LOCUS       NM_001146696            3406 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 4,
            mRNA.
ACCESSION   NM_001146696
VERSION     NM_001146696.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Liu,Y., Wang,S., Wei,S., Qiu,X., Mei,Y. and Yan,L.
  TITLE     The promotive role of lncRNA MIR205HG in proliferation, invasion,
            and migration of melanoma cells via the JMJD2C/ALKBH5 axis
  JOURNAL   PLoS One 19 (1), e0290986 (2024)
   PUBMED   38252669
  REMARK    GeneRIF: The promotive role of lncRNA MIR205HG in proliferation,
            invasion, and migration of melanoma cells via the JMJD2C/ALKBH5
            axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Wang,K., Gong,Z., Chen,Y., Zhang,M., Wang,S., Yao,S., Liu,Z.,
            Huang,Z. and Fei,B.
  TITLE     KDM4C-mediated senescence defense is a targetable vulnerability in
            gastric cancer harboring TP53 mutations
  JOURNAL   Clin Epigenetics 15 (1), 163 (2023)
   PUBMED   37848946
  REMARK    GeneRIF: KDM4C-mediated senescence defense is a targetable
            vulnerability in gastric cancer harboring TP53 mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Lopez,C., Schleussner,N., Bernhart,S.H., Kleinheinz,K.,
            Sungalee,S., Sczakiel,H.L., Kretzmer,H., Toprak,U.H., Glaser,S.,
            Wagener,R., Ammerpohl,O., Bens,S., Giefing,M., Sanchez,J.C.G.,
            Apic,G., Hubschmann,D., Janz,M., Kreuz,M., Mottok,A., Muller,J.M.,
            Seufert,J., Hoffmann,S., Korbel,J.O., Russell,R.B., Schule,R.,
            Trumper,L., Klapper,W., Radlwimmer,B., Lichter,P., Kuppers,R.,
            Schlesner,M., Mathas,S. and Siebert,R.
  TITLE     Focal structural variants revealed by whole genome sequencing
            disrupt the histone demethylase KDM4C in B-cell lymphomas
  JOURNAL   Haematologica 108 (2), 543-554 (2023)
   PUBMED   35522148
  REMARK    GeneRIF: Focal structural variants revealed by whole genome
            sequencing disrupt the histone demethylase KDM4C in B-cell
            lymphomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Pan,H.C., Chen,Y.H., Fang,W.C., Wu,V.C. and Sun,C.Y.
  TITLE     Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury
  JOURNAL   Int J Mol Sci 23 (16), 9318 (2022)
   PUBMED   36012577
  REMARK    GeneRIF: Essential Roles of the Histone Demethylase KDM4C in Renal
            Development and Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Berry,W.L. and Janknecht,R.
  TITLE     KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer
            cells
  JOURNAL   Cancer Res 73 (10), 2936-2942 (2013)
   PUBMED   23644528
  REMARK    Review article
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Cloos,P.A., Christensen,J., Agger,K., Maiolica,A., Rappsilber,J.,
            Antal,T., Hansen,K.H. and Helin,K.
  TITLE     The putative oncogene GASC1 demethylates tri- and dimethylated
            lysine 9 on histone H3
  JOURNAL   Nature 442 (7100), 307-311 (2006)
   PUBMED   16732293
  REMARK    GeneRIF: GASC1 interacts with H3K9me3; three members of this
            subfamily of proteins demethylate H3K9me3/me2 in vitro through a
            hydroxylation reaction requiring iron and alpha-ketoglutarate as
            cofactors
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Whetstine,J.R., Nottke,A., Lan,F., Huarte,M., Smolikov,S., Chen,Z.,
            Spooner,E., Li,E., Zhang,G., Colaiacovo,M. and Shi,Y.
  TITLE     Reversal of histone lysine trimethylation by the JMJD2 family of
            histone demethylases
  JOURNAL   Cell 125 (3), 467-481 (2006)
   PUBMED   16603238
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Yang,Z.Q., Imoto,I., Fukuda,Y., Pimkhaokham,A., Shimada,Y.,
            Imamura,M., Sugano,S., Nakamura,Y. and Inazawa,J.
  TITLE     Identification of a novel gene, GASC1, within an amplicon at
            9p23-24 frequently detected in esophageal cancer cell lines
  JOURNAL   Cancer Res 60 (17), 4735-4739 (2000)
   PUBMED   10987278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354707.17, AL445592.15,
            AL513412.3 and AL137020.14.
            
            On Jul 19, 2019 this sequence version replaced NM_001146696.1.
