LOCUS       NM_018433               4667 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens lysine demethylase 3A (KDM3A), transcript variant 1,
            mRNA.
ACCESSION   NM_018433
VERSION     NM_018433.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4667)
  AUTHORS   VON Fournier,A., Wilhelm,C., Tirtey,C., Stoth,M., Kasemo,T.E.,
            Hackenberg,S. and Scherzad,A.
  TITLE     Impact of Hypoxia and the Levels of Transcription Factor HIF-1alpha
            and JMJD1A on Epithelial-Mesenchymal Transition in Head and Neck
            Squamous Cell Carcinoma Cell Lines
  JOURNAL   Cancer Genomics Proteomics 21 (6), 591-607 (2024)
   PUBMED   39467631
  REMARK    GeneRIF: Impact of Hypoxia and the Levels of Transcription Factor
            HIF-1alpha and JMJD1A on Epithelial-Mesenchymal Transition in Head
            and Neck Squamous Cell Carcinoma Cell Lines.
REFERENCE   2  (bases 1 to 4667)
  AUTHORS   Han,Y., Maimaiti,N., Sun,Y. and Yao,J.
  TITLE     Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor
            malignancy and promotes apoptosis
  JOURNAL   J Mol Histol 55 (1), 139-148 (2024)
   PUBMED   38165573
  REMARK    GeneRIF: Knockout of KDM3A in MDA-MB-231 breast cancer cells
            inhibits tumor malignancy and promotes apoptosis.
REFERENCE   3  (bases 1 to 4667)
  AUTHORS   Monte-Serrano,E., Morejon-Garcia,P., Campillo-Marcos,I.,
            Campos-Diaz,A., Navarro-Carrasco,E. and Lazo,P.A.
  TITLE     The pattern of histone H3 epigenetic posttranslational
            modifications is regulated by the VRK1 chromatin kinase
  JOURNAL   Epigenetics Chromatin 16 (1), 18 (2023)
   PUBMED   37179361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4667)
  AUTHORS   Yang,L., Zhang,Q. and Yang,Q.
  TITLE     KDM3A promotes oral squamous cell carcinoma cell proliferation and
            invasion via H3K9me2 demethylation-activated DCLK1
  JOURNAL   Genes Genomics 44 (11), 1333-1342 (2022)
   PUBMED   36094735
  REMARK    GeneRIF: KDM3A promotes oral squamous cell carcinoma cell
            proliferation and invasion via H3K9me2 demethylation-activated
            DCLK1.
REFERENCE   5  (bases 1 to 4667)
  AUTHORS   Li,C., Zhang,A., Hu,T., Yang,Y., Tang,S. and Li,J.
  TITLE     Histone demethylase JHDM2A participates in the repair of
            arsenic-induced DNA damage in L-02 cells by regulating DDB2
  JOURNAL   Toxicol Ind Health 38 (6), 365-376 (2022)
   PUBMED   35579678
  REMARK    GeneRIF: Histone demethylase JHDM2A participates in the repair of
            arsenic-induced DNA damage in L-02 cells by regulating DDB2.
REFERENCE   6  (bases 1 to 4667)
  AUTHORS   Tateishi,K., Okada,Y., Kallin,E.M. and Zhang,Y.
  TITLE     Role of Jhdm2a in regulating metabolic gene expression and obesity
            resistance
  JOURNAL   Nature 458 (7239), 757-761 (2009)
   PUBMED   19194461
REFERENCE   7  (bases 1 to 4667)
  AUTHORS   Beyer,S., Kristensen,M.M., Jensen,K.S., Johansen,J.V. and
            Staller,P.
  TITLE     The histone demethylases JMJD1A and JMJD2B are transcriptional
            targets of hypoxia-inducible factor HIF
  JOURNAL   J Biol Chem 283 (52), 36542-36552 (2008)
   PUBMED   18984585
  REMARK    GeneRIF: histone demethylases JMJD1A and JMJD2B are transcriptional
            targets of hypoxia-inducible factor HIF
REFERENCE   8  (bases 1 to 4667)
  AUTHORS   Pollard,P.J., Loenarz,C., Mole,D.R., McDonough,M.A., Gleadle,J.M.,
            Schofield,C.J. and Ratcliffe,P.J.
