LOCUS       NM_018039               2951 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 4D (KDM4D), mRNA.
ACCESSION   NM_018039
VERSION     NM_018039.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2951)
  AUTHORS   Qiu,C., Feng,Y.D. and Yang,X.
  TITLE     MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib
            Resistance by Targeting KDM4D Expression
  JOURNAL   Curr Med Sci 43 (5), 935-946 (2023)
   PUBMED   37828372
  REMARK    GeneRIF: MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves
            Imatinib Resistance by Targeting KDM4D Expression.
REFERENCE   2  (bases 1 to 2951)
  AUTHORS   Liang,H., Li,Q., Wang,N., Wang,C., Shi,S., Yang,H., Cao,Y., Shi,R.,
            Jin,L. and Zhang,C.
  TITLE     KDM4D enhances osteo/dentinogenic differentiation and migration of
            SCAPs via binding to RPS5
  JOURNAL   Oral Dis 29 (7), 2827-2836 (2023)
   PUBMED   36579641
  REMARK    GeneRIF: KDM4D enhances osteo/dentinogenic differentiation and
            migration of SCAPs via binding to RPS5.
REFERENCE   3  (bases 1 to 2951)
  AUTHORS   Deng,Y., Li,M., Zhuo,M., Guo,P., Chen,Q., Mo,P., Li,W. and Yu,C.
  TITLE     Histone demethylase JMJD2D promotes the self-renewal of liver
            cancer stem-like cells by enhancing EpCAM and Sox9 expression
  JOURNAL   J Biol Chem 296, 100121 (2021)
   PUBMED   33434575
  REMARK    GeneRIF: Histone demethylase JMJD2D promotes the self-renewal of
            liver cancer stem-like cells by enhancing EpCAM and Sox9
            expression.
REFERENCE   4  (bases 1 to 2951)
  AUTHORS   Peng,K., Zhuo,M., Li,M., Chen,Q., Mo,P. and Yu,C.
  TITLE     Histone demethylase JMJD2D activates HIF1 signaling pathway via
            multiple mechanisms to promote colorectal cancer glycolysis and
            progression
  JOURNAL   Oncogene 39 (47), 7076-7091 (2020)
   PUBMED   32989255
  REMARK    GeneRIF: Histone demethylase JMJD2D activates HIF1 signaling
            pathway via multiple mechanisms to promote colorectal cancer
            glycolysis and progression.
            Erratum:[Oncogene. 2021 Mar;40(12):2336-2337. doi:
            10.1038/s41388-021-01678-9.. PMID: 33619324]
REFERENCE   5  (bases 1 to 2951)
  AUTHORS   Li,M., Deng,Y., Zhuo,M., Zhou,H., Kong,X., Xia,X., Su,Z., Chen,Q.,
            Guo,P., Mo,P., Yu,C. and Li,W.
  TITLE     Demethylase-independent function of JMJD2D as a novel antagonist of
            p53 to promote Liver Cancer initiation and progression
  JOURNAL   Theranostics 10 (19), 8863-8879 (2020)
   PUBMED   32754284
  REMARK    GeneRIF: Demethylase-independent function of JMJD2D as a novel
            antagonist of p53 to promote Liver Cancer initiation and
            progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2951)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   7  (bases 1 to 2951)
  AUTHORS   Shin,S. and Janknecht,R.
  TITLE     Activation of androgen receptor by histone demethylases JMJD2A and
            JMJD2D
  JOURNAL   Biochem Biophys Res Commun 359 (3), 742-746 (2007)
   PUBMED   17555712
  REMARK    GeneRIF: identified two related histone demethylases, JMJD2A and
            JMJD2D
REFERENCE   8  (bases 1 to 2951)
  AUTHORS   Whetstine,J.R., Nottke,A., Lan,F., Huarte,M., Smolikov,S., Chen,Z.,
            Spooner,E., Li,E., Zhang,G., Colaiacovo,M. and Shi,Y.
