LOCUS       NM_032590               5315 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens lysine demethylase 2B (KDM2B), transcript variant 1,
            mRNA.
ACCESSION   NM_032590
VERSION     NM_032590.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5315)
  AUTHORS   Glover,L., Lilly,A.G., Justice,A.E., Howard,A.G., Staley,B.S.,
            Wang,Y., Kamens,H.M., Ferrier,K., Bressler,J., Loehr,L.,
            Raffield,L.M., Sims,M., North,K.E. and Fernandez-Rhodes,L.
  TITLE     DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect
            of socioeconomic status on elevated body mass index in African
            American adults
  JOURNAL   Hum Mol Genet 33 (20), 1748-1757 (2024)
   PUBMED   39079086
  REMARK    GeneRIF: DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the
            effect of socioeconomic status on elevated body mass index in
            African American adults.
REFERENCE   2  (bases 1 to 5315)
  AUTHORS   Chellini,L., Scarfo,M., Bonvissuto,D., Sette,C. and Paronetto,M.P.
  TITLE     The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated
            transcriptional regulation of YAP1 in Ewing sarcoma
  JOURNAL   Oncogene 43 (4), 225-234 (2024)
   PUBMED   38017132
  REMARK    GeneRIF: The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated
            transcriptional regulation of YAP1 in Ewing sarcoma.
REFERENCE   3  (bases 1 to 5315)
  AUTHORS   Chavdoula,E., Anastas,V., La Ferlita,A., Aldana,J., Carota,G.,
            Spampinato,M., Soysal,B., Cosentini,I., Parashar,S., Sircar,A.,
            Nigita,G., Sehgal,L., Freitas,M.A. and Tsichlis,P.N.
  TITLE     Transcriptional regulation of amino acid metabolism by KDM2B, in
            the context of ncPRC1.1 and in concert with MYC and ATF4
  JOURNAL   Metabolism 150, 155719 (2024)
   PUBMED   37935302
  REMARK    GeneRIF: Transcriptional regulation of amino acid metabolism by
            KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4.
REFERENCE   4  (bases 1 to 5315)
  AUTHORS   Motoi,T., Hirata,M., Kukita,Y., Satomi,K., Tamura,H., Adachi,S.,
            Matsushita,Y., Horiguchi,S.I., Hishima,T., Ikegami,M., Okuma,T.,
            Tao,K., Arakawa,A., Ogawa,C., Matsuda,K., Ichimura,K., Nakamura,H.,
            Mori,T. and Yoshida,A.
  TITLE     KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept of
            BCOR-Associated Sarcoma
  JOURNAL   Mod Pathol 36 (11), 100317 (2023)
   PUBMED   37634866
  REMARK    GeneRIF: KDM2B-Rearranged Soft Tissue Sarcomas Expand the Concept
            of BCOR-Associated Sarcoma.
REFERENCE   5  (bases 1 to 5315)
  AUTHORS   Andricovich,J. and Tzatsos,A.
  TITLE     Biological Functions of the KDM2 Family of Histone Demethylases
  JOURNAL   Adv Exp Med Biol 1433, 51-68 (2023)
   PUBMED   37751135
  REMARK    GeneRIF: Biological Functions of the KDM2 Family of Histone
            Demethylases.
REFERENCE   6  (bases 1 to 5315)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: validated occurrence of an unusual TG 3' splice site in
            intron 15
REFERENCE   7  (bases 1 to 5315)
  AUTHORS   Gearhart,M.D., Corcoran,C.M., Wamstad,J.A. and Bardwell,V.J.
  TITLE     Polycomb group and SCF ubiquitin ligases are found in a novel BCOR
            complex that is recruited to BCL6 targets
  JOURNAL   Mol Cell Biol 26 (18), 6880-6889 (2006)
   PUBMED   16943429
REFERENCE   8  (bases 1 to 5315)
  AUTHORS   Tsukada,Y., Fang,J., Erdjument-Bromage,H., Warren,M.E.,
            Borchers,C.H., Tempst,P. and Zhang,Y.
