LOCUS       NM_001353979            4978 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 5,
            mRNA.
ACCESSION   NM_001353979 XM_017029886
VERSION     NM_001353979.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Audu,C.O., Wolf,S.J., Joshi,A.D., Moon,J.Y., Melvin,W.J.,
            Sharma,S.B., Davis,F.M., Obi,A.T., Wasikowski,R., Tsoi,L.C.,
            Barrett,E.C., Mangum,K.D., Bauer,T.M., Kunkel,S.L., Moore,B.B. and
            Gallagher,K.A.
  TITLE     Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic cells
  JOURNAL   JCI Insight 9 (12), e172959 (2024)
   PUBMED   38912581
  REMARK    GeneRIF: Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4978)
  AUTHORS   Deogharia,M., Venegas-Zamora,L., Agrawal,A., Shi,M., Jain,A.K.,
            McHugh,K.J., Altamirano,F., Marian,A.J. and Gurha,P.
  TITLE     Histone demethylase KDM5 regulates cardiomyocyte maturation by
            promoting fatty acid oxidation, oxidative phosphorylation, and
            myofibrillar organization
  JOURNAL   Cardiovasc Res 120 (6), 630-643 (2024)
   PUBMED   38230606
  REMARK    GeneRIF: Histone demethylase KDM5 regulates cardiomyocyte
            maturation by promoting fatty acid oxidation, oxidative
            phosphorylation, and myofibrillar organization.
REFERENCE   3  (bases 1 to 4978)
  AUTHORS   Qiang,Y., Fan,J., Xie,C., Yan,L., Song,X., Zhang,N., Lin,Y.,
            Xiong,J., Zhang,W., Liu,Y., Wei,L., Li,Y., Chen,S., Liang,K. and
            Li,F.
  TITLE     KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer
            Activation and BET Inhibitor Sensitivity
  JOURNAL   Cancer Res 84 (8), 1252-1269 (2024)
   PUBMED   38285760
  REMARK    GeneRIF: KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates
            Enhancer Activation and BET Inhibitor Sensitivity.
REFERENCE   4  (bases 1 to 4978)
  AUTHORS   Karwacki-Neisius,V., Jang,A., Cukuroglu,E., Tai,A., Jiao,A.,
            Predes,D., Yoon,J., Brookes,E., Chen,J., Iberg,A., Halbritter,F.,
            Ounap,K., Gecz,J., Schlaeger,T.M., Ho Sui,S., Goke,J., He,X.,
            Lehtinen,M.K., Pomeroy,S.L. and Shi,Y.
  TITLE     WNT signalling control by KDM5C during development affects
            cognition
  JOURNAL   Nature 627 (8004), 594-603 (2024)
   PUBMED   38383780
  REMARK    GeneRIF: WNT signalling control by KDM5C during development affects
            cognition.
REFERENCE   5  (bases 1 to 4978)
  AUTHORS   Yu,F., Li,L., Gu,Y., Wang,S., Zhou,L., Cheng,X., Jiang,H.,
            Huang,Y., Zhang,Y., Qian,W., Li,X. and Liu,Z.
  TITLE     Lysine demethylase 5C inhibits transcription of prefoldin subunit 5
            to activate c-Myc signal transduction and colorectal cancer
            progression
  JOURNAL   Mol Med 30 (1), 9 (2024)
   PUBMED   38216914
  REMARK    GeneRIF: Lysine demethylase 5C inhibits transcription of prefoldin
            subunit 5 to activate c-Myc signal transduction and colorectal
            cancer progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4978)
  AUTHORS   Jensen,L.R., Amende,M., Gurok,U., Moser,B., Gimmel,V., Tzschach,A.,
            Janecke,A.R., Tariverdian,G., Chelly,J., Fryns,J.P., Van Esch,H.,
            Kleefstra,T., Hamel,B., Moraine,C., Gecz,J., Turner,G.,
            Reinhardt,R., Kalscheuer,V.M., Ropers,H.H. and Lenzner,S.
  TITLE     Mutations in the JARID1C gene, which is involved in transcriptional
            regulation and chromatin remodeling, cause X-linked mental
            retardation
  JOURNAL   Am J Hum Genet 76 (2), 227-236 (2005)
   PUBMED   15586325
REFERENCE   7  (bases 1 to 4978)
  AUTHORS   Agate,R.J., Choe,M. and Arnold,A.P.