  TITLE     Regulation of Jumonji-domain-containing histone demethylases by
            hypoxia-inducible factor (HIF)-1alpha
  JOURNAL   Biochem J 416 (3), 387-394 (2008)
   PUBMED   18713068
  REMARK    GeneRIF: Results show that many genes regulated by hypoxia and
            HIF-1alpha show patterns of induction with JMJD (Jumonji-domain
            containing)1A and JMJD2B demonstrating robust, and JMJD2C more
            modest, up-regulation by hypoxia.
REFERENCE   9  (bases 1 to 4667)
  AUTHORS   Wellmann,S., Bettkober,M., Zelmer,A., Seeger,K., Faigle,M.,
            Eltzschig,H.K. and Buhrer,C.
  TITLE     Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
  JOURNAL   Biochem Biophys Res Commun 372 (4), 892-897 (2008)
   PUBMED   18538129
  REMARK    GeneRIF: These findings demonstrate that JMJD1A can be stimulated
            by hypoxia both in vitro and in vivo involving binding of HIF-1 to
            a specific HRE in the JMJD1A promoter.
REFERENCE   10 (bases 1 to 4667)
  AUTHORS   Yamane,K., Toumazou,C., Tsukada,Y., Erdjument-Bromage,H.,
            Tempst,P., Wong,J. and Zhang,Y.
  TITLE     JHDM2A, a JmjC-containing H3K9 demethylase, facilitates
            transcription activation by androgen receptor
  JOURNAL   Cell 125 (3), 483-495 (2006)
   PUBMED   16603237
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB087171.1, BX647271.1,
            AB018285.2 and BX648841.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018433.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038297.2, BX640698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312912.10/ ENSP00000323659.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DB087171.1         226-233
            9-2420              BX647271.1         1-2412
            2421-4666           AB018285.2         2407-4652
            4667-4667           BX648841.1         4622-4622
FEATURES             Location/Qualifiers
     source          1..4667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..4667
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /note="lysine demethylase 3A"
                     /db_xref="GeneID:55818"
                     /db_xref="HGNC:HGNC:20815"
                     /db_xref="MIM:611512"
     exon            1..74
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            75..290
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..4070
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /EC_number="1.14.11.65"
                     /note="testis-specific protein A; jumonji C
                     domain-containing histone demethylase 2A; jumonji
                     domain-containing protein 1A; jmjC domain-containing
                     histone demethylation protein 2A; lysine (K)-specific
                     demethylase 3A; [histone H3]-dimethyl-L-lysine(9)
                     demethylase 3A"
                     /codon_start=1
                     /product="lysine-specific demethylase 3A"
                     /protein_id="NP_060903.2"
                     /db_xref="CCDS:CCDS1990.1"
                     /db_xref="GeneID:55818"
                     /db_xref="HGNC:HGNC:20815"
                     /db_xref="MIM:611512"
                     /translation="MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWL
                     SGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSP
                     EISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSL
                     TDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPAS
                     KTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQA
                     KSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIP
                     QGCHKQSLPEEISSCLNTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQ
                     PKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVS
                     NAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAP
                     SRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPV
                     FCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILAN
                     IGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFG
                     VCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHS
                     VRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAV
                     GGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPL
                     PPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASL
                     VQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQ
                     GQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDV
                     PNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLP
                     NYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEV
                     LKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADH
                     DPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAE
                     DFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGK
                     P"
     exon            291..446
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            447..557
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            558..660
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            661..785
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            786..858
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            859..947
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1111
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1623
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1828
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2043
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2196
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2292
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2420
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2616
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2789
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..3026
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3198
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3286
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3417
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3537
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3677
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3854
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..3989
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            3990..4667
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4648..4653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /note="hexamer: ATTAAA"
     polyA_site      4667
                     /gene="KDM3A"
                     /gene_synonym="JHDM2A; JHMD2A; JMJD1; JMJD1A; TSGA"
                     /note="major polyA site"
ORIGIN      
        1 aagtcagcgc tggagtcggc taggcggctg gaaacggcgg ctgccgccgg tgactcaggg
       61 aggcgggagg cgggggagga gctcttcctg caggcgtgga aaccatggtg ctcacgctcg
      121 gagaaagttg gccggtattg gtggggagga ggtttctcag tctgtccgca gccgacggca
      181 gcgatggcag ccacgacagc tgggacgtgg agcgcgtcgc cgagtggccc tggctctccg
      241 ggaccattcg agctgtttcc cacaccgacg ttaccaagaa ggatctgaag gtgtgtgtgg
      301 aatttgatgg ggaatcttgg aggaaaagaa gatggataga agtctacagc cttctaagga
      361 gagcattttt agtagaacat aatttggttt tagctgaacg aaagtcacct gaaatttctg
      421 aacgaattgt acagtggcct gcaataacgt acaaacctct gttggacaaa gctggtttgg
      481 gatccataac ttctgttcgc tttctgggag atcaacaaag agtatttctt tctaaagacc
      541 ttttgaagcc tatacaggat gtaaacagtc ttcgactttc tcttacggat aatcagattg
      601 tcagtaaaga atttcaagct ttgattgtga agcatttaga tgaaagccat cttttaaaag
      661 gtgacaaaaa cttagttggt tcagaagtaa aaatttatag cttggaccca tctactcagt
      721 ggttttcagc aaccgttata aatggaaacc cagcatcaaa aactcttcaa gtcaactgtg
      781 aggagattcc agcactgaaa attgttgatc cgtcactgat tcatgttgaa gttgtacacg
      841 ataaccttgt gacatgtggt aattctgcaa gaattggagc tgtaaaacgc aagtcttctg
      901 agaataatgg aaccctggtt tccaaacaag caaaatcttg ctctgaggcc tctcccagta
      961 tgtgtcctgt gcagtctgta cctacaacag tttttaagga gatactgctt ggctgtactg
     1021 cggcaactcc acctagtaag gacccaagac agcaaagtac tccccaggct gccaactctc
     1081 cacctaacct tggagcaaaa attcctcaag gatgtcataa acaaagttta ccagaggaaa
     1141 tttcttcctg tctaaataca aagtctgaag ctctgagaac aaaaccagat gtctgcaaag
     1201 cagggttgct ctcaaagtcc tctcagattg gaactggaga cttgaaaatt ctgactgagc
     1261 caaaaggcag ctgtactcag cctaagacaa acactgatca ggaaaacaga ttggagtctg
