LOCUS       NM_001161630            2339 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens lysine demethylase 4E (KDM4E), mRNA.
ACCESSION   NM_001161630 XM_002343086 XM_002344611 XM_002347259
VERSION     NM_001161630.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2339)
  AUTHORS   Sanchez-Fernandez,E.M., Tarhonskaya,H., Al-Qahtani,K.,
            Hopkinson,R.J., McCullagh,J.S., Schofield,C.J. and Flashman,E.
  TITLE     Investigations on the oxygen dependence of a 2-oxoglutarate histone
            demethylase
  JOURNAL   Biochem J 449 (2), 491-496 (2013)
   PUBMED   23092293
  REMARK    GeneRIF: Results indicate that the histone demethylase activity is
            regulated by oxygen availability.
REFERENCE   2  (bases 1 to 2339)
  AUTHORS   Hillringhaus,L., Yue,W.W., Rose,N.R., Ng,S.S., Gileadi,C.,
            Loenarz,C., Bello,S.H., Bray,J.E., Schofield,C.J. and Oppermann,U.
  TITLE     Structural and evolutionary basis for the dual substrate
            selectivity of human KDM4 histone demethylase family
  JOURNAL   J Biol Chem 286 (48), 41616-41625 (2011)
   PUBMED   21914792
REFERENCE   3  (bases 1 to 2339)
  AUTHORS   Thalhammer,A., Mecinovic,J., Loenarz,C., Tumber,A., Rose,N.R.,
            Heightman,T.D. and Schofield,C.J.
  TITLE     Inhibition of the histone demethylase JMJD2E by 3-substituted
            pyridine 2,4-dicarboxylates
  JOURNAL   Org Biomol Chem 9 (1), 127-135 (2011)
   PUBMED   21076780
REFERENCE   4  (bases 1 to 2339)
  AUTHORS   Rai,G., Kawamura,A., Tumber,A., Liang,Y., Vogel,J.L.,
            Arbuckle,J.H., Rose,N.R., Dexheimer,T.S., Foley,T.L., King,O.N.,
            Quinn,A., Mott,B.T., Schofield,C.J., Oppermann,U., Jadhav,A.,
            Simeonov,A., Kristie,T.M. and Maloney,D.J.
  TITLE     Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated
            antiviral activity
  JOURNAL   (in) ? (Ed.);
            PROBE REPORTS FROM THE NIH MOLECULAR LIBRARIES PROGRAM;
            (2010)
   PUBMED   24260783
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC157851.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Aug 20, 2009 this sequence version replaced
            XM_002347259.1, XM_002344611.1, XM_002343086.1.
            
            Summary: The protein encoded by this intronless gene is a member of
            a large family of histone lysine demethylases, which use oxygen and
            2-oxoglutarate to demethylate di- and trimethylated lys9 of histone
            H3. Derepression of genes by demethylases is sometimes involved in
            viral infection or carcinogenesis, so inhibitors of these enzymes
            are desired. [provided by RefSeq, Dec 2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC157851.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000450979.2/ ENSP00000397239.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2339              BC157851.1         1-2339
FEATURES             Location/Qualifiers
     source          1..2339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2339
                     /gene="KDM4E"
                     /gene_synonym="JMJD2E; KDM4DL; KDM5E"
                     /note="lysine demethylase 4E"
                     /db_xref="GeneID:390245"
                     /db_xref="HGNC:HGNC:37098"
                     /db_xref="MIM:616581"
     exon            1..2339
                     /gene="KDM4E"
                     /gene_synonym="JMJD2E; KDM4DL; KDM5E"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1821
                     /gene="KDM4E"
                     /gene_synonym="JMJD2E; KDM4DL; KDM5E"
                     /EC_number="1.14.11.66"
                     /note="KDM4D-like protein; lysine (K)-specific demethylase
                     4E; [histone H3]-trimethyl-L-lysine(9) demethylase 4E"
                     /codon_start=1
                     /product="lysine-specific demethylase 4E"
