LOCUS       NM_016604               6724 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens lysine demethylase 3B (KDM3B), mRNA.
ACCESSION   NM_016604
VERSION     NM_016604.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6724)
  AUTHORS   Cruz,P., Pena-Lopez,D., Figueroa,D., Riobo,I., Benedetti,V.,
            Saavedra,F., Espinoza-Arratia,C., Escobar,T.M., Lladser,A. and
            Loyola,A.
  TITLE     Unraveling the Role of JMJD1B in Genome Stability and the
            Malignancy of Melanomas
  JOURNAL   Int J Mol Sci 25 (19), 10689 (2024)
   PUBMED   39409021
  REMARK    GeneRIF: Unraveling the Role of JMJD1B in Genome Stability and the
            Malignancy of Melanomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6724)
  AUTHORS   Jung,H. and Seo,S.B.
  TITLE     Histone lysine demethylase 3B (KDM3B) regulates the propagation of
            autophagy via transcriptional activation of autophagy-related genes
  JOURNAL   PLoS One 15 (7), e0236403 (2020)
   PUBMED   32716961
  REMARK    GeneRIF: Histone lysine demethylase 3B (KDM3B) regulates the
            propagation of autophagy via transcriptional activation of
            autophagy-related genes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6724)
  AUTHORS   Wang,Y., Zhao,Y., Wang,H., Zhang,C., Wang,M., Yang,Y., Xu,X. and
            Hu,Z.
  TITLE     Histone demethylase KDM3B protects against ferroptosis by
            upregulating SLC7A11
  JOURNAL   FEBS Open Bio 10 (4), 637-643 (2020)
   PUBMED   32107878
  REMARK    GeneRIF: Histone demethylase KDM3B protects against ferroptosis by
            upregulating SLC7A11.
REFERENCE   4  (bases 1 to 6724)
  AUTHORS   Sarac,H., Morova,T., Pires,E., McCullagh,J., Kaplan,A., Cingoz,A.,
            Bagci-Onder,T., Onder,T., Kawamura,A. and Lack,N.A.
  TITLE     Systematic characterization of chromatin modifying enzymes
            identifies KDM3B as a critical regulator in castration resistant
            prostate cancer
  JOURNAL   Oncogene 39 (10), 2187-2201 (2020)
   PUBMED   31822799
  REMARK    GeneRIF: Systematic characterization of chromatin modifying enzymes
            identifies KDM3B as a critical regulator in castration resistant
            prostate cancer.
REFERENCE   5  (bases 1 to 6724)
  AUTHORS   Saavedra,F., Gurard-Levin,Z.A., Rojas-Villalobos,C., Vassias,I.,
            Quatrini,R., Almouzni,G. and Loyola,A.
  TITLE     JMJD1B, a novel player in histone H3 and H4 processing to ensure
            genome stability
  JOURNAL   Epigenetics Chromatin 13 (1), 6 (2020)
   PUBMED   32070414
  REMARK    GeneRIF: JMJD1B, a novel player in histone H3 and H4 processing to
            ensure genome stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6724)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 6724)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of JMJD2 family genes in silico
  JOURNAL   Int J Oncol 24 (6), 1623-1628 (2004)
   PUBMED   15138608
REFERENCE   8  (bases 1 to 6724)
  AUTHORS   Hu,Z., Gomes,I., Horrigan,S.K., Kravarusic,J., Mar,B., Arbieva,Z.,
            Chyna,B., Fulton,N., Edassery,S., Raza,A. and Westbrook,C.A.
  TITLE     A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the
            myeloid leukemia tumor suppressor gene on chromosome 5 band q31
  JOURNAL   Oncogene 20 (47), 6946-6954 (2001)
   PUBMED   11687974
  REMARK    GeneRIF: A novel nuclear protein, 5qNCA is a candidate for the
            myeloid leukemia tumor suppressor gene on chromosome 5 band q31.
REFERENCE   9  (bases 1 to 6724)
  AUTHORS   Lai,F., Godley,L.A., Joslin,J., Fernald,A.A., Liu,J., Espinosa,R.
            3rd, Zhao,N., Pamintuan,L., Till,B.G., Larson,R.A., Qian,Z. and Le
            Beau,M.M.
