LOCUS       NM_001042603           10701 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 5A (KDM5A), mRNA.
ACCESSION   NM_001042603
VERSION     NM_001042603.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10701)
  AUTHORS   Deogharia,M., Venegas-Zamora,L., Agrawal,A., Shi,M., Jain,A.K.,
            McHugh,K.J., Altamirano,F., Marian,A.J. and Gurha,P.
  TITLE     Histone demethylase KDM5 regulates cardiomyocyte maturation by
            promoting fatty acid oxidation, oxidative phosphorylation, and
            myofibrillar organization
  JOURNAL   Cardiovasc Res 120 (6), 630-643 (2024)
   PUBMED   38230606
  REMARK    GeneRIF: Histone demethylase KDM5 regulates cardiomyocyte
            maturation by promoting fatty acid oxidation, oxidative
            phosphorylation, and myofibrillar organization.
REFERENCE   2  (bases 1 to 10701)
  AUTHORS   Yan,Y., Yan,H., Qiu,Z. and Long,L.
  TITLE     Mechanism of KDM5A-mediated H3K4me3 modification in the osteogenic
            differentiation of mesenchymal stem cells in steroid-induced
            osteonecrosis of the femoral head
  JOURNAL   Int J Rheum Dis 27 (3), e15090 (2024)
   PUBMED   38443978
  REMARK    GeneRIF: Mechanism of KDM5A-mediated H3K4me3 modification in the
            osteogenic differentiation of mesenchymal stem cells in
            steroid-induced osteonecrosis of the femoral head.
REFERENCE   3  (bases 1 to 10701)
  AUTHORS   Wang,D., Zhang,Y., Liao,Z., Ge,H., Gungor,C. and Li,Y.
  TITLE     KDM5 family of demethylases promotes CD44-mediated chemoresistance
            in pancreatic adenocarcinomas
  JOURNAL   Sci Rep 13 (1), 18250 (2023)
   PUBMED   37880235
  REMARK    GeneRIF: KDM5 family of demethylases promotes CD44-mediated
            chemoresistance in pancreatic adenocarcinomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10701)
  AUTHORS   Li,S., He,J., Liao,X., He,Y., Chen,R., Chen,J., Hu,S. and Sun,J.
  TITLE     Fbxo22 inhibits metastasis in triple-negative breast cancer through
            ubiquitin modification of KDM5A and regulation of H3K4me3
            demethylation
  JOURNAL   Cell Biol Toxicol 39 (4), 1641-1655 (2023)
   PUBMED   36112263
  REMARK    GeneRIF: Fbxo22 inhibits metastasis in triple-negative breast
            cancer through ubiquitin modification of KDM5A and regulation of
            H3K4me3 demethylation.
REFERENCE   5  (bases 1 to 10701)
  AUTHORS   Yoo,J., Kim,G.W., Jeon,Y.H., Kim,J.Y., Lee,S.W. and Kwon,S.H.
  TITLE     Drawing a line between histone demethylase KDM5A and KDM5B: their
            roles in development and tumorigenesis
  JOURNAL   Exp Mol Med 54 (12), 2107-2117 (2022)
   PUBMED   36509829
  REMARK    GeneRIF: Drawing a line between histone demethylase KDM5A and
            KDM5B: their roles in development and tumorigenesis.
            Review article
REFERENCE   6  (bases 1 to 10701)
  AUTHORS   Mao,S., Neale,G.A. and Goorha,R.M.
  TITLE     T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding
            protein 2
  JOURNAL   Oncogene 14 (13), 1531-1539 (1997)
   PUBMED   9129143
REFERENCE   7  (bases 1 to 10701)
  AUTHORS   Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
            Marynen,P.
  TITLE     Isolation and regional assignment of human chromosome 12p cDNAs
  JOURNAL   Genomics 29 (1), 44-52 (1995)
   PUBMED   8530100
REFERENCE   8  (bases 1 to 10701)
  AUTHORS   Kim,Y.W., Otterson,G.A., Kratzke,R.A., Coxon,A.B. and Kaye,F.J.
