LOCUS       NM_006618               9292 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens lysine demethylase 5B (KDM5B), transcript variant 2,
            mRNA.
ACCESSION   NM_006618
VERSION     NM_006618.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9292)
  AUTHORS   Wang,F., Huang,J., Zeng,S., Pan,Y. and Zhou,H.
  TITLE     ETS homologous factor, controlled by lysine-specific demethylase
            5B, suppresses clear cell renal cell carcinoma by inducing
            Filamin-B
  JOURNAL   Gene 927, 148702 (2024)
   PUBMED   38880187
  REMARK    GeneRIF: ETS homologous factor, controlled by lysine-specific
            demethylase 5B, suppresses clear cell renal cell carcinoma by
            inducing Filamin-B.
REFERENCE   2  (bases 1 to 9292)
  AUTHORS   Zhu,Y., Yang,W., Wang,X. and Chen,M.
  TITLE     AUP1 transcriptionally activated by KDM5B reprograms lipid
            metabolism to promote the malignant progression of cervical cancer
  JOURNAL   Int J Oncol 65 (5) (2024)
   PUBMED   39329209
  REMARK    GeneRIF: AUP1 transcriptionally activated by KDM5B reprograms lipid
            metabolism to promote the malignant progression of cervical cancer.
REFERENCE   3  (bases 1 to 9292)
  AUTHORS   Borroto,M.C., Michaud,C., Hudon,C., Agrawal,P.B., Agre,K.,
            Applegate,C.D., Beggs,A.H., Bjornsson,H.T., Callewaert,B.,
            Chen,M.J., Curry,C., Devinsky,O., Dudding-Byth,T., Fagan,K.,
            Finnila,C.R., Gavrilova,R., Genetti,C.A., Hiatt,S.M.,
            Hildebrandt,F., Wojcik,M.H., Kleefstra,T., Kolvenbach,C.M.,
            Korf,B.R., Kruszka,P., Li,H., Litwin,J., Marcadier,J., Platzer,K.,
            Blackburn,P.R., Reijnders,M.R.F., Reutter,H., Schanze,I.,
            Shieh,J.T., Stevens,C.A., Valivullah,Z., van den Boogaard,M.J.,
            Klee,E.W. and Campeau,P.M.
  TITLE     A Genotype/Phenotype Study of KDM5B-Associated Disorders Suggests a
            Pathogenic Effect of Dominantly Inherited Missense Variants
  JOURNAL   Genes (Basel) 15 (8), 1033 (2024)
   PUBMED   39202393
  REMARK    GeneRIF: A Genotype/Phenotype Study of KDM5B-Associated Disorders
            Suggests a Pathogenic Effect of Dominantly Inherited Missense
            Variants.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9292)
  AUTHORS   Li,J., Hou,F., Teng,Z., Xia,W. and Peng,J.
  TITLE     LncRNA HOXC-AS3 accelerates malignant proliferation of cervical
            cancer cells via stabilizing KDM5B
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 294 (2024)
   PUBMED   38842683
  REMARK    GeneRIF: LncRNA HOXC-AS3 accelerates malignant proliferation of
            cervical cancer cells via stabilizing KDM5B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9292)
  AUTHORS   Xiang,Y., Zhu,Z., Han,G., Ye,X., Xu,B., Peng,Z., Ma,Y., Yu,Y.,
            Lin,H., Chen,A.P. and Chen,C.D.
  TITLE     JARID1B is a histone H3 lysine 4 demethylase up-regulated in
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19226-19231 (2007)
   PUBMED   18048344
  REMARK    GeneRIF: JARID1B was identified as a demethylase capable of
            removing three methyl groups from histone H3 lysine 4 and
            up-regulated in prostate cancer.
REFERENCE   6  (bases 1 to 9292)
  AUTHORS   Barrett,A., Madsen,B., Copier,J., Lu,P.J., Cooper,L.,
            Scibetta,A.G., Burchell,J. and Taylor-Papadimitriou,J.
  TITLE     PLU-1 nuclear protein, which is upregulated in breast cancer, shows
            restricted expression in normal human adult tissues: a new
            cancer/testis antigen?