  TITLE     Reversal of histone lysine trimethylation by the JMJD2 family of
            histone demethylases
  JOURNAL   Cell 125 (3), 467-481 (2006)
   PUBMED   16603238
REFERENCE   9  (bases 1 to 2951)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   10 (bases 1 to 2951)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031862.1, AW593120.1, AK056162.1, CA311555.1 and AP002383.3.
            
            On Nov 23, 2018 this sequence version replaced NM_018039.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031862.1, SRR1803615.93427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335080.6/ ENSP00000334181.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               BC031862.1         34-361
            329-618             AW593120.1         1-290               c
            619-681             BC031862.1         652-714
            682-1294            BC031862.1         716-1328
            1295-2674           BC031862.1         1330-2709
            2675-2860           AK056162.1         2115-2300
            2861-2946           CA311555.1         15-100              c
            2947-2951           AP002383.3         122486-122490
FEATURES             Location/Qualifiers
     source          1..2951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2951
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /note="lysine demethylase 4D"
                     /db_xref="GeneID:55693"
                     /db_xref="HGNC:HGNC:25498"
                     /db_xref="MIM:609766"
     exon            1..360
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            361..455
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /inference="alignment:Splign:2.1.0"
     exon            456..2951
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             805..2376
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /EC_number="1.14.11.66"
                     /note="jumonji domain containing 2D; jumonji
                     domain-containing protein 2D; jmjC domain-containing
                     histone demethylation protein 3D; lysine (K)-specific
                     demethylase 4D; [histone H3]-trimethyl-L-lysine(9)
                     demethylase 4D"
                     /codon_start=1
                     /product="lysine-specific demethylase 4D"
                     /protein_id="NP_060509.2"
                     /db_xref="CCDS:CCDS8302.1"
                     /db_xref="GeneID:55693"
                     /db_xref="HGNC:HGNC:25498"
                     /db_xref="MIM:609766"
                     /translation="METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAH
                     RAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYR
                     HLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTI
                     QDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPE
                     HGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFP
                     YGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYD
                     LWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAAR
                     SGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGR
                     RGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGL
                     QHPVKASGCSWAPVP"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /note="hexamer: ATTAAA"
     polyA_site      2951
                     /gene="KDM4D"
                     /gene_synonym="JMJD2D"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgttt gaaatcagtg ccttagagta gaccctaaac ctcattttat accttcaaga
