LOCUS       NM_015015               5604 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens lysine demethylase 4B (KDM4B), transcript variant 1,
            mRNA.
ACCESSION   NM_015015 XM_290852
VERSION     NM_015015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5604)
  AUTHORS   Li,Y.Q., Shao,Y.L., Li,M.Y., Wang,L.L. and Gao,X.N.
  TITLE     [The Regulatory Effect of RNA m6 A Methylation Modification on
            KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (2), 382-388 (2024)
   PUBMED   38660840
  REMARK    GeneRIF: [The Regulatory Effect of RNA m[6] A Methylation
            Modification on KDM4B Gene Expression in t (8;21) AML Cells by
            MeRIP-qPCR].
REFERENCE   2  (bases 1 to 5604)
  AUTHORS   Wang,X.Y., Li,H.M., Xia,R., Li,X., Zhang,X., Jin,T.Z. and
            Zhang,H.S.
  TITLE     KDM4B down-regulation facilitated breast cancer cell stemness via
            PHGDH upregulation in H3K36me3-dependent manner
  JOURNAL   Mol Cell Biochem 479 (4), 915-928 (2024)
   PUBMED   37249813
  REMARK    GeneRIF: KDM4B down-regulation facilitated breast cancer cell
            stemness via PHGDH upregulation in H3K36me3-dependent manner.
REFERENCE   3  (bases 1 to 5604)
  AUTHORS   Wang,Z., Cai,H., Li,Z., Sun,W., Zhao,E. and Cui,H.
  TITLE     Histone demethylase KDM4B accelerates the progression of
            glioblastoma via the epigenetic regulation of MYC stability
  JOURNAL   Clin Epigenetics 15 (1), 192 (2023)
   PUBMED   38093312
  REMARK    GeneRIF: Histone demethylase KDM4B accelerates the progression of
            glioblastoma via the epigenetic regulation of MYC stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5604)
  AUTHORS   Tang,H., Guan,Y., Yuan,Z., Guo,T., Tan,X., Fan,Y., Zhang,E. and
            Wang,X.
  TITLE     Histone demethylase KDM4B contributes to advanced clear cell renal
            carcinoma and association with copy number variations and cell
            cycle progression
  JOURNAL   Epigenetics 18 (1), 2192319 (2023)
   PUBMED   36952476
  REMARK    GeneRIF: Histone demethylase KDM4B contributes to advanced clear
            cell renal carcinoma and association with copy number variations
            and cell cycle progression.
REFERENCE   5  (bases 1 to 5604)
  AUTHORS   Shao,Y.L., Li,Y.Q., Li,M.Y., Wang,L.L., Zhou,H.S., Liu,D.H., Yu,L.,
            Lin,J. and Gao,X.N.
  TITLE     HIF1alpha-mediated transactivation of WTAP promotes AML cell
            proliferation via m6A-dependent stabilization of KDM4B mRNA
  JOURNAL   Leukemia 37 (6), 1254-1267 (2023)
   PUBMED   37087529
  REMARK    GeneRIF: HIF1alpha-mediated transactivation of WTAP promotes AML
            cell proliferation via m[6]A-dependent stabilization of KDM4B mRNA.
REFERENCE   6  (bases 1 to 5604)
  AUTHORS   Whetstine,J.R., Nottke,A., Lan,F., Huarte,M., Smolikov,S., Chen,Z.,
            Spooner,E., Li,E., Zhang,G., Colaiacovo,M. and Shi,Y.
