LOCUS       NM_006801               1550 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens KDEL endoplasmic reticulum protein retention receptor
            1 (KDELR1), mRNA.
ACCESSION   NM_006801
VERSION     NM_006801.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Jia,J., Yue,X., Zhu,L., Jing,S., Wang,Y., Gim,B., Qian,Y. and
            Lee,I.
  TITLE     KDEL receptor is a cell surface receptor that cycles between the
            plasma membrane and the Golgi via clathrin-mediated transport
            carriers
  JOURNAL   Cell Mol Life Sci 78 (3), 1085-1100 (2021)
   PUBMED   32562023
  REMARK    GeneRIF: KDEL receptor is a cell surface receptor that cycles
            between the plasma membrane and the Golgi via clathrin-mediated
            transport carriers.
REFERENCE   2  (bases 1 to 1550)
  AUTHORS   Bauer,A., Santen,L., Schmitt,M.J., Shaebani,M.R. and Becker,B.
  TITLE     Cell-type-specific differences in KDEL receptor clustering in
            mammalian cells
  JOURNAL   PLoS One 15 (7), e0235864 (2020)
   PUBMED   32645101
  REMARK    GeneRIF: Cell-type-specific differences in KDEL receptor clustering
            in mammalian cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1550)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1550)
  AUTHORS   Blum,A., Khalifa,S., Nordstrom,K., Simon,M., Schulz,M.H. and
            Schmitt,M.J.
  TITLE     Transcriptomics of a KDELR1 knockout cell line reveals modulated
            cell adhesion properties
  JOURNAL   Sci Rep 9 (1), 10611 (2019)
   PUBMED   31337861
  REMARK    GeneRIF: Transcriptomics of a KDELR1 knockout cell line reveals
            modulated cell adhesion properties.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1550)
  AUTHORS   Bartels,A.K., Gottert,S., Desel,C., Schafer,M., Krossa,S.,
            Scheidig,A.J., Grotzinger,J. and Lorenzen,I.
  TITLE     KDEL Receptor 1 Contributes to Cell Surface Association of Protein
            Disulfide Isomerases
  JOURNAL   Cell Physiol Biochem 52 (4), 850-868 (2019)
   PUBMED   30958660
  REMARK    GeneRIF: The cell surface trafficking of PDIA1, PDIA3, and PDIA6 is
            dependent on KDELR1, which travels in a dynamic manner to the cell
            surface. This transport is assumed to result in PDI cell surface
            association, which differs from PDI inducible secretion into the
            extracellular space.
REFERENCE   6  (bases 1 to 1550)
  AUTHORS   Aoe,T., Cukierman,E., Lee,A., Cassel,D., Peters,P.J. and Hsu,V.W.
  TITLE     The KDEL receptor, ERD2, regulates intracellular traffic by
            recruiting a GTPase-activating protein for ARF1
  JOURNAL   EMBO J 16 (24), 7305-7316 (1997)
   PUBMED   9405360
REFERENCE   7  (bases 1 to 1550)
  AUTHORS   Pelham,H.R.
  TITLE     The dynamic organisation of the secretory pathway
  JOURNAL   Cell Struct Funct 21 (5), 413-419 (1996)
   PUBMED   9118249
  REMARK    Review article
REFERENCE   8  (bases 1 to 1550)
  AUTHORS   Townsley,F.M., Wilson,D.W. and Pelham,H.R.
  TITLE     Mutational analysis of the human KDEL receptor: distinct structural
            requirements for Golgi retention, ligand binding and retrograde
            transport
  JOURNAL   EMBO J 12 (7), 2821-2829 (1993)
   PUBMED   8392934
REFERENCE   9  (bases 1 to 1550)
  AUTHORS   Lewis,M.J. and Pelham,H.R.
  TITLE     Ligand-induced redistribution of a human KDEL receptor from the
            Golgi complex to the endoplasmic reticulum
  JOURNAL   Cell 68 (2), 353-364 (1992)
   PUBMED   1310258
REFERENCE   10 (bases 1 to 1550)
  AUTHORS   Lewis,M.J. and Pelham,H.R.
  TITLE     A human homologue of the yeast HDEL receptor
  JOURNAL   Nature 348 (6297), 162-163 (1990)
   PUBMED   2172835
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018778.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006801.2.