  TITLE     Histone demethylation by a family of JmjC domain-containing
            proteins
  JOURNAL   Nature 439 (7078), 811-816 (2006)
   PUBMED   16362057
REFERENCE   9  (bases 1 to 5315)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 5315)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145422.7, BX648928.1,
            AJ459424.1, AK027692.1 and CA430876.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032590.4.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbls class. Multiple alternatively spliced transcript variants
            have been found for this gene, but the full-length nature of some
            variants has not been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ459424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377071.9/ ENSP00000366271.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC145422.7         72590-72597
            9-39                BX648928.1         2-32
            40-2301             AJ459424.1         4-2265
            2302-5036           AK027692.1         199-2933
            5037-5315           CA430876.1         16-294              c
FEATURES             Location/Qualifiers
     source          1..5315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..5315
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /note="lysine demethylase 2B"
                     /db_xref="GeneID:84678"
                     /db_xref="HGNC:HGNC:13610"
                     /db_xref="MIM:609078"
     exon            1..238
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4123
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /EC_number="1.14.11.27"
                     /note="isoform a is encoded by transcript variant 1;
                     jumonji C domain-containing histone demethylase 1B; F-box
                     and leucine-rich repeat protein 10; JEMMA (Jumonji domain,
                     EMSY-interactor, methyltransferase motif) protein; F-box
                     protein FBL10; lysine (K)-specific demethylase 2B;
                     F-box/LRR-repeat protein 10; CXXC-type zinc finger protein
                     2; protein-containing CXXC domain 2;
                     [Histone-H3]-lysine-36 demethylase 1B; jmjC
                     domain-containing histone demethylation protein 1B"
                     /codon_start=1
                     /product="lysine-specific demethylase 2B isoform a"
                     /protein_id="NP_115979.3"
                     /db_xref="CCDS:CCDS41850.1"
                     /db_xref="GeneID:84678"
                     /db_xref="HGNC:HGNC:13610"
                     /db_xref="MIM:609078"
                     /translation="MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRP
                     IDRQRYDENEDLSDVEEIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREAL
                     RVPLIFREKDGLGIKMPDPDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYY
                     ETPEAQRDKLYNVISLEFSHTKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAI
                     AEMKYPKVKKYCLMSVKGCFTDFHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEE
                     WVLSGKQSDIFLGDRVERCQRIELKQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFN
                     VPMQLRIYEIEDRTRVQPKFRYPFYYEMCWYVLERYVYCVTQRSHLTQEYQRESMLID
                     APRKPSIDGFSSDSWLEMEEEACDQQPQEEEEKDEEGEGRDRAPKPPTDGSTSPTSTP
                     SEDQEALGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTH
                     LTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPSLAITG
                     VPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAANRTTAGARRRRTRCRKCEACLRTEC
                     GECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEEGKFN
                     LMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYA
                     SNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDEHSKKVPPDGLLRRKSDDV
                     HLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSSLSPWWRSSLTYFQQQL
                     KPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEAPPKTRESDHSRSSS
                     PTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQP
                     IKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSV
                     SPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMRV
                     CRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLIN
                     RLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPG
                     QMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAV
                     GTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSV
                     SVQFGQVEEKLLQKLS"
     exon            239..383
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..462
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..509
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..688
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..795
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..889
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1043
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1159
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1286
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1759
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1846
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2071
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2215
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2302
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2563
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2677
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2716
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..3396
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3560
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3722
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3941
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..5315
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4634
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /note="major polyA site"
     regulatory      5291..5296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /note="hexamer: AGTAAA"
     polyA_site      5315
                     /gene="KDM2B"
                     /gene_synonym="CXXC2; Fbl10; FBXL10; JHDM1B; PCCX2"
                     /note="major polyA site"
ORIGIN      
        1 gtacgtgtgt gtgtccacat ctttgagtgc cgggagttta aaagttaggc agtccttata
       61 ggtatggaag ccgagctaat ttccttctga gccccccaaa tgcctcctcc acatggcggg
      121 tccgcaaatg gggggatctg cagaggatca ccccccacga aaaagacatg cagcagaaaa
      181 gcaaaaaaag aaaacagtta tatatacaaa atgctttgaa tttgagtcgg ccacacagcg
      241 cccgattgac cgccagcgat acgacgagaa cgaggacttg tcggacgtgg aggagatcgt
      301 cagcgtccgc ggcttcagcc tggaggagaa gcttcgcagc cagctgtacc agggggactt
      361 cgtgcacgcc atggagggca aagatttcaa ctatgagtac gtacagagag aagctctcag
      421 ggttcccctg atatttcgag aaaaggatgg actgggaatt aagatgcctg accctgattt
      481 cacagtccga gacgtcaaac tcctagtggg gagccggcgg cttgtggacg tgatggatgt
      541 gaacacccag aagggcacgg agatgagcat gtcccagttt gtgcgttact acgagacgcc
      601 cgaggcccag cgggacaagc tgtacaacgt catcagccta gagttcagcc acaccaagct
      661 ggagcacttg gtcaagcgtc cgactgtggt agacctggtg gactgggtgg acaacatgtg
      721 gccccagcat ctgaaggaga agcagacaga agccacgaac gccattgcag agatgaagta
      781 cccgaaagtg aaaaagtact gtctgatgag cgtgaaaggt tgtttcaccg acttccacat
      841 cgactttgga ggcacttccg tttggtacca tgttttccgg ggtgggaaga ttttttggct
      901 gattcctcca acgctgcaca atttggcgct gtacgaggag tgggtgctgt caggcaaaca
      961 gagtgacatc tttctgggag accgtgtgga acgatgccaa agaattgagc tgaagcaggg
     1021 ctacacattt ttcatccctt ccggttggat ccatgccgtc tacacccctg tagactcttt
     1081 ggtgttcggc ggaaacatcc tgcacagctt taacgtgccc atgcagctgc ggatctacga
     1141 gatcgaggac aggacgcggg tgcagcccaa attccgttac cccttctact atgagatgtg
     1201 ctggtatgtc ctggagagat acgtgtactg tgtgacccag cgctcccacc tcactcagga
     1261 ataccagagg gagtcgatgc ttattgatgc cccgaggaag cccagcatag acggcttctc
     1321 ttcggattcc tggctggaga tggaggagga ggcctgtgat cagcagcctc aggaggagga
     1381 ggagaaggac gaggagggcg agggcaggga cagggcaccc aaaccgccca ccgatggctc
     1441 cacttcaccc accagcacgc cctctgagga ccaggaggcc ctcgggaaga agcccaaagc
     1501 acctgccctg cgattcctca aaaggacttt gtctaatgag tcggaggaaa gtgtgaagtc
     1561 caccacattg gccgtagact accccaagac ccccaccggc tctcccgcca cggaggtctc
     1621 tgccaaatgg acccatctca ctgagtttga actgaagggc ctgaaagctc tggtggagaa
     1681 actggaatcc ctcccggaga acaagaagtg tgtccccgag ggcatcgagg acccccaggc
     1741 actcctggag ggtgtgaaga acgtcctgaa ggagcacgca gatgatgacc ctagtctggc
     1801 catcactggg gtccctgtgg tgacttggcc aaagaagact ccaaagaacc gggctgtggg