  TITLE     Reversal of histone lysine trimethylation by the JMJD2 family of
            histone demethylases
  JOURNAL   Cell 125 (3), 467-481 (2006)
   PUBMED   16603238
REFERENCE   7  (bases 1 to 5604)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
REFERENCE   8  (bases 1 to 5604)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 5604)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
REFERENCE   10 (bases 1 to 5604)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB636535.1, AB020683.2, BF917212.1, DA379611.1, AF052144.1 and
            BC015378.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015015.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020683.2, DRR138518.343131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000159111.9/ ENSP00000159111.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DB636535.1         1-8
            9-543               AB020683.2         1-535
            544-658             BF917212.1         371-485
            659-1144            AB020683.2         651-1136
            1145-1341           DA379611.1         182-378
            1342-3933           AB020683.2         1334-3925
            3934-5066           AF052144.1         279-1411
            5067-5604           BC015378.1         310-847
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..5604
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /note="lysine demethylase 4B"
                     /db_xref="GeneID:23030"
                     /db_xref="HGNC:HGNC:29136"
                     /db_xref="MIM:609765"
     exon            1..118
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            119..201
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            202..367
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..3517
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /EC_number="1.14.11.66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     jumonji domain containing 2B; lysine-specific demethylase
                     4B; lysine (K)-specific demethylase 4B; jumonji
                     domain-containing protein 2B; jmjC domain-containing
                     histone demethylation protein 3B; tudor domain containing
                     14B; [histone H3]-trimethyl-L-lysine(9) demethylase 4B"
                     /codon_start=1
                     /product="lysine-specific demethylase 4B isoform 1"
                     /protein_id="NP_055830.1"
                     /db_xref="CCDS:CCDS12138.1"
                     /db_xref="GeneID:23030"
                     /db_xref="HGNC:HGNC:29136"
                     /db_xref="MIM:609765"
                     /translation="MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAG
                     LAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLA
                     NSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDM
                     VERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGK
                     RLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGY
                     HAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWK
                     QGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPG
                     EGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
                     KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNV
                     VPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVS
                     PMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPL
                     SVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEP
                     YCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENT
                     EPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECC
                     LCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCR
                     KRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQ
                     LLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCV
                     QLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEEL
                     PKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQV
                     QGRPGAPF"
     exon            368..543
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            544..658
