LOCUS       NM_015061               4338 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 1,
            mRNA.
ACCESSION   NM_015061
VERSION     NM_015061.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4338)
  AUTHORS   Liu,Y., Wang,S., Wei,S., Qiu,X., Mei,Y. and Yan,L.
  TITLE     The promotive role of lncRNA MIR205HG in proliferation, invasion,
            and migration of melanoma cells via the JMJD2C/ALKBH5 axis
  JOURNAL   PLoS One 19 (1), e0290986 (2024)
   PUBMED   38252669
  REMARK    GeneRIF: The promotive role of lncRNA MIR205HG in proliferation,
            invasion, and migration of melanoma cells via the JMJD2C/ALKBH5
            axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4338)
  AUTHORS   Wang,K., Gong,Z., Chen,Y., Zhang,M., Wang,S., Yao,S., Liu,Z.,
            Huang,Z. and Fei,B.
  TITLE     KDM4C-mediated senescence defense is a targetable vulnerability in
            gastric cancer harboring TP53 mutations
  JOURNAL   Clin Epigenetics 15 (1), 163 (2023)
   PUBMED   37848946
  REMARK    GeneRIF: KDM4C-mediated senescence defense is a targetable
            vulnerability in gastric cancer harboring TP53 mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4338)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   4  (bases 1 to 4338)
  AUTHORS   Lopez,C., Schleussner,N., Bernhart,S.H., Kleinheinz,K.,
            Sungalee,S., Sczakiel,H.L., Kretzmer,H., Toprak,U.H., Glaser,S.,
            Wagener,R., Ammerpohl,O., Bens,S., Giefing,M., Sanchez,J.C.G.,
            Apic,G., Hubschmann,D., Janz,M., Kreuz,M., Mottok,A., Muller,J.M.,
            Seufert,J., Hoffmann,S., Korbel,J.O., Russell,R.B., Schule,R.,
            Trumper,L., Klapper,W., Radlwimmer,B., Lichter,P., Kuppers,R.,
            Schlesner,M., Mathas,S. and Siebert,R.
  TITLE     Focal structural variants revealed by whole genome sequencing
            disrupt the histone demethylase KDM4C in B-cell lymphomas
  JOURNAL   Haematologica 108 (2), 543-554 (2023)
   PUBMED   35522148
  REMARK    GeneRIF: Focal structural variants revealed by whole genome
            sequencing disrupt the histone demethylase KDM4C in B-cell
            lymphomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4338)
  AUTHORS   Pan,H.C., Chen,Y.H., Fang,W.C., Wu,V.C. and Sun,C.Y.
  TITLE     Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury
  JOURNAL   Int J Mol Sci 23 (16), 9318 (2022)
   PUBMED   36012577
  REMARK    GeneRIF: Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4338)
  AUTHORS   Berry,W.L. and Janknecht,R.
  TITLE     KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer
            cells
  JOURNAL   Cancer Res 73 (10), 2936-2942 (2013)
   PUBMED   23644528
  REMARK    Review article
REFERENCE   7  (bases 1 to 4338)
  AUTHORS   Cloos,P.A., Christensen,J., Agger,K., Maiolica,A., Rappsilber,J.,
            Antal,T., Hansen,K.H. and Helin,K.
  TITLE     The putative oncogene GASC1 demethylates tri- and dimethylated
            lysine 9 on histone H3
  JOURNAL   Nature 442 (7100), 307-311 (2006)
   PUBMED   16732293
  REMARK    GeneRIF: GASC1 interacts with H3K9me3; three members of this
            subfamily of proteins demethylate H3K9me3/me2 in vitro through a
            hydroxylation reaction requiring iron and alpha-ketoglutarate as
            cofactors
REFERENCE   8  (bases 1 to 4338)
  AUTHORS   Whetstine,J.R., Nottke,A., Lan,F., Huarte,M., Smolikov,S., Chen,Z.,
            Spooner,E., Li,E., Zhang,G., Colaiacovo,M. and Shi,Y.