  TITLE     Differential specificity for binding of retinoblastoma binding
            protein 2 to RB, p107, and TATA-binding protein
  JOURNAL   Mol Cell Biol 14 (11), 7256-7264 (1994)
   PUBMED   7935440
REFERENCE   9  (bases 1 to 10701)
  AUTHORS   Fattaey,A.R., Helin,K., Dembski,M.S., Dyson,N., Harlow,E.,
            Vuocolo,G.A., Hanobik,M.G., Haskell,K.M., Oliff,A., Defeo-Jones,D.
            et al.
  TITLE     Characterization of the retinoblastoma binding proteins RBP1 and
            RBP2
  JOURNAL   Oncogene 8 (11), 3149-3156 (1993)
   PUBMED   8414517
REFERENCE   10 (bases 1 to 10701)
  AUTHORS   Defeo-Jones,D., Huang,P.S., Jones,R.E., Haskell,K.M., Vuocolo,G.A.,
            Hanobik,M.G., Huber,H.E. and Oliff,A.
  TITLE     Cloning of cDNAs for cellular proteins that bind to the
            retinoblastoma gene product
  JOURNAL   Nature 352 (6332), 251-254 (1991)
   PUBMED   1857421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU182136.1, DA211439.1,
            AB209999.1 and AC007406.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001042603.2.
            
            Summary: This gene encodes a member of the Jumonji, AT-rich
            interactive domain 1 (JARID1) histone demethylase protein family.
            The encoded protein plays a role in gene regulation through the
            histone code by specifically demethylating lysine 4 of histone H3.
            The encoded protein interacts with many other proteins, including
            retinoblastoma protein, and is implicated in the transcriptional
            regulation of Hox genes and cytokines. This gene may play a role in
            tumor progression. [provided by RefSeq, Aug 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209999.1, SRR14038192.821815.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399788.7/ ENSP00000382688.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               BU182136.1         158-374
            218-219             DA211439.1         207-208
            220-6433            AB209999.1         201-6414
            6434-10701          AC007406.1         106980-111247       c
FEATURES             Location/Qualifiers
     source          1..10701
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..10701
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /note="lysine demethylase 5A"
                     /db_xref="GeneID:5927"
                     /db_xref="HGNC:HGNC:9886"
                     /db_xref="MIM:180202"
     exon            1..394
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..5302
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /EC_number="1.14.11.67"
                     /note="retinoblastoma binding protein 2; Jumonji, AT rich
                     interactive domain 1A (RBP2-like); lysine (K)-specific
                     demethylase 5A; histone demethylase JARID1A; jumonji/ARID
                     domain-containing protein 1A; [histone
                     H3]-trimethyl-L-lysine(4) demethylase 5A"
                     /codon_start=1
                     /product="lysine-specific demethylase 5A"
                     /protein_id="NP_001036068.1"
                     /db_xref="CCDS:CCDS41736.1"
                     /db_xref="GeneID:5927"
                     /db_xref="HGNC:HGNC:9886"
                     /db_xref="MIM:180202"
                     /translation="MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAE
                     KTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQG
                     STLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKS
                     HYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRT
                     RRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFN
                     MQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGD
                     WRCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEK
                     EFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPV
                     LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPS
                     HAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTF
                     PRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADP
                     ECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTT
                     CFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYD
                     TWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVA
                     QLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEF
                     HERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDP
                     QQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVA
                     SLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKG
                     RPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKN
                     RRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRA
                     ANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQ
                     AKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQ
                     ALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSA
                     FNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEE
                     IPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLE
                     LSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPL
                     KVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLA
                     KKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC
                     AAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPG
                     PAPPPSFIMSYKLPMEDLKETS"
     exon            395..472
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..595
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..766
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..901
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1007
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1099
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1258
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1378
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1537
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1719
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1882
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2002
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2197
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2379
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2504
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2655
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2770
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..3126
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3265
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3445
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3607
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..4159
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4303
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4463
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4684
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4685..5095
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..10701
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9124..9129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /note="hexamer: AATAAA"
     polyA_site      9152
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
     regulatory      9848..9853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /note="hexamer: AATAAA"
     polyA_site      9870
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /note="major polyA site"
     regulatory      10593..10598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
                     /note="hexamer: AATAAA"
     polyA_site      10620
                     /gene="KDM5A"
                     /gene_synonym="NEDEHC; RBBP-2; RBBP2; RBP2"
ORIGIN      
        1 gacagcacgg taacttccgg aaaagtcctg aacctcagtg gaaaagcctt gcaagaaaca
       61 ataacaaacg ggaggaggaa gcgattctgg ggtttctgtg ttgaacggtt cttgtccgcg
      121 aagatgcgct tcggcctctg tcaggggact tgaacgggct tagtgggctt cagccagctt
      181 ttctccaccg gttccccacg gggacccccc cccccccccg gccgttgcaa tggcgggcgt
      241 ggggccgggg ggctacgcgg cggagttcgt gccaccgcca gagtgccccg tctttgagcc
      301 gagttgggag gagttcacag atccgctcag ctttatcggc cgcatccggc ctttggcgga
      361 gaaaaccggc atctgcaaaa ttcggccgcc caaggactgg cagcctccat ttgcctgtga
      421 agtaaaaagc tttcgtttca ctccaagagt ccagcgcctg aatgaacttg aggcaatgac
      481 cagagtgaga ttggatttct tggatcaact agcaaaattt tgggaacttc aaggatctac
      541 tctgaagatc cctgtggtag agagaaaaat cctggatctg tatgctttga gcaagattgt
      601 tgccagcaaa ggaggttttg aaatggtcac caaagagaag aaatggtcta aagtgggtag
      661 tcgcttggga tatctgccag gaaaaggaac tgggtctctt ttgaagtcac attatgaaag
      721 aattctctac ccatatgagc ttttccagtc tggtgtgagc cttatgggtg tgcagatgcc
      781 taatttagat cttaaagaaa aagtggagcc tgaggttctc agcactgata cccaaacttc
      841 cccagagcca ggcacaagga tgaacattct gccgaagaga acaagacgtg tgaagactca
      901 gtcagaatct ggagatgtga gtagaaacac ggaactgaag aaacttcaga tttttggggc
      961 tgggcccaag gttgtgggct tggcaatggg aacaaaagat aaagaagatg aggtcacccg
     1021 aagacgaaaa gttaccaaca ggtcagacgc atttaacatg caaatgagac aacggaaagg
     1081 cactctctct gttaactttg ttgatctcta tgtttgtatg ttttgtggtc ggggaaacaa
     1141 tgaagataaa ttgcttttgt gtgatggatg tgatgacagc tatcatacat tttgtctaat
     1201 tcctccacta cctgatgtgc ccaaaggaga ctggaggtgt cctaaatgtg tcgccgagga
     1261 atgtagcaaa cctcgagaag cctttggatt tgaacaagct gtacgagagt atacacttca
     1321 gagctttgga gagatggcag ataattttaa gtctgattat tttaatatgc cagtccatat
     1381 ggttcccaca gaactagtag aaaaggaatt ttggcggctg gtaagcagca ttgaagaaga
     1441 tgttattgtg gaatatggag cagatatctc ctcaaaagac tttggaagtg gatttccggt
     1501 gaaggatggg cggagaaaga ttctgccaga agaagaggaa tatgcacttt ctggttggaa
     1561 tttgaataac atgcctgtcc tggaacagtc tgttcttgca catattaatg tggacatctc
     1621 tggtatgaaa gtgccgtggc tctatgtggg aatgtgcttc tcttcttttt gctggcacat
     1681 tgaggatcac tggagttatt ccatcaacta cttgcactgg ggggagccaa agacatggta
     1741 tggtgtgcca tctcatgctg cagagcaact ggaggaggtg atgagagagc tggcccccga
     1801 gttatttgaa tcccagcctg atcttctgca tcagttagtt accatcatga accccaacgt
     1861 gctaatggag catggtgtgc ctgtgtacag gaccaatcag tgtgctggcg agtttgttgt
     1921 gacatttcct cgtgcctatc actctggatt taaccagggc tacaactttg ctgaagctgt
     1981 gaacttctgt actgctgact ggttgcccat tggacgtcaa tgtgtaaatc attaccgacg
     2041 cctaaggcgc cactgtgtct tttcacacga ggaactaatt ttcaagatgg cagcagatcc
     2101 agaatgctta gatgtggggc tggctgccat ggtctgcaaa gaattgactc tcatgactga
     2161 agaagaaaca cgattaagag agtctgttgt acagatgggt gtcctgatgt cagaagaaga
