LOCUS       NM_004187               5810 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 1,
            mRNA.
ACCESSION   NM_004187
VERSION     NM_004187.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5810)
  AUTHORS   Audu,C.O., Wolf,S.J., Joshi,A.D., Moon,J.Y., Melvin,W.J.,
            Sharma,S.B., Davis,F.M., Obi,A.T., Wasikowski,R., Tsoi,L.C.,
            Barrett,E.C., Mangum,K.D., Bauer,T.M., Kunkel,S.L., Moore,B.B. and
            Gallagher,K.A.
  TITLE     Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic cells
  JOURNAL   JCI Insight 9 (12), e172959 (2024)
   PUBMED   38912581
  REMARK    GeneRIF: Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5810)
  AUTHORS   Deogharia,M., Venegas-Zamora,L., Agrawal,A., Shi,M., Jain,A.K.,
            McHugh,K.J., Altamirano,F., Marian,A.J. and Gurha,P.
  TITLE     Histone demethylase KDM5 regulates cardiomyocyte maturation by
            promoting fatty acid oxidation, oxidative phosphorylation, and
            myofibrillar organization
  JOURNAL   Cardiovasc Res 120 (6), 630-643 (2024)
   PUBMED   38230606
  REMARK    GeneRIF: Histone demethylase KDM5 regulates cardiomyocyte
            maturation by promoting fatty acid oxidation, oxidative
            phosphorylation, and myofibrillar organization.
REFERENCE   3  (bases 1 to 5810)
  AUTHORS   Qiang,Y., Fan,J., Xie,C., Yan,L., Song,X., Zhang,N., Lin,Y.,
            Xiong,J., Zhang,W., Liu,Y., Wei,L., Li,Y., Chen,S., Liang,K. and
            Li,F.
  TITLE     KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer
            Activation and BET Inhibitor Sensitivity
  JOURNAL   Cancer Res 84 (8), 1252-1269 (2024)
   PUBMED   38285760
  REMARK    GeneRIF: KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates
            Enhancer Activation and BET Inhibitor Sensitivity.
REFERENCE   4  (bases 1 to 5810)
  AUTHORS   Karwacki-Neisius,V., Jang,A., Cukuroglu,E., Tai,A., Jiao,A.,
            Predes,D., Yoon,J., Brookes,E., Chen,J., Iberg,A., Halbritter,F.,
            Ounap,K., Gecz,J., Schlaeger,T.M., Ho Sui,S., Goke,J., He,X.,
            Lehtinen,M.K., Pomeroy,S.L. and Shi,Y.
  TITLE     WNT signalling control by KDM5C during development affects
            cognition
  JOURNAL   Nature 627 (8004), 594-603 (2024)
   PUBMED   38383780
  REMARK    GeneRIF: WNT signalling control by KDM5C during development affects
            cognition.
REFERENCE   5  (bases 1 to 5810)
  AUTHORS   Yu,F., Li,L., Gu,Y., Wang,S., Zhou,L., Cheng,X., Jiang,H.,
            Huang,Y., Zhang,Y., Qian,W., Li,X. and Liu,Z.
  TITLE     Lysine demethylase 5C inhibits transcription of prefoldin subunit 5
            to activate c-Myc signal transduction and colorectal cancer
            progression
  JOURNAL   Mol Med 30 (1), 9 (2024)
   PUBMED   38216914
  REMARK    GeneRIF: Lysine demethylase 5C inhibits transcription of prefoldin
            subunit 5 to activate c-Myc signal transduction and colorectal
            cancer progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5810)
  AUTHORS   Jensen,L.R., Amende,M., Gurok,U., Moser,B., Gimmel,V., Tzschach,A.,
            Janecke,A.R., Tariverdian,G., Chelly,J., Fryns,J.P., Van Esch,H.,
            Kleefstra,T., Hamel,B., Moraine,C., Gecz,J., Turner,G.,
            Reinhardt,R., Kalscheuer,V.M., Ropers,H.H. and Lenzner,S.
  TITLE     Mutations in the JARID1C gene, which is involved in transcriptional
            regulation and chromatin remodeling, cause X-linked mental
            retardation
  JOURNAL   Am J Hum Genet 76 (2), 227-236 (2005)
   PUBMED   15586325
REFERENCE   7  (bases 1 to 5810)
  AUTHORS   Agate,R.J., Choe,M. and Arnold,A.P.
  TITLE     Sex differences in structure and expression of the sex chromosome
            genes CHD1Z and CHD1W in zebra finches
  JOURNAL   Mol Biol Evol 21 (2), 384-396 (2004)
   PUBMED   14660691
REFERENCE   8  (bases 1 to 5810)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Mattei,M.G., Borsani,G., Avner,P.A.,
            Lerner,J.L. and Bishop,C.E.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   9  (bases 1 to 5810)
  AUTHORS   Wu,J., Ellison,J., Salido,E., Yen,P., Mohandas,T. and Shapiro,L.J.