  JOURNAL   Int J Cancer 101 (6), 581-588 (2002)
   PUBMED   12237901
  REMARK    GeneRIF: results suggest that the PLU-1 protein may belong to the
            class of testis/cancer antigens
REFERENCE   7  (bases 1 to 9292)
  AUTHORS   Zhu,L., Hu,J., Lin,D., Whitson,R., Itakura,K. and Chen,Y.
  TITLE     Dynamics of the Mrf-2 DNA-binding domain free and in complex with
            DNA
  JOURNAL   Biochemistry 40 (31), 9142-9150 (2001)
   PUBMED   11478881
REFERENCE   8  (bases 1 to 9292)
  AUTHORS   Lahoud,M.H., Ristevski,S., Venter,D.J., Jermiin,L.S.,
            Bertoncello,I., Zavarsek,S., Hasthorpe,S., Drago,J., de Kretser,D.,
            Hertzog,P.J. and Kola,I.
  TITLE     Gene targeting of Desrt, a novel ARID class DNA-binding protein,
            causes growth retardation and abnormal development of reproductive
            organs
  JOURNAL   Genome Res 11 (8), 1327-1334 (2001)
   PUBMED   11483573
REFERENCE   9  (bases 1 to 9292)
  AUTHORS   Kashuba,V., Protopopov,A., Podowski,R., Gizatullin,R., Li,J.,
            Klein,G., Wahlestedt,C. and Zabarovsky,E.
  TITLE     Isolation and chromosomal localization of a new human
            retinoblastoma binding protein 2 homologue 1a (RBBP2H1A)
  JOURNAL   Eur J Hum Genet 8 (6), 407-413 (2000)
   PUBMED   10878660
REFERENCE   10 (bases 1 to 9292)
  AUTHORS   Lu,P.J., Sundquist,K., Baeckstrom,D., Poulsom,R., Hanby,A.,
            Meier-Ewert,S., Jones,T., Mitchell,M., Pitha-Rowe,P., Freemont,P.
            and Taylor-Papadimitriou,J.
  TITLE     A novel gene (PLU-1) containing highly conserved putative
            DNA/chromatin binding motifs is specifically up-regulated in breast
            cancer
  JOURNAL   J Biol Chem 274 (22), 15633-15645 (1999)
   PUBMED   10336460
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098934.3 and AC104463.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 26, 2019 this sequence version replaced NM_006618.4.
            
            Summary: This gene encodes a lysine-specific histone demethylase
            that belongs to the jumonji/ARID domain-containing family of
            histone demethylases. The encoded protein is capable of
            demethylating tri-, di- and monomethylated lysine 4 of histone H3.
            This protein plays a role in the transcriptional repression or
            certain tumor suppressor genes and is upregulated in certain cancer
            cells. This protein may also play a role in genome stability and
            DNA repair. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Nov 2016].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' coding
            region compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.56526.1,
                                           SRR1803613.81220.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367265.9/ ENSP00000356234.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AC098934.3         69272-69591         c
            321-398             AC098934.3         38187-38264         c
            399-521             AC098934.3         35783-35905         c
            522-692             AC098934.3         34288-34458         c
            693-827             AC098934.3         28096-28230         c
            828-924             AC098934.3         25219-25315         c
            925-1034            AC098934.3         23869-23978         c
            1035-1193           AC098934.3         21585-21743         c
            1194-1313           AC098934.3         19561-19680         c
            1314-1472           AC098934.3         17528-17686         c
            1473-1654           AC098934.3         16441-16622         c
            1655-1817           AC104463.3         154645-154807       c
            1818-1937           AC104463.3         152399-152518       c
