LOCUS       NM_001146702            5044 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 2,
            mRNA.
ACCESSION   NM_001146702
VERSION     NM_001146702.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5044)
  AUTHORS   Audu,C.O., Wolf,S.J., Joshi,A.D., Moon,J.Y., Melvin,W.J.,
            Sharma,S.B., Davis,F.M., Obi,A.T., Wasikowski,R., Tsoi,L.C.,
            Barrett,E.C., Mangum,K.D., Bauer,T.M., Kunkel,S.L., Moore,B.B. and
            Gallagher,K.A.
  TITLE     Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic cells
  JOURNAL   JCI Insight 9 (12), e172959 (2024)
   PUBMED   38912581
  REMARK    GeneRIF: Histone demethylase JARID1C/KDM5C regulates Th17 cells by
            increasing IL-6 expression in diabetic plasmacytoid dendritic
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5044)
  AUTHORS   Deogharia,M., Venegas-Zamora,L., Agrawal,A., Shi,M., Jain,A.K.,
            McHugh,K.J., Altamirano,F., Marian,A.J. and Gurha,P.
  TITLE     Histone demethylase KDM5 regulates cardiomyocyte maturation by
            promoting fatty acid oxidation, oxidative phosphorylation, and
            myofibrillar organization
  JOURNAL   Cardiovasc Res 120 (6), 630-643 (2024)
   PUBMED   38230606
  REMARK    GeneRIF: Histone demethylase KDM5 regulates cardiomyocyte
            maturation by promoting fatty acid oxidation, oxidative
            phosphorylation, and myofibrillar organization.
REFERENCE   3  (bases 1 to 5044)
  AUTHORS   Qiang,Y., Fan,J., Xie,C., Yan,L., Song,X., Zhang,N., Lin,Y.,
            Xiong,J., Zhang,W., Liu,Y., Wei,L., Li,Y., Chen,S., Liang,K. and
            Li,F.
  TITLE     KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer
            Activation and BET Inhibitor Sensitivity
  JOURNAL   Cancer Res 84 (8), 1252-1269 (2024)
   PUBMED   38285760
  REMARK    GeneRIF: KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates
            Enhancer Activation and BET Inhibitor Sensitivity.
REFERENCE   4  (bases 1 to 5044)
  AUTHORS   Karwacki-Neisius,V., Jang,A., Cukuroglu,E., Tai,A., Jiao,A.,
            Predes,D., Yoon,J., Brookes,E., Chen,J., Iberg,A., Halbritter,F.,
            Ounap,K., Gecz,J., Schlaeger,T.M., Ho Sui,S., Goke,J., He,X.,
            Lehtinen,M.K., Pomeroy,S.L. and Shi,Y.
  TITLE     WNT signalling control by KDM5C during development affects
            cognition
  JOURNAL   Nature 627 (8004), 594-603 (2024)
   PUBMED   38383780
  REMARK    GeneRIF: WNT signalling control by KDM5C during development affects
            cognition.
REFERENCE   5  (bases 1 to 5044)
  AUTHORS   Yu,F., Li,L., Gu,Y., Wang,S., Zhou,L., Cheng,X., Jiang,H.,
            Huang,Y., Zhang,Y., Qian,W., Li,X. and Liu,Z.
  TITLE     Lysine demethylase 5C inhibits transcription of prefoldin subunit 5
            to activate c-Myc signal transduction and colorectal cancer
            progression
  JOURNAL   Mol Med 30 (1), 9 (2024)
   PUBMED   38216914
  REMARK    GeneRIF: Lysine demethylase 5C inhibits transcription of prefoldin
            subunit 5 to activate c-Myc signal transduction and colorectal
            cancer progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5044)
  AUTHORS   Jensen,L.R., Amende,M., Gurok,U., Moser,B., Gimmel,V., Tzschach,A.,
            Janecke,A.R., Tariverdian,G., Chelly,J., Fryns,J.P., Van Esch,H.,
            Kleefstra,T., Hamel,B., Moraine,C., Gecz,J., Turner,G.,
            Reinhardt,R., Kalscheuer,V.M., Ropers,H.H. and Lenzner,S.
