LOCUS       NP_055876               1056 aa            linear   PRI 30-APR-2025
DEFINITION  lysine-specific demethylase 4C isoform 1 [Homo sapiens].
ACCESSION   NP_055876
VERSION     NP_055876.2
DBSOURCE    REFSEQ: accession NM_015061.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1056)
  AUTHORS   Liu,Y., Wang,S., Wei,S., Qiu,X., Mei,Y. and Yan,L.
  TITLE     The promotive role of lncRNA MIR205HG in proliferation, invasion,
            and migration of melanoma cells via the JMJD2C/ALKBH5 axis
  JOURNAL   PLoS One 19 (1), e0290986 (2024)
   PUBMED   38252669
  REMARK    GeneRIF: The promotive role of lncRNA MIR205HG in proliferation,
            invasion, and migration of melanoma cells via the JMJD2C/ALKBH5
            axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1056)
  AUTHORS   Wang,K., Gong,Z., Chen,Y., Zhang,M., Wang,S., Yao,S., Liu,Z.,
            Huang,Z. and Fei,B.
  TITLE     KDM4C-mediated senescence defense is a targetable vulnerability in
            gastric cancer harboring TP53 mutations
  JOURNAL   Clin Epigenetics 15 (1), 163 (2023)
   PUBMED   37848946
  REMARK    GeneRIF: KDM4C-mediated senescence defense is a targetable
            vulnerability in gastric cancer harboring TP53 mutations.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1056)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   4  (residues 1 to 1056)
  AUTHORS   Lopez,C., Schleussner,N., Bernhart,S.H., Kleinheinz,K.,
            Sungalee,S., Sczakiel,H.L., Kretzmer,H., Toprak,U.H., Glaser,S.,
            Wagener,R., Ammerpohl,O., Bens,S., Giefing,M., Sanchez,J.C.G.,
            Apic,G., Hubschmann,D., Janz,M., Kreuz,M., Mottok,A., Muller,J.M.,
            Seufert,J., Hoffmann,S., Korbel,J.O., Russell,R.B., Schule,R.,
            Trumper,L., Klapper,W., Radlwimmer,B., Lichter,P., Kuppers,R.,
            Schlesner,M., Mathas,S. and Siebert,R.
  TITLE     Focal structural variants revealed by whole genome sequencing
            disrupt the histone demethylase KDM4C in B-cell lymphomas
  JOURNAL   Haematologica 108 (2), 543-554 (2023)
   PUBMED   35522148
  REMARK    GeneRIF: Focal structural variants revealed by whole genome
            sequencing disrupt the histone demethylase KDM4C in B-cell
            lymphomas.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1056)
  AUTHORS   Pan,H.C., Chen,Y.H., Fang,W.C., Wu,V.C. and Sun,C.Y.
  TITLE     Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury
  JOURNAL   Int J Mol Sci 23 (16), 9318 (2022)
   PUBMED   36012577
  REMARK    GeneRIF: Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1056)
  AUTHORS   Berry,W.L. and Janknecht,R.
  TITLE     KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer
            cells
  JOURNAL   Cancer Res 73 (10), 2936-2942 (2013)
   PUBMED   23644528
  REMARK    Review article
REFERENCE   7  (residues 1 to 1056)
  AUTHORS   Cloos,P.A., Christensen,J., Agger,K., Maiolica,A., Rappsilber,J.,
            Antal,T., Hansen,K.H. and Helin,K.
  TITLE     The putative oncogene GASC1 demethylates tri- and dimethylated
            lysine 9 on histone H3
  JOURNAL   Nature 442 (7100), 307-311 (2006)
   PUBMED   16732293
  REMARK    GeneRIF: GASC1 interacts with H3K9me3; three members of this
            subfamily of proteins demethylate H3K9me3/me2 in vitro through a
            hydroxylation reaction requiring iron and alpha-ketoglutarate as
            cofactors
REFERENCE   8  (residues 1 to 1056)
  AUTHORS   Whetstine,J.R., Nottke,A., Lan,F., Huarte,M., Smolikov,S., Chen,Z.,
            Spooner,E., Li,E., Zhang,G., Colaiacovo,M. and Shi,Y.
  TITLE     Reversal of histone lysine trimethylation by the JMJD2 family of
            histone demethylases
  JOURNAL   Cell 125 (3), 467-481 (2006)
   PUBMED   16603238
REFERENCE   9  (residues 1 to 1056)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
REFERENCE   10 (residues 1 to 1056)
  AUTHORS   Yang,Z.Q., Imoto,I., Fukuda,Y., Pimkhaokham,A., Shimada,Y.,
            Imamura,M., Sugano,S., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, GASC1, within an amplicon at
            9p23-24 frequently detected in esophageal cancer cell lines
  JOURNAL   Cancer Res 60 (17), 4735-4739 (2000)
   PUBMED   10987278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354707.17, AL445592.15,
            AL513412.3, AL137020.14 and AL161443.13.
