LOCUS       NP_001009999             876 aa            linear   PRI 26-OCT-2024
DEFINITION  lysine-specific histone demethylase 1A isoform a [Homo sapiens].
ACCESSION   NP_001009999
VERSION     NP_001009999.1
DBSOURCE    REFSEQ: accession NM_001009999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 876)
  AUTHORS   Liu,Y., Chen,Y., Batzorig,U., Li,J., Fernandez-Mendez,C.,
            Mahapatra,S., Li,F., Sam,S., Dokoshi,T., Hong,S.P., Nakatsuji,T.,
            Gallo,R.L. and Sen,G.L.
  TITLE     The transcription regulators ZNF750 and LSD1/KDM1A dampen
            inflammation on the skin's surface by silencing pattern recognition
            receptors
  JOURNAL   Immunity 57 (10), 2296-2309 (2024)
   PUBMED   39353440
  REMARK    GeneRIF: The transcription regulators ZNF750 and LSD1/KDM1A dampen
            inflammation on the skin's surface by silencing pattern recognition
            receptors.
REFERENCE   2  (residues 1 to 876)
  AUTHORS   Zhang,N., Chen,Z., Xin,B., Shi,Y., Yao,Y., Yang,J., Wang,X. and
            Hu,X.
  TITLE     LSD1 inhibits the invasion and migration of breast cancer through
            exosomes
  JOURNAL   Sci Rep 14 (1), 20817 (2024)
   PUBMED   39242625
  REMARK    GeneRIF: LSD1 inhibits the invasion and migration of breast cancer
            through exosomes.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 876)
  AUTHORS   Zhao,Y., Zheng,Y., Fu,J., Zhang,J., Shao,H., Liu,S., Lai,J.,
            Zhou,X., Liang,R., Jia,L., Cui,W., Yang,J., Wu,C. and Wang,L.
  TITLE     KDM1A, a potent and selective target, for the treatment of
            DNMT3A-deficient non-small cell lung cancer
  JOURNAL   Br J Cancer 131 (4), 655-667 (2024)
   PUBMED   38951697
  REMARK    GeneRIF: KDM1A, a potent and selective target, for the treatment of
            DNMT3A-deficient non-small cell lung cancer.
REFERENCE   4  (residues 1 to 876)
  AUTHORS   Jing,T., Wei,D., Xu,X., Wu,C., Yuan,L., Huang,Y., Liu,Y., Jiang,Y.
            and Wang,B.
  TITLE     Transposable elements-mediated recruitment of KDM1A epigenetically
            silences HNF4A expression to promote hepatocellular carcinoma
  JOURNAL   Nat Commun 15 (1), 5631 (2024)
   PUBMED   38965210
  REMARK    GeneRIF: Transposable elements-mediated recruitment of KDM1A
            epigenetically silences HNF4A expression to promote hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 876)
  AUTHORS   Venhuizen,J., van Bergen,M.G.J.M., Bergevoet,S.M., Gilissen,D.,
            Spruijt,C.G., Wingens,L., van den Akker,E., Vermeulen,M.,
            Jansen,J.H., Martens,J.H.A. and van der Reijden,B.A.
  TITLE     GFI1B and LSD1 repress myeloid traits during megakaryocyte
            differentiation
  JOURNAL   Commun Biol 7 (1), 374 (2024)
   PUBMED   38548886
  REMARK    GeneRIF: GFI1B and LSD1 repress myeloid traits during megakaryocyte
            differentiation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 876)
  AUTHORS   Lee,M.G., Wynder,C., Cooch,N. and Shiekhattar,R.
  TITLE     An essential role for CoREST in nucleosomal histone 3 lysine 4
            demethylation
  JOURNAL   Nature 437 (7057), 432-435 (2005)
   PUBMED   16079794
  REMARK    GeneRIF: nucleosomal demethylation is the result of CoREST
            enhancing the association between BHC110 and nucleosomes
REFERENCE   7  (residues 1 to 876)
  AUTHORS   Forneris,F., Binda,C., Vanoni,M.A., Mattevi,A. and Battaglioli,E.
  TITLE     Histone demethylation catalysed by LSD1 is a flavin-dependent
            oxidative process
  JOURNAL   FEBS Lett 579 (10), 2203-2207 (2005)
   PUBMED   15811342
  REMARK    GeneRIF: in vivo LSD1 might not necessarily function as an oxidase,
            but it might use alternative electron acceptors
REFERENCE   8  (residues 1 to 876)
  AUTHORS   Shi,Y., Lan,F., Matson,C., Mulligan,P., Whetstine,J.R., Cole,P.A.,
            Casero,R.A. and Shi,Y.
