg gccccggtcc gagggggggt gtcggcgttg gagttgtgaa ttcgctgcgt
      361 ttccatgaaa tcctgcggag tgtcgctcgc taccgccgcc gctgccgccg ccgctttcgg
      421 tgatgaggaa aagaaaatgg cggcgggaaa agcgagcggc gagagcgagg aggcgtcccc
      481 cagcctgaca gccgaggaga gggaggcgct cggcggactg gacagccgcc tctttgggtt
      541 cgtgagattt catgaagatg gcgccaggac gaaggcccta ctgggcaagg ctgttcgctg
      601 ctatgaatct ctaatcttaa aagctgaagg aaaagtggag tctgatttct tttgtcaatt
      661 aggtcacttc aacctcttat tggaagatta tccaaaagca ttatctgcat accagaggta
      721 ctacagttta cagtctgact actggaagaa tgctgccttt ttatatggtc ttggtttggt
      781 ctacttccat tataatgcat ttcagtgggc aattaaagca tttcaggagg tgctttatgt
      841 tgatcccagc ttttgtcgag ccaaggaaat tcatttacga cttgggctta tgttcaaagt
      901 gaacacagac tatgagtcta gtttaaagca ttttcagtta gctttggttg actgtaatcc
      961 ctgcactttg tccaatgctg aaattcaatt tcacattgcc cacttatatg aaacccagag
     1021 gaaatatcat tctgcaaaag aagcttatga acaacttttg cagacagaga atctttctgc
     1081 acaagtaaaa gcaactgtct tacaacagtt aggttggatg catcacactg tagatctcct
     1141 gggagataaa gccaccaagg aaagctatgc tattcagtat ctccaaaagt ccttggaagc
     1201 agatcctaat tctggccagt cctggtattt cctcggaagg tgctattcaa gtattgggaa
     1261 agttcaggat gcctttatat cttacaggca gtctattgat aaatcagaag caagtgcaga
     1321 tacatggtgt tcaataggtg tgctatatca gcagcaaaat cagcccatgg atgctttaca
     1381 ggcctatatt tgtgctgtac aattggacca tggccatgct gcagcctgga tggacctagg
     1441 cactctctat gaatcctgca accagcctca ggatgccatt aaatgctact taaatgcaac
     1501 tagaagcaaa agttgtagta atacctctgc acttgcagca cgaattaagt atttacaggc
     1561 tcagttgtgt aaccttccac aaggtagtct acagaataaa actaaattac ttcctagtat
     1621 tgaggaggcg tggagcctac caattcccgc agagcttacc tccaggcagg gtgccatgaa
     1681 cacagcacag caggcatgta aacctcatca tccaaatact gaacctgtat taggcctcag
     1741 tcaaacacca atttcacagc aatccttgcc actacacatg attccttcta gccaagtaga
     1801 tgacctgtcc agtcctgcca agaggaaaag aacatctagt ccaacaaaga atacttctga
     1861 caattggagt ggtggacatg ctgtgtcaca tcctccagta cagcaacaag ctcattcatg
     1921 gtgtttgaca ccacagaaat tacagcattt ggaacagctc cgcgcaaata gaaataattt
     1981 aaatccagca cagaaactga tgctggaaca gctggaaagt cagtttgtct taatgcaaca
     2041 acaccaaatg agaccaacag gagttgcaca ggtacgatct actggaattc ctaatgggcc
     2101 aacagctgac tcatcactgc ctacaaactc agtctctggc cagcagccac agcttgctct
     2161 gaccagagtg cctagcgtct ctcagcctgg agtccgtcct gcctgccctg ggcagccttt
     2221 ggccaatgga cccttttctg caggccatgt tccctgtagc acatcaagaa cgctgggaag
     2281 tacagacact attttgatag gcaataatca tataacagga agtggaagta atggaaacgt
     2341 gccttacctg cagcgaaacg cactcactct acctcataac cgcacaaacc tgaccagcag
     2401 cgcagaggag ccgtggaaaa accaactatc taactccact caggggcttc acaaaggtca
     2461 gagttcacat tcggcaggtc ctaatggtga acgacctctc tcttccactg ggccttccca
     2521 gcatctccag gcagctggct ctggtattca gaatcagaac ggacatccca ccctgcctag
     2581 caattcagta acacaggggg ctgctctcaa tcacctctcc tctcacactg ctacctcagg
     2641 tggacaacaa ggcattacct taaccaaaga gagcaagcct tcaggaaaca tattgacggt
     2701 gcctgaaaca agcaggcaca ctggagagac acctaacagc actgccagtg tcgagggact
     2761 tcctaatcat gtccatcaga tgacggcaga tgctgtttgc agtcctagcc atggagattc
     2821 taagtcacca ggtttactaa gttcagacaa tcctcagctc tctgccttgt tgatgggaaa
     2881 agccaataac aatgtgggta ctggaacctg tgacaaagtc aataacatcc acccagctgt
     2941 tcatacaaag actgataact ctgttgcctc ttcaccatct tcagccattt caacagcaac
     3001 accttctcca aaatccactg agcagacaac cacaaacagt gttaccagcc ttaacagccc
     3061 tcacagtggg ctacacacaa ttaatggaga agggatggaa gaatctcaga gccccatgaa
     3121 aacagatctg cttctggtta accacaaacc tagtccacag atcataccat caatgtctgt