            1938-2132           AC104463.3         150685-150879       c
            2133-2314           AC104463.3         147882-148063       c
            2315-2439           AC104463.3         147598-147722       c
            2440-2590           AC104463.3         144395-144545       c
            2591-2705           AC104463.3         144131-144245       c
            2706-3061           AC104463.3         143107-143462       c
            3062-3200           AC104463.3         142414-142552       c
            3201-3380           AC104463.3         137953-138132       c
            3381-3539           AC104463.3         137169-137327       c
            3540-4025           AC104463.3         135141-135626       c
            4026-4137           AC104463.3         133568-133679       c
            4138-4292           AC104463.3         132649-132803       c
            4293-4613           AC104463.3         131447-131767       c
            4614-9292           AC104463.3         126235-130913       c
FEATURES             Location/Qualifiers
     source          1..9292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..9292
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="lysine demethylase 5B"
                     /db_xref="GeneID:10765"
                     /db_xref="HGNC:HGNC:18039"
                     /db_xref="MIM:605393"
     exon            1..320
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..4751
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /EC_number="1.14.11.67"
                     /note="isoform 2 is encoded by transcript variant 2;
                     putative DNA/chromatin binding motif; cancer/testis
                     antigen 31; jumonji, AT rich interactive domain 1B;
                     retinoblastoma-binding protein 2, homolog 1A; histone
                     demethylase JARID1B; jumonji/ARID domain-containing
                     protein 1B; retinoblastoma-binding protein 2 homolog 1;
                     protein phosphatase 1, regulatory subunit 98; lysine
                     (K)-specific demethylase 5B; [histone
                     H3]-trimethyl-L-lysine(4) demethylase 5B"
                     /codon_start=1
                     /product="lysine-specific demethylase 5B isoform 2"
                     /protein_id="NP_006609.3"
                     /db_xref="CCDS:CCDS30974.1"
                     /db_xref="GeneID:10765"
                     /db_xref="HGNC:HGNC:18039"
                     /db_xref="MIM:605393"
                     /translation="MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFAD
                     PFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLN
                     FLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMG
                     FAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQS
                     VQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSS
                     IKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSY
                     HTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSD
                     YFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPE
                     EEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSI
                     NYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEV
                     PVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRY
                     CVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDF
                     ELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDD
                     LYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLR
                     HLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVL
                     SQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRL
                     EQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWD
                     DKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAG
                     GRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLE
                     VLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLG
                     EARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCV
                     AVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNW
                     QHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWD
                     NRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQ
                     QTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKK
                     KIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQ
                     PEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK"
     exon            321..398
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..521
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..692
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..827
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..924
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1034
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1193
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1313
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1472
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1654
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1817
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1937
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2132
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2314
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2439
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2590
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2705
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..3061
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3200
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3380
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3539
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..4025
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4137
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4138..4292
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4613
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..9292
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5565..5570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="hexamer: AATAAA"
     polyA_site      5588
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="major polyA site"
     regulatory      6363..6368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="hexamer: ATTAAA"
     polyA_site      6383
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="major polyA site"
     regulatory      8430..8435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="hexamer: TATAAA"
     polyA_site      8455
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
     regulatory      8580..8585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="hexamer: TATAAA"
     polyA_site      8626
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
     regulatory      9270..9275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
                     /note="hexamer: CATAAA"
     polyA_site      9292
                     /gene="KDM5B"
                     /gene_synonym="CT31; JARID1B; MRT65; PLU-1; PLU1; PPP1R98;
                     PUT1; RBBP2H1A; RBP2-H1"
ORIGIN      
        1 gtacaactcg gacttgctgt tgctcgagcc gcgtctgcac gggtctcgga ccgagcggag
       61 ctcgcagcct cggtcccgga gcccaccttc gcctcgccct tgcccagcct gcggtgatgg
      121 aggcggccac cacactgcac ccaggcccgc gcccggcgct gcccctcggg ggcccgggcc
      181 cgctgggcga gttcctgcct ccacccgagt gcccggtctt cgaacccagc tgggaagagt
