LOCUS       NM_004653               6825 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens lysine demethylase 5D (KDM5D), transcript variant 2,
            mRNA.
ACCESSION   NM_004653
VERSION     NM_004653.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6825)
  AUTHORS   Li,J., Lan,Z., Liao,W., Horner,J.W., Xu,X., Liu,J., Yoshihama,Y.,
            Jiang,S., Shim,H.S., Slotnik,M., LaBella,K.A., Wu,C.J., Dunner,K.
            Jr., Hsu,W.H., Lee,R., Khanduri,I., Terranova,C., Akdemir,K.,
            Chakravarti,D., Shang,X., Spring,D.J., Wang,Y.A. and DePinho,R.A.
  TITLE     Histone demethylase KDM5D upregulation drives sex differences in
            colon cancer
  JOURNAL   Nature 619 (7970), 632-639 (2023)
   PUBMED   37344599
  REMARK    GeneRIF: Histone demethylase KDM5D upregulation drives sex
            differences in colon cancer.
REFERENCE   2  (bases 1 to 6825)
  AUTHORS   Liu,M. and Gao,N.
  TITLE     KDM5D inhibits the transcriptional activation of FKBP4 by
            suppressing the expression of E2F1 in colorectal cancer in males
  JOURNAL   Biochem Pharmacol 194, 114814 (2021)
   PUBMED   34688635
  REMARK    GeneRIF: KDM5D inhibits the transcriptional activation of FKBP4 by
            suppressing the expression of E2F1 in colorectal cancer in males.
REFERENCE   3  (bases 1 to 6825)
  AUTHORS   Willis-Owen,S.A.G., Domingo-Sabugo,C., Starren,E., Liang,L.,
            Freidin,M.B., Arseneault,M., Zhang,Y., Lu,S.K., Popat,S., Lim,E.,
            Nicholson,A.G., Riazalhosseini,Y., Lathrop,M., Cookson,W.O.C. and
            Moffatt,M.F.
  TITLE     Y disruption, autosomal hypomethylation and poor male lung cancer
            survival
  JOURNAL   Sci Rep 11 (1), 12453 (2021)
   PUBMED   34127738
  REMARK    GeneRIF: Y disruption, autosomal hypomethylation and poor male lung
            cancer survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6825)
  AUTHORS   Pottmeier,P., Doszyn,O., Peuckert,C. and Jazin,E.
  TITLE     Increased Expression of Y-Encoded Demethylases During
            Differentiation of Human Male Neural Stem Cells
  JOURNAL   Stem Cells Dev 29 (23), 1497-1509 (2020)
   PUBMED   33040644
  REMARK    GeneRIF: Increased Expression of Y-Encoded Demethylases During
            Differentiation of Human Male Neural Stem Cells.
REFERENCE   5  (bases 1 to 6825)
  AUTHORS   Tricarico,R., Nicolas,E., Hall,M.J. and Golemis,E.A.
  TITLE     X- and Y-Linked Chromatin-Modifying Genes as Regulators of
            Sex-Specific Cancer Incidence and Prognosis
  JOURNAL   Clin Cancer Res 26 (21), 5567-5578 (2020)
   PUBMED   32732223
  REMARK    GeneRIF: X- and Y-Linked Chromatin-Modifying Genes as Regulators of
            Sex-Specific Cancer Incidence and Prognosis.
            Review article
REFERENCE   6  (bases 1 to 6825)
  AUTHORS   Agulnik,A.I., Bishop,C.E., Lerner,J.L., Agulnik,S.I. and
            Solovyev,V.V.
  TITLE     Analysis of mutation rates in the SMCY/SMCX genes shows that
            mammalian evolution is male driven
  JOURNAL   Mamm Genome 8 (2), 134-138 (1997)
   PUBMED   9060413
REFERENCE   7  (bases 1 to 6825)
  AUTHORS   Simpson,E., Scott,D. and Chandler,P.
  TITLE     The male-specific histocompatibility antigen, H-Y: a history of
            transplantation, immune response genes, sex determination and
            expression cloning
  JOURNAL   Annu Rev Immunol 15, 39-61 (1997)
   PUBMED   9143681
  REMARK    Review article
REFERENCE   8  (bases 1 to 6825)
  AUTHORS   Kent-First,M.G., Maffitt,M., Muallem,A., Brisco,P., Shultz,J.,
            Ekenberg,S., Agulnik,A.I., Agulnik,I., Shramm,D., Bavister,B.,
            Abdul-Mawgood,A. and VandeBerg,J.