     2221 agtgtttgaa cttgttcctg atgatgagcg gcagtgttca gcatgcagaa ccacatgttt
     2281 tctctctgct ctcacatgtt cctgtaatcc tgagcggctt gtatgtctct accatccaac
     2341 tgatctgtgc ccctgcccca tgcagaagaa atgtcttaga tatcgctacc cattagaaga
     2401 cctcccttct ctgctatatg gtgtaaaagt cagggcacag tcctatgaca cttgggtcag
     2461 tcgtgttaca gaagcattgt ctgctaactt caaccacaaa aaagatttga ttgaattgcg
     2521 agtaatgctg gaagatgctg aggataggaa atacccagag aatgatctct ttcgaaaact
     2581 cagggatgct gtaaaagaag ctgagacctg tgcttctgtg gctcagctgc ttctgagcaa
     2641 aaagcagaaa cacagacaga gcccagatag tgggaggact cggaccaaac tgacagtgga
     2701 agaattgaag gcctttgtcc aacaactttt tagtcttccg tgtgtcatca gccaagctcg
     2761 gcaagtaaag aatctgctag atgatgtgga agagtttcat gaacgtgctc aggaggccat
     2821 gatggatgaa accccagatt cttccaaact ccagatgttg atagatatgg gctctagtct
     2881 ctatgtggaa ctccctgaat taccacgact gaagcaagag ctacaacagg ctcggtggtt
     2941 ggacgaagta agactgacct tatcagatcc gcaacaagtc actttggatg tcatgaagaa
     3001 gctgatagac tctggggtag ggttggcacc ccaccatgct gtggagaaag caatggctga
     3061 actacaggag ctccttacag tctctgaacg atgggaagaa aaggctaagg tctgcctaca
     3121 ggcaagaccg aggcacagtg tggcaagttt agaaagcatt gtgaatgaag ccaagaacat
     3181 tccagccttt ctacccaatg tgttgtcctt gaaagaagcc ttacaaaagg ctcgagaatg
     3241 gaccgctaaa gtggaagcta ttcagagtgg cagcaattac gcttatttgg agcagcttga
     3301 gagcttgtct gcgaaaggac gccctattcc tgtgcgtctt gaagcactgc cgcaagtgga
     3361 atcacaggta gcagcagcac gggcatggag agaacggact gggcggacgt ttcttaagaa
     3421 gaattctagc catacattgt tacaggtgct gagcccccgg accgacattg gtgtatatgg
     3481 gagtggcaaa aataggagga aaaaagtaaa agaactaata gaaaaagaaa aagaaaagga
     3541 tctggacctg gagcctctga gtgatctgga ggaaggattg gaggaaacca gagatacagc
     3601 catggtggtg gcagttttca aagaacggga gcaaaaagag attgaagcca tgcattctct
     3661 cagagcagcc aacctagcca agatgacaat ggtggaccgc atagaagaag taaaattttg
     3721 catttgccgc aagacagcca gtgggtttat gctacagtgt gagctctgca aagactggtt
     3781 ccataacagc tgtgttcctc ttcctaaatc aagttcccaa aaaaaaggat ccagctggca
     3841 agctaaagaa gtaaaattcc tttgccctct ttgtatgcgg tctcgaaggc ccaggctaga
     3901 gactattctg tcactcctgg tatcccttca gaagttgccc gtacggttgc ctgaaggaga
     3961 ggccctgcag tgtttgacag aacgtgctat gagttggcaa gatagagcgc ggcaggctct
     4021 agccacagat gaactatcct ctgccctggc caaactatct gtgttgagcc agcgtatggt
     4081 ggaacaggcg gctcgagaaa aaactgaaaa gatcatcagt gcagaactcc aaaaagcagc
     4141 tgccaatcca gacttacagg gacacttacc tagtttccag cagtctgctt ttaaccgggt
     4201 ggtgagcagt gtgtcatctt ctcctcgaca aacaatggac tatgatgatg aagaaacaga
     4261 ctctgatgaa gacattcgag agacatatgg ctacgacatg aaggacacag ccagtgtgaa
     4321 gtcctctagt agtcttgaac ccaatctttt ttgtgatgaa gagattccca tcaaatccga
     4381 ggaggtggtg acccacatgt ggacagcacc ttcattttgt gcagagcatg cttattcttc
     4441 tgcttctaag agttgttctc aaggttctag caccccaagg aaacaacctc ggaagagccc
     4501 tttggtgccc cgaagtttgg aacctccagt gctggagttg tcacctggag ctaaggcaca
     4561 actggaagaa cttatgatgg ttggagatct cctggaagta tctctggacg agactcaaca
     4621 catatggcgg attttgcagg ccacacaccc accctctgaa gacagattct tgcatatcat
     4681 ggaggatgac agcatggaag agaaaccact aaaagtgaaa ggaaaggact cttcagagaa
     4741 gaaacggaaa cggaagctag aaaaggtaga gcaacttttt ggagaaggaa aacagaagtc
     4801 caaggagtta aagaaaatgg acaaacctag aaagaagaaa ttaaaattag gtgcagacaa
     4861 atcaaaggag ctgaataaac tggccaagaa actagcaaaa gaagaagaga gaaagaaaaa
     4921 gaaggagaag gctgctgcag ccaaagttga acttgtgaaa gagagcactg aaaagaaaag
     4981 agagaaaaag gtgctggaca tcccctcaaa gtatgactgg tcaggagcag aggagtctga
