LOCUS       NM_001364614            4538 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens lysine demethylase 1B (KDM1B), transcript variant 1,
            mRNA.
ACCESSION   NM_001364614 XM_005248926
VERSION     NM_001364614.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4538)
  AUTHORS   Yi,M., Lv,S., He,Y., Wu,Y., Zhang,J. and Chen,Q.
  TITLE     CircKDM1B promotes hepatocellular carcinoma progression through
            regulating miR-1322/PRC1 axis
  JOURNAL   Environ Toxicol 38 (8), 2031-2040 (2023)
   PUBMED   37227723
  REMARK    GeneRIF: CircKDM1B promotes hepatocellular carcinoma progression
            through regulating miR-1322/PRC1 axis.
REFERENCE   2  (bases 1 to 4538)
  AUTHORS   Hou,C., Ye,Z., Yang,S., Jiang,Z., Wang,J. and Wang,E.
  TITLE     Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming
            through inducing pluripotent gene expression and promoting cell
            proliferation
  JOURNAL   Exp Cell Res 420 (1), 113339 (2022)
   PUBMED   36075448
  REMARK    GeneRIF: Lysine demethylase 1B (Kdm1b) enhances somatic
            reprogramming through inducing pluripotent gene expression and
            promoting cell proliferation.
REFERENCE   3  (bases 1 to 4538)
  AUTHORS   Malagraba,G., Yarmohammadi,M., Javed,A., Barcelo,C. and
            Rubio-Tomas,T.
  TITLE     The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal
            System: An Update
  JOURNAL   Biomolecules 12 (3), 462 (2022)
   PUBMED   35327654
  REMARK    GeneRIF: The Role of LSD1 and LSD2 in Cancers of the
            Gastrointestinal System: An Update.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4538)
  AUTHORS   Zhang,X., Tian,S., Beese-Sims,S.E., Chen,J., Shin,N.,
            Colaiacovo,M.P. and Kim,H.M.
  TITLE     Histone demethylase AMX-1 is necessary for proper sensitivity to
            interstrand crosslink DNA damage
  JOURNAL   PLoS Genet 17 (7), e1009715 (2021)
   PUBMED   34329293
  REMARK    GeneRIF: Histone demethylase AMX-1 is necessary for proper
            sensitivity to interstrand crosslink DNA damage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4538)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4538)
  AUTHORS   Fang,R., Chen,F., Dong,Z., Hu,D., Barbera,A.J., Clark,E.A.,
            Fang,J., Yang,Y., Mei,P., Rutenberg,M., Li,Z., Zhang,Y., Xu,Y.,
            Yang,H., Wang,P., Simon,M.D., Zhou,Q., Li,J., Marynick,M.P., Li,X.,
            Lu,H., Kaiser,U.B., Kingston,R.E., Xu,Y. and Shi,Y.G.
  TITLE     LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and
            molecular model for regulation of H3K4 demethylation
  JOURNAL   Mol Cell 49 (3), 558-570 (2013)
   PUBMED   23260659
REFERENCE   7  (bases 1 to 4538)
  AUTHORS   Fang,R., Barbera,A.J., Xu,Y., Rutenberg,M., Leonor,T., Bi,Q.,
            Lan,F., Mei,P., Yuan,G.C., Lian,C., Peng,J., Cheng,D., Sui,G.,
            Kaiser,U.B., Shi,Y. and Shi,Y.G.
  TITLE     Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating
            intragenic H3K4me2 methylation
  JOURNAL   Mol Cell 39 (2), 222-233 (2010)
   PUBMED   20670891
  REMARK    GeneRIF: Human LSD2/KDM1b/AOF1 regulates gene transcription by
            modulating intragenic H3K4me2 methylation.
REFERENCE   8  (bases 1 to 4538)
  AUTHORS   Ciccone,D.N., Su,H., Hevi,S., Gay,F., Lei,H., Bajko,J., Xu,G.,
            Li,E. and Chen,T.
  TITLE     KDM1B is a histone H3K4 demethylase required to establish maternal
            genomic imprints
  JOURNAL   Nature 461 (7262), 415-418 (2009)
   PUBMED   19727073
REFERENCE   9  (bases 1 to 4538)
  AUTHORS   Karytinos,A., Forneris,F., Profumo,A., Ciossani,G., Battaglioli,E.,
            Binda,C. and Mattevi,A.