  TITLE     Mutations in the JARID1C gene, which is involved in transcriptional
            regulation and chromatin remodeling, cause X-linked mental
            retardation
  JOURNAL   Am J Hum Genet 76 (2), 227-236 (2005)
   PUBMED   15586325
REFERENCE   7  (bases 1 to 5044)
  AUTHORS   Agate,R.J., Choe,M. and Arnold,A.P.
  TITLE     Sex differences in structure and expression of the sex chromosome
            genes CHD1Z and CHD1W in zebra finches
  JOURNAL   Mol Biol Evol 21 (2), 384-396 (2004)
   PUBMED   14660691
REFERENCE   8  (bases 1 to 5044)
  AUTHORS   Agulnik,A.I., Mitchell,M.J., Mattei,M.G., Borsani,G., Avner,P.A.,
            Lerner,J.L. and Bishop,C.E.
  TITLE     A novel X gene with a widely transcribed Y-linked homologue escapes
            X-inactivation in mouse and human
  JOURNAL   Hum Mol Genet 3 (6), 879-884 (1994)
   PUBMED   7951230
REFERENCE   9  (bases 1 to 5044)
  AUTHORS   Wu,J., Ellison,J., Salido,E., Yen,P., Mohandas,T. and Shapiro,L.J.
  TITLE     Isolation and characterization of XE169, a novel human gene that
            escapes X-inactivation
  JOURNAL   Hum Mol Genet 3 (1), 153-160 (1994)
   PUBMED   8162017
REFERENCE   10 (bases 1 to 5044)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139396.18.
            
            On Nov 5, 2019 this sequence version replaced NM_001146702.1.
            
            Summary: This gene is a member of the SMCY homolog family and
            encodes a protein with one ARID domain, one JmjC domain, one JmjN
            domain and two PHD-type zinc fingers. The DNA-binding motifs
            suggest this protein is involved in the regulation of transcription
            and chromatin remodeling. Mutations in this gene have been
            associated with X-linked cognitive disability. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR,
            and coding region compared to variant 1, resulting in a protein
            (isoform 2) that maintains the reading frame but is shorter at both
            the N- and C-termini, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AL139396.18        111279-111746       c
            469-639             AL139396.18        104335-104505       c
            640-774             AL139396.18        103682-103816       c
            775-898             AL139396.18        102613-102736       c
            899-1080            AL139396.18        102334-102515       c
            1081-1239           AL139396.18        101228-101386       c
            1240-1359           AL139396.18        98326-98445         c
            1360-1518           AL139396.18        98036-98194         c
            1519-1700           AL139396.18        97215-97396         c
            1701-1863           AL139396.18        96953-97115         c
            1864-1983           AL139396.18        88393-88512         c
            1984-2178           AL139396.18        88089-88283         c
            2179-2360           AL139396.18        85516-85697         c
            2361-2485           AL139396.18        85303-85427         c
            2486-2633           AL139396.18        85029-85176         c
            2634-2739           AL139396.18        84310-84415         c
            2740-3098           AL139396.18        83225-83583         c
            3099-3237           AL139396.18        82455-82593         c
            3238-3417           AL139396.18        81770-81949         c
            3418-3555           AL139396.18        81470-81607         c
            3556-4155           AL139396.18        80678-81277         c
            4156-4225           AL139396.18        80321-80390         c
            4226-4364           AL139396.18        80037-80175         c
            4365-5044           AL139396.18        78697-79376         c