  TITLE     Histone demethylation mediated by the nuclear amine oxidase homolog
            LSD1
  JOURNAL   Cell 119 (7), 941-953 (2004)
   PUBMED   15620353
  REMARK    GeneRIF: results thus identify a histone demethylase conserved from
            S. pombe to human and reveal dynamic regulation of histone
            methylation by both histone methylases and demethylases
REFERENCE   9  (residues 1 to 876)
  AUTHORS   Hakimi,M.A., Dong,Y., Lane,W.S., Speicher,D.W. and Shiekhattar,R.
  TITLE     A candidate X-linked mental retardation gene is a component of a
            new family of histone deacetylase-containing complexes
  JOURNAL   J Biol Chem 278 (9), 7234-7239 (2003)
   PUBMED   12493763
REFERENCE   10 (residues 1 to 876)
  AUTHORS   Hakimi,M.A., Bochar,D.A., Chenoweth,J., Lane,W.S., Mandel,G. and
            Shiekhattar,R.
  TITLE     A core-BRAF35 complex containing histone deacetylase mediates
            repression of neuronal-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7420-7425 (2002)
   PUBMED   12032298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG717076.1, BC048134.1,
            BC040194.2 and BC025362.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a nuclear protein containing a SWIRM
            domain, a FAD-binding motif, and an amine oxidase domain. This
            protein is a component of several histone deacetylase complexes,
            though it silences genes by functioning as a histone demethylase.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.236503.1,
                                           SRR1803612.147078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400181.9/ ENSP00000383042.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     Protein         1..876
                     /product="lysine-specific histone demethylase 1A isoform
                     a"
                     /EC_number="1.14.99.66"
                     /note="amine oxidase (flavin containing) domain 2;
                     FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit;
                     BRAF35-HDAC complex protein BHC110; lysine-specific
                     histone demethylase 1; flavin-containing amine oxidase
                     domain-containing protein 2; lysine (K)-specific
                     demethylase 1A; [histone H3]-dimethyl-L-lysine(4)
                     FAD-dependent demethylase 1A"
                     /calculated_mol_wt=95024
     Region          <23..>98
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          203..849
                     /region_name="PLN02328"
                     /note="lysine-specific histone demethylase 1 homolog"
                     /db_xref="CDD:215187"
     CDS             1..876
                     /gene="KDM1A"
                     /gene_synonym="AIMAH3; AOF2; BHC110; CPRF; KDM1; LSD1"
                     /coded_by="NM_001009999.3:130..2760"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS53278.1"
                     /db_xref="GeneID:23028"
                     /db_xref="HGNC:HGNC:29079"
                     /db_xref="MIM:609132"
ORIGIN      
        1 mlsgkkaaaa aaaaaaaatg teagpgtagg sengsevaaq paglsgpaev gpgavgertp
       61 rkkepprasp pgglaeppgs agpqagptvv pgsatpmetg iaetpegrrt srrkrakvey
      121 remdeslanl sedeyyseee rnakaekekk lpppppqapp eeenesepee psgqagglqd
      181 dssggygdgq asgvegaafq srlphdrmts qeaacfpdii sgpqqtqkvf lfirnrtlql
      241 wldnpkiqlt featlqqlea pynsdtvlvh rvhsylerhg linfgiykri kplptkktgk
      301 viiigsgvsg laaarqlqsf gmdvtllear drvggrvatf rkgnyvadlg amvvtglggn
      361 pmavvskqvn melakikqkc plyeangqad tvkvpkekde mveqefnrll eatsylshql
      421 dfnvlnnkpv slgqalevvi qlqekhvkde qiehwkkivk tqeelkelln kmvnlkekik
      481 elhqqykeas evkpprdita eflvkskhrd ltalckeyde laetqgklee klqeleanpp
      541 sdvylssrdr qildwhfanl efanatplst lslkhwdqdd dfeftgshlt vrngyscvpv
      601 alaegldikl ntavrqvryt asgceviavn trstsqtfiy kcdavlctlp lgvlkqqppa
      661 vqfvpplpew ktsavqrmgf gnlnkvvlcf drvfwdpsvn lfghvgstta srgelflfwn
      721 lykapillal vageaagime nisddvivgr clailkgifg ssavpqpket vvsrwradpw
      781 argsysyvaa gssgndydlm aqpitpgpsi pgapqpiprl ffagehtirn ypatvhgall
      841 sglreagria dqflgamytl prqatpgvpa qqspsm
//