            
            Summary: Retention of resident soluble proteins in the lumen of the
            endoplasmic reticulum (ER) is achieved in both yeast and animal
            cells by their continual retrieval from the cis-Golgi, or a
            pre-Golgi compartment. Sorting of these proteins is dependent on a
            C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
            animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
            process is mediated by a receptor that recognizes, and binds the
            tetrapeptide-containing protein, and returns it to the ER. In
            yeast, the sorting receptor encoded by a single gene, ERD2, which
            is a seven-transmembrane protein. Unlike yeast, several human
            homologs of the ERD2 gene, constituting the KDEL receptor gene
            family, have been described. The protein encoded by this gene was
            the first member of the family to be identified, and it encodes a
            protein structurally and functionally similar to the yeast ERD2
            gene product. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.712212.1, BC018778.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330720.7/ ENSP00000329471.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1550              BC018778.1         3-1552
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1550
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /note="KDEL endoplasmic reticulum protein retention
                     receptor 1"
                     /db_xref="GeneID:10945"
                     /db_xref="HGNC:HGNC:6304"
                     /db_xref="MIM:131235"
     exon            1..284
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..832
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /note="KDEL receptor 1; putative MAPK-activating protein
                     PM23; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein
                     retention receptor 1"
                     /codon_start=1
                     /product="ER lumen protein-retaining receptor 1"
                     /protein_id="NP_006792.1"
                     /db_xref="CCDS:CCDS12718.1"
                     /db_xref="GeneID:10945"
                     /db_xref="HGNC:HGNC:6304"
                     /db_xref="MIM:131235"
                     /translation="MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVF
                     TARYLDLFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVVPT
                     AILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSHYLFALGVYRT
                     LYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSLPA"
     exon            285..385
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /inference="alignment:Splign:2.1.0"
     exon            386..544
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /inference="alignment:Splign:2.1.0"
     exon            545..797
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1550
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1530..1535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /note="hexamer: AATAAA"
     polyA_site      1550
                     /gene="KDELR1"
                     /gene_synonym="ERD2; ERD2.1; HDEL; PM23"
                     /note="major polyA site"
ORIGIN      
        1 cttcccggct ccagctccgc cgccagctcc agcctttgct ccccctccca aagtcccctc
       61 cccggagcgg agcgcaccta gggtccctct tccgtccccc cagcccagct acccgttcag
      121 accagcagcc tcggggggca cccccccgcc agcctgcctc cctcccgctc agccctgcca
      181 gggttcccca gccatgaatc tcttccgatt cctgggagac ctctcccacc tcctcgccat
      241 catcttgcta ctgctcaaaa tctggaagtc ccgctcgtgc gccggaattt cagggaagag
      301 ccaggtcctg tttgctgtgg tgttcactgc ccgatatctg gacctcttca ccaactacat
      361 ctcactctac aacacgtgta tgaaggtggt ctacatagcc tgctccttca ccacggtctg
      421 gttgatttat agcaagttca aagctactta cgatgggaac catgacacgt tcagagtgga
      481 gttcctggtc gttcccacag ccattctggc gttcctggtc aatcatgact tcacccctct
      541 ggagatcctc tggaccttct ccatctacct ggagtcagtg gccatcttgc cgcagctgtt
      601 catggtgagc aagaccggcg aggcggagac catcaccagc cactacttgt ttgcgctagg
      661 cgtttaccgc acgctctatc tcttcaactg gatctggcgc taccatttcg agggcttctt
      721 cgacctcatc gccattgtgg caggcctggt ccagacagtc ctctactgcg atttcttcta
      781 cctctatatc accaaagtcc taaaggggaa gaagttgagt ttgccggcat agccccggtc
      841 ctctccatct ctctcctcgg cagcagcggg aggcagagga aggcggcaga agatgaagag
      901 ctttcccatc caggggtgac ttttttaaga acccacctct tgtgctcccc atcccgcctc
      961 ctgccgggtt tcagggggac agtggaggat ccaggtcttg gggagctcag gacttgggct
     1021 gtttgtagtt ttttgccttt tagacaagaa aaaaaaatct ttccactctt tagtttttga
     1081 ttctgatgac tcgtttttct tctactctgt ggccccaatt tttataaagt gtttttgagt
     1141 gtcctatggg ccggggcagg gtccaagatc ttttcccttc cccaggcccc tcggctccct
     1201 cccagatccc acccccagcc ccactggttg ccaaacacta aatctgccga cacccatctg
     1261 ccccacctcc tgccatggcc atgaaccgcg acccccacta aatttctaga ttggggatag
     1321 ggagaaaggg aggcccagga aggtctcccc tgattttttt tcatagtaat ttttttcccc
     1381 agagtttgaa ttttttggtc ttctcctggt tttttggcaa attagggggg cccggggctc
     1441 aagtgcggga agggggctgg cccgaggatc ccatggctct cacaccatgt ttttgtacag
     1501 aactgatggt tgaatctttg ttctcttgaa ataaacagaa gaaaatgaaa
//