  TITLE     Reversal of histone lysine trimethylation by the JMJD2 family of
            histone demethylases
  JOURNAL   Cell 125 (3), 467-481 (2006)
   PUBMED   16603238
REFERENCE   9  (bases 1 to 4338)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
REFERENCE   10 (bases 1 to 4338)
  AUTHORS   Yang,Z.Q., Imoto,I., Fukuda,Y., Pimkhaokham,A., Shimada,Y.,
            Imamura,M., Sugano,S., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, GASC1, within an amplicon at
            9p23-24 frequently detected in esophageal cancer cell lines
  JOURNAL   Cancer Res 60 (17), 4735-4739 (2000)
   PUBMED   10987278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354707.17, AL445592.15,
            AL513412.3, AL137020.14 and AL161443.13.
            
            On Dec 30, 2019 this sequence version replaced NM_015061.5.
            
            Summary: This gene is a member of the Jumonji domain 2 (JMJD2)
            family. The encoded protein is a trimethylation-specific
            demethylase, and converts specific trimethylated histone residues
            to the dimethylated form. This enzymatic action regulates gene
            expression and chromosome segregation. Chromosomal aberrations and
            changes in expression of this gene may be found in tumor cells.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037901.1, BC143571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381309.8/ ENSP00000370710.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AL354707.17        90283-90513
            232-392             AL354707.17        125282-125442
            393-568             AL354707.17        137909-138084
            569-683             AL354707.17        146941-147055
            684-877             AL445592.15        12847-13040
            878-927             AL445592.15        43352-43401
            928-1031            AL445592.15        51300-51403
            1032-1169           AL445592.15        56435-56572
            1170-1363           AL513412.3         115535-115728
            1364-1602           AL513412.3         118776-119014
            1603-1925           AL513412.3         120954-121276
            1926-2034           AL513412.3         125026-125134
            2035-2216           AL513412.3         146308-146489
            2217-2430           AL513412.3         148398-148611
            2431-2507           AL513412.3         150463-150539
            2508-2563           AL513412.3         181472-181527
            2564-2672           AL513412.3         183702-183810
            2673-2858           AL137020.14        48627-48812
            2859-3029           AL137020.14        73008-73178
            3030-3149           AL161443.13        14148-14267
            3150-3242           AL161443.13        18708-18800
            3243-4338           AL161443.13        23463-24558
FEATURES             Location/Qualifiers
     source          1..4338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..4338
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="lysine demethylase 4C"
                     /db_xref="GeneID:23081"
                     /db_xref="HGNC:HGNC:17071"
                     /db_xref="MIM:605469"
     exon            1..231
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            232..392
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..3419
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /EC_number="1.14.11.66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific demethylase 4C; JmjC domain-containing
                     histone demethylation protein 3C; jumonji
                     domain-containing protein 2C; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4C; gene amplified
                     in squamous cell carcinoma 1 protein; tudor domain
                     containing 14C; lysine (K)-specific demethylase 4C"
                     /codon_start=1
                     /product="lysine-specific demethylase 4C isoform 1"
                     /protein_id="NP_055876.2"
                     /db_xref="CCDS:CCDS6471.1"
                     /db_xref="GeneID:23081"
                     /db_xref="HGNC:HGNC:17071"
                     /db_xref="MIM:605469"
