LOCUS       NM_198353               2595 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 8
            (KCTD8), mRNA.
ACCESSION   NM_198353
VERSION     NM_198353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Zhou,J., Zhang,M., Gao,A., Herman,J.G. and Guo,M.
  TITLE     Epigenetic silencing of KCTD8 promotes hepatocellular carcinoma
            growth by activating PI3K/AKT signaling
  JOURNAL   Epigenomics 16 (13), 929-944 (2024)
   PUBMED   39023358
  REMARK    GeneRIF: Epigenetic silencing of KCTD8 promotes hepatocellular
            carcinoma growth by activating PI3K/AKT signaling.
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Faryna,M., Konermann,C., Aulmann,S., Bermejo,J.L., Brugger,M.,
            Diederichs,S., Rom,J., Weichenhan,D., Claus,R., Rehli,M.,
            Schirmacher,P., Sinn,H.P., Plass,C. and Gerhauser,C.
  TITLE     Genome-wide methylation screen in low-grade breast cancer
            identifies novel epigenetically altered genes as potential
            biomarkers for tumor diagnosis
  JOURNAL   FASEB J 26 (12), 4937-4950 (2012)
   PUBMED   22930747
  REMARK    GeneRIF: Data indicate that median methylation levels of BCAN,
            HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30%
            higher than in normal samples, representing potential biomarkers
            for tumor diagnosis.
REFERENCE   5  (bases 1 to 2595)
  AUTHORS   Paus,T., Bernard,M., Chakravarty,M.M., Davey Smith,G., Gillis,J.,
            Lourdusamy,A., Melka,M.G., Leonard,G., Pavlidis,P., Perron,M.,
            Pike,G.B., Richer,L., Schumann,G., Timpson,N., Toro,R.,
            Veillette,S. and Pausova,Z.
  TITLE     KCTD8 gene and brain growth in adverse intrauterine environment: a
            genome-wide association study
  JOURNAL   Cereb Cortex 22 (11), 2634-2642 (2012)
   PUBMED   22156575
  REMARK    GeneRIF: KCTD8 might modulate adverse effects of smoking during
            pregnancy on brain development via apoptosis triggered by low
            intracellular levels of potassium, possibly reducing the number of
            progenitor cells
REFERENCE   6  (bases 1 to 2595)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   7  (bases 1 to 2595)
  AUTHORS   Athanasiadis,G., Buil,A., Souto,J.C., Borrell,M., Lopez,S.,
            Martinez-Perez,A., Lathrop,M., Fontcuberta,J., Almasy,L. and
            Soria,J.M.
  TITLE     A genome-wide association study of the Protein C anticoagulant
            pathway
  JOURNAL   PLoS One 6 (12), e29168 (2011)
   PUBMED   22216198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131951.1, AK123347.1 and DB561746.2.
            
            On Nov 23, 2018 this sequence version replaced NM_198353.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.737578.1, AK123347.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360029.4/ ENSP00000353129.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC131951.1         106009-106010       c
            3-2242              AK123347.1         1-2240
            2243-2595           DB561746.2         364-716
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p13"
     gene            1..2595
                     /gene="KCTD8"
                     /note="potassium channel tetramerization domain containing
                     8"
                     /db_xref="GeneID:386617"
                     /db_xref="HGNC:HGNC:22394"
                     /db_xref="MIM:618442"
     exon            1..1247
                     /gene="KCTD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1708
                     /gene="KCTD8"
                     /note="potassium channel tetramerisation domain containing
                     8"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD8"
                     /protein_id="NP_938167.1"
                     /db_xref="CCDS:CCDS3467.1"
                     /db_xref="GeneID:386617"
                     /db_xref="HGNC:HGNC:22394"
                     /db_xref="MIM:618442"
                     /translation="MALKDTGSGGSTILPISEMVSSSSSPGASAAAAPGPCAPSPFPE
                     VVELNVGGQVYVTKHSTLLSVPDSTLASMFSPSSPRGGARRRGELPRDSRARFFIDRD
                     GFLFRYVLDYLRDKQLALPEHFPEKERLLREAEYFQLTDLVKLLSPKVTKQNSLNDEG