  TITLE     Gene sequence and evolutionary conservation of human SMCY
  JOURNAL   Nat Genet 14 (2), 128-129 (1996)
   PUBMED   8841177
  REMARK    Erratum:[Nat Genet 1996 Nov;14(3):252]
REFERENCE   9  (bases 1 to 6825)
  AUTHORS   Wang,W., Meadows,L.R., den Haan,J.M., Sherman,N.E., Chen,Y.,
            Blokland,E., Shabanowitz,J., Agulnik,A.I., Hendrickson,R.C.,
            Bishop,C.E. et al.
  TITLE     Human H-Y: a male-specific histocompatibility antigen derived from
            the SMCY protein
  JOURNAL   Science 269 (5230), 1588-1590 (1995)
   PUBMED   7667640
REFERENCE   10 (bases 1 to 6825)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Lerner,J.L., Woods,D.R. and
            Bishop,C.E.
  TITLE     A mouse Y chromosome gene encoded by a region essential for
            spermatogenesis and expression of male-specific minor
            histocompatibility antigens
  JOURNAL   Hum Mol Genet 3 (6), 873-878 (1994)
   PUBMED   7524912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52191.1, BC132721.1,
            BC146767.1, AA864889.1 and AC010889.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004653.4.
            
            Summary: This gene encodes a protein containing zinc finger
            domains. A short peptide derived from this protein is a minor
            histocompatibility antigen which can lead to graft rejection of
            male donor cells in a female recipient. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            coding region, compared to variant 1. This results in a shorter
            protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52191.1, GQ900944.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317961.9/ ENSP00000322408.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1053              U52191.1           201-1253
            1054-4879           BC132721.1         1190-5015
            4880-5271           BC146767.1         4744-5135
            5272-5275           AA864889.1         15-18               c
            5276-6825           AC010889.3         104100-105649       c
FEATURES             Location/Qualifiers
     source          1..6825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..6825
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="lysine demethylase 5D"
                     /db_xref="GeneID:8284"
                     /db_xref="HGNC:HGNC:11115"
                     /db_xref="MIM:426000"
     exon            1..56
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            57..225
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4695
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /EC_number="1.14.11.67"
                     /note="isoform 2 is encoded by transcript variant 2; SMC
                     homolog, Y chromosome; lysine (K)-specific demethylase 5D;
                     Jumonji, AT rich interactive domain 1D (RBP2-like);
                     histocompatibility Y antigen; selected mouse cDNA on Y,
                     human homolog of; H-Y; protein SmcY; histone demethylase
                     JARID1D; jumonji/ARID domain-containing protein 1D; Smcy
                     homolog, Y-linked; epididymis secretory sperm binding
                     protein; [histone H3]-trimethyl-L-lysine(4) demethylase
                     5D"
                     /codon_start=1
                     /product="lysine-specific demethylase 5D isoform 2"
                     /protein_id="NP_004644.2"
                     /db_xref="CCDS:CCDS14794.1"
                     /db_xref="GeneID:8284"
                     /db_xref="HGNC:HGNC:11115"
                     /db_xref="MIM:426000"
                     /translation="MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERI
                     IYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQP
                     DPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQS
                     GGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDG
                     CDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMAD
                     SFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQ
                     NLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDH
                     WSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTL
                     MSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYR
                     RLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEA
                     EREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYR
                     YTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPN
                     SELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQ
                     IGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQ
                     AQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEE
                     KAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGD
                     HYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEV
                     LCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKE
                     GILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVP
                     HLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEG
                     EALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATAC
                     DPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEA
                     IRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRS
                     RALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFL
                     TPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL"
     exon            226..303
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            304..426
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            427..597
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            598..732
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            733..862
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1008
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1167
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1287
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1446
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1628
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1791
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1911
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2106
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2288
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2413
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2561
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2658
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..3017
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3156
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3336
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3474
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..4074
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            4075..4144
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4344
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..6825
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5064..5069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="hexamer: CATAAA"
     polyA_site      5088
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
     regulatory      5243..5248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="hexamer: AATAAA"
     polyA_site      5275
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="major polyA site"
     regulatory      6804..6809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
                     /note="hexamer: AATAAA"
     polyA_site      6825
                     /gene="KDM5D"
                     /gene_synonym="HY; HYA; JARID1D; SMCY"
ORIGIN      
        1 actgcagggc ccggaggtca agatggtggc tgtaaaacta ggatccctga cgattgctta
       61 gcattaaggc ccgacatgga accggggtgt gacgagttcc tgccgccacc ggagtgcccg
      121 gtttttgagc ctagctgggc tgaattccaa gacccgcttg gctacattgc gaaaataagg
      181 cccatagcag agaagtctgg catctgcaaa atccgcccac ccgcggattg gcagcctcct
      241 tttgcagtag aagttgacaa tttcagattt actcctcgcg tccaaaggct aaatgaactg