            
            Summary: This gene is a member of the Jumonji domain 2 (JMJD2)
            family. The encoded protein is a trimethylation-specific
            demethylase, and converts specific trimethylated histone residues
            to the dimethylated form. This enzymatic action regulates gene
            expression and chromosome segregation. Chromosomal aberrations and
            changes in expression of this gene may be found in tumor cells.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK310439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL354707.17        53173-53307
            136-296             AL354707.17        125282-125442
            297-472             AL354707.17        137909-138084
            473-587             AL354707.17        146941-147055
            588-781             AL445592.15        12847-13040
            782-831             AL445592.15        43352-43401
            832-935             AL445592.15        51300-51403
            936-1073            AL445592.15        56435-56572
            1074-1267           AL513412.3         115535-115728
            1268-1506           AL513412.3         118776-119014
            1507-1829           AL513412.3         120954-121276
            1830-1938           AL513412.3         125026-125134
            1939-2120           AL513412.3         146308-146489
            2121-2334           AL513412.3         148398-148611
            2335-2411           AL513412.3         150463-150539
            2412-2467           AL513412.3         181472-181527
            2468-2576           AL513412.3         183702-183810
            2577-3406           AL137020.14        21376-22205
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..3406
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="lysine demethylase 4C"
                     /db_xref="GeneID:23081"
                     /db_xref="HGNC:HGNC:17071"
                     /db_xref="MIM:605469"
     exon            1..135
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2594
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /EC_number="1.14.11.66"
                     /note="isoform 4 is encoded by transcript variant 4;
                     lysine-specific demethylase 4C; JmjC domain-containing
                     histone demethylation protein 3C; jumonji
                     domain-containing protein 2C; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4C; gene amplified
                     in squamous cell carcinoma 1 protein; tudor domain
                     containing 14C; lysine (K)-specific demethylase 4C"
                     /codon_start=1
                     /product="lysine-specific demethylase 4C isoform 4"
                     /protein_id="NP_001140168.1"
                     /db_xref="CCDS:CCDS55285.1"
                     /db_xref="GeneID:23081"
                     /db_xref="HGNC:HGNC:17071"
                     /db_xref="MIM:605469"
                     /translation="MKHYGLPWKRTEEAAADTALTIMEVAEVESPLNPSCKIMTFRPS
                     MEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQ
                     SGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADI
                     NGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDL
                     YSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKK
                     YGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRK
                     DMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQRRRKVRKAS
                     RSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEAS
                     SEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADD
                     SIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEPGEI
                     PAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLS
                     IEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
                     NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISC
                     AKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHV
                     MCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLGRLGI"
     exon            136..296
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            297..472
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            473..587
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            588..781
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            782..831
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            832..935
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1073
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1267
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1506
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1829
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1938
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2120