FEATURES             Location/Qualifiers
     source          1..5044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..5044
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
     exon            1..468
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..4458
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /EC_number="1.14.11.67"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Jumonji, AT rich interactive domain 1C (RBP2-like);
                     lysine-specific demethylase 5C; Smcx homolog, X
                     chromosome; lysine (K)-specific demethylase 5C; JmjC
                     domain-containing protein SMCX; Jumonji/ARID
                     domain-containing protein 1C; histone demethylase JARID1C;
                     Smcy homolog, X-linked; [histone H3]-trimethyl-L-lysine(4)
                     demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C isoform 2"
                     /protein_id="NP_001140174.1"
                     /db_xref="CCDS:CCDS55417.1"
                     /db_xref="GeneID:8242"
                     /db_xref="HGNC:HGNC:11114"
                     /db_xref="MIM:314690"
                     /translation="MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPAIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQS
                     GANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDI
                     EKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVES
                     TSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCD
                     GCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMA
                     DSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSK
                     RHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIED
                     HWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNT
                     LMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHY
                     RRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITE
                     AEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRY
                     RYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFP
                     NSELLQQLKNCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPC
                     AMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQR
                     QVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAE
                     RWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQALKEALAKARAWIADVDEI
                     QNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYT
                     LLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQ
                     KEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLCQDWFHGRC
                     VSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVR
                     LPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPA
                     APASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSDLELLSSLLPQLTGPVLE
                     LPEATRAPLEELMMEGDLLEVTLDENHSIPESLDFCILTPRYCSDLSSWGPAPGVFPP
                     W"
     exon            469..639
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            640..774
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            775..898
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1080
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1239
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1359
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1518
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1700
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1863
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1983
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2178