     5041 tgatgagaat gctgtgtgcg cagcacagaa ctgccaaagg ccctgcaagg acaaggtaga
     5101 ctgggtacaa tgtgatggtg gctgtgatga gtggtttcat caagtttgtg tgggtgtatc
     5161 tccagaaatg gctgaaaatg aagattacat ctgtataaac tgtgcaaaga agcaggggcc
     5221 agttagccca ggtccagcac cacctccttc cttcataatg agctacaaac taccaatgga
     5281 ggatcttaaa gagaccagtt agcagatgct tggttagttt gggacatggg gggacatgga
     5341 ccacattgag accttagtca tcaagtagag tggtttatat ccacttggaa tgttgcttcc
     5401 aaagatgaat ggccttcaga gaaagtcccc ttagtgctgg cttcctcttt gcatggactc
     5461 tgtgggttac attctctatc aacatatcta tgcagagggt gtcttctttg gtacaacagc
     5521 caatatttca tgtctccttt gagtgtggtt tactgcatta aggccagatg cttaattgag
     5581 ctctagggtg gctggttagt attaatacat tggtgtgcta acagggcata taggatgtgg
     5641 cttttgtcca gctgatagta gttagaggct tacaacttag gagcagcacc aactgaaggt
     5701 gctaattgct tggatctcct tcattgggat agttggagag ggattggagt accactttcc
     5761 ttccactgtt acctggtact taatgcccta aagatacaac taggagtaac agggccaaag
     5821 ttatttctgt tagacgtcaa ggaatggtat cacagtctat tgacctcagc gatttgtgct
     5881 tgtttgtgct agaagaacat cccaaatagg agaacctctc acaagctggg gcaggtcacc
     5941 ttatctttgt aagatgagga tatcatctag atcagaaatc tgactagatt ggattctgag
     6001 gagaagaacc tactacaagg caaggagccg ttttttggct ttgaaaagtc ttgctgtctt
     6061 gggtctacat tttagggaag agcaggtaca tggatccagg cttctgccaa aaaaaaaaag
     6121 agaagaagat gacgatgatg accagtcgta ctatcttact gagccacagt gatgcatgct
     6181 tttcggggaa aacttcattc acaagtattc cagacaccag gcttcaggca tggccatgag
     6241 caagaccagc aaataacagc tttttgcctt gcagccctga ccccaatgtc tgctgtttcc
     6301 aacactggtg atttctaact acggcccaca gcagatgctg ttgaataaca ccatggcttc
     6361 atcagaggat gtggggttgt agtacctctg ggtgatgaag ttgttttagt aaatccattt
     6421 ttaaaaaaaa aaaaggactt gtttttactt ttttctaaat gtctctgact actgactgtt
     6481 ctatacatag attatttttc cttttttaat atacatatat gaatatataa atatatatat
     6541 ttactgttac cagcagcata tgacagagtt tcaacatcaa aaatccattt gggggcttgc
     6601 tttttctttt ttgctttaaa aaaaaaaatc ccattccttc tttgtagtac aaggagttag
     6661 cactccctcc tccatcccag cctgaccaga tcttccattt tgcttttgtt catatagata
     6721 attatatgtc ctttgtgtgt tgggacttgt ccctgtctgt tgggaaactt ggtctcactc
     6781 tagtctgtgc tggctctttt ttcttttgtg tgtgaatgtt tgaaactatg gtgctgtgtc
     6841 ctcttccctc ctgttgtgtt ctctgttctt cttaaggtat taggtaagct gtatgtaaac
     6901 tcttattaga aggggactaa ttttttttta aaggacaaaa aaaaaaatga ctaaaaatag
     6961 tgttttgtca tcactgtctg gtgtctttat tttggtttaa aaaaatctgt ggtttgactt
     7021 aaattcatca gttttccttt taaagggggg attggggtgg acctagcaac agcttatagt
     7081 ttcctcttcc ctttttgccc cagtctcttt taaagaactg tcttctagta actagaagtg
     7141 aaatgtactg tccagttaca gtttgagtgg gtatgagatt taactcaaaa ggaatcttac
     7201 aaaaaaaaag atgttttctt ataaaatcca atttctgtaa atgttttctc tgaagttcat
     7261 actacctact ttttattcat tcttaatact gtataacatt ttgagtgttt tgacttgttc
     7321 agaggtttgt tagtgttgct gtgcatatgt cttgaggtct catctgaagt aagtttgtgt
     7381 atgatcgaag atttcaatgg atattgcaag gtaactaatt aactgatttc ataagttttc
     7441 gttttgccaa gctaacgatt atcaattaag aatttcctct ggttgatgtt atacaagaaa
     7501 gcacaatatt ttttgcctgt tgatcttctt tgtaacagtc ttcagatatt tgtgggttaa
     7561 aaattgaatg taattttaag tgacagatgc ctggaataca tttaaaattt ttatttttcc
     7621 ttcctaatca tccattaact attccactat cagtggagag tcatgaggat gctgagaaag
     7681 tatgaatagc ttcctgtcac cttctgacgt tttgaaactt aaatatgtct tttcgttgat
     7741 actgtgggat tttctgtatt tacttgacag tcatggagga tttggtatga cttgaccaca
     7801 ggtttagacc aaggctgaga agaacagaag ggagaaatta atggcaaaac aaaaaataca