                     /translation="MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRA
                     GLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQL
                     ANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLD
                     VVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHG
                     KRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYG
                     YHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLW
                     KQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVS
                     DEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKL
                     SGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWP
                     KSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENK
                     TSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTK
                     SPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKT
                     KPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDG
                     WLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDV
                     GRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYV
                     VNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDD
                     GSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFED
                     GSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRF
                     KNEYVADPVYRTFLKSSFQKKCQKRQ"
     exon            393..568
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            569..683
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            684..877
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            878..927
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1031
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1169
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1363
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1602
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1925
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2034
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2216
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2430
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2507
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2563
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2672
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2858
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3029
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3149
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3242
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..4338
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4316..4321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="hexamer: AATAAA"
     polyA_site      4338
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="major polyA site"
ORIGIN      
        1 agagccggcg gtgcgcgcgc cttcgccgct gcctcccacc caccccctcg acgggagggt
       61 gaggcgcggc gcagtgatcg ggcggccggg gtcctgtgcg cgtgcgcagc gaacagctgt
      121 cacctagtgc ggaacaagtc tcccaaattt cccaaatctc cctgggccgg aggccactgt
      181 cttctcttcc tcctccaccg agtcgtgctc tcgccccaac ccgcgcgcca gacactgccc
      241 taaccatcat ggaggtggcc gaggtggaaa gtcctctgaa ccccagctgt aagataatga
      301 ccttcagacc ctccatggag gagttccggg agttcaacaa ataccttgca tacatggagt
      361 ctaaaggagc ccatcgtgcg ggtcttgcaa aggtgattcc tcctaaggag tggaagccaa
      421 gacagtgcta tgatgacatt gataatttgc tcattccagc accaattcag cagatggtca
      481 cagggcagtc aggactgttc actcagtaca acatccagaa aaaagcgatg actgtgaagg
      541 agttcaggca gctggccaac agtggcaaat attgtactcc aagatacttg gattacgaag
      601 atttggagcg caagtactgg aagaacttaa cttttgtggc acctatctat ggtgcagata
      661 ttaatgggag catatatgat gagggtgtgg atgaatggaa catagctcgc ctcaatacag
      721 tcttggatgt ggttgaagaa gagtgtggca tttctattga gggtgtaaat accccatatc
      781 tctattttgg catgtggaag accacgtttg catggcacac cgaagacatg gacctctata
      841 gcattaatta tctccacttt ggagagccca agtcttggta tgctatacct ccggagcatg
      901 gaaaacgact tgaaagacta gctcaaggtt ttttcccaag cagctcccaa gggtgtgatg
      961 catttcttcg ccacaagatg acattgattt ctccatcagt attgaagaaa tatggtattc