  TITLE     Isolation and characterization of XE169, a novel human gene that
            escapes X-inactivation
  JOURNAL   Hum Mol Genet 3 (1), 153-160 (1994)
   PUBMED   8162017
REFERENCE   10 (bases 1 to 5810)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139396.18, L25270.1,
            BC054499.2 and BC047751.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 5, 2019 this sequence version replaced NM_004187.4.
            
            Summary: This gene is a member of the SMCY homolog family and
            encodes a protein with one ARID domain, one JmjC domain, one JmjN
            domain and two PHD-type zinc fingers. The DNA-binding motifs
            suggest this protein is involved in the regulation of transcription
            and chromatin remodeling. Mutations in this gene have been
            associated with X-linked cognitive disability. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L25270.1, SRR7346977.2866321.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375401.8/ ENSP00000364550.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AL139396.18        111531-111746       c
            217-3912            L25270.1           430-4125
            3913-3914           BC054499.2         3879-3880
            3915-5106           L25270.1           4128-5319
            5107-5697           L25270.1           5321-5911
            5698-5810           BC047751.1         1010-1122
FEATURES             Location/Qualifiers
     source          1..5810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..5810
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
     exon            1..468
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..5001
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /EC_number="1.14.11.67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Jumonji, AT rich interactive domain 1C (RBP2-like);
                     lysine-specific demethylase 5C; Smcx homolog, X
                     chromosome; lysine (K)-specific demethylase 5C; JmjC
                     domain-containing protein SMCX; Jumonji/ARID
                     domain-containing protein 1C; histone demethylase JARID1C;
                     Smcy homolog, X-linked; [histone H3]-trimethyl-L-lysine(4)
                     demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C isoform 1"
                     /protein_id="NP_004178.2"
                     /db_xref="CCDS:CCDS14351.1"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
                     /translation="MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERI
                     VYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQP
                     DPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEE
                     LGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGD
                     EDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREY
                     TLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFG
                     SGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVF
                     SAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQ
                     LVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLP
                     AGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRK
                     ALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKC
                     SSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALE
                     SEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAF
                     LDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVE
                     VPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAE
                     LQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKAR
                     AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKT
                     FLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSV
                     IVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDL
                     CQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALL
                     VALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPR
                     PEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLS
                     SLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRT
                     LLELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQE
                     EEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCP
                     QQPPQQQL"
     exon            469..546
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            547..669