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            659..852
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            853..902
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1006
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1144
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1341
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1541
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..2011
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2132
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2311
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2534
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2611
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2667
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2776
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2962
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3127
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3247
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3340
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..5604
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5579..5584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /note="hexamer: ATTAAA"
     polyA_site      5604
                     /gene="KDM4B"
                     /gene_synonym="JMJD2B; MRD65; TDRD14B"
                     /note="major polyA site"
ORIGIN      
        1 agggctcggt cgccagcaac cgagcggggc ccggcccgag cggggcctgg gggtgcgacg
       61 ccgagggcgg gggagagcgc gccgctgctc ccggaccggg ccgcgcacgc cgcctcagga
      121 accatcactg ttgctggagg cacctgacaa atcctagcga atttttggag catctccacc
      181 caggaacctc gccatccaga agtgtgcttc ccgcacagct gcagccatgg ggtctgagga
      241 ccacggcgcc cagaacccca gctgtaaaat catgacgttt cgcccaacca tggaagaatt
      301 taaagacttc aacaaatacg tggcctacat agagtcgcag ggagcccacc gggcgggcct
      361 ggccaagatc atccccccga aggagtggaa gccgcggcag acgtatgatg acatcgacga
      421 cgtggtgatc ccggcgccca tccagcaggt ggtgacgggc cagtcgggcc tcttcacgca
      481 gtacaatatc cagaagaagg ccatgacagt gggcgagtac cgccgcctgg ccaacagcga
      541 gaagtactgt accccgcggc accaggactt tgatgacctt gaacgcaaat actggaagaa
      601 cctcaccttt gtctccccga tctacggggc tgacatcagc ggctctttgt atgatgacga
      661 cgtggcccag tggaacatcg ggagcctccg gaccatcctg gacatggtgg agcgcgagtg
      721 cggcaccatc atcgagggcg tgaacacgcc ctacctgtac ttcggcatgt ggaagaccac
      781 cttcgcctgg cacaccgagg acatggacct gtacagcatc aactacctgc actttgggga
      841 gcctaagtcc tggtacgcca tcccaccaga gcacggcaag cgcctggagc ggctggccat
      901 cggcttcttc cccgggagct cgcagggctg cgacgccttc ctgcggcata agatgaccct
      961 catctcgccc atcatcctga agaagtacgg gatccccttc agccggatca cgcaggaggc
     1021 cggggaattc atgatcacat ttccctacgg ctaccacgcc ggcttcaatc acgggttcaa
     1081 ctgcgcagaa tctaccaact tcgccaccct gcggtggatt gactacggca aagtggccac
     1141 tcagtgcacg tgccggaagg acatggtcaa gatctccatg gacgtgttcg tgcgcatcct
     1201 gcagcccgag cgctacgagc tgtggaagca gggcaaggac ctcacggtgc tggaccacac
     1261 gcggcccacg gcgctcacca gccccgagct gagctcctgg agtgcatccc gggcctcgct
     1321 gaaggccaag ctcctccgca ggtctcaccg gaaacggagc cagcccaaga agccgaagcc
     1381 cgaagacccc aagttccctg gggagggtac ggctggggca gcgctcctag aggaggctgg
     1441 gggcagcgtg aaggaggagg ctgggccgga ggttgacccc gaggaggagg aggaggagcc
     1501 gcagccactg ccacacggcc gggaggccga gggcgcagaa gaggacggga ggggcaagct
     1561 gcggccaacc aaggccaaga gcgagcggaa gaagaagagc ttcggcctgc tgcccccaca
     1621 gctgccgccc ccgcctgctc acttcccctc agaggaggcg ctgtggctgc catccccact
     1681 ggagcccccg gtgctgggcc caggccctgc agccatggag gagagccccc tgccggcacc
     1741 ccttaatgtc gtgccccctg aggtgcccag tgaggagcta gaggccaagc ctcggcccat
     1801 catccccatg ctgtacgtgg tgccgcggcc gggcaaggca gccttcaacc aggagcacgt
     1861 gtcctgccag caggcctttg agcactttgc ccagaagggt ccgacctgga aggaaccagt
     1921 ttcccccatg gagctgacgg ggccagagga cggtgcagcc agcagtgggg caggtcgcat
     1981 ggagaccaaa gcccgggccg gagaggggca ggcaccgtcc acattttcca aattgaagat
     2041 ggagatcaag aagagccggc gccatcccct gggccggccg cccacccggt ccccactgtc
     2101 ggtggtgaag caggaggcct caagtgacga ggaggcatcc cctttctccg gggaggaaga
     2161 tgtgagtgac ccggacgcct tgaggccgct gctgtctctg cagtggaaga acagggcggc