            
            On Jun 19, 2006 this sequence version replaced NP_055876.1.
            
            Summary: This gene is a member of the Jumonji domain 2 (JMJD2)
            family. The encoded protein is a trimethylation-specific
            demethylase, and converts specific trimethylated histone residues
            to the dimethylated form. This enzymatic action regulates gene
            expression and chromosome segregation. Chromosomal aberrations and
            changes in expression of this gene may be found in tumor cells.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037901.1, BC143571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381309.8/ ENSP00000370710.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     Protein         1..1056
                     /product="lysine-specific demethylase 4C isoform 1"
                     /EC_number="1.14.11.66"
                     /note="lysine-specific demethylase 4C; JmjC
                     domain-containing histone demethylation protein 3C;
                     jumonji domain-containing protein 2C; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4C; gene amplified
                     in squamous cell carcinoma 1 protein; tudor domain
                     containing 14C; lysine (K)-specific demethylase 4C"
                     /calculated_mol_wt=119851
     Region          16..57
                     /region_name="JmjN"
                     /note="jmjN domain; cl15840"
                     /db_xref="CDD:472837"
     Region          177..293
                     /region_name="JmjC"
                     /note="JmjC domain, hydroxylase; pfam02373"
                     /db_xref="CDD:396791"
     Region          370..414
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H3R0.2)"
     Region          423..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H3R0.2)"
     Region          480..598
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H3R0.2)"
     Region          644..746
                     /region_name="PHD_JMJD2C"
                     /note="PHD finger found in Jumonji domain-containing
                     protein 2C (JMJD2C); cd15577"
                     /db_xref="CDD:277052"
     Site            order(644,714..718,722,741)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277052"
     Region          755..864
                     /region_name="ePHD_JMJD2C"
                     /note="Extended PHD finger found in Jumonji
                     domain-containing protein 2C (JMJD2C); cd15715"
                     /db_xref="CDD:277185"
     Site            order(809,823..827,833,859)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277185"
     Region          879..932
                     /region_name="Tudor_JMJD2C_rpt1"
                     /note="first Tudor domain found in Jumonji
                     domain-containing protein 2C (JMJD2C) and similar
                     proteins; cd20465"
                     /db_xref="CDD:410536"
     Site            order(911..912,914..917,919)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410536"
     Region          936..995
                     /region_name="Tudor_JMJD2C_rpt2"
                     /note="second Tudor domain found in Jumonji
                     domain-containing protein 2C (JMJD2C) and similar
                     proteins; cd20468"
                     /db_xref="CDD:410539"
     Site            order(947..949,953)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410539"
     CDS             1..1056
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /coded_by="NM_015061.6:249..3419"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS6471.1"
                     /db_xref="GeneID:23081"
                     /db_xref="HGNC:HGNC:17071"
                     /db_xref="MIM:605469"
ORIGIN      
        1 mevaevespl npsckimtfr psmeefrefn kylaymeskg ahraglakvi ppkewkprqc
       61 yddidnllip apiqqmvtgq sglftqyniq kkamtvkefr qlansgkyct pryldyedle
      121 rkywknltfv apiygading siydegvdew niarlntvld vveeecgisi egvntpylyf
      181 gmwkttfawh tedmdlysin ylhfgepksw yaippehgkr lerlaqgffp sssqgcdafl
      241 rhkmtlisps vlkkygipfd kitqeagefm itfpygyhag fnhgfncaes tnfatvrwid
      301 ygkvaklctc rkdmvkismd ifvrkfqpdr yqlwkqgkdi ytidhtkptp astpevkawl
      361 qrrrkvrkas rsfqcarsts krpkadeeee vsdevdgaev pnpdsvtddl kvsekseaav
      421 klrnteasse eessasrmqv eqnlsdhikl sgnsclstsv tedikteddk ayayrsvpsi
      481 sseaddsipl ssgyekpeks dpselswpks pescssvaes ngvltegees dveshgngle
      541 pgeipavpsg ernsfkvpsi aegenktsks wrhplsrppa rspmtlvkqq apsdeelpev
      601 lsieeeveet eswakplihl wqtkspnfaa eqeynatvar mkphcaictl lmpyhkpdss
      661 neendarwet kldevvtseg ktkplipemc fiyseeniey sppnafleed gtslliscak
      721 ccvrvhascy gipsheicdg wlcarckrna wtaecclcnl rggalkqtkn nkwahvmcav
      781 avpevrftnv pertqidvgr iplqrlklkc ifcrhrvkrv sgaciqcsyg rcpasfhvtc
      841 ahaagvlmep ddwpyvvnit cfrhkvnpnv kskacekvis vgqtvitkhr ntryyscrvm
      901 avtsqtfyev mfddgsfsrd tfpedivsrd clklgppaeg evvqvkwpdg klygakyfgs
      961 niahmyqvef edgsqiamkr ediytldeel pkrvkarfst asdmrfedtf ygadiiqger
     1021 krqrvlssrf kneyvadpvy rtflkssfqk kcqkrq
//