     3181 gtccatatac cccagctcag cagaagttct gaaggcatgc aggaatctag gtaaaaatgg
     3241 cttatctaac agtagcattt tgttggataa atgtccacct ccaagaccac catcttcacc
     3301 ataccctccc ttgccaaagg acaagttgaa tccacctaca cctagtattt acttggaaaa
     3361 taaacgtgat gctttctttc ctccattaca tcaattttgt acaaatccga acaaccctgt
     3421 tacagtaata cgtggccttg ctggagctct taagttagac ctgggacttt tctctactaa
     3481 aactttggtg gaagctaaca atgaacatat ggtagaagtg aggacacagt tgttgcagcc
     3541 agcagatgaa aactgggatc ccactggaac aaagaaaatc tggcattgtg aaagtaatag
     3601 atctcatact acaattgcta aatatgcaca gtaccaggcc tcctcattcc aggaatcatt
     3661 gagagaagaa aatgaaaaaa gaagtcatca taaagaccac tcagatagtg aatctacatc
     3721 gtcagataat tctgggagga ggaggaaagg accctttaaa accataaagt ttgggaccaa
     3781 tattgaccta tctgatgaca aaaagtggaa gttgcagcta catgagctga ctaaacttcc
     3841 tgcttttgtg cgtgtcgtat cagcaggaaa tcttctaagc catgttggtc ataccatatt
     3901 gggcatgaac acagttcaac tatacatgaa agttccaggg agcagaacac caggtcatca
     3961 ggaaaataac aacttctgtt cagttaacat aaatattggc ccaggtgact gtgaatggtt
     4021 tgttgttcct gaaggttact ggggtgttct gaatgacttc tgtgaaaaaa ataatttgaa
     4081 tttcctaatg ggttcttggt ggcccaatct tgaagatctt tatgaagcaa atgttccagt
     4141 gtataggttt attcagcgac ctggagattt ggtctggata aatgcaggca ctgttcattg
     4201 ggttcaggct attggctggt gcaacaacat tgcttggaat gttggtccac ttacagcctg
     4261 ccagtataaa ttggcagtgg aacggtacga atggaacaaa ttgcaaagtg tgaagtcaat
     4321 agtacccatg gttcatcttt cctggaatat ggcacgaaat atcaaggtct cagatccaaa
     4381 gctttttgaa atgattaagt attgtcttct aagaactctg aagcaatgtc agacattgag
     4441 ggaagctctc attgctgcag gaaaagagat tatatggcat gggcggacaa aagaagaacc
     4501 agctcattac tgtagcattt gtgaagtgga ggtttttgat ctgctttttg tcactaatga
     4561 gagtaattca cgaaagacct acatagtaca ttgccaagat tgtgcacgaa aaacaagcgg
     4621 aaacttggaa aactttgtgg tgctagaaca gtacaaaatg gaggacctga tgcaagtcta
     4681 tgaccaattt acattagctc ctccattacc atccgcctca tcttgatatt gttccatgga
     4741 cattaaatga gaccttttct gctattcagg aaataaccca gttctgcacc actggttttt
     4801 gtagctatct cgtaaggctg ctggctgaaa actgtgtcta tgcaaccttc caagtgcgga
     4861 gtgtcaacca actggacggg agagagtact gctcctactc caggactctc acaaagctga
     4921 tgagctgtac ttcagaaaaa aataataatt tccatgtttt gtatatatct gacaaaactg
     4981 gcaacatctt acagactact gacttgaaga caacctcttt tatatttctc tatttctggg
     5041 ctgatgaatt tgttttcatc tgtcttttcc cccttcagaa ttttccttgg aaaaaaaata
     5101 ctagcctagc tggtcatttc tttgtaaggt agttagcaat tttaagtctt tctttggtca
     5161 actttttttt aatgtgaaaa gttaggtaag acactttttt actgctttta tgtttttctg
     5221 tcttgttttg agaccatgat ggttacactt ttggttccta aataaaattt aaaaaattaa
     5281 cagccaagtc acaaaggtaa tggattgcac atagactaag gaataaactt cagatttgtg
     5341 atttttgttt ctaatcttga tgtaaattta cactatttat aaatacatat ttattgcttg
     5401 aaaatatttg tgaatggaat gctgttattt tttccagatt tacctgccat tgaaatttta
     5461 aggagttctg taatttcaaa cactactcct attacatttt ctatgtgtaa ataaaactgc
     5521 ttagcattgt acagaaactt ttattaaaat tgtttaatgt ttaaagagtt ttctattgtt
     5581 tgagttttaa aaaagacttt atgtacagtg cccagttttt gttcattttt gaaatctgat
     5641 tatatatatt ttatatatac ttatgtatgt atatataata tatatagaaa tctggatata
     5701 tatgtataaa tctttagaac ttaaattttt ctcgttttaa gtttcacatc tatggtagat
     5761 ttttgaggtg tctactgtaa agtattgctt acaaaaagta tgattatttt taaagaaata
     5821 tatatggtat gtatcctcaa gacctaaaat gtcagactgg tttattgtta agttgcaatt
     5881 actgcaatga cagaccaata aacaattgct gccaaaatgt agtataatag tagaaaacaa
     5941 atagtgattg aacttaagat tttaaaggga ctgttatatg ggcttgacaa atcctgtaca
     6001 atacttagta ccattttata tggaaaaggg gattcaggat gaagggctct attttagaat
     6061 gcaaataaat taagagactt attttttaat gtta
//