     1861 tcggcccaag gggaagctgg gcccggcctc cgcggtgaag ttggccgcca accggacaac
     1921 ggcaggagct cggcggcgcc ggacgcgatg ccgcaagtgc gaggcctgcc tgcggaccga
     1981 gtgcggagag tgccacttct gcaaggacat gaagaagttc gggggccccg ggcgcatgaa
     2041 gcagagctgc atcatgcggc agtgcatcgc gccagtgctg ccccacaccg ccgtgtgcct
     2101 tgtgtgtggc gaggcgggga aggaagacac ggtggaagag gaggaaggca agtttaacct
     2161 catgctcatg gagtgctcca tctgcaatga aatcatccac cctggatgcc ttaagattaa
     2221 ggagtcagag ggtgtggtca acgacgagct tccaaactgc tgggagtgtc cgaagtgtaa
     2281 ccacgccggc aagaccggga aacaaaagcg tggccctggc tttaagtacg cctccaacct
     2341 gcccggctcc ctgctcaagg agcagaagat gaaccgggac aacaaggaag ggcaggaacc
     2401 tgccaagcgg aggagtgagt gtgaggaggc gccccggcgc aggtcggatg agcactcgaa
     2461 gaaggtgccg ccggacggcc ttctgcgcag aaagtctgac gacgtgcacc tgaggaagaa
     2521 gcggaaatac gagaagcccc aggagctgag tggacgcaag cgggcctcat cgcttcaaac
     2581 gtcccccggt tcctcctctc acctctcgcc gaggccccct ctaggcagca gcctcagccc
     2641 ctggtggaga tccagtctca cttacttcca gcagcagctc aaacctggca aagaagataa
     2701 gcttttcagg aaaaagcggc ggtcctggaa gaacgccgag gaccgcatgg cgctggccaa
     2761 caagcccctc cggcgcttca agcaggaacc cgaggacgaa ctgcccgagg cgccccccaa
     2821 gaccagggag agcgaccact cccgctccag ctcccccacc gcgggaccca gcaccgaagg
     2881 ggccgagggc ccggaggaga agaagaaggt gaagatgcgc cggaagcggc ggcttcccaa
     2941 caaggagctg agcagggagc tgagcaagga gctcaaccac gagatccaga ggacggagaa
     3001 cagcctggcc aacgagaacc agcagcccat caagtcggag cctgagagcg agggcgagga
     3061 gcccaagcgg cccccgggca tctgcgagcg tccccaccgc ttcagcaagg ggctcaacgg
     3121 caccccccgg gagctgcggc accagctggg gcccagcctg cgcagcccgc cccgtgtcat
     3181 ctcccggccc ccaccctccg tgtccccgcc caagtgtatc cagatggagc gccatgtgat
     3241 ccggccaccc cccatcagcc ccccgcctga ctcgctaccc ctggacgatg gggcagccca
     3301 cgtcatgcac agggaggtgt ggatggccgt cttcagctac ctcagccacc aagacctgtg
     3361 tgtgtgcatg cgggtctgca ggacctggaa ccgctggtgc tgcgataagc ggttgtggac
     3421 ccgcattgac ctgaaccact gcaagtctat cacacccctg atgctgagtg gcatcatccg
     3481 gcgacagccc gtctccctcg acctcagctg gaccaatatc tccaagaagc agctgagctg
     3541 gctcatcaac cggctgcctg ggctccggga cttggtgctg tcaggctgct catggatcgc
     3601 ggtctcggcc ctttgcagct ccagttgtcc gctgctccgg accctggatg tccagtgggt
     3661 ggagggacta aaggatgccc agatgcggga tctcctgtcc ccgcccacag acaacaggcc
     3721 aggtcagatg gacaatcgga gcaagctccg gaacatcgtg gagctgcgcc tggcaggcct
     3781 ggacatcaca gatgcctccc tgcggctcat catccgccac atgcccctgc tctccaagct
     3841 ccacctcagt tactgtaacc acgtcaccga ccagtctatc aacctgctca ctgctgttgg
     3901 caccaccacc cgagactcct taaccgagat caacctgtct gactgcaata aggtcactga
     3961 tcagtgcctg tccttcttca aacgctgtgg aaacatctgt catattgacc tgaggtactg
     4021 caagcaagtc accaaggaag gctgtgagca gttcatagcc gagatgtctg tgagtgtcca
     4081 gtttgggcaa gtagaagaaa aactcctgca aaaactgagt tagtccaagg ataagtatgt
     4141 aaatacgggg cgggctctgg gaggggagag actttacaaa aatgagggct tttattttcc
     4201 atttggaacg tgggacaaca gaccacaacg caattccatt ttgcaagtct ttccaaggga
     4261 gaagctgttc aaccacccgt ttgggggatg agtgagccga cactttcctt tggtctttct
     4321 gaatcgtaac tgcactgctt tctggaccat ttctaaggcg gcctttacaa gaagacattc
     4381 ctgtcggaga ggagggtgga cttcggagaa attctcatac tgaagcatga gcttaggagt
     4441 ttctgttagt ggtagtggtg ttttggacac ttcattcctt gcaacaccga ggttttgggt
     4501 gttgacataa agtggaccac acaccacatc tgctgccgtc ttgacacttt tttttgtttg
     4561 gttggttttg ttacatctta cattatgcag aactattttt gtacaaattg tttaaaagtt
     4621 atttatgcaa ggtttgaatg cataccagtg tttttattgt tttgagattg ccaattttcc
     4681 tgatttcctt aaggtaggag agaatttaac gtgtacttca tcgacacaac ccatctacaa
     4741 atgtgcccag atctaacaaa gtaggctaag accttccact taaaagcatg tttaactgga
     4801 agttgagagt ctgctttgta cctcaagagt tacatgagca tgttgtggat aaatgtaaat
     4861 tatagtcaaa gtaagatact ctgccaagtt tcctctgtag agaattcact tttctcaaat
     4921 tttaaaattt cgacttcagc ctttgcactc aggaggttct gctccagcat gagctcttgt
     4981 acttacatag atctaattta tacagtgagt caagacgtag aataaatgct cccacatagc
     5041 ctttcttttg cttttgcttc tctcctctga agtgtgagtt gagttctcat ttaggtttgt
     5101 aacatggcta tttcctagtt gtaaagttct gcatttataa gtgccattgt tgtaaggtgg
     5161 tgtttcctag accttccctg atgcgatttt acctttgttg aatttgtata aacaattgta
     5221 caaaaaaaac cactcttgaa ctttgagggt ttctgttcta ggagtggact agaagtttaa
     5281 gcccagagtc agtaaacact gttttgaagt ccaaa
//