  TITLE     Transcript map and comparative analysis of the 1.5-Mb commonly
            deleted segment of human 5q31 in malignant myeloid diseases with a
            del(5q)
  JOURNAL   Genomics 71 (2), 235-245 (2001)
   PUBMED   11161817
REFERENCE   10 (bases 1 to 6724)
  AUTHORS   Lai,F., Godley,L.A., Fernald,A.A., Orelli,B.J., Pamintuan,L.,
            Zhao,N. and Le Beau,M.M.
  TITLE     cDNA cloning and genomic structure of three genes localized to
            human chromosome band 5q31 encoding potential nuclear proteins
  JOURNAL   Genomics 70 (1), 123-130 (2000)
   PUBMED   11087669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104116.3 and AC113403.4.
            
            On Nov 23, 2018 this sequence version replaced NM_016604.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146788.1, AF338242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314358.10/ ENSP00000326563.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC104116.3         81016-81318
            304-471             AC113403.4         2160-2327
            472-585             AC113403.4         4579-4692
            586-691             AC113403.4         7206-7311
            692-816             AC113403.4         9070-9194
            817-891             AC113403.4         11002-11076
            892-1491            AC113403.4         15508-16107
            1492-2740           AC113403.4         20499-21747
            2741-2942           AC113403.4         22657-22858
            2943-3157           AC113403.4         27664-27878
            3158-3310           AC113403.4         29346-29498
            3311-3418           AC113403.4         44618-44725
            3419-3546           AC113403.4         46969-47096
            3547-3826           AC113403.4         48439-48718
            3827-4083           AC113403.4         50192-50448
            4084-4350           AC113403.4         53561-53827
            4351-4522           AC113403.4         54897-55068
            4523-4613           AC113403.4         56461-56551
            4614-4744           AC113403.4         56675-56805
            4745-4864           AC113403.4         57453-57572
            4865-5004           AC113403.4         59312-59451
            5005-5181           AC113403.4         59735-59911
            5182-5316           AC113403.4         60911-61045
            5317-6724           AC113403.4         65106-66513
FEATURES             Location/Qualifiers
     source          1..6724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..6724
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /note="lysine demethylase 3B"
                     /db_xref="GeneID:51780"
                     /db_xref="HGNC:HGNC:1337"
                     /db_xref="MIM:609373"
     exon            1..303
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..5397
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /EC_number="1.14.11.65"
                     /note="jumonji domain containing 1B; nuclear protein
                     5qNCA; lysine (K)-specific demethylase 3B; jumonji
                     domain-containing protein 1B; jmjC domain-containing
                     histone demethylation protein 2B; [histone
                     H3]-dimethyl-L-lysine(9) demethylase 3B"
                     /codon_start=1
                     /product="lysine-specific demethylase 3B"
                     /protein_id="NP_057688.3"
                     /db_xref="CCDS:CCDS34242.1"
                     /db_xref="GeneID:51780"
                     /db_xref="HGNC:HGNC:1337"
                     /db_xref="MIM:609373"
                     /translation="MADAAASPVGKRLLLLFADTAASASASAPAAAAASGDPGPALRT
                     RAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHSWVKVHAEEVIVLLLEGSLVWAPRE
                     DPVLLQGIRVSIAQWPALTFTPLVDKLGLGSVVPVEYLLDRELRFLSDANGLHLFQMG
                     TDSQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKIYQPEGEEGWLYGV
                     VSHQDSITRLMEVSVTESGEIKSVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKR
                     ESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPG
                     LDQRAKQPPSTFVPQINRNIRFATYTKENGRTLVVQDEPVGGDTPASFTPYSTATGQT
                     PLAPEVGGAENKEAGKTLEQVGQGIVASAAVVTTASSTPNTVRISDTGLAAGTVPEKQ
                     KGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGVLATENKPLGFSFG
                     CSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQSLESLSS
                     GLCKGRSVLGTDTKPGSKAGSSVDRKVPAESMPTLTPAFPRSLLNARTPENHENLFLQ
                     PPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKVAPSWPESHSSAD
                     SASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPT
                     LSSSPTEERPTVGPGQQDNPLLKTFSNVFGRHSGGFLSSPADFSQENKAPFEAVKRFS
                     LDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEHLMGKLGPNGERSAELL
                     LGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPHLHKC
                     RECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSPQQSDPDAMNLW
                     IPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREM
                     CDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSH
                     EPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVTNGMSQL
                     PSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSE
                     LKAIRPPCPDTAPPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSFNS
                     TAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFS
                     TSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDP
                     HTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQ
                     EFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDF
                     RDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDR
                     RVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKP
                     GALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGV
                     QGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNT
                     HTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS"
     exon            304..471
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            472..585
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            586..691
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            692..816
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            817..891
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1491
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..2740
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2942
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3157
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3310
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3418
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3546
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3826
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..4083
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4350
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4351..4522
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..4613
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..4744
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4864
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5004
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5181
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            5182..5316
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     exon            5317..6724
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6704..6709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /note="hexamer: ATTAAA"
     polyA_site      6711
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
     polyA_site      6724
                     /gene="KDM3B"
                     /gene_synonym="5qNCA; C5orf7; DIJOS; JMJD1B; NET22"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcggc cgcgggtggt gcggagggag gccttgcggg cggatcgggc gcttggcggc
       61 ggaggtggtg ggaggcggcg ggcgggagcg cgggtcaggc cggccccggc gatggcggac
      121 gcggcggcct ccccggtggg caagcggctg ctgctgctgt tcgcggacac tgcggcctca