      241 tcgcggaccc cttcgctttc atccacaaga tccggcccat agccgagcag actggcatct
      301 gtaaggtgcg gccgccgccg gattggcagc caccatttgc atgtgatgtt gataaacttc
      361 attttacgcc acgtatccag agactgaatg aattggaggc ccaaactcgt gtaaaattga
      421 atttcttgga ccagattgca aagtactggg agttacaggg aagtactctg aaaattccac
      481 atgtggagag gaagatcttg gacttatttc agcttaataa gttagttgca gaagaaggtg
      541 gatttgcagt tgtttgcaag gatagaaaat ggaccaaaat tgctaccaag atggggtttg
      601 ctcctggcaa agcagtgggc tcacatatca gagggcatta tgaacgaatt ctcaacccct
      661 acaacttatt cctgtccgga gacagcctaa ggtgtttgca gaagccaaac ctgaccacag
      721 acactaagga caaggagtac aaaccccatg atattcccca gaggcagtct gtgcagcctt
      781 cggaaacgtg ccccccagcc cgacgagcaa aacgcatgag agcagaggcc atgaatatta
      841 aaatagaacc cgaggagaca acggaagcca gaactcataa tctgagacgt cgaatgggtt
      901 gtccaactcc aaaatgtgaa aatgagaaag aaatgaagag tagcatcaag caagaaccta
      961 ttgagaggaa agattatatt gtagaaaatg agaaggaaaa gcccaagagt cgatctaaaa
     1021 aagccaccaa tgctgtggac ctgtatgtct gtcttttatg tggcagtggc aatgatgaag
     1081 accggctact gttgtgtgat ggctgtgatg acagttacca taccttttgc ttgatcccac
     1141 ctctccatga tgttcccaag ggagactgga ggtgtcctaa gtgtttggct caggaatgta
     1201 gtaagccaca agaagcattt ggctttgaac aagcagccag ggactatacc ctccgtactt
     1261 ttggggaaat ggcagatgcg ttcaaatctg attacttcaa catgccagtc catatggtcc
     1321 ccacagagct tgttgagaaa gaattttgga gactagtaag cactattgag gaggatgtca
     1381 cagtggaata tggagctgac attgcctcaa aggaatttgg cagtggcttt cctgtccgag
     1441 atgggaaaat caaactctca cctgaggaag aggagtatct tgatagtggc tggaatttga
     1501 acaacatgcc agtgatggag cagtctgtcc ttgcacatat tactgctgat atatgtggca
     1561 tgaaacttcc ttggttgtat gtgggaatgt gcttttcttc attctgttgg cacattgaag
     1621 accactggag ctattcaatt aactacttgc actggggtga gccaaaaacc tggtatggag
     1681 tcccagggta tgctgctgag cagctagaaa atgtaatgaa gaaactagct ccagaactct
     1741 ttgtgtccca gccggatctc ctccatcagc ttgtgaccat catgaacccc aataccctga
     1801 tgactcatga agtgcctgtt taccgaacta atcagtgtgc tggggagttt gtgattacat
     1861 ttccaagagc ctaccacagt ggttttaacc agggttttaa ttttgctgag gctgttaact
     1921 tctgcactgt tgattggctg ccattaggcc gacagtgtgt ggagcattat cgcttgcttc
     1981 atcgatattg tgtgttttcc cacgatgaga tgatctgcaa gatggcttcc aaggctgatg
     2041 tattagatgt tgtagtggct tcaactgttc agaaagacat ggccattatg attgaggatg
     2101 agaaagcttt aagagaaact gtccgtaaat tgggagtgat tgattcggaa agaatggatt
     2161 ttgagctgtt gccagatgat gaacgtcagt gtgtaaaatg caaaactaca tgcttcatgt
     2221 ctgccatctc ctgttcttgt aaacctggcc ttcttgtttg cctgcatcat gtaaaagaat
     2281 tgtgttcctg tcctccttac aaatataaat tgcggtatag gtacacgctg gatgatctct
     2341 accctatgat gaatgcattg aagcttcgag cagaatctta caacgaatgg gccttgaatg
     2401 tgaatgaagc tttggaggca aagatcaaca agaagaaaag ccttgtcagc ttcaaggctt
     2461 taattgaaga atctgaaatg aagaaattcc cagacaatga tcttttgcga caccttcgcc
     2521 tagtcacaca ggatgcagag aagtgtgcct ctgttgcgca gcagttgctt aatggcaaaa
     2581 ggcaaactag atatcgatct ggtggaggga aatcccaaaa tcagttgaca gtgaatgagc
     2641 tccggcagtt tgtaacacag ctgtatgctc ttccatgtgt cctcagtcag acaccattac
     2701 taaaggatct cttgaatcgt gtagaagatt ttcaacagca tagtcagaaa ctactctctg
     2761 aggaaacgcc tagtgctgcg gagctgcagg acttgctaga tgtcagcttt gaatttgatg
     2821 ttgaacttcc acagcttgct gagatgcgta tccgtttgga acaagcccgt tggctagaag
     2881 aggtgcagca agcttgccta gaccccagct cccttacttt agatgatatg agacgtctca
     2941 tagacctagg ggtagggctg gccccgtatt cagcagtgga gaaagctatg gcccggctgc
     3001 aggaactgct cacagtgtca gagcactggg acgacaaagc caagagtctc ctcaaggcca
     3061 ggccacgaca ttcattgaat agccttgcta cggcagtaaa ggaaatcgaa gagatccctg
     3121 catatctgcc caatggtgcg gctctgaaag actcagtgca gagagccaga gactggcttc
     3181 aggatgtaga gggcctgcag gctggaggac gtgtgccagt gttagacaca ctcatagaac
     3241 ttgttacacg aggccgatct atccccgtac atctgaattc tttgccaaga ctggaaaccc
