LOCUS       NM_012308               7386 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens lysine demethylase 2A (KDM2A), transcript variant 1,
            mRNA.
ACCESSION   NM_012308
VERSION     NM_012308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7386)
  AUTHORS   Diaz-Hernandez,M.E., Murakami,K., Murata,S., Khan,N.M.,
            Shenoy,S.P.V., Henke,K., Yamada,H. and Drissi,H.
  TITLE     Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs
  JOURNAL   Cells 13 (17), 1482 (2024)
   PUBMED   39273051
  REMARK    GeneRIF: Inhibition of KDM2/7 Promotes Notochordal Differentiation
            of hiPSCs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7386)
  AUTHORS   You,H.J., Ma,L.H., Wang,X., Wang,Y.X., Zhang,H.Y., Bao,E.S.,
            Zhong,Y.J., Liu,X.Y., Kong,D.L., Zheng,K.Y., Kong,F.Y. and
            Tang,R.X.
  TITLE     Hepatitis B virus core protein stabilizes RANGAP1 to upregulate
            KDM2A and facilitate hepatocarcinogenesis
  JOURNAL   Cell Oncol (Dordr) 47 (2), 639-655 (2024)
   PUBMED   37845585
  REMARK    GeneRIF: Hepatitis B virus core protein stabilizes RANGAP1 to
            upregulate KDM2A and facilitate hepatocarcinogenesis.
REFERENCE   3  (bases 1 to 7386)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 7386)
  AUTHORS   Li,F., Wang,Y., Hwang,I., Jang,J.Y., Xu,L., Deng,Z., Yu,E.Y.,
            Cai,Y., Wu,C., Han,Z., Huang,Y.H., Huang,X., Zhang,L., Yao,J.,
            Lue,N.F., Lieberman,P.M., Ying,H., Paik,J. and Zheng,H.
  TITLE     Histone demethylase KDM2A is a selective vulnerability of cancers
            relying on alternative telomere maintenance
  JOURNAL   Nat Commun 14 (1), 1756 (2023)
   PUBMED   36991019
  REMARK    GeneRIF: Histone demethylase KDM2A is a selective vulnerability of
            cancers relying on alternative telomere maintenance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7386)
  AUTHORS   Andricovich,J. and Tzatsos,A.
  TITLE     Biological Functions of the KDM2 Family of Histone Demethylases
  JOURNAL   Adv Exp Med Biol 1433, 51-68 (2023)
   PUBMED   37751135
  REMARK    GeneRIF: Biological Functions of the KDM2 Family of Histone
            Demethylases.
REFERENCE   6  (bases 1 to 7386)
  AUTHORS   Tanaka,Y., Okamoto,K., Teye,K., Umata,T., Yamagiwa,N., Suto,Y.,
            Zhang,Y. and Tsuneoka,M.
  TITLE     JmjC enzyme KDM2A is a regulator of rRNA transcription in response
            to starvation
  JOURNAL   EMBO J 29 (9), 1510-1522 (2010)
   PUBMED   20379134
  REMARK    GeneRIF: KDM2A represses the transcription of ribosomal RNA. KDM2A
            was localized in nucleoli and bound to the ribosomal RNA gene
            promoter.
REFERENCE   7  (bases 1 to 7386)
  AUTHORS   Watanabe,N., Arai,H., Nishihara,Y., Taniguchi,M., Watanabe,N.,
            Hunter,T. and Osada,H.
  TITLE     M-phase kinases induce phospho-dependent ubiquitination of somatic
            Wee1 by SCFbeta-TrCP
  JOURNAL   Proc Natl Acad Sci U S A 101 (13), 4419-4424 (2004)
   PUBMED   15070733
REFERENCE   8  (bases 1 to 7386)
  AUTHORS   Ilyin,G.P., Rialland,M., Pigeon,C. and Guguen-Guillouzo,C.
  TITLE     cDNA cloning and expression analysis of new members of the
            mammalian F-box protein family
  JOURNAL   Genomics 67 (1), 40-47 (2000)
   PUBMED   10945468
REFERENCE   9  (bases 1 to 7386)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 7386)
  AUTHORS   Cenciarelli,C., Chiaur,D.S., Guardavaccaro,D., Parks,W., Vidal,M.
            and Pagano,M.