  TITLE     A novel mammalian flavin-dependent histone demethylase
  JOURNAL   J Biol Chem 284 (26), 17775-17782 (2009)
   PUBMED   19407342
REFERENCE   10 (bases 1 to 4538)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589723.7 and AL031774.1.
            
            On or before May 17, 2019 this sequence version replaced
            XM_005248926.2, NM_001364614.1.
            
            Summary: Flavin-dependent histone demethylases, such as KDM1B,
            regulate histone lysine methylation, an epigenetic mark that
            regulates gene expression and chromatin function (Karytinos et al.,
            2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1619476.1,
                                           ERR3218372.563052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650836.2/ ENSP00000499208.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL589723.7         117977-118126
            151-194             AL589723.7         118438-118481
            195-294             AL589723.7         122438-122537
            295-422             AL589723.7         123882-124009
            423-512             AL589723.7         125390-125479
            513-624             AL589723.7         128822-128933
            625-741             AL589723.7         133918-134034
            742-780             AL031774.1         108951-108989       c
            781-991             AL031774.1         106759-106969       c
            992-1176            AL031774.1         103380-103564       c
            1177-1353           AL031774.1         97528-97704         c
            1354-1428           AL031774.1         97100-97174         c
            1429-1566           AL031774.1         94185-94322         c
            1567-1738           AL031774.1         93104-93275         c
            1739-1866           AL031774.1         89097-89224         c
            1867-1998           AL031774.1         87232-87363         c
            1999-2073           AL031774.1         86555-86629         c
            2074-2190           AL031774.1         82157-82273         c
            2191-2316           AL031774.1         80980-81105         c
            2317-2439           AL031774.1         79632-79754         c
            2440-2592           AL031774.1         76876-77028         c
            2593-4538           AL031774.1         70907-72852         c
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..4538
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /note="lysine demethylase 1B"
                     /db_xref="GeneID:221656"
                     /db_xref="HGNC:HGNC:21577"
                     /db_xref="MIM:613081"
     exon            1..150
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..194
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..294
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2676
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /EC_number="1.14.99.66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific histone demethylase 1B; lysine-specific
                     histone demethylase 2; lysine (K)-specific demethylase 1B;
                     flavin-containing amine oxidase domain-containing protein
                     1"
                     /codon_start=1
                     /product="lysine-specific histone demethylase 2 isoform 1"
                     /protein_id="NP_001351543.1"
                     /db_xref="CCDS:CCDS93866.1"
                     /db_xref="GeneID:221656"
                     /db_xref="HGNC:HGNC:21577"
                     /db_xref="MIM:613081"
                     /translation="MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDG
                     GSEKKYRKCEKAGCTATCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRS
                     HKDGYDKYTTWKKIWTSNGKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLT
                     PQIAKTYRCGMKPNTAIKPETSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAP
                     LLSAYYPDCVGMSPSCTSTNRAAATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPN
                     ECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPH
                     IIVRGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYLLPKDYHNKSVIIIGAGP
                     AGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPVALM
                     CEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQDVP
                     LGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFA
                     QFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVL
                     VTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFG
                     HVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLREL
                     FKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATN
                     RHFPQTVTGAYLSGVREASKIAAF"
     exon            295..422
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..512
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..624
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..741
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            742..780
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..991
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1176
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1353
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1428
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1566
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1738
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1866
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1998
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2073
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2190
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2316
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2439
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2592
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..4538
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /note="hexamer: AATAAA"
     polyA_site      4538
                     /gene="KDM1B"
                     /gene_synonym="AOF1; C6orf193; LSD2"
                     /note="major polyA site"
ORIGIN      
        1 gtgacagggg cggaagcggc ggcggcggcg gcggccgaga agaggctggg gctcgcggcg
       61 cggctgcagc cgtcctgtgc gcgcggcgcg cggctccgga gaggcgcccg cagtccaggg
      121 cggcgcgcac cgcctcgctg gcgctcagag cggtgccttt tccccgagac tcccggcacc
      181 tcttcagcgc aaagattatt taatgtaatg gcaactccac gggggaggac aaagaaaaaa
      241 gcatcttttg atcattctcc ggatagcctt cctttgagga gctccggtag gcaggcgaag
      301 aagaaagcaa cagagacaac agatgaggat gaagatggtg gctcagagaa gaagtacagg
      361 aaatgtgaaa aggcaggctg tacggcaaca tgtcctgtgt gctttgcaag tgcttctgaa
      421 agatgtgcca aaaatggcta cacctcccga tggtatcatc tctcctgtgg ggaacatttc
      481 tgtaatgaat gctttgacca ttactacaga agccataagg atggatatga caaatatact
      541 acatggaaaa aaatatggac tagcaatggc aaaaccgaac ctagtcccaa agctttcatg
      601 gcagaccagc aactccccta ctgggttcag tgtacaaaac ctgagtgtag aaaatggagg
      661 cagcttacca aggaaatcca gcttactcca cagatagcca agacttatcg atgcggtatg
      721 aaaccaaata ctgctattaa gcctgagacc tcagatcatt gttccctccc agaggatcta
      781 agagtattgg aagtttccaa ccattggtgg tactctatgc tcatcctacc tcctttgctg
      841 aaagacagtg tggcagcgcc cctgctgtct gcctactacc ctgactgtgt tggcatgagc
      901 ccctcctgca ccagcacaaa ccgcgccgct gccactggca atgccagccc tgggaagctg
      961 gagcactcca aggctgccct ctccgtgcac gttccaggca tgaaccgata cttccagcct
     1021 ttctaccagc ccaatgagtg tggcaaagcc ctctgtgtga ggccggatgt gatggaactg
     1081 gatgagctct atgagtttcc agagtattcc cgagacccca ccatgtacct ggctttgaga
     1141 aacctcatcc tcgcactgtg gtatactaac tgcaaagaag ctcttactcc tcagaaatgt
     1201 attcctcaca tcatcgtccg gggtctcgtg cgtattcgat gcgttcagga agtggagaga
     1261 atactgtatt ttatgaccag aaaaggtctc atcaacactg gagttctcag cgtgggagcc
     1321 gaccagtatc ttctccctaa ggactaccac aataaatcag tcatcattat cggggctggt