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            670..840
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            841..975
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1099
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1281
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1440
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1560
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1719
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1901
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2064
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2184
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2379
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2561
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2686
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2834
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2940
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3299
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3438
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3618
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3756
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..4356
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4435
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4635
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..5810
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5660..5665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="hexamer: AATAAA"
     polyA_site      5685
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="major polyA site"
     regulatory      5781..5786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="hexamer: AATAAA"
     polyA_site      5810
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="major polyA site"
ORIGIN      
        1 gacaaaccaa gatggcggcg gcggcgctga aggccgcggc gtttgggagg taactgtggt
       61 ggcgaaggct gcggtagtgg ggaggcaacc acacagtttg gaagaaacgg agcgggacga
      121 agaggcggta gcagtagagt cagcctgaga ctctcagagc acgacggcca cacgccccct
      181 taggccctcg gcgggcggcg gctgccccgc ttagggccta gcctccgagc attgcctcgg
      241 cttcaaacag cggcggcgcc atgagtcctt aagggcggtc caagcctccc gatccctggc
      301 ccagacctcg ggcccaccat ggagccgggg tccgacgatt tcctaccgcc accggagtgc
      361 ccggtgttcg agcctagctg ggccgagttc cgagaccctc ttggctacat cgcgaaaatc
      421 aggcccatcg cagagaaatc gggcatttgc aagatccgcc cacccgcgga ctggcagcca
      481 ccctttgctg tggaagtgga caacttcagg tttacccccc gaatccagag gctgaatgag
      541 ctagaggccc agacgagagt gaaactgaac tacttggacc agattgccaa attctgggaa
      601 atccagggct cctccttaaa gattcccaat gtagaacggc ggatcttgga cctctacagt
      661 ctcagcaaaa ttgtggtgga ggaaggtggt tatgaagcta tctgcaagga ccgtcggtgg
      721 gctcgggtag cccagcgcct caactatcca ccaggcaaaa atattggctc cttgctacgc
      781 tcccactacg aacgcattgt ttatccctat gaaatgtacc agtctggagc caaccttgtg
      841 cagtgtaaca cacgtccatt tgataatgag gagaaggaca aggaatacaa accccacagc
      901 atccccctac gacagtctgt gcagccttcc aagttcaaca gctatggccg gcgggccaag
      961 agactgcagc ctgatccgga acccacagag gaagacattg agaagaatcc agagctgaaa
     1021 aagctacaga tctatggggc aggccccaag atgatgggcc tgggcctcat ggccaaagac
     1081 aagactctgc ggaagaaaga taaggagggg cctgagtgtc cccccacagt agtggtgaag
     1141 gaggagttag gtggggatgt gaaggtggag tcaacatcgc ctaagacctt cctggagagc
     1201 aaggaggagc tgagtcacag cccagaaccc tgcaccaaga tgaccatgag gctacggagg
     1261 aaccacagca atgcccagtt tattgagtca tatgtctgcc ggatgtgttc tcgaggggat
     1321 gaggatgaca agctcctgct gtgtgatggc tgtgatgaca actaccacat cttctgcctg
     1381 ctgcctcctc tgcctgagat ccccaagggt gtctggcggt gcccaaagtg tgtcatggcg
     1441 gagtgtaagc ggcccccaga agcctttggc tttgagcagg ctacccggga atacactctg
     1501 cagagctttg gcgagatggc cgactccttt aaagctgact acttcaacat gcccgtgcat
     1561 atggtgccca cagaacttgt ggagaaggag ttctggaggc tggtaaatag cattgaggaa
     1621 gatgtgactg ttgagtatgg agctgacatc cattccaaag aatttggcag cggtttccct
     1681 gtcagtgaca gtaaacggca cctaaccccc gaagaggagg agtatgctac cagtggttgg
     1741 aacctaaatg tgatgccggt gttggaacag tctgtactgt gccacatcaa tgcagatatc
     1801 tctggcatga aggtgccctg gctctacgtg ggcatggtct tctcagcctt ttgctggcat
     1861 attgaggatc actggagtta ctccattaac tacctccact ggggtgagcc gaagacctgg
     1921 tatggggtgc cctcacttgc agcagaacat ttggaagaag tgatgaagaa gctgacacct
     1981 gaactatttg atagccagcc tgacctcctg caccaacttg tcaccctcat gaatcccaac
     2041 accctcatgt cccatggtgt gccagttgtc cgcacaaacc agtgtgcagg agagtttgtc
     2101 atcaccttcc cccgtgctta ccacagcggc ttcaaccaag gctacaactt tgccgaggct