  TITLE     Identification of a family of human F-box proteins
  JOURNAL   Curr Biol 9 (20), 1177-1179 (1999)
   PUBMED   10531035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000729.4, BC047486.1,
            BC064360.1, AP001885.4, AF179221.1 and BE675843.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012308.2.
            
            Summary: This gene encodes a member of the F-box protein family
            which is characterized by an approximately 40 amino acid motif, the
            F-box. The F-box proteins constitute one of the four subunits of
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbls class and, in addition to an F-box, contains at least six
            highly degenerated leucine-rich repeats. This family member plays a
            role in epigenetic silencing. It nucleates at CpG islands and
            specifically demethylates both mono- and di-methylated lysine-36 of
            histone H3. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064360.1, AB023221.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000529006.7/ ENSP00000432786.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AP000729.4         126845-126850
            7-591               BC047486.1         3-587
            592-1922            BC064360.1         1-1331
            1923-1923           AP001885.4         81680-81680
            1924-5666           BC064360.1         1333-5075
            5667-6974           AF179221.1         2800-4107
            6975-7368           AP001885.4         111219-111612
            7369-7386           BE675843.1         14-31               c
FEATURES             Location/Qualifiers
     source          1..7386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..7386
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="lysine demethylase 2A"
                     /db_xref="GeneID:22992"
                     /db_xref="HGNC:HGNC:13606"
                     /db_xref="MIM:605657"
     exon            1..787
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            788..912
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     CDS             871..4359
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /EC_number="1.14.11.27"
                     /note="isoform a is encoded by transcript variant 1;
                     jumonji C domain-containing histone demethylase 1A; F-box
                     and leucine-rich repeat protein 11; lysine-specific
                     demethylase 2A; F-box/LRR-repeat protein 11; CXXC-type
                     zinc finger protein 8; lysine (K)-specific demethylase 2A;
                     [Histone-H3]-lysine-36 demethylase 1A; jmjC
                     domain-containing histone demethylation protein 1A"
                     /codon_start=1
                     /product="lysine-specific demethylase 2A isoform a"
                     /protein_id="NP_036440.1"
                     /db_xref="CCDS:CCDS44657.1"
                     /db_xref="GeneID:22992"
                     /db_xref="HGNC:HGNC:13606"
                     /db_xref="MIM:605657"
                     /translation="MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKL
                     HTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCV
                     GSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRP
                     STVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGT
                     SVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTF
                     VIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCW
                     YVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVL
                     TSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
                     VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLAL
                     TGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARR
                     RRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCG
                     EVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSE
                     KAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSS
                     PGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSY
                     LTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGE
                     EEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECM
                     RVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWL
                     VNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKP
                     GQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAV
                     GSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHFISDLSI
                     NSLYCLSDEKLIQKIS"
     exon            913..1051
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1130
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1177
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1356
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1463
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1557
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1711
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1827
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1954
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2349
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2433
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2703
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2835
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2925
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3638
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3802
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3961
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4177
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..7386
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6947..6952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="hexamer: AATAAA"
     polyA_site      6977
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="major polyA site"
     regulatory      7264..7269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="hexamer: AATAAA"
     polyA_site      7289
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
     regulatory      7362..7367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="hexamer: AATAAA"
     polyA_site      7386
                     /gene="KDM2A"
                     /gene_synonym="CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA"
                     /note="major polyA site"
ORIGIN      
        1 atgtgagagt ctgacgggtt caaaatggcg gcggctgctt cagcggctcc tcctgtgtga
       61 gggaaacaac acccctcccc ggcagcggcg gcggcggcgg cggctctcgg agcaccttcc
      121 cagcggctgg gcccgtggcc gctctgtctt tcctgggcag gggacgctcc gggaggaggg
      181 gcaacgccag ggggcccatc ccccggaatc cctcttctgc gactggggag tagccggggg
      241 gctcgtcccg cagcgcggag ccagacctga gggggagacg cgaggggagc cagggccccc
      301 atcccggcgc gccgcgccgc tcccgccctg tccgcccccc ggggccgggg cccgcgttcc
      361 ggggggccgg ggcggcgcgg ggagcctcgg gccggccggt ctcagctgat cggccgctgc
      421 tcccgcaggc gaccagcccc tgctggccga gggcacggcg aggagggcgc tccctgcggc
      481 cggggccggc ccggggctcg ggcccgggct gctgaccgct ggcctggggg aggcgggggc
      541 gccccgggct cggcgccgag gggtcgcgct cctctctcct gacgcctccg actcccggtc
      601 tccaaagcca gaagagaagg tttgattcag caactgtttg ctcccttttc ctggtcgctc
      661 tgaccctctc tggatactgg gttgatccac ggaaaaaccg aagacgacgt ttgggattta
      721 attattcctc tcagctttgg aatcttttac ttctcacttg gacaagaact caagagcaga
      781 atctccgtgt tgcaatctgg ttcctaagga ggaagaggaa ggcagccctg gagtggtttc
      841 tttacagtaa tttcaacaga agagtgagag atggaacccg aagaagaaag gattcgttac
      901 agccagagat tgcgtggtac catgcgacga cgctatgaag atgatggcat ttcagatgat
      961 gaaattgaag gaaaaagaac ttttgacttg gaagagaaac tgcacaccaa caaatataat
     1021 gccaattttg ttacttttat ggaaggaaaa gattttaatg tagagtatat tcagcggggt
     1081 ggcttgagag atcctctgat tttcaagaat tctgatggac tcggaataaa aatgccggat