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2360
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2485
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2633
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2739
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..3098
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3237
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..3417
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3555
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..4155
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4225
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4364
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..5044
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="major polyA site"
     regulatory      5015..5020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="hexamer: AATAAA"
     polyA_site      5044
                     /gene="KDM5C"
                     /gene_synonym="DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ;
                     MRXSJ; SMCX; XE169"
                     /note="major polyA site"
ORIGIN      
        1 gacaaaccaa gatggcggcg gcggcgctga aggccgcggc gtttgggagg taactgtggt
       61 ggcgaaggct gcggtagtgg ggaggcaacc acacagtttg gaagaaacgg agcgggacga
      121 agaggcggta gcagtagagt cagcctgaga ctctcagagc acgacggcca cacgccccct
      181 taggccctcg gcgggcggcg gctgccccgc ttagggccta gcctccgagc attgcctcgg
      241 cttcaaacag cggcggcgcc atgagtcctt aagggcggtc caagcctccc gatccctggc
      301 ccagacctcg ggcccaccat ggagccgggg tccgacgatt tcctaccgcc accggagtgc
      361 ccggtgttcg agcctagctg ggccgagttc cgagaccctc ttggctacat cgcgaaaatc
      421 aggcccatcg cagagaaatc gggcatttgc aagatccgcc cacccgcgat tgtggtggag
      481 gaaggtggtt atgaagctat ctgcaaggac cgtcggtggg ctcgggtagc ccagcgcctc
      541 aactatccac caggcaaaaa tattggctcc ttgctacgct cccactacga acgcattgtt
      601 tatccctatg aaatgtacca gtctggagcc aaccttgtgc agtgtaacac acgtccattt
      661 gataatgagg agaaggacaa ggaatacaaa ccccacagca tccccctacg acagtctgtg
      721 cagccttcca agttcaacag ctatggccgg cgggccaaga gactgcagcc tgatccggaa
      781 cccacagagg aagacattga gaagaatcca gagctgaaaa agctacagat ctatggggca
      841 ggccccaaga tgatgggcct gggcctcatg gccaaagaca agactctgcg gaagaaagat
      901 aaggaggggc ctgagtgtcc ccccacagta gtggtgaagg aggagttagg tggggatgtg
      961 aaggtggagt caacatcgcc taagaccttc ctggagagca aggaggagct gagtcacagc
     1021 ccagaaccct gcaccaagat gaccatgagg ctacggagga accacagcaa tgcccagttt
     1081 attgagtcat atgtctgccg gatgtgttct cgaggggatg aggatgacaa gctcctgctg
     1141 tgtgatggct gtgatgacaa ctaccacatc ttctgcctgc tgcctcctct gcctgagatc
     1201 cccaagggtg tctggcggtg cccaaagtgt gtcatggcgg agtgtaagcg gcccccagaa
     1261 gcctttggct ttgagcaggc tacccgggaa tacactctgc agagctttgg cgagatggcc
     1321 gactccttta aagctgacta cttcaacatg cccgtgcata tggtgcccac agaacttgtg
     1381 gagaaggagt tctggaggct ggtaaatagc attgaggaag atgtgactgt tgagtatgga
     1441 gctgacatcc attccaaaga atttggcagc ggtttccctg tcagtgacag taaacggcac
     1501 ctaacccccg aagaggagga gtatgctacc agtggttgga acctaaatgt gatgccggtg
     1561 ttggaacagt ctgtactgtg ccacatcaat gcagatatct ctggcatgaa ggtgccctgg
     1621 ctctacgtgg gcatggtctt ctcagccttt tgctggcata ttgaggatca ctggagttac
     1681 tccattaact acctccactg gggtgagccg aagacctggt atggggtgcc ctcacttgca
     1741 gcagaacatt tggaagaagt gatgaagaag ctgacacctg aactatttga tagccagcct
     1801 gacctcctgc accaacttgt caccctcatg aatcccaaca ccctcatgtc ccatggtgtg
     1861 ccagttgtcc gcacaaacca gtgtgcagga gagtttgtca tcaccttccc ccgtgcttac
     1921 cacagcggct tcaaccaagg ctacaacttt gccgaggctg tcaacttttg cactgctgac
     1981 tggttgcctg ctgggcgcca gtgcattgag cactaccgcc ggctccggag atactgcgtc
     2041 ttctcccatg aggagcttat ctgcaagatg gctgcctgcc cagagaagct agacctgaac