                     /protein_id="NP_001155102.1"
                     /db_xref="CCDS:CCDS44713.1"
                     /db_xref="GeneID:390245"
                     /db_xref="HGNC:HGNC:37098"
                     /db_xref="MIM:616581"
                     /translation="MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAG
                     LAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLA
                     NSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDL
                     LEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQ
                     HLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGY
                     HAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWK
                     HRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCY
                     NPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRG
                     CSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL"
ORIGIN      
        1 ccaagcctga gaatcaggag aagcctcaca gtgacacccc caactgagga aactcacaga
       61 gctgggacat actctacttc ttcagaaaaa agtatactga ctagagtgga gtccccctgg
      121 ggagtcagaa agcctgtgaa agatctcact tgttcaaaag tccaagtgtg aattactgtc
      181 tcacagataa accaaagtat tttgaaaaac aaaggggaga aaagaaatta ctccccagaa
      241 ctctcaggca tctagaggac acccaagaac gtgggagtca gctgcttctt gtgtgcagcc
      301 atgaagtctg tgcactccag tccccagaac acgagtcata ccatcatgac gttttaccca
      361 accatggaag aatttgcaga tttcaacaca tatgttgctt acatggagtc ccaaggcgca
      421 catcaagctg gccttgccaa ggtaattcca cccaaggaat ggaaagccag acagatgtat
      481 gatgatatcg aagacatctt aatagccact cccctccagc aggtgacctc tgggcaggga
      541 ggtgtgttta ctcaatacca taaaaagaag aaagccatga gggtggggca gtatcgccgc
      601 ttggcaaaca gtaaaaaata tcagactccg ccacaccaga attttgcaga tttggagcaa
      661 cgatactgga agagccaccc cggtaatcca ccaatttatg gtgctgatat cagcggctcc
      721 ttatttgaag aaagcactaa acaatggaac ctaggacacc tgggaacaat tctggacctg
      781 ttggagcagg aatgtggggt tgtcatcgag ggtgtcaaca caccctacct gtactttggc
      841 atgtggaaga ccacgtttgc ctggcacaca gaggacatgg acctttacag catcaactac
      901 ctgcactttg gggagcccaa aacttggtac gtggtgcccc cagaacatgg tcagcacctg
      961 gaacgcctgg ccagggagct cttcccagac atttctcggg gctgtgaggc cttcctgcgg
     1021 cacaaagtgg ccctcatctc gcctacagtt ctcaaggaaa atgggattcc cttcaattgc
     1081 atgactcagg aggctgggga gttcatggtg acctttccct atggctacca tgctggcttc
     1141 aatcacggct tcaactgcgc agaagccatt aattttgcca ctccacgatg gattgattat
     1201 ggcaaaatgg cctctcagtg tagctgtggg gagtcgacag tgaccttttc catggacccc
     1261 tttgtgcgca ttgtgcaacc cgagagttat gagctctgga aacacaggca agacttggcc
     1321 attgtggaac acacagagcc cagggttgca gaaagccaag agctgagcaa ctggagagat
     1381 gatatagtac ttagaagagc tgctctgggc ctgaggcttc tcccaaacct cacagcccag
     1441 tgtcccacac agcctgtgtc ctcagggcac tgttacaacc caaaaggctg tggcactgat
     1501 gctgtgcctg gatccgcatt ccaaagctct gcatatcata cccagaccca gtcacttacc
     1561 ctggggatgt cagccagggt tcttctccct tccactggaa gctggggttc tggtcgtggt
     1621 cgtggtcgtg gtcaaggtca aggtcgaggt tgcagtcgtg gtcgtggtca tggttgttgt
     1681 actcgagaac tggggactga ggagccaact gttcagcctg catccaagag gcgcctttta
     1741 atgggtacaa ggagtagagc tcaaggccac aggcctcagc tcccgcttgc caatgatttg
     1801 atgacaaatc tgtccctttg agtggtggcc ttcagcatct tgccaaggct tctggctgct
     1861 gctgtgtccc tgatcttcaa ctcctggggc ccccactgga tcgtgatgaa accatgcacc
     1921 ctggcctgtg cctgctatcc ctcaacagca ctactagtaa tctccctgat gttgtctgca
     1981 tgactcctcc caatgtcatt gtgcctttga ttaagttttc cagggacact ggtggggact
     2041 ggaactgatt aagttcacca gggacacttg cctggtgaac atgggcaagg ctgtagcaat
     2101 ggaccacttt tacggctcta gggttctgac tccaactaag ttttccagaa tctcctgggc
     2161 tcctgactca tctgctgggt ctaaagacac tgagtttagg gatattttcc tccaatacat
     2221 gatcaatcct ctggatccac ggctatggaa tatggtgaca aatgtcagtg tctctcttat
     2281 tccaacccca ggatcagaga agattcttta cctgcagtaa ctgacacatt tccaaggcc
//