      301 gaggcccaaa ctagagtgaa attgaactat ttggatcaga ttgcaaaatt ctgggaaatt
      361 caaggctcct ctttaaagat tcccaatgtg gagcggaaga tcttggacct ctacagcctt
      421 agtaagattg tgattgagga aggtggctat gaagccatct gcaaggatcg tcggtgggct
      481 cgagttgccc agcgtctcca ctacccacca ggcaaaaaca ttggctccct gctacgatca
      541 cattacgaac gcattattta cccctatgaa atgtttcagt ctggagccaa ccatgtgcaa
      601 tgtaacacac acccgtttga caatgaggta aaagataagg aatacaagcc ccacagcatc
      661 ccccttagac agtctgtgca gccttcaaag ttcagcagct acagtcgacg ggcaaaaagg
      721 ctacagcctg atccagagcc tacagaggag gacattgaga agcatccaga gctaaagaag
      781 ttacagatat atgggccagg tcccaaaatg atgggcttgg gccttatggc taaggataag
      841 gataagactg tgcataagaa agtcacatgc cccccaactg ttacggtgaa ggatgagcaa
      901 agtggaggtg ggaacgtgtc atcaacattg ctcaagcagc acttgagcct agagccctgc
      961 actaagacaa ccatgcaact tcgaaagaat cacagcagtg cccagtttat tgactcatat
     1021 atttgccaag tatgctcccg tggggatgaa gatgataagc ttcttttctg tgatggctgt
     1081 gatgacaatt accacatctt ctgcttgtta ccaccccttc ctgaaatccc cagaggcatc
     1141 tggaggtgcc caaaatgtat cttggcggag tgtaaacagc ctcctgaagc ttttggattt
     1201 gaacaggcta cccaggagta cagtttgcag agttttggtg aaatggctga ttccttcaag
     1261 tccgactact tcaacatgcc tgtacatatg gtgcctacag aacttgtaga gaaggaattc
     1321 tggaggctgg tgagcagcat tgaggaagac gtgacagttg aatatggagc tgatattcat
     1381 tccaaagaat ttggcagtgg ctttcctgtc agcaatagca aacaaaactt atctcctgag
     1441 gagaaggagt atgcgaccag tggttggaac ctgaatgtga tgccagtgct agatcagtct
     1501 gttctctgtc acatcaatgc agacatctca ggcatgaagg tgccctggct gtacgtgggc
     1561 atggttttct cagcattttg ttggcatatt gaggatcact ggagttactc tattaactat
     1621 ctgcattggg gtgagccgaa gacctggtat ggtgtaccct ccctggcagc agagcatttg
     1681 gaggaggtga tgaagatgct gacacctgag ctgtttgata gccagcctga tctcctacac
     1741 cagcttgtca ctctcatgaa tcccaacact ttgatgtccc atggtgtgcc agttgtccgc
     1801 acaaaccagt gtgcagggga gtttgtcatc acttttcctc gtgcttacca cagtggtttt
     1861 aaccaaggct acaattttgc tgaagctgtc aacttttgta ctgctgactg gctacctgct
     1921 ggacgccagt gcattgaaca ctaccgccgg ctccggcgct attgtgtctt ctcccacgag
     1981 gagctcatct gcaagatggc tgccttccca gagacgttgg atctcaatct agcagtagct
     2041 gtgcacaagg agatgttcat tatggttcag gaggagcgac gtctacgaaa ggcccttttg
     2101 gagaagggcg tcacggaggc tgagcgagag gcttttgagc tgctcccaga tgatgaacgc
     2161 cagtgcatca agtgcaagac cacgtgcttc ttgtcagccc tggcctgcta cgactgccca
     2221 gatggccttg tatgcctttc ccacatcaat gacctctgca agtgctctag tagccgacag
     2281 tacctccggt atcggtacac cttggatgag ctccccacca tgctgcataa actgaagatt
     2341 cgggctgagt cttttgacac ctgggccaac aaagtgcgag tggccttgga ggtggaggat
     2401 ggccgtaaac gcagctttga agagctaagg gcactggagt ctgaggctcg tgagaggagg
     2461 tttcctaata gtgagctgct tcagcgactg aagaactgcc tgagtgaggt ggaggcttgt
     2521 attgctcaag tcctggggct ggtcagtggt caggtggcca ggatggacac tccacagctg
     2581 accttgactg aactccgggt ccttcttgag cagatgggca gcctgccctg tgccatgcat
     2641 cagattgggg atgtcaagga tgtcctggaa caggtggagg cctatcaagc tgaggctcgt
     2701 gaggctctgg ccacactgcc ctctagtcca gggctattgc ggtccctgtt ggagaggggg
     2761 cagcagctgg gtgtagaggt gcctgaagcc catcagcttc agcagcaggt ggagcaggcg
     2821 caatggctag atgaagtgaa gcaggccctg gccccttctg ctcacagggg ctctctggtc
     2881 atcatgcagg ggcttttggt tatgggtgcc aagatagcct ccagcccttc tgtggacaag
     2941 gcccgggctg agctgcaaga actactgacc attgcagagc gctgggaaga aaaggctcat
     3001 ttctgcctgg aggccaggca gaagcatcca ccagccacat tggaagccat aattcgtgag
     3061 acagaaaaca tccctgttca cctgcctaac atccaggctc tcaaagaagc tctgactaag
     3121 gcacaagctt ggattgctga tgtggatgag atccaaaatg gtgaccacta cccctgtcta
     3181 gatgacttgg agggcctggt ggctgtgggc cgggacctgc ctgtggggct ggaagagctg
     3241 agacagctag agctgcaggt attgacagca cattcctgga gagagaaggc ctccaagacc
     3301 tttctcaaga agaattcttg ctacacactg cttgaggtgc tttgcccgtg tgcagacgct
     3361 ggctcagaca gcaccaagcg tagccggtgg atggagaagg cgctggggtt gtaccagtgt
     3421 gacacagagc tgctggggct gtctgcacag gacctcagag acccaggctc tgtgattgtg
     3481 gccttcaagg aaggggaaca gaaggagaag gagggtatcc tgcagctgcg tcgcaccaac
     3541 tcagccaagc ccagtccact ggcaccatcc ctcatggcct cttctccgac ttctatctgt