  TITLE     Sex differences in structure and expression of the sex chromosome
            genes CHD1Z and CHD1W in zebra finches
  JOURNAL   Mol Biol Evol 21 (2), 384-396 (2004)
   PUBMED   14660691
REFERENCE   8  (bases 1 to 4978)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Mattei,M.G., Borsani,G., Avner,P.A.,
            Lerner,J.L. and Bishop,C.E.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   9  (bases 1 to 4978)
  AUTHORS   Wu,J., Ellison,J., Salido,E., Yen,P., Mohandas,T. and Shapiro,L.J.
  TITLE     Isolation and characterization of XE169, a novel human gene that
            escapes X-inactivation
  JOURNAL   Hum Mol Genet 3 (1), 153-160 (1994)
   PUBMED   8162017
REFERENCE   10 (bases 1 to 4978)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139396.18.
            
            On Jun 2, 2019 this sequence version replaced NM_001353979.1.
            
            Summary: This gene is a member of the SMCY homolog family and
            encodes a protein with one ARID domain, one JmjC domain, one JmjN
            domain and two PHD-type zinc fingers. The DNA-binding motifs
            suggest this protein is involved in the regulation of transcription
            and chromatin remodeling. Mutations in this gene have been
            associated with X-linked cognitive disability. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.96268.1,
                                           SRR14372079.836986.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AL139396.18        111279-111746       c
            469-546             AL139396.18        107378-107455       c
            547-669             AL139396.18        104815-104937       c
            670-840             AL139396.18        104335-104505       c
            841-972             AL139396.18        103682-103813       c
            973-1096            AL139396.18        102613-102736       c
            1097-1278           AL139396.18        102334-102515       c
            1279-1437           AL139396.18        101228-101386       c
            1438-1557           AL139396.18        98326-98445         c
            1558-1716           AL139396.18        98036-98194         c
            1717-1898           AL139396.18        97215-97396         c
            1899-2061           AL139396.18        96953-97115         c
            2062-2181           AL139396.18        88393-88512         c
            2182-2376           AL139396.18        88089-88283         c
            2377-2558           AL139396.18        85516-85697         c
            2559-2683           AL139396.18        85303-85427         c
            2684-2831           AL139396.18        85029-85176         c
            2832-2937           AL139396.18        84310-84415         c
            2938-3296           AL139396.18        83225-83583         c
            3297-3435           AL139396.18        82455-82593         c
            3436-3615           AL139396.18        81770-81949         c
            3616-3753           AL139396.18        81470-81607         c
            3754-4353           AL139396.18        80678-81277         c
            4354-4432           AL139396.18        80312-80390         c
            4433-4632           AL139396.18        79976-80175         c
            4633-4978           AL139396.18        62816-63161         c
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..4978
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
     exon            1..468
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..4674
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /EC_number="1.14.11.67"
                     /note="isoform 5 is encoded by transcript variant 5;
                     Jumonji, AT rich interactive domain 1C (RBP2-like);
                     lysine-specific demethylase 5C; Smcx homolog, X
                     chromosome; lysine (K)-specific demethylase 5C; JmjC
                     domain-containing protein SMCX; Jumonji/ARID
                     domain-containing protein 1C; histone demethylase JARID1C;
                     Smcy homolog, X-linked; [histone H3]-trimethyl-L-lysine(4)
                     demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C isoform 5"
                     /protein_id="NP_001340908.1"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
                     /translation="MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERI
                     VYPYEMYQSGANLVCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPD
                     PEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEEL
                     GGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDE
                     DDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYT
                     LQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGS
                     GFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFS
                     AFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQL
                     VTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPA
                     GRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKA
                     LLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCS
                     SSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALES
                     EARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFL
                     DQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEV
                     PEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAEL
                     QELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARA
                     WIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTF
                     LKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVI
                     VAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLC
                     QDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLV
                     ALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRP
                     EEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSS
                     LLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTL
                     LEETNHQASQRESRN"
     exon            469..546
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            547..669
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            670..840
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            841..972
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1096
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1278
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1437
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1557
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1716
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1898
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2061
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2181
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2376
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2558
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2683
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2831
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2937
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3296
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3435
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3615
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3753
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..4353
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4432
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4632
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4978
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4955..4960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="hexamer: ATTAAA"
     polyA_site      4978
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="major polyA site"
ORIGIN      
        1 gacaaaccaa gatggcggcg gcggcgctga aggccgcggc gtttgggagg taactgtggt
       61 ggcgaaggct gcggtagtgg ggaggcaacc acacagtttg gaagaaacgg agcgggacga
      121 agaggcggta gcagtagagt cagcctgaga ctctcagagc acgacggcca cacgccccct
      181 taggccctcg gcgggcggcg gctgccccgc ttagggccta gcctccgagc attgcctcgg
      241 cttcaaacag cggcggcgcc atgagtcctt aagggcggtc caagcctccc gatccctggc
      301 ccagacctcg ggcccaccat ggagccgggg tccgacgatt tcctaccgcc accggagtgc
      361 ccggtgttcg agcctagctg ggccgagttc cgagaccctc ttggctacat cgcgaaaatc
      421 aggcccatcg cagagaaatc gggcatttgc aagatccgcc cacccgcgga ctggcagcca
      481 ccctttgctg tggaagtgga caacttcagg tttacccccc gaatccagag gctgaatgag
      541 ctagaggccc agacgagagt gaaactgaac tacttggacc agattgccaa attctgggaa
      601 atccagggct cctccttaaa gattcccaat gtagaacggc ggatcttgga cctctacagt
      661 ctcagcaaaa ttgtggtgga ggaaggtggt tatgaagcta tctgcaagga ccgtcggtgg
      721 gctcgggtag cccagcgcct caactatcca ccaggcaaaa atattggctc cttgctacgc
      781 tcccactacg aacgcattgt ttatccctat gaaatgtacc agtctggagc caaccttgtg
      841 tgtaacacac gtccatttga taatgaggag aaggacaagg aatacaaacc ccacagcatc
      901 cccctacgac agtctgtgca gccttccaag ttcaacagct atggccggcg ggccaagaga
      961 ctgcagcctg atccggaacc cacagaggaa gacattgaga agaatccaga gctgaaaaag
     1021 ctacagatct atggggcagg ccccaagatg atgggcctgg gcctcatggc caaagacaag
     1081 actctgcgga agaaagataa ggaggggcct gagtgtcccc ccacagtagt ggtgaaggag
     1141 gagttaggtg gggatgtgaa ggtggagtca acatcgccta agaccttcct ggagagcaag