     1321 ttccacaagc attgactggc cttcctaagg agtgcttacc tacaaaggct tcttctaagg
     1381 cagaattgga aattgccaat cctcctgaac tgcagaagca cctagaacat gcaccttccc
     1441 catcggatgt ttcaaatgca ccagaagtga aagcaggtgt caatagtgat agccctaata
     1501 actgttcagg aaaaaaggta gaaccttcag ctttagcttg ccgatcacag aatttaaagg
     1561 aatcttcagt aaaagtagat aatgaaagct gttgttcaag aagcaacaat aaaatccaga
     1621 atgccccatc caggaagtcg gttttgacag acccagctaa actcaaaaag ctgcaacaga
     1681 gtggcgaggc cttcgtacag gatgattctt gtgtgaacat cgtggcacag ttgcctaaat
     1741 gccgagagtg tcgcttggac agtctccgca aggataagga gcaacagaag gactcacctg
     1801 tgttttgccg cttctttcac ttcaggaggt tacaattcaa caaacatggt gtgttgcggg
     1861 tagaaggctt cttaacacca aacaagtatg acaatgaagc aattggcttg tggttacctt
     1921 taaccaaaaa cgttgtgggg attgatttgg acacagcaaa gtacatcttg gccaacattg
     1981 gagaccactt ctgtcaaatg gtgatttctg aaaaggaagc tatgtcaact attgagccac
     2041 acagacaggt tgcttggaag cgagctgtca aaggtgttcg agaaatgtgt gatgtgtgcg
     2101 acaccaccat cttcaacctg cactgggtgt gtcctcggtg tgggtttgga gtatgtgtgg
     2161 actgctaccg gatgaagaga aagaattgcc aacagggtgc tgcttacaag actttctctt
     2221 ggctaaaatg tgtgaagagt cagatacatg aaccagagaa cttaatgccc acacagatca
     2281 ttcctggaaa agcactctat gatgttggag acattgttca ttctgtaaga gcgaaatggg
     2341 gaataaaggc aaactgccct tgttcaaaca ggcaattcaa actcttttca aagccagcct
     2401 caaaggaaga cctaaaacag acttctttag ctggagaaaa accgactctt ggtgcagtgc
     2461 tccagcagaa tccctcagtg ttggagccag cagctgtggg tggggaagca gcctccaagc
     2521 cagccggcag catgaagcct gcctgtccag ccagcacatc tcctctaaac tggctggccg
     2581 acctaaccag cgggaatgtc aacaaggaaa acaaggaaaa acaaccaaca atgccaattt
     2641 taaagaatga aatcaaatgc cttccacccc tcccaccttt aagcaaatcc agcacagtcc
     2701 tccatacgtt taacagcaca attttgacac ccgtaagcaa caacaattct ggtttcctcc
     2761 ggaatctctt gaattcttct acaggaaaga cagaaaatgg actcaagaat acaccaaaaa
     2821 tccttgatga catctttgcc tctttggtgc aaaataagac gacttctgat ttatctaaga
     2881 ggcctcaagg actaaccatc aagcccagca ttctgggctt tgacactcct cactattggc
     2941 tttgtgataa tcgcttgctg tgcttgcaag accccaacaa taagagcaac tggaatgtgt
     3001 ttagggagtg ctggaaacaa gggcagccag tgatggtgtc tggagtgcat cataaattga
     3061 actctgaact ttggaaacct gaatccttca ggaaagagtt tggtgagcag gaagtagacc
     3121 tagttaattg taggaccaat gaaatcatca caggagccac agtaggagac ttctgggatg
     3181 gatttgaaga tgttccaaat cgtttgaaaa atgaaaaaga accaatggtg ttgaaactta
     3241 aggactggcc accaggagaa gattttagag atatgatgcc ttccaggttt gatgatctga
     3301 tggccaacat tccactgccc gagtacacaa ggcgagatgg caaactgaat ttggcctcta
     3361 ggctgccaaa ctactttgtt cggccagatc tgggccccaa gatgtataat gcttatggat
     3421 taatcactcc tgaagatcgg aaatatggaa caacaaatct tcacttagat gtatctgatg
     3481 cagctaatgt catggtctat gtgggaattc ccaaaggaca gtgtgagcaa gaagaagaag
     3541 tccttaagac catccaagat ggagattctg acgaactcac aataaagcga tttattgaag
     3601 gaaaagagaa gccaggagca ctgtggcaca tatatgctgc aaaggacacg gagaagataa
     3661 gggaatttct taaaaaggta tcagaagagc aaggtcaaga aaacccagca gaccacgatc
     3721 ctattcatga tcaaagctgg tatttagacc gatcattaag aaaacgtctt catcaagagt
     3781 atggagttca aggctgggct attgtacagt ttcttgggga tgtggtgttt atcccggcag
     3841 gagctccaca tcaggttcat aacttatata gctgcatcaa agtggctgaa gattttgttt
     3901 ctccagagca tgttaaacac tgcttctggc ttactcagga attccgatat ctgtcacaga
     3961 ctcataccaa tcacgaagat aaattacagg tgaagaatgt tatctaccat gcagtgaaag
     4021 atgcagttgc tatgctgaaa gccagtgaat ccagttttgg caaaccttaa tctccctgca
     4081 cattggaaat gaattacagg cagctgttca aactcttcag gcaggattcc tgtggacttt
     4141 gagattcatg ttacctcatc ttctttttta aactgtaccc aacttgtgag ggtactctgt
     4201 ctaatgtata tttctagtgt ttacagacag taaatgtgta tatgtagtaa ctatttacag
     4261 aacatgcatc cttaaactgt gacttctcac ctagtgcaga acttttacca ggctgtaaaa
     4321 gcaaaacctc gtatcagctc tggaacaata cctgcagtta ttcttcagct gtttggacaa
     4381 cttagattgg gtttataact attaggaatc actgcacagt ttatttgggt tgtgttttgt
     4441 gtctgagtcc cctccctcat cccttagggt ccagaagagc aatggaggaa gtgacagcta
     4501 atgttgcagt tcttattgta tggcatagga ctggcattat atagcagaaa tcaactactg
     4561 tacaatttct tggggttaac catctttagt taaatggaat tttaatttaa atgacgcttt
     4621 gctaatttta agtgttaagc attttgcatt aaaatattca tataata
//