      181 gcctcggcct cggctcccgc ggcggcagcg gcgagcggag atccggggcc tgcgctgcgc
      241 actcgagcct ggcgggccgg cacggtgcgg gccatgagcg gggcggtgcc ccaggaccta
      301 gcgatctttg tagaatttga tggctgtaac tggaagcaac actcctgggt aaaagttcat
      361 gctgaggaag ttatcgtgct tctgctggaa gggtctcttg tatgggcgcc ccgtgaggac
      421 ccagtccttc tccagggcat tcgagtctcc attgcacaat ggccagccct gacttttact
      481 ccccttgtag ataaactggg tttgggttct gtggttccag tggaatatct tctggatcga
      541 gagcttcggt tcctgtcaga tgccaatggg ttgcatctgt ttcagatggg aacagatagc
      601 caaaaccaga ttcttttgga acatgctgca ctgagagaaa cagttaatgc tttgatcagt
      661 gaccaaaagc tacaagagat attcagccga ggtccctaca gtgttcaagg tcacagggtc
      721 aaaatatatc agccagaggg ggaagaaggg tggctctatg gtgttgtgag ccatcaggac
      781 tccatcactc gtcttatgga ggtgtctgta actgagagtg gtgagatcaa gtcggtagat
      841 cccagactaa tccatgtgat gctgatggat aattcagcgc ctcaaagcga ggggggtacg
      901 ttaaaagcag taaaatcttc caaaggaaag aagaagagag aaagcataga ggggaaagat
      961 ggccggagga ggaaaagtgc ttcggactct gggtgtgacc ctgcatcaaa gaaattaaaa
     1021 ggagacaggg gtgaagtaga cagtaatggg agcgatggag gtgaggcaag ccgagggccc
     1081 tggaaaggag ggaatgccag tggagagcca gggctggatc agagagccaa gcagccaccg
     1141 tctacatttg tcccccagat aaaccgcaac attcgctttg ccacttacac caaagaaaac
     1201 ggcaggactc tggtggtgca ggatgagcct gtaggtgggg acacacctgc atctttcact
     1261 ccatattcta cagccacagg tcagacacct ttggccccag aggtgggtgg agccgaaaac
     1321 aaagaggcag gaaaaacact ggaacaagtt ggccagggca tagtggcttc cgcagctgtg
     1381 gtcactaccg ccagctccac cccaaacaca gtgaggatct cagacactgg ccttgcagca
     1441 gggactgtgc cagaaaaaca gaaaggcagc cggtcgcagg cctcgggaga gaattcaaga
     1501 aattctattc tggcctcttc tggatttgga gcacctctcc ctagttcatc gcaacctttg
     1561 acttttggaa gtggaaggag ccagtccaat ggtgttctag ccacagagaa caaacctttg
     1621 ggcttctctt ttggctgtag ctctgcacaa gaggcacaga aagacactga tctctccaaa
     1681 aacttgtttt ttcaatgcat gtcccaaact ttacctacca gtaactactt cactactgtt
     1741 tcagagagtt tggctgatga ttcttctagt cgggactcat tcaaacaaag ccttgagagc
     1801 ctgagctcag gcctgtgtaa aggcagatcc gttcttggaa cagacactaa gccaggctct
     1861 aaggctggca gctctgtgga ccggaaagtg cctgcagagt ccatgcccac cctcactcca
     1921 gccttcccac ggagcctcct aaatgcccgt accccagaga atcatgaaaa tctattttta
     1981 cagcccccca aattgtcccg agaagagcct tctaatcctt tcctggcatt tgtggagaaa
     2041 gttgaacaca gccctttcag tagttttgca tctcaggcat caggtagctc ctcttctgct
     2101 accactgtca cctccaaggt ggcacccagc tggcccgagt ctcactcctc tgcagattcg
     2161 gcatctttag caaagaagaa acccctcttc attacaactg actcctccaa gctagtatct
     2221 ggtgttctgg gctcagctct taccagtggg ggcccaagcc tctctgccat ggggaatggc
     2281 cgctccagct cgcccaccag cagcctcact cagcccattg agatgccaac tctctcctct
     2341 agccccacag aggagaggcc aactgtgggg cctgggcagc aggacaatcc cctcctcaaa
     2401 acctttagta acgtctttgg caggcactca ggcggctttc tgtcctcccc ggcagatttt
     2461 tcacaggaga acaaagctcc ttttgaagct gtgaaaaggt tctcactgga tgaacgaagc
     2521 ttggcttgca gacaagactc ggactccagc accaacagtg acctgtcaga tttgagtgac
     2581 tctgaggagc agctgcaggc taagacaggc ctgaagggaa ttccagagca cctgatgggg
     2641 aagctgggcc ccaatgggga gcgcagtgct gagctgttgc tgggcaaaag caaagggaag
     2701 caggccccca agggccggcc tcggactgcc cccctgaaag ttggccagtc agtgctgaaa
     2761 gatgtaagca aagtgaagaa gctgaagcaa tctggagagc ccttcctgca ggatgggtca
     2821 tgcatcaatg tggcacctca tctgcacaag tgtcgtgaat gccgcctgga gcggtaccgg
     2881 aagtttaagg aacaggagca agatgattct actgtagcct gccgtttctt tcacttccgg
     2941 aggttgatct tcactcgaaa aggggtactc cgtgtggagg ggtttttaag cccccagcaa
     3001 agtgaccctg atgccatgaa cctgtggatt ccctcttcct ccctagcaga agggatagat
     3061 ctagagacct caaaatacat cctggccaat gttggggacc agttctgcca gctcgtaatg
     3121 tctgagaagg aggccatgat gatggtggag ccacaccaga aagtggcatg gaagcgagct
     3181 gtgcgtggtg tacgggagat gtgtgatgtg tgtgaaacaa ctctcttcaa catccactgg
     3241 gtttgtcgca aatgtggatt tggggtctgc cttgactgtt accggctcag gaaaagccgg
     3301 ccacgcagtg agacagaaga gatgggtgat gaagaagttt tctcctggtt gaagtgtgca
     3361 aagggacagt cccacgaacc agagaatctc atgcccacac aaattattcc tggcacagct
     3421 ctttacaata ttggagacat ggtacatgct gcccggggca agtggggaat taaagcaaac