     1141 ccagacttca ctgtgaatga tgtcaaaatg tgtgtgggga gtcgtcgcat ggtggatgtc
     1201 atggacgtga acacacagaa aggcattgaa atgaccatgg ctcagtggac acgctactat
     1261 gagaccccag aggaggagcg agagaaactc tataatgtca tcagcctcga gtttagccac
     1321 accaggctgg agaatatggt gcagaggccc tccacggtgg atttcattga ctgggtagac
     1381 aacatgtggc caaggcactt gaaggaaagc cagactgaat caacaaatgc catcttggag
     1441 atgcagtacc ctaaagtgca gaagtactgt ctaatgagtg ttcgaggctg ctatactgac
     1501 ttccatgtgg actttggtgg tacctctgtt tggtatcaca tccatcaagg gggaaaggtc
     1561 ttctggctca tcccccctac agcccacaac ctggagctgt acgagaattg gctgctgtca
     1621 gggaaacagg gagacatctt tctgggtgac cgggtatcag attgtcagcg cattgagctc
     1681 aagcagggct ataccttcgt cattccctca ggctggattc atgctgtgta tactcctaca
     1741 gacacattag tgtttggggg caattttttg catagcttca acatccctat gcagttaaaa
     1801 atatacaaca ttgaagatcg gacacgggtt ccaaataagt ttcgctatcc attctactat
     1861 gagatgtgtt ggtatgtgtt ggagcgctat gtgtactgca taaccaaccg ttcccaccta
     1921 actaaggaat ttcagaaaga gtccctcagc atggatttgg agttaaatgg gttggagtct
     1981 gggaatgggg atgaggaagc agtggatcga gaaccccgac gcttgagcag caggcgttct
     2041 gtcctcacta gccctgtagc gaatggagtc aacctggatt atgatggact gggcaaaacc
     2101 tgccgaagtc ttccaagtct gaagaaaact ttggctgggg actcatcttc tgactgtagc
     2161 cggggctccc acaatggaca agtgtgggat ccccagtgtg ctccccgaaa ggacaggcaa
     2221 gtgcatctga cccattttga gcttgaaggc cttcgctgcc ttgtagataa gttggagtct
     2281 ctgccactgc acaagaaatg tgtccccaca gggatagaag atgaagatgc tctcattgct
     2341 gatgtaaaga ttttgctgga ggagcttgcc aacagcgatc ccaagttagc cctcactgga
     2401 gttcctatag tacagtggcc aaaaagggat aagcttaaat tccccactcg gccaaaggtg
     2461 cgggttccta ccatccccat tacgaagcct cacactatga aaccagctcc acggttaaca
     2521 cctgtgaggc cagctgctgc ctccccgatt gtgtcaggag ccagacggag acgagtgcga
     2581 tgtcgaaaat gcaaagcctg tgtgcaagga gagtgtggtg tttgccacta ctgcagagac
     2641 atgaagaagt ttggggggcc tggacgcatg aagcagtcct gtgtcctccg acagtgcttg
     2701 gcacccagac tgcctcactc agtcacatgt tccctctgtg gagaggtgga tcagaatgaa
     2761 gagacacaag actttgagaa gaaactcatg gaatgctgta tctgcaatga gattgttcat
     2821 cctggctgcc tccagatgga cggagagggg ttgcttaacg aagaattgcc aaattgctgg
     2881 gaatgtccaa agtgctacca ggaggacagc tcggagaaag cccagaagcg gaaaatggaa
     2941 gagagtgacg aagaagctgt gcaagccaaa gtcctgcggc ccctgcggag ctgcgatgag
     3001 cctctcacgc ccccgcctca ttcacccact tccatgctgc agctcatcca tgacccggtt
     3061 tccccccggg gtatggtgac tcggtcatcc cctggggctg gccccagcga ccaccacagt
     3121 gccagccgcg atgagcgctt caaacggcgg cagttgctgc ggctgcaggc cacagagcgc
     3181 accatggtac gggaaaagga gaacaatccc agcggcaaaa aggagctgtc tgaagttgag
     3241 aaagccaaga tccggggatc gtacctcact gtcacgctac agaggcccac caaagagctc
     3301 cacgggacat ccattgtgcc caagctgcag gccatcacgg cctcctctgc caaccttcgc
     3361 cattcccccc gtgtgctagt gcagcactgc ccagcccgaa ccccccagcg tggggatgag
     3421 gaggggctgg ggggagagga ggaggaagag gaggaggagg aggaggaaga tgacagtgca
     3481 gaggaggggg gtgcagccag gctgaatggc cggggcagtt gggctcagga tggagacgaa
     3541 agctggatgc agcgggaggt ctggatgtct gtcttccgct acctcagccg cagagaactt
     3601 tgtgaatgta tgcgagtgtg caagacgtgg tataaatggt gctgcgacaa gagactttgg
     3661 acaaaaattg acttgagtag gtgtaaggcc attgtgcccc aggccctcag tggcatcatc
     3721 aagaggcagc cagtcagcct tgacctcagt tggaccaaca tctctaaaaa gcaactgaca
     3781 tggctcgtca ataggctgcc aggactgaaa gacctcctcc tagcaggctg ctcctggtct
     3841 gcagtctctg ccctcagcac ctccagctgc ccccttctca ggacccttga tcttcggtgg
     3901 gcagtaggaa tcaaggaccc tcaaattcgg gacttgctta ctccaccggc tgataaacca
     3961 ggtcaggaca atcgcagcaa gctccggaac atgaccgact tccggctggc aggccttgac
     4021 atcacagatg ccacgcttcg cctcataatt cgccacatgc ccctcctgtc tcgactcgac
     4081 ctcagtcact gcagccacct tacagatcag tcctccaatc tactcactgc tgtcgggtct
     4141 tccactcgct actctctcac agagctcaat atggcaggtt gcaataaatt gacagaccag
     4201 accctgatct acctacggcg cattgccaac gtcaccttga tcgaccttcg aggatgcaag