     3301 tagtagctga ggttcaggct tggaaagaat gtgctgttaa tacattcttg actgagaatt
     3361 ctccatattc tctcttagag gtgctgtgtc ctcgatgtga tattggcctt ttgggattga
     3421 aaaggaagca gagaaagtta aaggagccct tgccaaatgg aaagaaaaaa agcaccaaat
     3481 tagagagtct gagtgacctg gagagagctt taactgaaag caaggagact gcttcagcta
     3541 tggcaactct tggggaagct cgcctaaggg aaatggaagc cttgcagtct ctcagactcg
     3601 ccaatgaagg gaaattgctg tcgcctctcc aagatgtgga tataaaaatc tgcctatgtc
     3661 agaaggcccc agctgcccct atgattcaat gtgaactctg cagggatgct ttccacacca
     3721 gttgtgtggc ggtacccagt atttcacagg gcctgcgaat ctggctttgt ccccattgtc
     3781 ggaggtcaga gaaacctcca ttagagaaaa ttctgcccct gctcgcctcc cttcagcgta
     3841 tccgagttcg ccttcctgag ggagatgcac ttcgatatat gattgaaaga accgtgaact
     3901 ggcagcacag agcccagcaa ctgctttcgt cagggaatct taaatttgtg caagatcgag
     3961 tgggctcagg actgttatat agcagatggc aagcctcagc aggacaggtg tcagacacaa
     4021 acaaggtatc tcaacctcct ggcacaacat cattttcttt gcctgatgac tgggacaaca
     4081 gaacctcata tttgcactcc cccttctcaa ctggacgaag ttgtatcccc ctccatggtg
     4141 ttagtccaga agtgaatgaa ctattgatgg aagcccagct gctccaggta tcccttcctg
     4201 aaattcagga actttaccag actttacttg caaagccaag ccctgctcag cagactgacc
     4261 gaagctcacc agtgagaccc agcagtgaga agaatgactg ttgccgaggg aagcgagatg
     4321 gaattaacag tcttgagaga aaactgaaga gacgcctgga aagagagggc ctctccagtg
     4381 agcggtggga acgagttaag aaaatgcgga cccccaaaaa gaagaaaatc aaactgagcc
     4441 accccaagga catgaacaat ttcaagttag agagagagcg tagctatgaa ttagttcgtt
     4501 ctgctgaaac tcattccctg ccctcagaca catcctattc cgaacaggaa gactctgagg
     4561 atgaagatgc catctgccca gctgtgagct gcctgcagcc agaaggagat gaggtggact
     4621 gggtccagtg tgatggcagc tgcaatcagt ggtttcatca ggtctgtgtt ggtgtctccc
     4681 cagagatggc agagaaagaa gactacatct gtgtgcgctg tactgtgaag gacgcaccaa
     4741 gccgaaagta aaaacacaaa aacagatacc cccctactta atgtaattca ggactccaac
     4801 caagaggatt tcttcaaatc tcagcaaagc tacaggactg gtactcaagc cagcctgtaa
     4861 acggtgctat ttctattcct tatgggatca tttttccagg actctttgaa gaaaagaaaa
     4921 aacaactaaa aaaatttttg acactttttg tattttttcc ttaagagcta tttgtggttg
     4981 ttgaggtttg aaaagctgac tgtttttttt gcaggggttc ccaccaattt ggaaggcatt
     5041 gaagcttgca ccttttcatg tacagcatta aaattttacc tctctctggg atttaccagc
     5101 ttaagagtcc aactcacttc cagtgcccaa aagggcaccc accagaaatt ccagtaaatc
     5161 ctcatttgag gaagctctcc cttgtttact ctgttaccac attggggaaa tttttaagtt
     5221 tttcactttg ggagtttttg tttgtttctt cttttccttt atccactttt cttcttcctg
     5281 gtagactagg tttatttatc tgagcaataa cttctatgtt ggtttcagtg gctggaatta
     5341 aaacaaaaca aaacaaactt ccaaacagtg tgttggtgct ttagcgattg attgatgtac
     5401 agaacacaaa tgtctagttt ctagtgtcac tgatgaacta gtgatgtaga aaagagactt
     5461 ctctgtaagt aattgccaca gctgtatttt ggctttctcc ctgtcccttc ctttctcccc
     5521 tattttttgg tagcttgtat caaatgttac agtttatatt gtggaataaa tccttcgtcc
     5581 taacataaca ctaaatgctg attatttaga gccattagag cacagcttct tctgcccctc
     5641 tactgttgca cagccagaag gggctgcttg cttttgcctc tgcccaacca ggttgcagta
     5701 gcagtggatg ttagcctgca aacaacatta ggggattctt cttttgtgtc ctgctctgtt
     5761 tggtgggcca tatgcctaca gccctcacta acaaagaacc cctctgtctt caaggactag
     5821 aacctatctt taaagccgtg ctcttttaaa ataagctttc tcagaatgtt ggcaaatcac
     5881 ttcaatcctc aaatcagtct tccttgtgga atgctgcctt tattatattt gaattgacag
     5941 gggaacttgg tttagggtta agacgttgga aggaaatcta aggaaaatta atcctcacag
     6001 aggtccgggt ttagtatatg tcttgagagg agacttgtga attcccagac tctgcctcct
     6061 ggtttccttt ctcatttctt tctaactgta gctatcatta ctggctgtgg atagcccata
     6121 gctattttcc ttgcttttct tttttaaagg ggtctgttct gcagtggaga agacattctg
     6181 gtgaccagac ttttgcttac cttttcctat tctgttgcca atttttgttt tccccacatt
     6241 ctatagccat aaacctgaag atgagtaaaa ctggtgggtc tttaataaaa caacaacaaa