     3481 tgcccttgta tcagtcgaca gaacaaatct gtattgagac ctgccgtcac caatgggatg
     3541 tcacagcttc ctagcataaa ccctagtgcc tcttctggaa acgaaactac cttctctggt
     3601 ggaggaggac cggcaccagt aacaactcca gagccggacc atgttcccaa agccgacagc
     3661 actgacatca gatctgaaga gcctctgaaa acagacagtt cggcatcaaa tagcaatagt
     3721 gaactgaaag ccatcaggcc tccttgccct gacacggccc caccctcctc cgccctgcac
     3781 tggttggcag atttagcaac tcagaaggct aaagaagaaa caaaagaagc agggtccctg
     3841 aggtcggtgc tcaataaaga gtctcattca ccctttgggc tggactcgtt caactccact
     3901 gcaaaggtct ctccgctgac tccaaagctt tttaacagtc tgttgctggg tcccactgcc
     3961 tccaacaaca aaaccgaagg gtctagcctt cgagacctcc ttcactccgg gccgggaaaa
     4021 cttcctcaaa cccccttgga cacaggcata ccctttcccc cggtcttctc tacatcctca
     4081 gcaggagtga agagcaaggc cagcctaccc aactttcttg accacatcat tgcctcagtg
     4141 gtagaaaata agaaaacctc agatgcttca aagcgggcct gcaacttgac tgatacccag
     4201 aaggaagtga aggagatggt gatggggtta aatgtgctag atccccatac ttctcactcc
     4261 tggctttgtg atgggaggct tctgtgtctc catgacccca gcaacaaaaa caattggaag
     4321 atcttccggg agtgttggaa gcaaggtcag ccagtgctgg tttcgggggt acataaaaag
     4381 ctcaagtctg agctctggaa gccagaagcc tttagccagg aatttggaga ccaggatgta
     4441 gacttggtga actgcaggaa ctgtgctata atttccgatg tgaaagttcg ggatttctgg
     4501 gatggtttcg agatcatatg caaacgacta cggtcagaag atgggcagcc aatggtgctc
     4561 aaactcaagg actggcctcc tggggaagat tttcgagaca tgatgccaac caggtttgaa
     4621 gatctgatgg agaaccttcc tctgccagaa tataccaaac gagatggcag gctcaatctg
     4681 gcctctaggc tacctagcta ctttgtaagg cctgatctgg gccccaagat gtacaacgcc
     4741 tatgggttga taacagcaga agatagaaga gttggtacaa caaatcttca cttagatgtg
     4801 tctgatgctg ttaatgtgat ggtgtatgtt gggattccca tcggggaggg tgctcatgat
     4861 gaagaggtac tcaagacaat tgacgaggga gatgccgatg aggtgacgaa gcagaggatt
     4921 catgatggaa aagagaagcc aggtgcttta tggcacatct atgcagccaa ggatgcagag
     4981 aagatccggg agctgctccg aaaggttgga gaagaacaag gccaagagaa cccccctgat
     5041 catgacccaa ttcatgacca aagttggtac ctggaccaga ccctccgtaa gcgactctat
     5101 gaggagtatg gcgtgcaagg ctgggctatt gtgcagttcc taggtgatgc tgttttcata
     5161 cctgctggag ccccacacca ggttcacaat ctatacagtt gcataaaagt agcagaagac
     5221 tttgtatctc cagaacatgt aaagcactgt ttccgcctga ctcaggaatt caggcatctc
     5281 tctaacactc atacaaatca tgaggataaa ctgcaggtga agaacatcat ttaccatgca
     5341 gtgaaagatg cggttggcac cctcaaggct catgaatcca aactggcaag gtcctaggca
     5401 tggagaaact ccaagctcct ctgtgaagca ggtctttcac tcacaacact taacagggaa
     5461 cggcagggct ctttgctgga gcagaggccc ttcacccaga gccagtgtgg tcagtattcc
     5521 aaactctcca gccactctct tctacgctgc ctcaacactg aaggttgaca caggaaagtc
     5581 gtactgttca cacacacagt ttgagactcc aagccaagag tgccacatcc ctatcctgtg
     5641 gccttttgga aatccaaatt gcctgaacat ggcggggctt tcctgcacat tctcctgatt
     5701 tgagattcac gggcacacct ttcttttctt ttcctcttgt gcctagttaa gtggaaatgt
     5761 gtttggagat aggggaaatc acataactgg tacaagtatg gggtaattgc ttaaacatgc
     5821 ctggtggaag tctgatagcg tctctgcacg tgacctctga caaagcccat cccaggagac
     5881 ggggtgaagc tattccccac actctcctgt gaacactgga gtcttgcaag acccagggag
     5941 aacccactgc ttttcccagg aggctccagg attaggaaat gtgtgtattt agtgaaaaat
     6001 aggtttgtag tgaaatagtt actatttcat gaaagtagat atttttagaa tttttgaaat
     6061 accacagttg ttttcctgga ttataaggaa aggcacatta catttagtct tcctttcgat
     6121 ataaaactct ttgaagaaat atgattttta gaaatcagct acccattata gcacaaaatc
     6181 agccaaagca gaatttttaa aaattggctt ttttaggatt ctttttctcc ccctcccatc
     6241 ttagtcttac cttgagggaa cagtcatatg agaaggaact ttgtcacatc taagctgtgg
     6301 tgtgttcccc atgtgtgtgt acaacactgg tgactccagg aaccattttc acctattacc
     6361 agtgttccct ggggactcct cttaatgttt ccaaatggga aggacagttg atttccaaca
     6421 tgaggttttt tgttttttat ccagaaatat tttcagcaaa actttccaac tgagtggagt
     6481 ctgattaagg atttatttga aaatggtggg attcattggc ccataggtac attggaaaat
     6541 gtatatctct ccagctgtac tgtagtgccc tgcaggctgt ttatatgttc acagttactt
     6601 tttttttttt ttttaaataa aagtcattta atgtagaata cttttaattt cactttctgt
     6661 attttaattt tgttgaaggg ctgattggga tttccatgtt cttattaaaa atctaacaaa
     6721 tctg
//