       61 accaattact taatgtctct tccgtctttt ccgtccccga ccccctccca gactccttca
      121 ttccggtact gcgtggacgg aaagccccgg gtagccgaca ccacgtcccc ggctagcggg
      181 agagagcgtg gaaaaggatt acaccaaact gtttaaatcc aacgactcct gcttccatcc
      241 tttctcctga gctagaacca acaaacctag agagttgggc ttcggaaaaa ctagtgtttt
      301 catttaattg gatatgaaga aagaacaaat atgtacgggg caaccacgat ctttacaaag
      361 aacataagtt ccaggaaagc aggaaccttg tctctcttgt tcactgggtg tatcctctgc
      421 atatagaaca gtgcctggca cataataggt gctgaatttt gttctaaaca ctgaggacat
      481 tctctgctac atttgggtcg tacccccagg tctgagtaat tcaatagact taagaagaca
      541 gagcccagca gcaaccgaaa cataacagag ttgcaggatc agctaacgtc aatgcctggg
      601 caaagctgct gcccagagtg gaatctcact agtgaataaa caagcccaag aaagattatc
      661 atctcatttg caaaaaaaaa agtacgctgg tagatcctgc tacctcatag ataacaccag
      721 tcaaattttt ttttaaagta gcattttcct acattgtcaa ctatctagaa catacctaaa
      781 aactaagagt ttactgctta ttaaatggaa actatgaagt ctaaggccaa ctgtgcccag
      841 aatccaaatt gtaacataat gatatttcat ccaaccaaag aagagtttaa tgattttgat
      901 aaatatattg cttacatgga atcccaaggt gcacacagag ctggcttggc taagataatt
      961 ccacccaaag aatggaaagc cagagagacc tatgataata tcagtgaaat cttaatagcc
     1021 actcccctcc agcaggtggc ctctgggcgg gcaggggtgt ttactcaata ccataaaaaa
     1081 aagaaagcca tgactgtggg ggagtatcgc catttggcaa acagtaaaaa atatcagact
     1141 ccaccacacc agaatttcga agatttggag cgaaaatact ggaagaaccg catctataat
     1201 tcaccgattt atggtgctga catcagtggc tccttgtttg atgaaaacac taaacaatgg
     1261 aatcttgggc acctgggaac aattcaggac ctgctggaaa aggaatgtgg ggttgtcata
     1321 gaaggcgtca atacacccta cttgtacttt ggcatgtgga aaaccacgtt tgcttggcat
     1381 acagaggaca tggaccttta cagcatcaac tacctgcacc ttggggagcc caaaacttgg
     1441 tatgtggtgc ccccagaaca tggccagcgc ctggaacgcc tggccaggga gctcttccca
     1501 ggcagttccc ggggttgtgg ggccttcctg cggcacaagg tggccctcat ctcgcctaca
     1561 gttctcaagg aaaatgggat tcccttcaat cgcataactc aggaggctgg agagttcatg
     1621 gtgacctttc cctatggcta ccatgctggc ttcaaccatg gtttcaactg cgcagaggcc
     1681 atcaattttg ccactccgcg atggattgat tatggcaaaa tggcctccca gtgtagctgt
     1741 ggggaggcaa gggtgacctt ttccatggat gccttcgtgc gcatcctgca acctgaacgc
     1801 tatgacctgt ggaaacgtgg gcaagaccgg gcagttgtgg accacatgga gcccagggta
     1861 ccagccagcc aagagctgag cacccagaag gaagtccagt tacccaggag agcagcgctg
     1921 ggcctgagac aactcccttc ccactgggcc cggcattccc cttggcctat ggctgcccgc
     1981 agtgggacac ggtgccacac ccttgtgtgc tcttcactcc cacgccgatc tgcagttagt
     2041 ggcactgcta cgcagccccg ggctgctgct gtccacagct ctaagaagcc cagctcaact
     2101 ccatcatcca cccctggtcc atctgcacag attatccacc cgtcaaatgg cagacgtggt
     2161 cgtggtcgcc ctcctcagaa actgagagct caggagctga ccctccagac tccagccaag
     2221 aggcccctct tggcgggcac aacatgcaca gcttcgggcc cagaacctga gcccctacct
     2281 gaggatgggg ctttgatgga caagcctgta ccactgagcc cagggctcca gcatcctgtc
     2341 aaggcttctg ggtgcagctg ggcccctgtg ccctaagtcc acgggctgtc tttatatccc
     2401 actgccctgc tgtgtgacag tttgatgaaa ctggttacat ttacatccca aaactttggt
     2461 tgagtttgca ggactctagg catgcatgaa agagcccccc tggtgatgcc cttggatgct
     2521 gccaagtcca tggtagtttt caattttgcc atacttttgt tcttcctacc ggaccctgga
     2581 atgtctttgg atattgctaa aatctatttc tgcagctgag gttttatcca ctggacacat
     2641 ttgtgtgtga gaactaggtc ttgttgaggt tagcgtaacc tggtatatgc aactaccatc
     2701 ctctgggcca actgtggaag ctgctgcact tgtgaagaat cctgagcttt gattcctctt
     2761 cagtctacgc atttctctct tcccctccct cacccccttt ttcttataaa actaggttct
     2821 ttatacagat aaggtcagta gagttccaga ataaaagata tgacttttct gagttattta
     2881 tgtacttaaa atatgttgtc acagtatttg ttcccaaata tattaaaggt aaccaaaatg
     2941 ttaaaatctg a
//