     2101 ctggcggcag ctgtgcataa ggagatgttc atcatggtgc aagaagagcg gcgtctacga
     2161 aaggccctgc tggagaaggg tatcacagag gctgagcgag aggctttcga gctgctccca
     2221 gatgatgagc gccagtgtat caagtgcaag actacgtgtt tcctgtcagc cctggcctgc
     2281 tacgactgcc cagacggcct tgtctgcctt tcccacatca atgatctctg caagtgctcc
     2341 agtagccggc agtacctgcg gtatcggtat accttggatg agcttcctgc catgctgcat
     2401 aagctgaagg ttcgggctga gtcctttgac acctgggcca acaaagtgcg agtggccctg
     2461 gaggtggagg atgggcggaa gcgcagcctt gaagaactga gggcactaga gtctgaagcc
     2521 cgtgagcgga ggtttcctaa tagtgagctg ctgcagcaac taaagaactg cctgagtgag
     2581 gcagaggctt gcgtgtcccg agctctggga ctggtcagcg gccaggaagc tggcccccac
     2641 agggtggctg gtctacagat gaccctgact gagctccggg cctttctgga ccagatgaac
     2701 aacctgcctt gcgccatgca ccagattggg gatgtcaagg gtgttctgga acaggtggag
     2761 gcctaccagg ctgaggctcg tgaggccctg gcctcactgc cctccagtcc agggctactg
     2821 cagtccctgt tggagagggg gcggcagctg ggggtggagg tgcctgaggc ccagcagctc
     2881 cagcggcagg tggaacaggc gcgatggctg gatgaggtga aacgcacact ggccccctca
     2941 gcccgaaggg gcaccttggc tgtcatgcga ggactgttgg tcgcgggtgc cagtgtagcc
     3001 cctagccctg ctgtggataa agcccaggcc gagctgcagg aactgctgac cattgctgaa
     3061 cgctgggagg agaaagccca cctctgcctg gaggccaggc agaagcatcc accagccaca
     3121 cttgaggcca taatccgtga agcggaaaac atccctgttc acctgcccaa catccaggct
     3181 ctcaaggagg ctcttgctaa ggcccgggcc tggattgctg atgttgatga gatccaaaat
     3241 ggtgaccact acccctgcct ggatgacttg gagggcctag tagctgtggg ccgggaccta
     3301 cctgtggggc tggaggagct gagacagcta gagctacagg tactgacagc gcactcctgg
     3361 agggagaagg cctccaagac cttcctcaag aaaaattctt gctacacgct gctggaggtt
     3421 ctctgcccat gtgcagatgc cggctcagac agcaccaagc gcagccggtg gatggagaag
     3481 gagctggggt tgtacaaatc tgacacagag ctgctggggc tgtctgcgca ggacctcagg
     3541 gacccaggct ctgtgatcgt ggccttcaag gagggggaac agaaggagaa ggagggtatc
     3601 ctgcagctgc gtcgcaccaa ttcggccaag cccagtccac tggcatcatc gagcacggcc
     3661 tcctctacaa cctctatctg tgtgtgtggg caggtgctgg ctggggcggg agctctgcag
     3721 tgtgacctgt gtcaggactg gttccatggg cggtgtgtgt cagtgcctcg cctcctcagc
     3781 tctccgaggc ccaatcccac ctcatcccca ctgctggcct ggtgggaatg ggacaccaaa
     3841 ttcctgtgtc cactgtgtat gcgctcaagg cgcccgcgcc tggagaccat cctggcactg
     3901 ctggtagccc tgcagagact gcctgtgcgg ctgcccgagg gcgaggccct gcagtgcctc
     3961 acagagaggg ccatcagctg gcaaggccgc gccaggcagg ctctggcctc tgaagatgtg
     4021 actgctcttt tgggacggct ggctgagctc cgccaacggc tacaggctga acctagacct
     4081 gaggagcctc ctaactaccc tgcagcccct gcttctgacc ccctcagaga gggcagtggc
     4141 aaggatatgc ctaaggtcca gggcttactg gagaatggag acagtgtgac cagtcctgag
     4201 aaggtagccc cggaggaggg ctcagatctg gagctgctgt cctcgctgtt gccacagttg
     4261 actggccctg tgttggaact gcctgaggca acccgggccc ccttggagga gctcatgatg
     4321 gagggggacc tgctcgaggt gaccctggat gagaaccaca gcatccctga gtcccttgac
     4381 ttttgtattc tgactccaag gtattgttca gacctcagct cctgggggcc ggcccctgga
     4441 gtcttccctc cctggtagcc tctaaccagc attcccagac acctgaggca gatagatgga
     4501 tgggctggtg ggcagggggg tggctggggc tgggccatca ccattccaga gacaaggcca
     4561 gtgtatatgc aaactggggg actctcctcc cttctctccc cagttctggt cctggccagg
     4621 ccatgctaca ctaacccctg cccccactct cctcccctct tttccttcct tcctaccccc
     4681 ttctccctct cccttcccct gactgttcca cccaggagga ggaaacttca catagccgtg
     4741 ctcacagttt tttattttaa aggaatttgg ctggggagct gaacagggct ccctgtgatc
     4801 tgaagaaagc ttttggtgct tgtcctcaca accacctcag tcctccctcc ctgtcctccc
     4861 ctgtctcctt tcctcctcct gggttcatgt tgtaataaaa gaagattgtt ggtgtgtaat
     4921 taatttgttc aaaagaaaaa aaaaagcaaa acaagaaact tggttccaac tgaagcctat
     4981 tttaatttta ttttattatt ttcctcttgt tagaaataaa acccttagaa acattttttg
     5041 gaaa
//