     7861 caaatctgcg gttttggaat taatgaaaca agattcatct atttaaagaa atgttggtgt
     7921 tctaatacaa agcattattt tcacttagag aaaattactt acttgctccc ttctgtattg
     7981 taatattttg tattaagaca tgatttaaaa tgtctttcta cccttatctc ctctaaactg
     8041 caactgaagt tgcaattctt catcattagt attttaactc tggcaaaggt tatagaaaga
     8101 aaaatggaaa tatggtaggc ctgtggtatt cttaaaagct aagtcattag aactatgcag
     8161 atccccaagt ttaaaagtac aaatacagca ccagtagtta gctttctagc tgggggagaa
     8221 gacaggagat ttttcttcca cagatgttta ttttgcttcc tgataggtac tgcagcaaag
     8281 ccatgttgat gtgtagatgc atgacttcct cactaagctg ctgcacacca gctttgcctg
     8341 catgattcaa atttgtgcct cagtaaaatt ataaattatt gcatgtcata ccttgaataa
     8401 tggaaacggc aaacattaaa cctgtgatta cccataatgt actttaataa taaaaaacat
     8461 ggcagccagg tgcagtagag tgcacctgtg gtcaggaggc tgaagtggga agattgcttc
     8521 aacctgtgag tttgagtccc gcctggtcaa cagcgagacc ccatgtgtct gtctgtctct
     8581 ctcttttttt aaaggacaga ggctaagctg taaggttagc atggttctgc ctgggctttg
     8641 cttctgtgct tctgtgcagg ctgagctgta aggttagcat ggttctgcct gggctttgct
     8701 tctgcgcttc tgtgcaggct gagctgtaag gttagcatgg ttctgcctgg gctttgcttc
     8761 tgcgcttctg tgcaggctga gctgtaaggt tagcatggtt ctgcctgggc tttgcttctg
     8821 cgcttctgtg ctagcaggtg cccacaaaat gtctttttga atttcttaat ttttgggttc
     8881 tggatgcaat tcgtgcacgc caagaaacta cttgcttgtc agtattttaa ttctgtagta
     8941 catgtgtgtg aatatcagcc agtacttaca gtaggaggat gaacagaaaa actgagaaga
     9001 cctgtctttc aaaagatggg tttatccact ttttaaggga aaaagtgaca gtttggcatg
     9061 ggatttgaaa agtggaaatt gtggaaaaat tgagctgttg aagtcccaca tataaccaga
     9121 tttaataaag cttcacatgt gaattagctc catatgtgtg tagaaggttg cttttatagc
     9181 aggtccttaa gtactccttt tgaaattcct cctttttttt taagtcatac cattacttct
     9241 ttggatatga atgtcccaag tggtatctcc tactgtagta tgaggaagaa tggctgttaa
     9301 tgtatttttt gaattttggt cttgtcttgg cctggatcat atccagtcac cactatgcaa
     9361 caaatgatgt gcactgggca aggatatgat gggttatgaa agctgtatct tgtttgtttt
     9421 ttcttttgca gtactccaag tggtctaaac aggaatgtct tgtaaaacct caagactccc
     9481 tattgattat tcccttacat atttatttac aatttatcag ggtaattggt ggtgccttat
     9541 gaaaagtata actcgatttc ttgatctttg agcatgtttt gtgtttcttg tgttttctaa
     9601 aagaatatta gatatggtta attgcattac atctaaaaga tttaaaaaat tgtgtgtatg
     9661 ctcaggttcc ccacacccat acccacccta acccctgtca tttacattgg tggcaacttt
     9721 aaatggtaac caagcaaaag tacattttga taatgagtat tgataatcct gaggaaaact
     9781 agtgagtata tgggagccac ctttgacctg tgccaaagca gtttctaatt tcatttgcta
     9841 actataaaat aaagaactga gccaaaataa tttgatcagt ggtgtgatta gcctattatc
     9901 attgctgaga atagtgtttt tggagtgtga agtgattcct gaagatttca cctgccttct
     9961 gtttccagca agaatccagt gatgaccaac acatttcctc acttttggtt cttgagaagt
    10021 ttatcccttt gcaacaaacc attaataggg aaaacaagga aatgctttcc ctttctcttt
    10081 ggcttcttaa agctcacaac caattcagac cccaagttac ttcagagaag caaatggcac
    10141 cttttcccca ttgccaagga tcccagctta tgcagatatg aaggacggat catttctgaa
    10201 aatgttaaga ctctgcttgc agtggacttg gcctcagttt catgaaatgt gtaactctgt
    10261 atgtgtatgt taggaggagg gttggttgaa agagcggggg cagggagggg aatctgatta
    10321 cctcttggga aataattttc ttgccaacaa aaagatacac ttgaagtttc ttaaggtggc
    10381 aagtccatta aaaaaaaaaa ttgtgttgga ccctcccagt ttagatcaag tatttcttgg
    10441 gggtcttgct attgtggttg ataccaataa atggaagatc cagaatattt tcatttaaag
    10501 ctcaaccatt aattggaaca tggtgaaaca ttgtacacat tgtaaaagta gggaacagta
    10561 caaaagaatg gaatcaaata ctatattatg tgaataaact agagtgattt tggaatttca
    10621 ctctcttcac cccttctcac ttgtatgttc tgtaaagtgt atttctactt tggtaggaag
    10681 aaagacttga tttaatattt c
//