     2161 gtcaactttt gcactgctga ctggttgcct gctgggcgcc agtgcattga gcactaccgc
     2221 cggctccgga gatactgcgt cttctcccat gaggagctta tctgcaagat ggctgcctgc
     2281 ccagagaagc tagacctgaa cctggcggca gctgtgcata aggagatgtt catcatggtg
     2341 caagaagagc ggcgtctacg aaaggccctg ctggagaagg gtatcacaga ggctgagcga
     2401 gaggctttcg agctgctccc agatgatgag cgccagtgta tcaagtgcaa gactacgtgt
     2461 ttcctgtcag ccctggcctg ctacgactgc ccagacggcc ttgtctgcct ttcccacatc
     2521 aatgatctct gcaagtgctc cagtagccgg cagtacctgc ggtatcggta taccttggat
     2581 gagcttcctg ccatgctgca taagctgaag gttcgggctg agtcctttga cacctgggcc
     2641 aacaaagtgc gagtggccct ggaggtggag gatgggcgga agcgcagcct tgaagaactg
     2701 agggcactag agtctgaagc ccgtgagcgg aggtttccta atagtgagct gctgcagcaa
     2761 ctaaagaact gcctgagtga ggcagaggct tgcgtgtccc gagctctggg actggtcagc
     2821 ggccaggaag ctggccccca cagggtggct ggtctacaga tgaccctgac tgagctccgg
     2881 gcctttctgg accagatgaa caacctgcct tgcgccatgc accagattgg ggatgtcaag
     2941 ggtgttctgg aacaggtgga ggcctaccag gctgaggctc gtgaggccct ggcctcactg
     3001 ccctccagtc cagggctact gcagtccctg ttggagaggg ggcggcagct gggggtggag
     3061 gtgcctgagg cccagcagct ccagcggcag gtggaacagg cgcgatggct ggatgaggtg
     3121 aaacgcacac tggccccctc agcccgaagg ggcaccttgg ctgtcatgcg aggactgttg
     3181 gtcgcgggtg ccagtgtagc ccctagccct gctgtggata aagcccaggc cgagctgcag
     3241 gaactgctga ccattgctga acgctgggag gagaaagccc acctctgcct ggaggccagg
     3301 cagaagcatc caccagccac acttgaggcc ataatccgtg aagcggaaaa catccctgtt
     3361 cacctgccca acatccaggc tctcaaggag gctcttgcta aggcccgggc ctggattgct
     3421 gatgttgatg agatccaaaa tggtgaccac tacccctgcc tggatgactt ggagggccta
     3481 gtagctgtgg gccgggacct acctgtgggg ctggaggagc tgagacagct agagctacag
     3541 gtactgacag cgcactcctg gagggagaag gcctccaaga ccttcctcaa gaaaaattct
     3601 tgctacacgc tgctggaggt tctctgccca tgtgcagatg ccggctcaga cagcaccaag
     3661 cgcagccggt ggatggagaa ggagctgggg ttgtacaaat ctgacacaga gctgctgggg
     3721 ctgtctgcgc aggacctcag ggacccaggc tctgtgatcg tggccttcaa ggagggggaa
     3781 cagaaggaga aggagggtat cctgcagctg cgtcgcacca attcggccaa gcccagtcca
     3841 ctggcatcat cgagcacggc ctcctctaca acctctatct gtgtgtgtgg gcaggtgctg
     3901 gctggggcgg gagctctgca gtgtgacctg tgtcaggact ggttccatgg gcggtgtgtg
     3961 tcagtgcctc gcctcctcag ctctccgagg cccaatccca cctcatcccc actgctggcc
     4021 tggtgggaat gggacaccaa attcctgtgt ccactgtgta tgcgctcaag gcgcccgcgc
     4081 ctggagacca tcctggcact gctggtagcc ctgcagagac tgcctgtgcg gctgcccgag
     4141 ggcgaggccc tgcagtgcct cacagagagg gccatcagct ggcaaggccg cgccaggcag
     4201 gctctggcct ctgaagatgt gactgctctt ttgggacggc tggctgagct ccgccaacgg
     4261 ctacaggctg aacctagacc tgaggagcct cctaactacc ctgcagcccc tgcttctgac
     4321 cccctcagag agggcagtgg caaggatatg cctaaggtcc agggcttact ggagaatgga
     4381 gacagtgtga ccagtcctga gaaggtagcc ccggaggagg gctcaggtaa gagagatctg
     4441 gagctgctgt cctcgctgtt gccacagttg actggccctg tgttggaact gcctgaggca
     4501 acccgggccc ccttggagga gctcatgatg gagggggacc tgctcgaggt gaccctggat
     4561 gagaaccaca gcatatggca gctgctgcag gctggacagc ccccagacct ggagaggatc
     4621 cgcacacttc tggagctgga gaaggcagag cgtcacggga gtcgggctcg gggccgggcc
     4681 ctggagaggc ggcggcggcg gaaggtggat cggggtgggg agggcgatga cccagcccga
     4741 gaggagctag agccaaagag ggtacggagc tcagggccag aggctgagga ggtccaggag
     4801 gaggaagagc tggaggagga gactgggggt gagggccccc ctgcacccat ccccaccact
     4861 ggcagcccca gcacccagga gaaccagaat ggcttggaac cggcggaagg gaccacttca
     4921 ggcccctcgg cccctttctc cactctgact ccccggctgc atctgccctg cccacagcag
     4981 ccgcctcagc aacagttgtg acagtggctg agcctagcac agaccctgac agagaccccc
     5041 ctcggcctca aggatcctct ttctgaccat caagcctgct tcttgggggg tgggcgggta
     5101 ggggggtggc catccctgct acccgcccac ccctgagtcc cttgactttt gtattctgac
     5161 tccaaggtat tgttcagacc tcagctcctg ggggccggcc cctggagtct tccctccctg
     5221 gtagcctcta accagcattc ccagacacct gaggcagata gatggatggg ctggtgggca
     5281 ggggggtggc tggggctggg ccatcaccat tccagagaca aggccagtgt atatgcaaac
     5341 tgggggactc tcctcccttc tctccccagt tctggtcctg gccaggccat gctacactaa
     5401 cccctgcccc cactctcctc ccctcttttc cttccttcct acccccttct ccctctccct
     5461 tcccctgact gttccaccca ggaggaggaa acttcacata gccgtgctca cagtttttta
     5521 ttttaaagga atttggctgg ggagctgaac agggctccct gtgatctgaa gaaagctttt
     5581 ggtgcttgtc ctcacaacca cctcagtcct ccctccctgt cctcccctgt ctcctttcct
     5641 cctcctgggt tcatgttgta ataaaagaag attgttggtg tgtaattaat ttgttcaaaa
     5701 gaaaaaaaaa agcaaaacaa gaaacttggt tccaactgaa gcctatttta attttatttt
     5761 attattttcc tcttgttaga aataaaaccc ttagaaacat tttttggaaa
//