     1381 ccagcaggat tagcagctgc taggcaactg cataactttg gaattaaggt gactgtcctg
     1441 gaagccaaag acagaattgg aggccgagtc tgggatgata aatcttttaa aggcgtcaca
     1501 gtgggaagag gagctcagat tgtcaatggg tgtattaaca acccagtagc attaatgtgt
     1561 gaacaacttg gcatcagcat gcataaattt ggagaaagat gtgacttaat tcaggaaggt
     1621 ggaagaataa ctgaccccac tattgacaag cgcatggatt ttcattttaa tgctctcttg
     1681 gatgttgtct ctgagtggag aaaggataag actcagctcc aagatgtccc tttaggagaa
     1741 aagatagaag aaatctacaa ggcatttatt aaggaatctg gtatccaatt cagtgagctg
     1801 gagggacagg tgcttcagtt ccatctcagt aacctggagt acgcctgtgg cagcaacctt
     1861 caccaggtat ctgctcgctc gtgggaccac aatgaattct ttgcccagtt tgctggtgac
     1921 cacactctgc taactcccgg gtactcggtg ataattgaaa aactggcaga agggcttgac
     1981 attcaactca aatctccagt gcagtgtatt gattattctg gagatgaagt gcaggttacc
     2041 actacagatg gcacagggta ttctgcacaa aaggtattag tcactgtacc actggcttta
     2101 ctacagaaag gtgccattca gtttaatcca ccgttgtcag agaagaagat gaaggctatc
     2161 aacagcttag gcgcaggcat cattgaaaag attgccttgc aatttccgta tagattttgg
     2221 gacagtaaag tacaaggggc tgactttttt ggtcacgttc ctcccagtgc cagcaagcga
     2281 gggctttttg ccgtgttcta tgacatggat ccccagaaga agcacagcgt gctgatgtct
     2341 gtgattgccg gggaggctgt cgcatccgtg aggaccctgg atgacaaaca ggtgctgcag
     2401 cagtgcatgg ccacgctccg ggagctgttc aaggagcagg aggtcccaga tcccacaaag
     2461 tattttgtca ctcggtggag cacagaccca tggatccaga tggcatacag ttttgtgaag
     2521 acaggtggaa gtggggaggc ctacgatatc attgctgaag acattcaagg aaccgtcttt
     2581 ttcgctggtg aggcaacaaa caggcatttc ccacaaactg ttacaggggc atatttgagt
     2641 ggcgttcgag aagcaagcaa gattgcagca ttttaagaat tcggtggacc cagctttctt
     2701 ctgtacccca gatggggaaa tttgaatcac atgttaaacc tcagttttat aagaggggga
     2761 aaaaaccgtc tctacatagt aaaactgaaa tgtttctaag gcgatatgat aatgcaaacc
     2821 tatttcatca ctctaaaagc actgacctca aaaaacctta taagcactta gatttaattg
     2881 cattttccat aggttcaact actgctgaaa gtctggattt cagaataaag cagaatgtaa
     2941 gtttcagttg aggccatgga tttgattgtt ccatggctgg aagttccctt tagatttcac
     3001 attttatatg gctgatcaat tttcatacat tgagaaacca agtcaatcaa gcaggaatca
     3061 tttaaaaacc agataaagcc atgtttttct tctgtgacaa tttatcagta tctttaccaa
     3121 tgagccttaa tttttatata ggtccaatat tgagctttta cttaaaattt agatagaact
     3181 tttttttgga tacagcacaa actccagttg acagtaaaat gaagcttcta ggtattttgt
     3241 attgtacata tttcctccta ctgggtgttc aaaagaaatt taaattcaag taccttttgt
     3301 gataaaatgt tttagatttg tgcacccatt ggcaaaacag gaaagtttcc agataggtat
     3361 tgtatcattg agaatgcagc acagatagtg tgggcttcac actatagaca cagaatatag
     3421 ctttttctta aagccaaatt tgggtgatag gacactttaa atatccttaa ttttggcaac
     3481 cactagcaaa aaaacttgtc agaataattt aaccaagccc ctctccactt cttttattta
     3541 aaagcactga ttcaattgct aggaatattt ttgcagattt ttctttacag tattccatag
     3601 gcaggtccac tggaaaactg cagaaaaatg tgagctctcc tggtaaatag tatacatttt
     3661 ataagctata ttttaaaggc ctaagaacat ggcaagtatt tacttttatc ttttttttaa
     3721 aaacactcat gacagaaaac agtttaataa tatctcattc taaaataaaa cactggttgc
     3781 agggtcttca ggatgcctat tttgccaaga aacttcagta tacaggttag aaatatgctt
     3841 ttgtttttga acaataatat actggtttgc tttaaagaag ggactaaata tgactttaaa
     3901 gagacttcaa aatattgagt attttaaaaa tttaaaagta ggtcagttta taacgagtaa
     3961 atacctaaca caccaagaat gtgcagtgaa cctcaggcat ttaagacacc tcccccaccg
     4021 cccgcccccc gcccccccca atcaaagtgt ggtcccaaaa caagccaaca gctgtatatc
     4081 tcaaaagtta acccaagaca actctgatat ttaggttatt tgttgagact cattggtact
     4141 gactggcaag tattctgctt taaagtatca tgtattaaaa tgtttagaca gcatgtgttt
     4201 taaagtgata aatgcaaaat gttaagtttg aaatggttaa cagtaaatta ttatgttagt
     4261 ttccaggcac ttgaactgtg ctacaagtag gggaaaacct actttaaagt atggtaaatg
     4321 tgtgttttaa acttcctatc aagtgacata cttcatttga ttttttgttt aagaagccat
     4381 ggtacttttt tcttgagtta ctttggatat gttttttcaa tgccatctga agattttgta
     4441 attgagtagc agtaaatata cagatttaca atgttttaac tacagttcat gaatagctgg
     4501 ttgtgtaaaa ctaataaaaa actagacttt cacatgta
//