     2221 cagcttccag gccgagagga agttcaacgc agcggctgcg cgcacggagc cctactgcgc
     2281 catctgcacg ctcttctacc cctactgcca ggccctacag actgagaagg aggcacccat
     2341 agcctccctc ggagagggct gcccggccac attaccctcc aaaagccgtc agaagacccg
     2401 accgctcatc cctgagatgt gcttcacctc tggcggtgag aacacggagc cgctgcctgc
     2461 caactcctac atcggcgacg acgggaccag ccccctgatc gcctgcggca agtgctgcct
     2521 gcaggtccat gccagttgct atggcatccg tcccgagctg gtcaatgaag gctggacgtg
     2581 ttcccggtgc gcggcccacg cctggactgc ggagtgctgc ctgtgcaacc tgcgaggagg
     2641 tgcgctgcag atgaccaccg ataggaggtg gatccacgtg atctgtgcca tcgcagtccc
     2701 cgaggcgcgc ttcctgaacg tgattgagcg ccaccctgtg gacatcagcg ccatccccga
     2761 gcagcggtgg aagctgaaat gcgtgtactg ccggaagcgg atgaagaagg tgtcaggtgc
     2821 ctgtatccag tgctcctacg agcactgctc cacgtccttc cacgtgacct gcgcccacgc
     2881 cgcaggcgtg ctcatggagc cggacgactg gccctatgtg gtctccatca cctgcctcaa
     2941 gcacaagtcg gggggtcacg ctgtccaact cctgagggcc gtgtccctag gccaggtggt
     3001 catcaccaag aaccgcaacg ggctgtacta ccgctgtcgc gtcatcggtg ccgcctcgca
     3061 gacctgctac gaagtgaact tcgacgatgg ctcctacagc gacaacctgt accctgagag
     3121 catcacgagt agggactgtg tccagctggg acccccttcc gagggggagc tggtggagct
     3181 ccggtggact gacggcaacc tctacaaggc caagttcatc tcctccgtca ccagccacat
     3241 ctaccaggtg gagtttgagg acgggtccca gctgacggtg aagcgtgggg acatcttcac
     3301 cctggaggag gagctgccca agagggtccg ctctcggctg tcactgagca cgggggcacc
     3361 gcaggagccc gccttctcgg gggaggaggc caaggccgcc aagcgcccgc gtgtgggcac
     3421 cccgcttgcc acggaggact ccgggcggag ccaggactac gtggccttcg tggagagcct
     3481 cctgcaggtg cagggccggc ccggagcccc cttctaggac agctggccgc tcaggcgacc
     3541 ctcagcccgg cggggaggcc atggcatgcc ccgggcgttc gcttgctgtg aattcctgtc
     3601 ctcgtgtccc cgacccccga gaggccacct ccaagccgcg ggtgccccct agggcgacag
     3661 gagccagcgg gacgccgcac gcggccccag actcagggag cagggccagg cgggctcggg
     3721 ggccggccag gggagcaccc cactcaacta ctcagaattt taaaccatgt aagctctctt
     3781 cttctcgaaa aggtgctact gcaatgccct actgagcaac ctttgagatt gtcacttctg
     3841 tacataaacc acctttgtga ggctctttct ataaatacat attgtttaaa aaaaagcaag
     3901 aaaaaaagga aaacaaagga aaatatcccc aaagttgttt tctagatttg tggctttaag
     3961 aaaaacaaaa caaaacaaac acattgtttt tctcagaacc aggattctct gagaggtcag
     4021 agcatctcgc tgtttttttg ttgttgtttt aaaatattat gatttggcta cagaccaggc
     4081 agggaaagag acccggtaat tggagggtga gcctcggggg gggggcagga cgccccggtt
     4141 tcggcacagc ccggtcactc acggcctcgc tctcgcctca ccccggctcc tgggctttga
     4201 tggtctggtg ccagtgcctg tgcccactct gtgcctgctg ggaggaggcc caggctctct
     4261 ggtggccgcc cctgtgcacc tggccagggg aagcccgggg gtctggggcc tccctccgtc
     4321 tgcgcccacc tttgcagaat aaactctctc ctggggtttg tctatctttg tttctctcac
     4381 ctgagagaaa cgcaggtgtt ccagaggctt ccttgcagac aaagcacccc tgcacctcct
     4441 atggctcagg atgagggagg cccccaggcc cttctggttg gtagtgagtg tggacagctt
     4501 cccagctctt cgggtacaac cctgagcagg tcgggggaca cagggccgag gcaggccttc
     4561 ggggcccctt tcgcctgctt ccgggcaggg acgaggcctg gtgtcctcgc tccacccacc
     4621 cacgctgctg tcacctgagg ggaatctgct tcttaggagt gggttgagct gatagagaaa
     4681 aaacggcctt cagcccaggc tgggaagcgc cttctccagg tgcctctccc tcaccagctc
     4741 tgcacccctc tggggagcct tccccacctt agctgtctcc tgccccaggg agggatggag
     4801 gagataattt gcttatatta aaaacaaaaa atggctgagg caggagtttg ggaccagcct
     4861 gggctatata gcaagacccc atcactacaa attttttaca aattagctag gtgtggtggt
     4921 gcgcacctgt ggtcccagct actcgggagg ctgtggtggg aggattgctt gagtccagga
     4981 ggttgaggct gcagtcagct cagattgcac cactgcactc cagcctgggc aacagagcga
     5041 gaccctgtct ccaaaaaaaa aaaaaagcaa tgtttatatt ataaaagagt gtcctaacag
     5101 tccccgggct agagaggact aaggaaaaca gagagagtgt tacgcaggag caagcctttc
     5161 atttccttgg tgggggaggg gggcggttgc cctggagagg gccggggtcg gggaggttgg
     5221 ggggtgtcag ccaaaacgtg gaggtgtccc tctgcacgca gccctcgccc ggcgtggcgc
     5281 tgacactgta ttcttatgtt gtttgaaaat gctatttata ttgtaaagaa gcgggcgggt
     5341 gcccctgctg cccttgtccc ttgggggtca cacccatccc ctggtgggct cctgggcggc
     5401 ctgcgcagat gggccacaga agggcaggcc ggagctgcac actctcccca cgaaggtatc
     5461 tctgtgtctt actctgtgca aagacgcggc aaaacccagt gccctggttt ttccccaccc
     5521 gagatgaagg atacgctgta ttttttgcct aatgtccctg cctctaggtt cataatgaat
     5581 taaaggttca tgaacgctgc gaaa
//