     6301 aacagcagtt tgtgatatag cagaggttta aatgtaccct ccccttttat gcacttcaaa
     6361 taattaaatc tctttaagaa tgacttctag ttgtctgcag ttttctgcag ttgttgtgat
     6421 gtttctcttc gtctgatggt ggttctgggg ccaatagaga agaatagtct ccagagtaca
     6481 atttggaatc atcgtggttt ggccttgtta gtattcaaat tcttagaatc ccctccatca
     6541 cccccgactt tgagatagga tgccaactgt cccagtcctc accttccatt gagaaattaa
     6601 gcttaaaagg agaccctgct gctaatataa agccactgcc tttagagagc ttttgccatc
     6661 ttagtaagca caacccctac ccccatcccc actagttttt cttcttcacc tgtgggtggt
     6721 ggtacacagt ccctgacaat agcatctttg aggaagtcag atctttgtat ctctgagtga
     6781 gttagaaaag gtaggcatgt gtgtatttga accactccct ccctggatga gaaccactga
     6841 tcattttatg tgtgatgatg ctgaatttaa agagaatgtc agttgcccaa agctacactg
     6901 tactactagt aaataacaaa gcctgggttt tatcttccag ttttcctaca gtattcctcc
     6961 taccttgtac accatcacac tactaatgaa cacagataac gtttactttc cagtttatgc
     7021 ctttgttgta tccctaaaat gactacagac tgatgtgatc taaaaaccat gtttcattgt
     7081 gtgttagctg tgaagctggc ctgtaccaga gaaacctctg aacttgtagg ggaaaatgat
     7141 aaaatgcaca tggaaactga cacttcagtt tccatctcag tagtcctgca gctttgtgag
     7201 gtgggagagg ggaagggact gtgttaagtt agagcctgaa ccagaaggag ggtcagtggg
     7261 taaagaaaga aagggtagat gaggtgtgcc ttccacctca cctaaatgaa tactgtttgt
     7321 tttttgtttt tccttccaga ttagactttg ggggatttct tatatagaat aaagggcttg
     7381 attatatgta gcctctatcc tggagaaagg ttatgtaatt tggactatgt aaaggaagtt
     7441 gacttcttta cagcttcgtt tcagtatcct aggaggtggg attcattttt ctatcttaag
     7501 ttaacctaaa ggagagatgc cacttgtggt gatggaggtt gttaaaaacc tgaatttccc
     7561 tgcttcattc tccagtgaag agcttaagaa aatgaggctt tggatatttt ggcagaagtg
     7621 tctgaaatgc acctgatttg ccattatacc caccatcaaa agcaacatgg ccctttgggt
     7681 attagtgcaa gattagccta agaatagagt agatctctac ctggaagagg gtgaaacatg
     7741 gctctctact gatttgggtt gtactctgaa ggccctttgt aatgggtttc tgcctctttg
     7801 tatttcactt aaaaaatctt gatggatatt tggcagtctg ttaagacctg cttctggctt
     7861 ggagcaggta ttgattggta tttagtaccc atgggtgttt ttctgggctc agtcttgcct
     7921 atgtttcttg ccatatgaca cataccggaa tggattccag atgctatata cctgtaacag
     7981 gagacagaat tggacaacaa ggattttaag agtcattgcc cattgtaaag cattaagcca
     8041 gagctggtta ttcattatca gactaactac atactagtcc atgctagtgt cagcctatat
     8101 taaaatagtc tttccttgcc atagtgctgg cgaaaaccca atcccttctg atgaaacatt
     8161 gcttcttggg aagacaagct gaggaaagca atgaagatcc cagtgtcggc ctttattgag
     8221 ctatgtatga gggtcagggt ccctcaactc ctagtgacta tgaagcagca gtgtgatggc
     8281 ttcgccctct ttgcccctct gtcatcaatc ctttgcatgt ggctatttta agcttctcag
     8341 ctttcttttg ggaggcttca tgtgtaactt attatagaaa tgttactgaa aagctgccta
     8401 aacaaaaaat tgtataaagt aggaatttgt ataaagtaat actgttgtaa atccatcttc
     8461 aagatgtaaa gaatcaattt gtaaagtgta tattttcact tctcccttca aatttatgtg
     8521 aacaagtttt tcatgtttca atattgctta cataggaata caccttacgt ttttatcagt
     8581 ataaatggaa catttaaaac cagtcaacaa cagaacagat aatccagctc cctgtttgtg
     8641 ttctgggtta attttgcaag gatgaagggc tagaaagtgg tgagtttcgg tgtgtttctt
     8701 attttcagga taaccggctg cattgcagta gaggaatgga atggtgaggt catttgacct
     8761 gttccaggtg agtggaggcc aaagaacatt ctttctgcct ccccttggat gggaaaattg
     8821 agaaattaaa aagttgcctt tctgaggaaa caaaagttat tttctctatt taaaataaat
     8881 gtccaaaggc acccctctaa acaccaaaac ttttagctcc tggcaaactt acctagctag
     8941 aagttggaga agagtgcggt ttcaaaccat gcttcctttc tgcccttgcc aatacgttct
     9001 cactgactgt gattctgctg tgaacacaca cacacacaca aacacacaca caagcccctt
     9061 ctgtgtatga tcaggacaag tagttcaaca gttaataaaa aagttaaatt attggatgag
     9121 aaagatatat ttaacctaaa tcataaatat gtatatccat ttaataaaca ctaaaattga
     9181 gaaaaattag tttggggatg agggccttca ttcataatag ccataatgca ttatctatga
     9241 tgtgagcttg attgagcttc tttaaaatgc ataaagaatt tgaacaacaa aa
//