     3601 gtgtgtgggc aggtgccagc tggggtggga gttctgcagt gtgacctgtg tcaggactgg
     3661 ttccatgggc agtgtgtgtc agtgccccat ctcctcacct ctccaaagcc cagtctcact
     3721 tcatctccac tgctagcctg gtgggaatgg gacacaaaat tcctgtgtcc actgtgtatg
     3781 cgctcacgac ggccacgcct agagacaatc ctagccttgc tggttgccct gcagaggctg
     3841 cccgtgcggc tgcctgaggg tgaggccctt cagtgtctca cagagagggc cattggctgg
     3901 caagaccgtg ccagaaaggc tctggcctct gaagatgtga ctgctctgtt gcgacagctg
     3961 gctgagcttc gccaacagct acaggccaaa cccagaccag aggaggcctc agtctacact
     4021 tcagccactg cctgtgaccc tatcagagaa ggcagtggca acaatatttc taaggtccaa
     4081 gggctgctgg agaatggaga cagtgtgacc agtcctgaga acatggctcc aggaaagggc
     4141 tctgacctgg agctactgtc ctcactgttg ccgcagttga ctggccctgt gttggagctg
     4201 cctgaggcaa tccgggctcc cctggaggag ctcatgatgg aaggggacct gcttgaggtg
     4261 accctggatg agaaccacag catctggcag ctgctgcagg ctggacagcc tccagacctg
     4321 gacagaattc gcacacttct ggagctggaa aaatttgaac atcaagggag tcggacaagg
     4381 agccgggctc tggagaggcg acggcggcgg cagaaggtgg atcagggtag aaacgttgag
     4441 aatcttgttc aacaggagct tcagtcaaaa agggctcgga gctcagggat tatgtctcag
     4501 gtgggccgag aagaagaaca ttatcaggag aaagcagacc gtgaaaatat gttcctgaca
     4561 ccttccacag accacagccc tttcttgaaa ggaaaccaaa atagcttaca acacaaggat
     4621 tcaggctctt cagctgcttg tccttcttta atgcctttgc tacaactctc ctactctgat
     4681 gagcaacagt tgtgacagtg gcaccaaagg tcatttgtgg ttgtttttgt ttgtttgttt
     4741 cttaaatcct actatctcct ggcctggacc tcagaaggag ctttttgctt atctataatt
     4801 tttcactgcc aatttttgat atcctctctc ctagagttac tgttaaaagg ttggttcgta
     4861 aagtccacac cccgatgctc agaagtgtct tgccagcaac attcctgcta gcatacagga
     4921 gtgatttcct aaaccagttt cattctagtc tgaataggga caaacaaatc ttgaggaagc
     4981 ccaagtgcgt acctttattt ttgcccccac caccctcttt ctgtacttca atttttgttt
     5041 gttttttgtt tttttgtccc tgtcataaaa tattttggtg cttcaaaact tgtaccttca
     5101 ttgtacatcc ttttcttttc tccccttggg tcttattata aaagaagaca atgtacgttg
     5161 taattaccaa aaagaatagg gaaaaacaag aatttcatga ctctacctgt ggtctatctt
     5221 taatttcatt tcttttgtta aaaataaaac aatgagtatg tttggatact atgaatatga
     5281 tttgaacttc ttaaattgta cgagtgaagg actgaggtta ggaaacaaca gtagcatggg
     5341 tcaacgtaat ttttaatagt ctttttcggg gcagtgggga agggtaaatt ttacttagaa
     5401 aacatacatg agacttaggc caaggttaat gttttctcaa aggatgtcca gttgacccag
     5461 caccagcaat agaaaactta cctgtcctac acttaattgc tttgtgcttt ttattgaaaa
     5521 tctgttggct ggacttgcat gtgccaatat ctgagttaac ttgttgcatt gcatcattta
     5581 actatgtgtc tgtcccctgt ggccagatca caatgtcttg gttacagtcg ctttataata
     5641 agtcttacat cagggtagac agattcatct cacttttttg tttttcagat tgttttagca
     5701 agttaagtca ccagctctct ttttcattat gtagtagctt ttgtgtccta aatctgatta
     5761 agttgcactg acacaagtta tctccctcaa tattttctgt tctttcaact ggtgaataca
     5821 atagctaatc taaatcattt gttgtaagaa ttcagtagga ttgatgtgta aatatttcag
     5881 gtaaaaccac tctattagta taccactaat tcaattcacg gttcttgttt tgtgtgtctc
     5941 tgggtgatct aataatacag actgtattat acttctttta atccctttaa aggtgaacgc
     6001 attctgtcat cctggattga atctctcgct tttccaccta ctccttgctg acttgagtca
     6061 gtgtagaaca cgttattacc catagcattt ctcatgccta taatcatacc taccttcctt
     6121 attgtctact cttttcacct ctttctttct ttgatactgt catagggaac tataattagc
     6181 tttcccagta acaaagctat gcttggtgat gacctagtag agtagaaatt gcttcacctg
     6241 tccaagtaca gtgtacttta ccttaccaca ccatagggac caggtaaaat atatagaaaa
     6301 tcctgagata atttatctaa atctgagaat tgtcttcgaa atttcttttt tctcctcttc
     6361 cataaatagg aggaaagtca tgattctcaa gccattacag attctctgac acttgttaac
     6421 ggaaaattct gatgaggcat gatgagaact tctgcctata aaaatctcac taaagttctg
     6481 agtcacaaat tgttcacata cttcacagta agcaggcaat ccaatgtcag gacagttgta
     6541 cacctttctt aggttgcctc ccctaattgg ggctgtattt gacatgaggg gccagttttg
     6601 acacttttta aaaccataca caaggatgca gcactaagtt tttgcacata ggcaagaatt
     6661 tatcttgtga ttagaagtta gttatatgtt cattaagaaa catgacgaaa tctgcagcaa
     6721 aaattgaatt tcataggcca ttcagtgttc tctgcgataa ttctaattca gaaaaaaatt
     6781 gaatcttggt ttaaaaaaat tgtaataaaa ctttaccact ggtaa
//