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2334
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2411
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2467
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2576
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..3406
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="hexamer: ATTAAA"
     polyA_site      3406
                     /gene="KDM4C"
                     /gene_synonym="GASC1; JHDM3C; JMJD2C; TDRD14C"
                     /note="major polyA site"
ORIGIN      
        1 atggctgaca tgatggtctg tgacctgaaa gttgttgaat agttggagtg ttctgcattc
       61 atgtggaaga ggctaaagga tgtttgatga agcactatgg gctgccctgg aagaggactg
      121 aagaagcagc tgcagacact gccctaacca tcatggaggt ggccgaggtg gaaagtcctc
      181 tgaaccccag ctgtaagata atgaccttca gaccctccat ggaggagttc cgggagttca
      241 acaaatacct tgcatacatg gagtctaaag gagcccatcg tgcgggtctt gcaaaggtga
      301 ttcctcctaa ggagtggaag ccaagacagt gctatgatga cattgataat ttgctcattc
      361 cagcaccaat tcagcagatg gtcacagggc agtcaggact gttcactcag tacaacatcc
      421 agaaaaaagc gatgactgtg aaggagttca ggcagctggc caacagtggc aaatattgta
      481 ctccaagata cttggattac gaagatttgg agcgcaagta ctggaagaac ttaacttttg
      541 tggcacctat ctatggtgca gatattaatg ggagcatata tgatgagggt gtggatgaat
      601 ggaacatagc tcgcctcaat acagtcttgg atgtggttga agaagagtgt ggcatttcta
      661 ttgagggtgt aaatacccca tatctctatt ttggcatgtg gaagaccacg tttgcatggc
      721 acaccgaaga catggacctc tatagcatta attatctcca ctttggagag cccaagtctt
      781 ggtatgctat acctccggag catggaaaac gacttgaaag actagctcaa ggttttttcc
      841 caagcagctc ccaagggtgt gatgcatttc ttcgccacaa gatgacattg atttctccat
      901 cagtattgaa gaaatatggt attccctttg acaagataac ccaggaggct ggagaattca
      961 tgatcacttt cccatatggc taccatgctg gttttaatca tggtttcaac tgtgcagaat
     1021 ctacaaattt tgctactgtc agatggattg actatggaaa agttgccaaa ttgtgcactt
     1081 gcaggaaaga catggtgaag atttcaatgg atatctttgt gaggaaattt cagccagaca
     1141 gatatcagct ttggaaacaa ggaaaggata tatacaccat tgatcacacg aagcctactc
     1201 cagcatccac ccctgaagta aaagcatggc tgcagaggag gaggaaagta agaaaagcat
     1261 cccgaagctt ccagtgtgct aggtctacct ctaaaaggcc taaggctgat gaggaagagg
     1321 aagtgtcaga tgaagtcgat ggggcagagg tccctaaccc cgactcagtc acagatgacc
     1381 tcaaggtcag tgaaaagtca gaagcagcag tgaagctgag gaacacagaa gcatcttcag
     1441 aagaagagtc atctgctagc aggatgcagg tggagcagaa tttatcagat catatcaaac
     1501 tctcaggaaa cagctgctta agtacatctg taacagaaga cataaaaact gaggatgaca
     1561 aagcttatgc atatagaagt gtaccttcta tatccagtga ggctgatgat tccattccat
     1621 tgtctagtgg ctatgagaag cccgagaaat cagacccatc cgagctttca tggccaaagt
     1681 cacctgagtc atgctcatca gtggcagaga gtaatggtgt gttaacagag ggagaagaga
     1741 gtgatgtgga gagccatggg aatggccttg aacctgggga aatcccagcg gtccccagtg
     1801 gagagagaaa tagcttcaaa gtccccagta tagcagaggg agagaacaaa acctctaaga
     1861 gttggcgcca tccacttagc aggcctccag caagatctcc gatgactctt gtgaagcagc
     1921 aggcgccaag tgatgaagaa ttgcctgagg ttctgtccat tgaggaggaa gtggaagaaa
     1981 cagagtcttg ggcgaaacct ctcatccacc tttggcagac gaagtcccct aacttcgcag
     2041 ctgagcaaga gtataatgca acagtggcca ggatgaagcc acactgtgcc atctgcactc
     2101 tgctcatgcc gtaccacaag ccagatagca gcaatgaaga aaatgatgct agatgggaga
     2161 caaaattaga tgaagtcgtt acatcggagg gaaagactaa gcccctcata ccagagatgt
     2221 gttttattta tagtgaagaa aatatagaat attctccacc caatgccttc cttgaagagg
     2281 atggaacaag tctccttatt tcctgtgcaa agtgctgcgt acgggttcat gcaagttgtt
     2341 atggtattcc ttctcatgag atctgtgatg gatggctgtg tgcccggtgc aaaagaaatg
     2401 cgtggacagc agaatgctgt ctctgcaatt tgagaggagg tgctcttaag caaacgaaga
     2461 acaataagtg ggcccatgtc atgtgcgccg ttgcggtccc agaagttcga ttcactaatg
     2521 tcccagaaag gacacaaata gatgtaggca gaataccttt acagaggtta aaattgggaa
     2581 ggctgggaat ctagacacag caacagtaac aacaacaaca ataacaatga aggctcactg
     2641 tgaaaacatc aattcattag gaaagttaca tcccctccgc cactgtttca gatgctgttt
     2701 ctcattctcc atgggagcag ccagcatcgt gtttaggatg gggatacaat agcctgagct
     2761 cctgattgag tcagaccctg gactttccct tttgtatctg tcattttcct ctggatcctc
     2821 acacctttgt gtttaatttt tttaaatttc atttgttgac ttcctatgtg gggtaaaatg
     2881 acttcctttg attaatgtac tttctgtatc ctagagtttc cctttccctt tgtgatttag
     2941 tccaacgtgt cctactacag cctcaaaaat tgtcattgga atcaaaagct ttccaaggtg
     3001 catcaggtta atgatttgga tgcatcctga ggttgtctcc tgtagcatgg aggcattata
     3061 ataggagtct cagaagttac accatttttc tacagcacat cacaggccca gaggcttgaa
     3121 tctaagagaa tccactctat gtctgtcagc ctgaatcctt ccttcttgct gcacaacaaa
     3181 gcaactgaac gtattttgag tttaggtgaa aactatcact cattcatcaa agttctatct
     3241 gggtgatata tgctatcgaa acagatgtgg acactgggct gacagatgtt gagaacggac
     3301 ctgttgctga agctcatgtt atcacacatg ctgtgggaag agaggtcatt ggcattcaag
     3361 atgcaacacc tacaatatgg tgaattaaag atgccatttg catgga
//