     1201 gaggagctga gtcacagccc agaaccctgc accaagatga ccatgaggct acggaggaac
     1261 cacagcaatg cccagtttat tgagtcatat gtctgccgga tgtgttctcg aggggatgag
     1321 gatgacaagc tcctgctgtg tgatggctgt gatgacaact accacatctt ctgcctgctg
     1381 cctcctctgc ctgagatccc caagggtgtc tggcggtgcc caaagtgtgt catggcggag
     1441 tgtaagcggc ccccagaagc ctttggcttt gagcaggcta cccgggaata cactctgcag
     1501 agctttggcg agatggccga ctcctttaaa gctgactact tcaacatgcc cgtgcatatg
     1561 gtgcccacag aacttgtgga gaaggagttc tggaggctgg taaatagcat tgaggaagat
     1621 gtgactgttg agtatggagc tgacatccat tccaaagaat ttggcagcgg tttccctgtc
     1681 agtgacagta aacggcacct aacccccgaa gaggaggagt atgctaccag tggttggaac
     1741 ctaaatgtga tgccggtgtt ggaacagtct gtactgtgcc acatcaatgc agatatctct
     1801 ggcatgaagg tgccctggct ctacgtgggc atggtcttct cagccttttg ctggcatatt
     1861 gaggatcact ggagttactc cattaactac ctccactggg gtgagccgaa gacctggtat
     1921 ggggtgccct cacttgcagc agaacatttg gaagaagtga tgaagaagct gacacctgaa
     1981 ctatttgata gccagcctga cctcctgcac caacttgtca ccctcatgaa tcccaacacc
     2041 ctcatgtccc atggtgtgcc agttgtccgc acaaaccagt gtgcaggaga gtttgtcatc
     2101 accttccccc gtgcttacca cagcggcttc aaccaaggct acaactttgc cgaggctgtc
     2161 aacttttgca ctgctgactg gttgcctgct gggcgccagt gcattgagca ctaccgccgg
     2221 ctccggagat actgcgtctt ctcccatgag gagcttatct gcaagatggc tgcctgccca
     2281 gagaagctag acctgaacct ggcggcagct gtgcataagg agatgttcat catggtgcaa
     2341 gaagagcggc gtctacgaaa ggccctgctg gagaagggta tcacagaggc tgagcgagag
     2401 gctttcgagc tgctcccaga tgatgagcgc cagtgtatca agtgcaagac tacgtgtttc
     2461 ctgtcagccc tggcctgcta cgactgccca gacggccttg tctgcctttc ccacatcaat
     2521 gatctctgca agtgctccag tagccggcag tacctgcggt atcggtatac cttggatgag
     2581 cttcctgcca tgctgcataa gctgaaggtt cgggctgagt cctttgacac ctgggccaac
     2641 aaagtgcgag tggccctgga ggtggaggat gggcggaagc gcagccttga agaactgagg
     2701 gcactagagt ctgaagcccg tgagcggagg tttcctaata gtgagctgct gcagcaacta
     2761 aagaactgcc tgagtgaggc agaggcttgc gtgtcccgag ctctgggact ggtcagcggc
     2821 caggaagctg gcccccacag ggtggctggt ctacagatga ccctgactga gctccgggcc
     2881 tttctggacc agatgaacaa cctgccttgc gccatgcacc agattgggga tgtcaagggt
     2941 gttctggaac aggtggaggc ctaccaggct gaggctcgtg aggccctggc ctcactgccc
     3001 tccagtccag ggctactgca gtccctgttg gagagggggc ggcagctggg ggtggaggtg
     3061 cctgaggccc agcagctcca gcggcaggtg gaacaggcgc gatggctgga tgaggtgaaa
     3121 cgcacactgg ccccctcagc ccgaaggggc accttggctg tcatgcgagg actgttggtc
     3181 gcgggtgcca gtgtagcccc tagccctgct gtggataaag cccaggccga gctgcaggaa
     3241 ctgctgacca ttgctgaacg ctgggaggag aaagcccacc tctgcctgga ggccaggcag
     3301 aagcatccac cagccacact tgaggccata atccgtgaag cggaaaacat ccctgttcac
     3361 ctgcccaaca tccaggctct caaggaggct cttgctaagg cccgggcctg gattgctgat
     3421 gttgatgaga tccaaaatgg tgaccactac ccctgcctgg atgacttgga gggcctagta
     3481 gctgtgggcc gggacctacc tgtggggctg gaggagctga gacagctaga gctacaggta
     3541 ctgacagcgc actcctggag ggagaaggcc tccaagacct tcctcaagaa aaattcttgc
     3601 tacacgctgc tggaggttct ctgcccatgt gcagatgccg gctcagacag caccaagcgc
     3661 agccggtgga tggagaagga gctggggttg tacaaatctg acacagagct gctggggctg
     3721 tctgcgcagg acctcaggga cccaggctct gtgatcgtgg ccttcaagga gggggaacag
     3781 aaggagaagg agggtatcct gcagctgcgt cgcaccaatt cggccaagcc cagtccactg
     3841 gcatcatcga gcacggcctc ctctacaacc tctatctgtg tgtgtgggca ggtgctggct
     3901 ggggcgggag ctctgcagtg tgacctgtgt caggactggt tccatgggcg gtgtgtgtca
     3961 gtgcctcgcc tcctcagctc tccgaggccc aatcccacct catccccact gctggcctgg
     4021 tgggaatggg acaccaaatt cctgtgtcca ctgtgtatgc gctcaaggcg cccgcgcctg
     4081 gagaccatcc tggcactgct ggtagccctg cagagactgc ctgtgcggct gcccgagggc
     4141 gaggccctgc agtgcctcac agagagggcc atcagctggc aaggccgcgc caggcaggct
     4201 ctggcctctg aagatgtgac tgctcttttg ggacggctgg ctgagctccg ccaacggcta
     4261 caggctgaac ctagacctga ggagcctcct aactaccctg cagcccctgc ttctgacccc
     4321 ctcagagagg gcagtggcaa ggatatgcct aaggtccagg gcttactgga gaatggagac
     4381 agtgtgacca gtcctgagaa ggtagccccg gaggagggct caggtaagag agatctggag
     4441 ctgctgtcct cgctgttgcc acagttgact ggccctgtgt tggaactgcc tgaggcaacc
     4501 cgggccccct tggaggagct catgatggag ggggacctgc tcgaggtgac cctggatgag
     4561 aaccacagca tatggcagct gctgcaggct ggacagcccc cagacctgga gaggatccgc
     4621 acacttctgg aggaaaccaa ccatcaggcc tcccagagag aatcgaggaa ctgaaatctc
     4681 ccatatcacc acatccagac aatgagacat ggctgctgcc tgttgacaaa ctcctcttct
     4741 ttatacctcc cgaatttctg ttttcctgca tatggttacg gtgagacacc agacccctca
     4801 tccaaccacc tgctgcccgt tgaccaactc ctcttcctta ctcctcccta attcttgttt
     4861 tacgttcctt ccctactata taaaccccta actttagtca attggagaga tggatttgag
     4921 actggtctcc catctcctgg ctgacattac tggcattaaa gctgttcttc cctggcaa
//