     1021 cctttgacaa gataacccag gaggctggag aattcatgat cactttccca tatggctacc
     1081 atgctggttt taatcatggt ttcaactgtg cagaatctac aaattttgct actgtcagat
     1141 ggattgacta tggaaaagtt gccaaattgt gcacttgcag gaaagacatg gtgaagattt
     1201 caatggatat ctttgtgagg aaatttcagc cagacagata tcagctttgg aaacaaggaa
     1261 aggatatata caccattgat cacacgaagc ctactccagc atccacccct gaagtaaaag
     1321 catggctgca gaggaggagg aaagtaagaa aagcatcccg aagcttccag tgtgctaggt
     1381 ctacctctaa aaggcctaag gctgatgagg aagaggaagt gtcagatgaa gtcgatgggg
     1441 cagaggtccc taaccccgac tcagtcacag atgacctcaa ggtcagtgaa aagtcagaag
     1501 cagcagtgaa gctgaggaac acagaagcat cttcagaaga agagtcatct gctagcagga
     1561 tgcaggtgga gcagaattta tcagatcata tcaaactctc aggaaacagc tgcttaagta
     1621 catctgtaac agaagacata aaaactgagg atgacaaagc ttatgcatat agaagtgtac
     1681 cttctatatc cagtgaggct gatgattcca ttccattgtc tagtggctat gagaagcccg
     1741 agaaatcaga cccatccgag ctttcatggc caaagtcacc tgagtcatgc tcatcagtgg
     1801 cagagagtaa tggtgtgtta acagagggag aagagagtga tgtggagagc catgggaatg
     1861 gccttgaacc tggggaaatc ccagcggtcc ccagtggaga gagaaatagc ttcaaagtcc
     1921 ccagtatagc agagggagag aacaaaacct ctaagagttg gcgccatcca cttagcaggc
     1981 ctccagcaag atctccgatg actcttgtga agcagcaggc gccaagtgat gaagaattgc
     2041 ctgaggttct gtccattgag gaggaagtgg aagaaacaga gtcttgggcg aaacctctca
     2101 tccacctttg gcagacgaag tcccctaact tcgcagctga gcaagagtat aatgcaacag
     2161 tggccaggat gaagccacac tgtgccatct gcactctgct catgccgtac cacaagccag
     2221 atagcagcaa tgaagaaaat gatgctagat gggagacaaa attagatgaa gtcgttacat
     2281 cggagggaaa gactaagccc ctcataccag agatgtgttt tatttatagt gaagaaaata
     2341 tagaatattc tccacccaat gccttccttg aagaggatgg aacaagtctc cttatttcct
     2401 gtgcaaagtg ctgcgtacgg gttcatgcaa gttgttatgg tattccttct catgagatct
     2461 gtgatggatg gctgtgtgcc cggtgcaaaa gaaatgcgtg gacagcagaa tgctgtctct
     2521 gcaatttgag aggaggtgct cttaagcaaa cgaagaacaa taagtgggcc catgtcatgt
     2581 gcgccgttgc ggtcccagaa gttcgattca ctaatgtccc agaaaggaca caaatagatg
     2641 taggcagaat acctttacag aggttaaaat tgaaatgcat cttctgcaga caccgggtta
     2701 agagggtctc tggagcctgc atccagtgtt cctacggtcg ctgcccggcc tccttccatg
     2761 tcacttgtgc ccatgctgct ggggtactga tggagcctga tgactggcct tatgtggtga
     2821 acattacatg ctttcgacat aaggtcaacc ccaacgtgaa gtccaaggct tgcgagaagg
     2881 tcatttccgt gggtcaaacg gtcatcacga agcatcggaa cacccggtat tacagttgca
     2941 gagtgatggc tgtgacatcg cagaccttct atgaggtcat gtttgatgat ggctccttta
     3001 gcagagacac atttcctgag gatatcgtga gccgagactg tctgaagctg ggcccacctg
     3061 ctgagggaga agtcgtccaa gtcaagtggc ccgatggcaa actctatgga gcaaaatatt
     3121 ttggatcaaa tattgcccac atgtaccagg ttgagtttga agatggatcc cagatagcaa
     3181 tgaagagaga ggacatctac actttagatg aagagttacc caagagagtg aaagctcgat
     3241 tttccacagc ctctgacatg cgatttgaag acacgtttta tggagcagac attatccaag
     3301 gggagagaaa gagacaaaga gtgctgagct ccaggtttaa gaatgaatat gtggccgacc
     3361 ctgtataccg cacttttttg aagagctctt tccagaagaa gtgccagaag agacagtagt
     3421 ctgcatacat cgctgcaggc cacagagcag cttgggttgg aagagagaag atgaagggac
     3481 atccttgggg ctgtgccgtg agttttgctg gcataggtga cagggtgtgt ctctgacagt
     3541 ggtaaatcgg gtttccagag tttggtcacc aaaaatacaa aatacaccca atgaattgga
     3601 cgcagcaatc tgaaatcatc tctagtcttg ctttcacttg tgagcagttg tcttctatga
     3661 tcccaaagaa gttttctaag tgaaaggaaa tactagtgaa tcacccacaa ggaaaagcca
     3721 ctgccacaga ggaggcgggt ccccttgtgc ggcttagggc cctgtcagga aacacacggg
     3781 gacctctctc tctagctcca gcaggtggca cctcggtacc cagcgggtag ggcgataatt
     3841 tatatatttt ccacagtcag ggaaggactc tcacttattt gtttcaaatt gcagttttta
     3901 taaaacattt ttaaaacaca aatggcatgt atgctaatga gatttacccg tgtgctatct
     3961 gtatttccct tgtacagaac ttttacattt ttgaatattc ctattacttt tgattgtgtc
     4021 tgatgggaac tgagttgttg gcctttgtga aatgaaattt ttggctcttg agaaagaatt
     4081 cttatgaatt gttatgcgaa ttttatatat ttaaagaggg agatctgggg ctgttatttt
     4141 taaacacttt ttttcataat acatattccg agtagatatt tataaaatat atgtttcttt
     4201 cattatgtgt ttgtaaaatt agagtttaaa taaatatgct ttgatgcata gttttgaact
     4261 aatgtaacat gatttttctt ttttaaaaca gcctgaaaat gtactagtgt ttaaaaataa
     4321 agatttccat tttctcca
//