     4261 cagatcactc gaaaagcctg cgagcacttc atctcagact tgtccatcaa cagcctctac
     4321 tgcctgtctg acgagaagct gatacagaag atcagctaag acacacccag cccagattca
     4381 acaggaaacc gatcttcccc tgactcccca ccgaggagag cctctcctcg accctgcacg
     4441 ggctctgagg ccagcgtcac actccctctc tgctctcctg tcccttgagc ccttcctcta
     4501 caggtggggc agagagggtg gtggacacca ggcttatctg cctgctcctc tccctcctaa
     4561 ggaaaaggga gtagcagatt gatctgaggg gaaagcacag gctgtgctgt cgaggcgcct
     4621 gctcgcttac tcgcctgcca ggaggccggg ctctcagttt ggggtgtttg tgcaaccttc
     4681 atctgcactg ggccctgtgc ccctcctccc catccatggt ccccagcagt gcctggttct
     4741 gagcaaactc ccagggaaga aaacggccct gtctccatgg ccaggttctt gtggtgtcca
     4801 gtgcgcgtct ctcctccatc acactctccc ggcttgcgca ggaggggcca gcagccccag
     4861 gagtcccaga cccgtgccga tcacactggt gctgttgaga tctcccaaac ctcacgtcct
     4921 taactgtgct ctccctcctt tcctctccct tgagcttggt tctgcccagc actcgtgctt
     4981 gttcacataa ttaggtttcc caccccagcc tacccgactt acttgctagt ctctatgagg
     5041 tccttattgc acttattggg gttgaagctc ttcagaggag ctggaactgt ctaccccagg
     5101 gacacaccca tttcgttgct acccaagtgg attctgagac aggcaccatc tccttgttcc
     5161 ccctctctct tttgcctccc actgactgcc cttttccatg tgtcttcatt ctgcctgaag
     5221 aaggctttcc caggatgcac gtcctcagag ggagcagcct atctccccca agctggaggc
     5281 ggcagaggac tgggccaagc cccaacctgc ctcccagcca ggctcctcca ggcctctggt
     5341 ttagcggagc cccctgagcc caggcctgtg tctagcccca gtggctcact gaactttcag
     5401 ggcagtcagg gggtcctgct tagaagccag tcaccagccc tctgcctgca gccatggaag
     5461 ggggtgtgca cgtgcctctg tgtgtgtggc tgagtgtatt ctgcgcgtgt gtgtggaggg
     5521 agggagggag gggagcatgg tgtctcccgc tccaccgccc tttgttgagc cccatcagct
     5581 gccccctttt actttgcatt gaacggcctg tccaaagatc ctctctctag ggcagcagag
     5641 agctttttgc actttaaaaa aaaaaagaaa gaaagaaagg tcggaatttc ttttgggtca
     5701 atatttttaa gtgtgtgagg agatgctcag tagcagcagc ctatggcaag agcttataaa
     5761 tgattgatgc aaatttgcac tctgctcccc ctctgtaagg atactgatag cacaacctct
     5821 tccccccacc ccgccccgcc ttttggtcgt ccatccctgt ccctttctgg ccctcttcct
     5881 gtagcccagt ctcaggcttt cctcttcctg aagccctaca gagttaggga atggagccca
     5941 ggcaccaggg gtctaaagtg tgagccactg agaagagaga cgccaactgc acccttgcca
     6001 cttccaaagc aatagaggca gagtggtccc ctctttgcca cctaggccag ttttgaccct
     6061 ggcattaact ggccttagaa gaaactggat cctggtaggg ggtggcattt tgtttgtttc
     6121 ttccaatctg ctgaatcttt tgactgcacc ttacaaacag cagtctgctc ccatgaccct
     6181 ctgcccactt ccattggtct ccaggcccca ataatctggg gttgaaactt tgaggaaatg
     6241 ccagtgactt attccagagt gcctcagtta ggggaacttc tctgtaaaga accctgggta
     6301 ttgagcaaaa accttattat cgttaatgac ctataattgg aagcttcctg cctttttctt
     6361 tggttgctcc tgtggaaaat actgaaaaga ttactttgtt ttattttgtt gtctttttat
     6421 aaaaggggag gtggagagac cccttcagag cagggattgt gccgggagag tgcctctgac
     6481 tttgggacat ttcatccaca gaaatttcca agccaatggt ttcttttggg ttttggtttt
     6541 tatgtttgtt ttttggggtt tggaaaaaca tgcattttta ccgtgcacgt aaattggtca
     6601 gcagaaaagg gagcccagaa aaggcagcag atggaccatg cccttgctgg gttttccttt
     6661 tctttgggac tgtgagggga aatggttttt agaggtgagg gttggtccat gtggaggaaa
     6721 gaagtgtctc tgttggggga cagaggaacc tggggagtcc atcgcatgtc ctacaatctg
     6781 ctcttagaca cggccttgcc aggagagcct gccctcagac tgcaggacca gaacccctgc
     6841 ctccatcttt ccaagcaccg gggcgaaaaa ccacaaagga aaggaagaaa atttatatat
     6901 atataatata aaatcacttg gtgattaaaa aaataactgc tccataaata aaactcctaa
     6961 agtcacttat gtttaaaggg tttggttgtg ttttttgttt ttcggagaaa tattgtaaat
     7021 atatattttt ttgttgctga tttagagtca atctccaatg ttgtgctaaa aagtttaaat
     7081 taaatgtaag cattaagggg ataagtctta tgctatctca gttgacacat tgaggttatt
     7141 ttgggccaga gaaggaggaa gctagttgga ctttgttttg ttttccaaaa gttctccact
     7201 attggtttta gagagagcaa ggacatcttt cctctgacac gtgggaatgg gtgatatttg
     7261 tgtaataaaa tttttaaaag acaaaaaaag aaatagcctc caatgggaaa tattttaatt
     7321 taggttttgt ttttgtttgg gggtttttgt ttttttaaaa aaataaaaag gctttaaaaa
     7381 caaaaa
//