                     CQSDLEDNVSQGSSDALLLRGAAAAVPSGPGAHGGGGGGGAQDKRSGFLTLGYRGSYT
                     TVRDNQADAKFRRVARIMVCGRIALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYL
                     EQAFDRLSEAGFHMVACNSSGTAAFVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHE
                     DRKHDKVTDKGSESGTSCNELSTSSCDSHSEASTPQDNPSSAQQATAHQPNTLTLDRP
                     SKKAPVQWIPPPDKRRNSELFQTLISKSRETNLSKKKVCEKLSVEEEMKKCIQDFKKI
                     HIPDYFPERKRQWQSELLQKYGL"
     exon            1248..2595
                     /gene="KCTD8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2534
                     /gene="KCTD8"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD8"
                     /note="hexamer: AAGAAA"
     polyA_site      2595
                     /gene="KCTD8"
                     /note="major polyA site"
ORIGIN      
        1 acacttcccc gccctcgccc caaaggagca gcagctcctt cttgcctctc cattgccgcc
       61 gccgcaccgg cggagctcct ctctcgcgcg tctctcctcc gatggagctc gggcgccgcc
      121 gacgccgccg ctgccccgaa ccctgagcgg ggccgccccg gtcggaggaa cgcgccgccc
      181 agtccgaggg cgcagagcgc caggagcacg cggagggctg gggcgcgggc tccgggaacg
      241 agaaagtgca gctctctcgg gtcactgggc cggcggcggg gggactatgg ctctgaagga
      301 cacgggcagc ggcggcagca ccatcctgcc cattagcgag atggtttcct cgtccagctc
      361 gcccggcgcg tcggccgccg ccgccccggg gccctgcgca ccctcgccct tccctgaagt
      421 agtggagctg aacgtaggcg gccaggttta tgtgaccaag cactcgacgc tgctcagcgt
      481 cccggacagt actttggcca gcatgttctc gccctctagt ccccgtggcg gcgcccggcg
      541 ccggggcgag ctgcccaggg acagccgggc gcgcttcttc atcgaccggg acggcttcct
      601 tttcaggtac gtgctggatt atctgcggga caagcaactc gcgctgccgg agcacttccc
      661 cgagaaggag cggctgctgc gcgaggccga gtatttccag ctcaccgact tggtcaagct
      721 gctgtcgccc aaggtcacca agcagaactc tctcaacgac gagggctgcc agagcgacct
      781 ggaggacaac gtctcgcagg gtagcagcga cgcgctgctg ctgcgcgggg cggcggccgc
      841 cgtgccctcg ggcccgggag cgcacggtgg tggcggcggc ggcggcgcgc aggacaagcg
      901 ctcgggcttc ctcacgctgg gctaccgggg ctcctacacc accgtgcgcg acaaccaggc
      961 cgacgccaaa ttccggcgtg tggcgcgcat catggtgtgc gggcgcatcg cgctggccaa
     1021 ggaggtcttc ggggacacgc tcaacgagag ccgcgacccc gaccggcagc cggagaagta
     1081 cacgtcccgc ttctacctca agttcaccta cttggagcag gcctttgatc gcctgtccga
     1141 ggccggcttc cacatggtgg cgtgtaactc ctcgggcacc gccgccttcg tcaaccagta
     1201 ccgcgacgac aagatctgga gcagctacac cgagtacatt ttcttccgac cacctcagaa
     1261 aatagtatca cctaaacaag aacatgaaga taggaaacat gacaaagtca ctgataaagg
     1321 aagtgaaagt gggacttcct gtaatgagct ctccacttcc agttgtgaca gccattcaga
     1381 ggcaagcact ccccaggaca acccatccag tgcccagcag gcaacagctc accaacctaa
     1441 cactttaaca ttggatcgcc cctctaaaaa agcacctgta caatggatac ccccaccaga
     1501 caaacgcaga aacagtgaac tctttcagac cctcatcagc aagtcccggg aaacaaatct
     1561 gtccaaaaag aaagtctgtg agaagctaag tgtggaagaa gaaatgaaaa agtgtattca
     1621 ggattttaaa aaaatccaca ttccagatta ttttccagag cgcaaacgcc aatggcaatc
     1681 tgaactgttg cagaagtatg ggttatagta attgtcacat tcctgcagta ttttgatgac
     1741 attcaatgtt tactacagtg tcaccacctg actgatgtcc taacaatggt cagtgtgatt
     1801 cttgctgctc ttccttgttg tgaacagtgg atgtgggaca gtattttctt ttatgtttta
     1861 gttgttgttc tttttagaaa catgattaaa aaggaaaaaa tattaaatca ataagtgtta
     1921 aatcaaaatg gaatatctga ttcaaaccat tttacaagaa tgaaagtaaa atgtgcatga
     1981 tcaagcttag tatcttggtt tttgaactct ggtcaactgg atatgtttgt cattttgtaa
     2041 cttaccaaaa acaaaccatc atatcatacc aactaaaatg atatatggat gaagcaacat
     2101 caagtaaaat tttagacgat ggctatagga cccaaatcta aagctgtcta aatgttaatt
     2161 caatgaaaca agtattattt ttgcatgaat acaatgttac aaataaatca caagaaatag
     2221 ggaagatctg tttgttgctt ggaaagaaaa aaattacaaa aaaaagcaaa aaaaaatgtt
     2281 ttagacaaag cctataaatg taagctgtct aggagattga attttctttg ttctggatct
     2341 gtgacttttt tgtgtatgtg tatggtgttt atgtatatta agatggtgta aatatgcctt
     2401 atactgttat ttatggcatc aacattcatt tactaatgct agtcatgatt attactgtga
     2461 aatgagtctt acatcgggct gtgaaaattg gtataatgat gctttgaaag atcctattat
     2521 catgttaatc aaaataatag agggaaatgg taaagagctt tatgtattta ttaaaaaaag
     2581 aaaaatgtat tagaa
//
